| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ester Mazepa, Elizabeth Sousa Cunha, Hellen Paula Valerio, Paolo Di Mascio, Michel Batista, Fabricio Klerynton Marchini, Willian Vanderlei Meira, Guilhermina Rodrigues Noleto, Sheila Maria Brochado Winnischofer, Glaucia Regina Martine. Unveiling novel targets in melanoma under melanogenesis stimulation and photodynamic therapy by redox proteomics. Photochemistry and photobiology. 2024-07-04. PMID:38961772. |
aconitase was oxidized at cys-448 and cys-451, citrate synthase was oxidized at cys-202 and aspartate aminotransferase (got2) was oxidized at cys-272 and cys-274, exclusively after melanogenesis stimulation. |
2024-07-04 |
2024-07-10 |
Not clear |
| Ruifang Yang, Shuo Cheng, Jie Xiao, Yujie Pei, Zhonglin Zhu, Jifa Zhang, Jing Feng, Jing L. GLS and GOT2 as prognostic biomarkers associated with dendritic cell and immunotherapy response in breast cancer. Heliyon. vol 10. issue 1. 2024-01-18. PMID:38234908. |
in this study, we found that the key factors of glutamine metabolism, glutaminase 1 (gls) and mitochondrial aspartate transaminase (got2), showed opposite expression patterns in breast cancer samples. |
2024-01-18 |
2024-01-20 |
Not clear |
| Yifan Jiang, Chao He, Haokai Ye, Qianhan Xu, Xiuyuan Chen, Ying Chen, Jianying Sun, Sonia Rocha, Mu Wan. Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells. Life science alliance. vol 6. issue 11. 2023-09-08. PMID:37684043. |
further analyses revealed the significance of got2 protein in regulating nucleotide synthesis by providing aspartate, which is critical for the survival and proliferation of pca cells. |
2023-09-08 |
2023-10-07 |
Not clear |
| Brian T Do, Matthew G Vander Heide. GOT2 consider the tumor microenvironment. Trends in cancer. 2022-09-24. PMID:36153305. |
three recent studies find that the pdac tumor microenvironment modulates the functional consequences of depleting the mitochondrially localized aspartate transaminase got2, thus providing new insights into the metabolism of this lethal cancer. |
2022-09-24 |
2023-08-14 |
Not clear |
| Wanyu Jiang, Hongqian Chu, Zekang Li, Jianhong Ge, Xiaoyun Wang, Jianjun Jiang, Qianqian Xiao, Qinghe Meng, Yaxin Lou, Weidong Hao, Xuetao We. Integrated proteomic analysis to explore the molecular regulation mechanism of IL-33 mRNA increased by black carbon in the human endothelial cell line EA.hy926. Environmental toxicology. 2022-07-01. PMID:35776887. |
we identified that bc induced mitochondrial damage and suppressed autophagy function in ea.hy926 cells, as evidenced by elevation of the aspartate aminotransferase (got2), reactive oxygen species (ros) and p62, and the reduction of mitochondrial membrane potential (ΔΨm). |
2022-07-01 |
2023-08-14 |
human |
| Piet Bors. The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway. IUBMB life. vol 72. issue 11. 2021-11-22. PMID:32916028. |
the year 2019 saw the discovery of two new inborn errors in the mas, deficiencies in malate dehydrogenase 1 and in aspartate transaminase 2 (got2). |
2021-11-22 |
2023-08-13 |
Not clear |
| Piet Bors. The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway. IUBMB life. vol 72. issue 11. 2021-11-22. PMID:32916028. |
the mas was initially proposed as a route for the oxidation of cytosolic nadh by the mitochondria in ehrlich ascites cell tumor lacking other routes, and to explain the need for a mitochondrial aspartate aminotransferase (glutamate oxaloacetate transaminase 2 [got2]). |
2021-11-22 |
2023-08-13 |
Not clear |
| Le Qi, Misty S Martin-Sandoval, Salma Merchant, Wen Gu, Matthias Eckhardt, Thomas P Mathews, Zhiyu Zhao, Michalis Agathocleous, Sean J Morriso. Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration. Cell stem cell. vol 28. issue 11. 2021-11-15. PMID:34450065. |
conversely, deletion of got2 reduced aspartate levels and the function of hscs but not colony-forming progenitors. |
2021-11-15 |
2023-08-13 |
mouse |
| Florinda Meléndez-Rodríguez, Andrés A Urrutia, Doriane Lorendeau, Gianmarco Rinaldi, Olga Roche, Nuray Böğürcü-Seidel, Marta Ortega Muelas, Claudia Mesa-Ciller, Guillermo Turiel, Antonio Bouthelier, Pablo Hernansanz-Agustín, Ainara Elorza, Elia Escasany, Qilong Oscar Yang Li, Mar Torres-Capelli, Daniel Tello, Esther Fuertes, Enrique Fraga, Antonio Martínez-Ruiz, Belen Pérez, Jose Miguel Giménez-Bachs, Antonio S Salinas-Sánchez, Till Acker, Ricardo Sánchez Prieto, Sarah-Maria Fendt, Katrien De Bock, Julián Aragoné. HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis. Cell reports. vol 26. issue 9. 2020-04-16. PMID:30811976. |
here, we discovered that hif1α acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic glutamic-oxaloacetic transaminase-1 (got1) and mitochondrial got2. |
2020-04-16 |
2023-08-13 |
human |
| Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zha. Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30714292. |
impairment of this complex results in upregulation of got2, which in turn increases aspartate and alpha ketoglutarate production, leading to rapid cell proliferation of breast cancer cells. |
2019-12-02 |
2023-08-13 |
Not clear |
| Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zha. Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30714292. |
preventing brca1/zbrk1 repressor complex binding to the got2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. |
2019-12-02 |
2023-08-13 |
Not clear |
| Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zha. Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30714292. |
here, we identified several metabolic genes, including the gene which encodes glutamate-oxaloacetate transaminase 2 (got2), a key enzyme for aspartate biosynthesis, which are repressed by brca1. |
2019-12-02 |
2023-08-13 |
Not clear |
| Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zha. Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. Molecular oncology. vol 13. issue 4. 2019-12-02. PMID:30714292. |
in summary, our findings reveal that brca1 modulates aspartate biosynthesis through transcriptional repression of got2, and provides a biological basis for treatment choices in breast cancer. |
2019-12-02 |
2023-08-13 |
Not clear |
| Seungyeon Yang, Sunsook Hwang, Minjoong Kim, Sung Bin Seo, Jeong-Hwa Lee, Seung Min Jeon. Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition. Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352139. |
glutamine deprivation or inhibition of mitochondrial aspartate transaminase (got2) results in a profound induction of senescence and a suppression of pdac growth. |
2019-06-10 |
2023-08-13 |
human |
| O H Minchenko, O O Riabovol, D O Tsymbal, D O Minchenko, O O Ratushn. Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells. Ukrainian biochemical journal. vol 88. issue 3. 2018-01-16. PMID:29235326. |
it was shown that hypoxia down-regulated gene expression of malate dehydrogenase 2 (mdh2), malic enzyme 2 (me2), mitochondrial aspartate aminotransferase (got2), and subunit b of succinate dehydrogenase (sdhb) in control (transfected by empty vector) glioma cells in a gene specific manner. |
2018-01-16 |
2023-08-13 |
Not clear |
| E H Grel. Genetic analysis of aspartate aminotransferase isozymes from hybrids between Drosophila melanogaster and Drosophila simulans and mutagen-induced isozyme variants. Genetics. vol 83. issue 4. 1976-12-03. PMID:823072. |
the aspartate aminotransferases (designated got1 and got2) are two enzymes of drosophila melanogaster for which naturally occurring electrophoretic variants were not found. |
1976-12-03 |
2023-08-11 |
drosophila_melanogaster |