| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daisuke Yabe, Yutaka Sein. Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21820006. |
two incretin hormones glp-1 and gip: comparison of their actions in insulin secretion and β cell preservation. |
2012-09-20 |
2023-08-12 |
Not clear |
| Daisuke Yabe, Yutaka Sein. Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21820006. |
gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (glp-1) are the two primary incretin hormones secreted from the intestine upon ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β cells. |
2012-09-20 |
2023-08-12 |
Not clear |
| Jae-Hyung Park, Yung E Earm, Dae-Kyu Son. Cellular glucose availability and glucagon-like peptide-1. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21907232. |
the major roles of glp-1 in t2d are reduction of appetite, gastric motility, glucagon secretion, enhancement of insulin secretion and β-cell survival. |
2012-09-20 |
2023-08-12 |
Not clear |
| Jae-Hyung Park, Yung E Earm, Dae-Kyu Son. Cellular glucose availability and glucagon-like peptide-1. Progress in biophysics and molecular biology. vol 107. issue 2. 2012-09-20. PMID:21907232. |
for insulin secretion and peripheral insulin function, glp-1 and its mimetics sensitise β-cells to glucose; accelerate blood glucose withdrawal, in-cell glucose utilisation and glycogen synthesis in insulin-sensitive tissues; and assist in the function and survival of neurons mainly using glucose as an energy source. |
2012-09-20 |
2023-08-12 |
Not clear |
| Wendell J Lu, Qing Yang, Li Yang, Dana Lee, David D'Alessio, Patrick Ts. Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP. Lipids. vol 47. issue 6. 2012-09-20. PMID:22297815. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. |
2012-09-20 |
2023-08-12 |
Not clear |
| Marine Grigoryan, Mamdouh H Kedees, Maureen J Charron, Yelena Guz, Gladys Teitelma. Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides. Endocrinology. vol 153. issue 7. 2012-09-20. PMID:22569789. |
glucagon like peptide-1 (glp-1) and glp-2 are hormones secreted by intestinal l cells that stimulate glucose-dependent insulin secretion and regulate intestinal growth, respectively. |
2012-09-20 |
2023-08-12 |
mouse |
| Dirk Eineck. [Basal insulin and GLP-1 agonist potentiate each other (interview by Dr. med Dirk Einecke)]. MMW Fortschritte der Medizin. vol 154. issue 12. 2012-09-20. PMID:22880293. |
[basal insulin and glp-1 agonist potentiate each other (interview by dr. med dirk einecke)]. |
2012-09-20 |
2023-08-12 |
Not clear |
| Elisa Guarino, Laura Nigi, Aurora Patti, Cecilia Fondelli, Francesco Dott. Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus. Expert opinion on pharmacotherapy. vol 13. issue 9. 2012-09-14. PMID:22397507. |
dipeptidyl peptidase-4 (dpp-4) inhibitors are among the most recent additions to the therapeutic options for t2dm and are able to increase circulating levels of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), thus stimulating glucose-dependent insulin secretion. |
2012-09-14 |
2023-08-12 |
Not clear |
| Nuria Alonso, M Teresa Julián, Manuel Puig-Domingo, Marta Vives-P. Incretin hormones as immunomodulators of atherosclerosis. Frontiers in endocrinology. vol 3. 2012-09-14. PMID:22973260. |
glucagon-like peptide-1 (glp-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orally as opposed to intravenously and it retains its insulinotropic activity in patients with type 2 diabetes mellitus (t2d). |
2012-09-14 |
2023-08-12 |
mouse |
| Bharat Shimpukade, Brian D Hudson, Christine Kiel Hovgaard, Graeme Milligan, Trond Ulve. Discovery of a potent and selective GPR120 agonist. Journal of medicinal chemistry. vol 55. issue 9. 2012-09-12. PMID:22519963. |
gpr120 is a receptor of unsaturated long-chain fatty acids reported to mediate glp-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. |
2012-09-12 |
2023-08-12 |
Not clear |
| Gisela I Robles, Devada Singh-Franc. A review of exenatide as adjunctive therapy in patients with type 2 diabetes. Drug design, development and therapy. vol 3. 2012-09-10. PMID:19920937. |
incretin glucagon-like peptide-1 (glp-1) is a hormone released from cells in the gastrointestinal tract (gi), leading to glucose-dependent insulin release from the pancreas. |
2012-09-10 |
2023-08-12 |
human |
| N B Jørgensen, S H Jacobsen, C Dirksen, K N Bojsen-Møller, L Naver, L Hvolris, T R Clausen, B S Wulff, D Worm, D Lindqvist Hansen, S Madsbad, J J Hols. Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22535748. |
glucose, insulin, c-peptide, glucagon-like peptide-1 (glp-1), glucose-dependent-insulinotropic polypeptide (gip), and glucagon concentrations were measured. |
2012-09-10 |
2023-08-12 |
human |
| N B Jørgensen, S H Jacobsen, C Dirksen, K N Bojsen-Møller, L Naver, L Hvolris, T R Clausen, B S Wulff, D Worm, D Lindqvist Hansen, S Madsbad, J J Hols. Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22535748. |
improvement in glycemic control in t2d after rygb occurs within days after surgery and is associated with increased insulin sensitivity and improved β-cell function, the latter of which may be explained by dramatic increases in glp-1 secretion. |
2012-09-10 |
2023-08-12 |
human |
| Takashi Kawano, Katsuya Tanaka, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki, Sonoe Kitamura, Naoko Kumagai, Masataka Yokoyam. Biophysical and pharmacological properties of glucagon-like peptide-1 in rats under isoflurane anesthesia. Anesthesia and analgesia. vol 115. issue 1. 2012-08-31. PMID:22504208. |
glucagon-like peptide-1 (glp-1) increases insulin secretion and has an important role in maintaining glucose homeostasis. |
2012-08-31 |
2023-08-12 |
rat |
| Yazhou Li, Srinivasulu Chigurupati, Harold W Holloway, Mohamed Mughal, David Tweedie, Daniel A Bruestle, Mark P Mattson, Yun Wang, Brandon K Harvey, Balmiki Ray, Debomoy K Lahiri, Nigel H Grei. Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384126. |
the incretin hormone, glucagon-like peptide-1 (glp-1), facilitates insulin signaling, and the long acting glp-1 receptor agonist exendin-4 (ex-4) is currently used as an anti-diabetic drug. |
2012-08-27 |
2023-08-12 |
mouse |
| A P Gjesing, C T Ekstrøm, H Eiberg, S A Urhammer, J J Holst, O Pedersen, T Hanse. Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits. Diabetologia. vol 55. issue 5. 2012-08-24. PMID:22349073. |
therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum c-peptide, plasma glucose-dependent insulinotropic polypeptide (gip) and plasma glucagon-like peptide-1 (glp-1) among non-diabetic relatives of danish type 2 diabetic patients. |
2012-08-24 |
2023-08-12 |
Not clear |
| M Lehrke, N Mar. [Cardiovascular effects of incretin-based therapies]. Herz. vol 37. issue 3. 2012-08-24. PMID:22430284. |
furthermore glp-1 was found to improve chronic heart failure by increasing insulin independent cellular glucose transport. |
2012-08-24 |
2023-08-12 |
Not clear |
| Rimke C Vos, Hanno Pijl, Jan M Wit, Erik W van Zwet, Chris van der Bent, Euphemia C A M Houdij. The effect of multidisciplinary lifestyle intervention on the pre- and postprandial plasma gut Peptide concentrations in children with obesity. ISRN endocrinology. vol 2011. 2012-08-23. PMID:22363876. |
at baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples were taken for glucose, insulin, ghrelin, peptide yy (pyy), and glucagon-like peptide 1 (glp-1). |
2012-08-23 |
2023-08-12 |
Not clear |
| Rimke C Vos, Hanno Pijl, Jan M Wit, Erik W van Zwet, Chris van der Bent, Euphemia C A M Houdij. The effect of multidisciplinary lifestyle intervention on the pre- and postprandial plasma gut Peptide concentrations in children with obesity. ISRN endocrinology. vol 2011. 2012-08-23. PMID:22363876. |
intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum pyy and glp-1 concentrations and insulin sensitivity remained unchanged. |
2012-08-23 |
2023-08-12 |
Not clear |
| Anita Mofidi, Zachary M Ferraro, Katherine A Stewart, Hilary M F Tulk, Lindsay E Robinson, Alison M Duncan, Terry E Graha. The acute impact of ingestion of sourdough and whole-grain breads on blood glucose, insulin, and incretins in overweight and obese men. Journal of nutrition and metabolism. vol 2012. 2012-08-23. PMID:22474577. |
in a randomized, crossover study, overweight or obese males ingested 11-grain, sprouted-grain, 12-grain, sourdough, or white bread on different occasions, matched for available carbohydrate (50 g) in part 1 (n = 12) and bread mass (107 g) in part 2 (n = 11), and blood glucose, insulin and glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) were determined for 3 h. |
2012-08-23 |
2023-08-12 |
human |