| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer Leohr, Maria C Kjellsso. Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1. CPT: pharmacometrics & systems pharmacology. 2023-09-05. PMID:37667531. |
evaluation of postprandial total triglycerides within the tigg model for characterizing postprandial response of glucose, insulin, and glp-1. |
2023-09-05 |
2023-09-07 |
Not clear |
| Jennifer Leohr, Maria C Kjellsso. Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1. CPT: pharmacometrics & systems pharmacology. 2023-09-05. PMID:37667531. |
the two models were compared on their predictability to characterize the postprandial response of glucose, insulin, and active glp-1. |
2023-09-05 |
2023-09-07 |
Not clear |
| Marine Monney, Fran\\xc3\\xa7ois R Jornayvaz, Karim Garian. GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes. Diabetes & metabolism. 2023-09-01. PMID:37657738. |
glp-1 receptor agonist has a peripheral and a central action, including stimulation of glucose-dependent insulin secretion and insulin biosynthesis, inhibition of glucagon secretion and gastric emptying, and inhibition of food intake. |
2023-09-01 |
2023-09-07 |
Not clear |
| Peyman Rezaie, Vida Bitarafan, Braden David Rose, Kylie Lange, Zinat Mohammadpour, Jens Frederik Rehfeld, Michael Horowitz, Christine Feinle-Bisse. Effects of Quinine on the Glycaemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Females and Males. Nutrients. vol 15. issue 16. 2023-08-26. PMID:37630774. |
intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (glp-1), cholecystokinin and insulin; slows gastric emptying (ge); and lowers post-meal glucose in men. |
2023-08-26 |
2023-09-07 |
human |
| Marisa Jadna Silva Frederico, Andreza Cipriani, Jocelyn Brice Alexandre Heim, Ana Karla Bittencourt Mendes, Marcela Arag\\xc3\\xb3n, Joana Margarida Gaspar, Nylane Maria Nunes De Alencar, F\\xc3\\xa1tima Regina Mena Barreto Silv. Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 8. 2023-08-26. PMID:37631083. |
electrophilic agonists, cin and aitc, inhibited disaccharidases and acted as secretagogues in the intestine by inducing glp-1 release in vivo and in vitro and contributed to insulin secretion and glycemia. |
2023-08-26 |
2023-09-07 |
rat |
| Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersle. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of diabetes investigation. 2023-08-21. PMID:37602910. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (su)-treated kcnj11 permanent neonatal diabetes. |
2023-08-21 |
2023-09-07 |
human |
| Frans Schuit, Jonathan E Campbel. GPCR Promiscuity Reshapes Islet Physiology. Diabetes. vol 72. issue 9. 2023-08-21. PMID:37603722. |
glp-1 is described as a postprandial hormone that stimulates anabolic actions via insulin, while glucagon is viewed as a fasting hormone that drives catabolic actions to maintain euglycemia. |
2023-08-21 |
2023-09-07 |
Not clear |
| Mingkai Zhang, Ling Zhu, Hui Zhang, Xingguo Wang, Gangcheng Wu, Xiguang Q. Transepithelial Transport of the Bifunctional Peptide IPYWTY Indirectly Induced Insulin Release Mediated by Active GLP-1. Journal of agricultural and food chemistry. 2023-08-17. PMID:37587911. |
transepithelial transport of the bifunctional peptide ipywty indirectly induced insulin release mediated by active glp-1. |
2023-08-17 |
2023-09-07 |
Not clear |
| Colleen Gavigan, Thomas Donne. Predictors of Responsiveness to GLP-1 Receptor Agonists in Insulin-Treated Patients with Type 2 Diabetes. Journal of diabetes research. vol 2023. 2023-08-17. PMID:37589043. |
physicians lack guidance as to which patients with insulin-requiring type 2 diabetes will respond best to glp-1 ras with respect to glycemic control, insulin dose reduction, and weight loss. |
2023-08-17 |
2023-09-07 |
Not clear |
| Colleen Gavigan, Thomas Donne. Predictors of Responsiveness to GLP-1 Receptor Agonists in Insulin-Treated Patients with Type 2 Diabetes. Journal of diabetes research. vol 2023. 2023-08-17. PMID:37589043. |
this study evaluated the efficacy of glp-1 ras in patients with type 2 diabetes on insulin and patient factors that may predict a beneficial clinical response. |
2023-08-17 |
2023-09-07 |
Not clear |
| Gary E Aspnes, Scott W Bagley, Steven B Coffey, Edward L Conn, John M Curto, David J Edmonds, Julien Genovino, David A Griffith, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M Mathiowetz, David W Piotrowski, Colin R Rose, Roger B Ruggeri, Liuqing We. 6-Azaspiro[2.5]octanes as Small Molecule Agonists of the Human Glucagon-Like Peptide-1 Receptor. Bioorganic & medicinal chemistry letters. 2023-08-17. PMID:37591316. |
activation of the glucagon-like peptide-1 (glp-1) receptor stimulates insulin release, lowers plasma glucose levels, delays gastric emptying, increases satiety, suppresses food intake, and affords weight loss in humans. |
2023-08-17 |
2023-09-07 |
human |
| Philip N Newsome, Phil Amber. Incretins (GLP1 r agonists and dual, triple agonists) and the liver. Journal of hepatology. 2023-08-10. PMID:37562748. |
there remains debate as to whether glp-1 receptor agonists have direct, independent effects to improve mash or whether they impact on pathophysiology through improvements in weight, insulin resistance and glycaemic control. |
2023-08-10 |
2023-08-16 |
Not clear |
| Chantal Mathieu, Iraj Ahmadza. Incretins beyond type 2 diabetes. Diabetologia. 2023-08-08. PMID:37552238. |
in type 1 diabetes, the addition of glp-1 receptor agonists to intensive insulin therapy lowers weight and required insulin doses compared with placebo, but the effects on glucose control (hba |
2023-08-08 |
2023-08-14 |
Not clear |
| Stine Smedegaard, Ulla Kampmann, Per G Ovesen, Henrik St\\xc3\\xb8vring, Nikolaj Ritti. Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis. The American journal of clinical nutrition. vol 118. issue 2. 2023-08-03. PMID:37536867. |
the underlying mechanisms are only partly understood but may involve stimulation of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and insulin secretion together with a slower gastric emptying rate. |
2023-08-03 |
2023-08-14 |
Not clear |
| Marah Alsayed Hasan, Stanley Schwartz, Victoria McKenna, Richard In. An Imbalance of Pathophysiologic Factors in Late Postprandial Hypoglycemia Post Bariatric Surgery: A Narrative Review. Obesity surgery. 2023-08-02. PMID:37530920. |
after bariatric surgery, significant changes are seen in insulin sensitivity, beta cell function, glucagon-like peptide 1 (glp-1) levels, the gut microbiome, and bile acid metabolism. |
2023-08-02 |
2023-08-14 |
Not clear |
| Michelantonio De Fano, Francesca Porcellati, Carmine G Fanelli, Sofia Corio, Alessio Mazzieri, Paola Lucidi, Geremia B Bolli, Gabrio Bassott. THE ROLE OF GASTRIC EMPTYING IN GLUCOSE HOMEOSTASIS AND DEFENSE AGAINST HYPOGLYCEMIA: INNOCENT BYSTANDER OR PARTNER IN CRIME? Diabetes research and clinical practice. 2023-07-22. PMID:37481116. |
recent guidelines recommend glp-1 receptor agonists (glp-1ras) either as the first injectable therapy for type 2 diabetes mellitus or in combination with insulin. |
2023-07-22 |
2023-08-14 |
human |
| Eugenio Cersosimo, Mariam Alatrach, Carolina Solis-Herrera, Baskoy Gozde, John Adams, Andrea Hansis-Diarte, Amalia Gastaldelli, Alberto Chavez, Curtis Triplitt, Ralph A DeFronz. Emergence of a New Gluco-Regulatory Mechanism for Glycemic Control with Dapagliflozin/Exenatide Therapy in Type 2 Diabetes. The Journal of clinical endocrinology and metabolism. 2023-07-22. PMID:37481263. |
our hypothesis was that increased egp in response to sglt2i-induced glycosuria persists for a long period and is not abolished by glp-1 ra stimulation of insulin secretion, glucagon suppression. |
2023-07-22 |
2023-08-14 |
Not clear |
| Xiaoxue Lu, Rongrong Ma, Jinling Zhan, Yaoqi Tia. Structural changes of thermally treated starch during digestion and the impact on postprandial glucose homeostasis. Carbohydrate polymers. vol 318. 2023-07-21. PMID:37479434. |
the insulin response to the intake of thermally treated starch increased (4.73\xc2\xa0%-6.83\xc2\xa0% higher than the control), whereas the concentration of glp-1, a hormone used to promote insulin secretion, decreased (1.54\xc2\xa0%-8.56\xc2\xa0% lower than the control). |
2023-07-21 |
2023-08-14 |
mouse |
| Ishani Kapoor, Swara M Sarvepalli, David D'Alessio, Dilraj S Grewal, Majda Hadziahmetovi. GLP-1 Receptor Agonists and Diabetic Retinopathy: A Meta-Analysis of Randomized Clinical Trials. Survey of ophthalmology. 2023-07-16. PMID:37454782. |
we searched clinicaltrials.gov for trials comparing fda-approved glp-1 ras to placebo, insulin, or oral antidiabetic medicine. |
2023-07-16 |
2023-08-14 |
Not clear |
| Ishani Kapoor, Swara M Sarvepalli, David D'Alessio, Dilraj S Grewal, Majda Hadziahmetovi. GLP-1 Receptor Agonists and Diabetic Retinopathy: A Meta-Analysis of Randomized Clinical Trials. Survey of ophthalmology. 2023-07-16. PMID:37454782. |
compared to insulin, glp-1 ra use protected against late-stage dr (rr = 0.38, 95% ci [0.15, 0.98]). |
2023-07-16 |
2023-08-14 |
Not clear |