| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we found that gaba shares a common feature with glp-1 on inhibiting txnip, while this function was attenuated in glp-1r-/- islets. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we, hence, identified txnip as a common target of gaba and glp-1 and suggest that, upon stz or other stress challenge, the glp-1r-camp-β-cat signaling cascade also mediates beneficial effects of gaba in pancreatic β-cell, involving txnip reduction. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we found that gaba and sitagliptin possess additive effect on pancreatic β-cells, which prompted us to ask the existence of common or unique targets of glp-1 and gaba in pancreatic β-cells. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
knockdown txnip in ins-1 cells increased glp-1r, pdx1, nkx6.1 and mafa levels, associated with increased responses to gaba or glp-1 on stimulating insulin secretion. |
2021-01-25 |
2023-08-13 |
mouse |
| Qian Wang, Xiaoqian Zhang, Hui Leng, Xiao Luan, Feifei Guo, Xiangrong Sun, Shengli Gao, Xuehuan Liu, Hao Qin, Luo X. Zona incerta projection neurons and GABAergic and GLP-1 mechanisms in the nucleus accumbens are involved in the control of gastric function and food intake. Neuropeptides. vol 80. 2020-12-10. PMID:32000986. |
our aim was to explore the effect of γ-aminobutyric acid (gaba) signaling in the nucleus accumbens (nac) on promoting gastric function and food intake through glucagon-like peptide 1 (glp-1)-sensitive gastric distension (gd) neurons under the regulatory control of the zona incerta (zi). |
2020-12-10 |
2023-08-13 |
Not clear |
| Gaurav Gupta, Rajiv Dahiya, Kamal Dua, Dinesh Kumar Chellappan, Juhi Tiwari, Ganesh Narayan Sharma, Santosh Kumar Singh, Anurag Mishra, Rakesh Kumar Sharma, Mohit Agrawa. Anticonvulsant effect of liraglutide, GLP-1 agonist by averting a change in GABA and brain glutathione level on picrotoxin-induced seizures. EXCLI journal. vol 16. 2020-09-30. PMID:28827991. |
anticonvulsant effect of liraglutide, glp-1 agonist by averting a change in gaba and brain glutathione level on picrotoxin-induced seizures. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
treatment with gaba or glucagon-like peptide-1 (glp-1) can preserve pancreatic β-cell mass and prevent diabetes. |
2019-12-13 |
2023-08-13 |
mouse |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
however, in human islets, it remains unclear whether gaba and glp-1 exert similar effects. |
2019-12-13 |
2023-08-13 |
mouse |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
recently, we reported that the combination of gaba and sitagliptin (a dipeptidyl peptidase-4 inhibitor that increases endogenous glp-1) was more effective than either agent alone in reducing drug-induced β-cell damage and promoting β-cell regeneration in mice. |
2019-12-13 |
2023-08-13 |
mouse |
| Claudia Rebosio, Matilde Balbi, Mario Passalacqua, Roberta Ricciarelli, Ernesto Fedel. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus. BioFactors (Oxford, England). vol 44. issue 2. 2018-09-13. PMID:29265673. |
presynaptic glp-1 receptors enhance the depolarization-evoked release of glutamate and gaba in the mouse cortex and hippocampus. |
2018-09-13 |
2023-08-13 |
mouse |
| Omar Babateen, Sergiy V Korol, Zhe Jin, Amol K Bhandage, Aikeremu Ahemaiti, Bryndis Birni. Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism. BMC pharmacology & toxicology. vol 18. issue 1. 2018-08-17. PMID:29246184. |
in this study we examined effects of liraglutide, a glp-1 analog, on gaba signaling in ca3 hippocampal pyramidal neurons. |
2018-08-17 |
2023-08-13 |
rat |
| Fumio Kondo, Masahiko Tachi, Masahiko Gosho, Minoru Fukayama, Kazuhiro Yoshikawa, Shoshiro Okad. Changes in hypothalamic neurotransmitter and prostanoid levels in response to NMDA, CRF, and GLP-1 stimulation. Analytical and bioanalytical chemistry. vol 407. issue 18. 2016-03-18. PMID:25633219. |
in the present study, we investigated whether centrally administered nmda, crf, and glp-1 can release five neurotransmitters, acetylcholine (ach), histamine, glutamate (glu), γ-aminobutyric acid (gaba), and serotonin (5-ht), along with six prostanoids, txb2, prostaglandin (pg) e2, pgd2, 15-deoxy-∆(12,14) (15d)-pgj2, 6-keto-pgf1α, and pgf2α in rat pvn microdialysates after optimization of lc-itms(n) conditions . |
2016-03-18 |
2023-08-13 |
rat |
| Sergiy V Korol, Zhe Jin, Omar Babateen, Bryndis Birni. GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons. Diabetes. vol 64. issue 1. 2015-03-11. PMID:25114295. |
we studied effects of glp-1 and exendin-4, a glp-1 receptor agonist, on γ-aminobutyric acid (gaba) signaling in hippocampal ca3 pyramidal neurons. |
2015-03-11 |
2023-08-13 |
rat |
| Chen Wang, Rui Mao, Mark Van de Casteele, Daniel Pipeleers, Zhidong Lin. Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase. American journal of physiology. Endocrinology and metabolism. vol 292. issue 4. 2007-05-21. PMID:17190904. |
in the present study, glucagon-like peptide-1 (glp-1) was shown to stimulate gaba formation at the level of gad, its effect being suppressed by the gad inhibitor allylglycine and remaining unaltered by the gaba-t inhibitor gamma-vinyl-gaba. |
2007-05-21 |
2023-08-12 |
rat |
| A Gameiro, F Reimann, A M Habib, D O'Malley, L Williams, A K Simpson, F M Gribbl. The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line. The Journal of physiology. vol 569. issue Pt 3. 2006-05-04. PMID:16223757. |
our results suggest that gaba and glycine stimulate electrical activity and glp-1 release from glutag cells by ligand-gated ion channel activation, a mechanism that might be important in responses to endogenous ligands from the enteric nervous system or dietary sources. |
2006-05-04 |
2023-08-12 |
Not clear |
| H Zheng, L M Patterson, C Morrison, B W Banfield, J A Randall, K N Browning, R A Travagli, H-R Berthou. Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance. Neuroscience. vol 135. issue 2. 2006-01-25. PMID:16111819. |
close anatomical appositions can be demonstrated between melanin-concentrating hormone-ir axon profiles and tyrosine hydroxylase, gaba, glp-1, nos-expressing, and nucleus of the solitary tract neurons activated by gastric nutrient infusion. |
2006-01-25 |
2023-08-12 |
rat |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
in this study the actions of glp-1 and its related peptides, exendin-4 (glp-1r agonist), exendin (9-39) (glp-1r antagonist) and glp-1 (9-36) amide (the major glp-1 metabolite) on levels of serotonin (5-ht), 5-hydroxyindolacetic acid (5-hiaa) and amino acids (glu, asp, gln, gly, tyr, trp, gaba) in the hypothalamus were investigated. |
2002-06-12 |
2023-08-12 |
rat |
| P L Brubaker, J Schloos, D J Drucke. Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line. Endocrinology. vol 139. issue 10. 1998-10-08. PMID:9751489. |
in tests of several neurotransmitters, only the cholinergic agonists carbachol and bethanechol stimulated peptide secretion in a dose-dependent fashion (by 2.3 +/- 0.5- and 1.7 +/- 0.3-fold at 1000 microm; p < 0.05-0.001); the beta-adrenergic agonist isoproterenol and the chloride channel inhibitor gamma-aminobutyric acid did not affect release of glp-1. |
1998-10-08 |
2023-08-12 |
Not clear |