| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by \\xce\\xb3-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
these results demonstrate that gaba and phe identified in zeins synergistically stimulate glp-1 secretion in enteroendocrine cells. |
2023-09-05 |
2023-09-07 |
Not clear |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by \\xce\\xb3-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
in particular, \xce\xb3-aminobutyric acid (gaba) exhibited significant glp-1 releasing activity both alone and synergistically with l-phenylalanine (phe). |
2023-09-05 |
2023-09-07 |
Not clear |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by \\xce\\xb3-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
moreover, zeins-induced glp-1 secretion was attenuated by antagonists for the gaba receptor and calcium sensing receptor. |
2023-09-05 |
2023-09-07 |
Not clear |
| Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. |
the glucagon-like peptide-1 (glp-1) analogue semaglutide reduces alcohol drinking and modulates central gaba neurotransmission. |
2023-05-16 |
2023-08-14 |
mouse |
| Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. |
in conclusion, the glp-1 analogue semaglutide decreased alcohol intake across different drinking models and species and modulated central gaba neurotransmission in rodents, providing support for clinical testing of semaglutide as a potential novel pharmacotherapy for aud. |
2023-05-16 |
2023-08-14 |
mouse |
| Anna Grete Wessel. Influence of the Gut Microbiome on Feed Intake of Farm Animals. Microorganisms. vol 10. issue 7. 2022-07-27. PMID:35889024. |
based on current evidence, the major mediators appear to be short-chain fatty acids (scfa), peptide hormones such as peptide yy (pyy) and glucagon-like peptide-1 (glp-1), as well as the amino acid tryptophan with the associated neurotransmitter serotonin, dopamine and \xce\xb3-aminobutyrate (gaba). |
2022-07-27 |
2023-08-14 |
Not clear |
| Tao Zhang, Hang-Ze Ruan, Yong-Chen Wang, Yu-Qi Shao, Wei Zhou, Shi-Jun Weng, Yong-Mei Zhon. Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells. Neuroscience bulletin. 2022-03-12. PMID:35278196. |
signaling mechanism for modulation by glp-1 and exendin-4 of gaba receptors on rat retinal ganglion cells. |
2022-03-12 |
2023-08-13 |
rat |
| Volkan Solmaz, Aslan Tekatas, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Oytun Erba\\xc5\\x9. Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32745285. |
exenatide, a glp-1 analog, has healing effects on lps-induced autism model: inflammation, oxidative stress, gliosis, cerebral gaba, and serotonin interactions. |
2021-08-26 |
2023-08-13 |
rat |
| Wenjuan Liu, Harry Kevin Lau, Dong Ok Son, Tianru Jin, Yehong Yang, Zhaoyun Zhang, Yiming Li, Gerald J Prud'homme, Qinghua Wan. Combined use of GABA and sitagliptin promotes human \\xce\\xb2-cell proliferation and reduces apoptosis. The Journal of endocrinology. vol 248. issue 2. 2021-07-20. PMID:33258801. |
we previously demonstrated that gaba and sitagliptin (sita), a dipeptidyl peptidase-4 inhibitor which increases endogenous glp-1 levels, mediated a synergistic \xce\xb2-cell protective effect in mice islets. |
2021-07-20 |
2023-08-13 |
mouse |
| Samantha M Fortin, Rachele K Lipsky, Rinzin Lhamo, Jack Chen, Eun Kim, Tito Borner, Heath D Schmidt, Matthew R Haye. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Science translational medicine. vol 12. issue 533. 2021-06-23. PMID:32132220. |
gaba neurons in the nucleus tractus solitarius express glp-1 receptors and mediate anorectic effects of liraglutide in rats. |
2021-06-23 |
2023-08-13 |
rat |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
knockdown txnip in ins-1 cells increased glp-1r, pdx1, nkx6.1 and mafa levels, associated with increased responses to gaba or glp-1 on stimulating insulin secretion. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we found that gaba and sitagliptin possess additive effect on pancreatic \xce\xb2-cells, which prompted us to ask the existence of common or unique targets of glp-1 and gaba in pancreatic \xce\xb2-cells. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we, hence, identified txnip as a common target of gaba and glp-1 and suggest that, upon stz or other stress challenge, the glp-1r-camp-\xce\xb2-cat signaling cascade also mediates beneficial effects of gaba in pancreatic \xce\xb2-cell, involving txnip reduction. |
2021-01-25 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
we found that gaba shares a common feature with glp-1 on inhibiting txnip, while this function was attenuated in glp-1r-/- islets. |
2021-01-25 |
2023-08-13 |
mouse |
| Qian Wang, Xiaoqian Zhang, Hui Leng, Xiao Luan, Feifei Guo, Xiangrong Sun, Shengli Gao, Xuehuan Liu, Hao Qin, Luo X. Zona incerta projection neurons and GABAergic and GLP-1 mechanisms in the nucleus accumbens are involved in the control of gastric function and food intake. Neuropeptides. vol 80. 2020-12-10. PMID:32000986. |
our aim was to explore the effect of \xce\xb3-aminobutyric acid (gaba) signaling in the nucleus accumbens (nac) on promoting gastric function and food intake through glucagon-like peptide 1 (glp-1)-sensitive gastric distension (gd) neurons under the regulatory control of the zona incerta (zi). |
2020-12-10 |
2023-08-13 |
Not clear |
| Gaurav Gupta, Rajiv Dahiya, Kamal Dua, Dinesh Kumar Chellappan, Juhi Tiwari, Ganesh Narayan Sharma, Santosh Kumar Singh, Anurag Mishra, Rakesh Kumar Sharma, Mohit Agrawa. Anticonvulsant effect of liraglutide, GLP-1 agonist by averting a change in GABA and brain glutathione level on picrotoxin-induced seizures. EXCLI journal. vol 16. 2020-09-30. PMID:28827991. |
anticonvulsant effect of liraglutide, glp-1 agonist by averting a change in gaba and brain glutathione level on picrotoxin-induced seizures. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic \\xce\\xb2-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
treatment with gaba or glucagon-like peptide-1 (glp-1) can preserve pancreatic \xce\xb2-cell mass and prevent diabetes. |
2019-12-13 |
2023-08-13 |
mouse |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic \\xce\\xb2-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
however, in human islets, it remains unclear whether gaba and glp-1 exert similar effects. |
2019-12-13 |
2023-08-13 |
mouse |
| Dong Ok Son, Wenjuan Liu, Xiaoming Li, Gerald J Prud'homme, Qinghua Wan. Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic \\xce\\xb2-cell line and isolated human islets. Journal of diabetes. vol 11. issue 7. 2019-12-13. PMID:30520247. |
recently, we reported that the combination of gaba and sitagliptin (a dipeptidyl peptidase-4 inhibitor that increases endogenous glp-1) was more effective than either agent alone in reducing drug-induced \xce\xb2-cell damage and promoting \xce\xb2-cell regeneration in mice. |
2019-12-13 |
2023-08-13 |
mouse |
| Claudia Rebosio, Matilde Balbi, Mario Passalacqua, Roberta Ricciarelli, Ernesto Fedel. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus. BioFactors (Oxford, England). vol 44. issue 2. 2018-09-13. PMID:29265673. |
presynaptic glp-1 receptors enhance the depolarization-evoked release of glutamate and gaba in the mouse cortex and hippocampus. |
2018-09-13 |
2023-08-13 |
mouse |