| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Riley Merkel, Nicole Hernandez, Vanessa Weir, Yafang Zhang, Matthew T Rich, Richard C Crist, Benjamin C Reiner, Heath D Schmid. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979354. |
an endogenous glp-1 circuit engages vta gaba neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. |
2024-07-09 |
2024-07-12 |
rat |
| Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhon. Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes. Neural regeneration research. 2024-06-27. PMID:38934389. |
these results suggest that glp-1 facilitates the release of gaba onto rgcs through the activation of glp-1 receptor, leading to the de-excitation of rgc circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy. |
2024-06-27 |
2024-06-29 |
rat |
| Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhon. Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes. Neural regeneration research. 2024-06-27. PMID:38934389. |
in the brain, defects in y-aminobutyric acid (gaba) synaptic transmission are associated with pathophysiological and neurodegenerative disorders, whereas glucagon-like peptide-1 (glp-1) has demonstrated neuroprotective effects. |
2024-06-27 |
2024-06-29 |
rat |
| Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhon. Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes. Neural regeneration research. 2024-06-27. PMID:38934389. |
topical administration of glp-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic gaba release in early experimental diabetes. |
2024-06-27 |
2024-06-29 |
rat |
| Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhon. Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes. Neural regeneration research. 2024-06-27. PMID:38934389. |
concurrently, the protective effects of glp-1 on rgcs in diabetic rats were eliminated by topical administration of exendin-9-39, a specific glp-1 receptor antagonist, or sr95531, a specific antagonist of the gaba subtype a receptor. |
2024-06-27 |
2024-06-29 |
rat |
| Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Effect of Single Oral Coingestion of GABA and Malic Acid on Postprandial GLP-1, Glucose, and Insulin Responses in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Molecular nutrition & food research. 2024-03-15. PMID:38487986. |
this study examines whether coingestion of γ-aminobutyric acid (gaba) and malic acid (ma) before meals enhances glucagon-like peptide-1 (glp-1) secretion, and which affects subsequent insulin and glycemic responses in humans. |
2024-03-15 |
2024-03-17 |
human |
| Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Effect of Single Oral Coingestion of GABA and Malic Acid on Postprandial GLP-1, Glucose, and Insulin Responses in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Molecular nutrition & food research. 2024-03-15. PMID:38487986. |
effect of single oral coingestion of gaba and malic acid on postprandial glp-1, glucose, and insulin responses in healthy volunteers: a randomized, double-blind, placebo-controlled, crossover study. |
2024-03-15 |
2024-03-17 |
human |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
as a result, all this leads to a decrease in apoptosis and death of β-cells, an increase in β-cell mass, insulin production and, at the same time, a decrease in glucagon levels and insulin resistance.the review substantiates the feasibility of using gaba and drugs with a positive gabaeric effect in combination with new generation antidiabetic agents: glp-1 receptor agonists, dpp-4 inhibitors and sglt-2 inhibitors in order to increase their antidiabetic potential.the search was carried out in the databases pubmed, elibrary, medline. |
2023-09-11 |
2023-10-07 |
Not clear |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
it has been established that in animals with dm, gaba suppresses apoptosis and stimulates the regeneration of β-cells, increases β-cell mass and insulin production.experimental data have been obtained indicating a synergistic effect of gaba when combined with glucagon-like peptide-1 (glp-1) receptor agonists, dpp-4 inhibitors and sodium-glucose cotransporter 2 (sglt-2) inhibitors, when a more pronounced pancreoprotective effect is observed, due to decrease in oxidative and nitrosative stress, inflammation, increase in the level of klotho protein, nrf-2 activity and antioxidant defense enzymes, suppression of nf-kb activity and expression of pro-inflammatory cytokines. |
2023-09-11 |
2023-10-07 |
Not clear |
| I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. |
keywords: diabetes mellitus, gamma-aminobutyric acid, glucagon-like peptide-1, glp-1 receptor agonists, glucose-dependent insulinotropic peptide, dipeptidyl peptidase inhibitors, sodium-glucose cotransporter 2 inhibitors. |
2023-09-11 |
2023-10-07 |
Not clear |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
in particular, γ-aminobutyric acid (gaba) exhibited significant glp-1 releasing activity both alone and synergistically with l-phenylalanine (phe). |
2023-09-05 |
2023-09-07 |
Not clear |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
these results demonstrate that gaba and phe identified in zeins synergistically stimulate glp-1 secretion in enteroendocrine cells. |
2023-09-05 |
2023-09-07 |
Not clear |
| Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. |
moreover, zeins-induced glp-1 secretion was attenuated by antagonists for the gaba receptor and calcium sensing receptor. |
2023-09-05 |
2023-09-07 |
Not clear |
| Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. |
the glucagon-like peptide-1 (glp-1) analogue semaglutide reduces alcohol drinking and modulates central gaba neurotransmission. |
2023-05-16 |
2023-08-14 |
mouse |
| Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. |
in conclusion, the glp-1 analogue semaglutide decreased alcohol intake across different drinking models and species and modulated central gaba neurotransmission in rodents, providing support for clinical testing of semaglutide as a potential novel pharmacotherapy for aud. |
2023-05-16 |
2023-08-14 |
mouse |
| Anna Grete Wessel. Influence of the Gut Microbiome on Feed Intake of Farm Animals. Microorganisms. vol 10. issue 7. 2022-07-27. PMID:35889024. |
based on current evidence, the major mediators appear to be short-chain fatty acids (scfa), peptide hormones such as peptide yy (pyy) and glucagon-like peptide-1 (glp-1), as well as the amino acid tryptophan with the associated neurotransmitter serotonin, dopamine and γ-aminobutyrate (gaba). |
2022-07-27 |
2023-08-14 |
Not clear |
| Tao Zhang, Hang-Ze Ruan, Yong-Chen Wang, Yu-Qi Shao, Wei Zhou, Shi-Jun Weng, Yong-Mei Zhon. Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells. Neuroscience bulletin. 2022-03-12. PMID:35278196. |
signaling mechanism for modulation by glp-1 and exendin-4 of gaba receptors on rat retinal ganglion cells. |
2022-03-12 |
2023-08-13 |
rat |
| b' Volkan Solmaz, Aslan Tekatas, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Oytun Erba\\xc5\\x9. Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32745285.' |
exenatide, a glp-1 analog, has healing effects on lps-induced autism model: inflammation, oxidative stress, gliosis, cerebral gaba, and serotonin interactions. |
2021-08-26 |
2023-08-13 |
rat |
| Wenjuan Liu, Harry Kevin Lau, Dong Ok Son, Tianru Jin, Yehong Yang, Zhaoyun Zhang, Yiming Li, Gerald J Prud'homme, Qinghua Wan. Combined use of GABA and sitagliptin promotes human β-cell proliferation and reduces apoptosis. The Journal of endocrinology. vol 248. issue 2. 2021-07-20. PMID:33258801. |
we previously demonstrated that gaba and sitagliptin (sita), a dipeptidyl peptidase-4 inhibitor which increases endogenous glp-1 levels, mediated a synergistic β-cell protective effect in mice islets. |
2021-07-20 |
2023-08-13 |
mouse |
| Samantha M Fortin, Rachele K Lipsky, Rinzin Lhamo, Jack Chen, Eun Kim, Tito Borner, Heath D Schmidt, Matthew R Haye. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Science translational medicine. vol 12. issue 533. 2021-06-23. PMID:32132220. |
gaba neurons in the nucleus tractus solitarius express glp-1 receptors and mediate anorectic effects of liraglutide in rats. |
2021-06-23 |
2023-08-13 |
rat |