All Relations between glp-1 and gaba

Publication Sentence Publish Date Extraction Date Species
Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Effect of Single Oral Coingestion of GABA and Malic Acid on Postprandial GLP-1, Glucose, and Insulin Responses in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Molecular nutrition & food research. 2024-03-15. PMID:38487986. effect of single oral coingestion of gaba and malic acid on postprandial glp-1, glucose, and insulin responses in healthy volunteers: a randomized, double-blind, placebo-controlled, crossover study. 2024-03-15 2024-03-17 human
Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Effect of Single Oral Coingestion of GABA and Malic Acid on Postprandial GLP-1, Glucose, and Insulin Responses in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Molecular nutrition & food research. 2024-03-15. PMID:38487986. this study examines whether coingestion of γ-aminobutyric acid (gaba) and malic acid (ma) before meals enhances glucagon-like peptide-1 (glp-1) secretion, and which affects subsequent insulin and glycemic responses in humans. 2024-03-15 2024-03-17 human
I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. as a result, all this leads to a decrease in apoptosis and death of β-cells, an increase in β-cell mass, insulin production and, at the same time, a decrease in glucagon levels and insulin resistance.the review substantiates the feasibility of using gaba and drugs with a positive gabaeric effect in combination with new generation antidiabetic agents: glp-1 receptor agonists, dpp-4 inhibitors and sglt-2 inhibitors in order to increase their antidiabetic potential.the search was carried out in the databases pubmed, elibrary, medline. 2023-09-11 2023-10-07 Not clear
I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. it has been established that in animals with dm, gaba suppresses apoptosis and stimulates the regeneration of β-cells, increases β-cell mass and insulin production.experimental data have been obtained indicating a synergistic effect of gaba when combined with glucagon-like peptide-1 (glp-1) receptor agonists, dpp-4 inhibitors and sodium-glucose cotransporter 2 (sglt-2) inhibitors, when a more pronounced pancreoprotective effect is observed, due to decrease in oxidative and nitrosative stress, inflammation, increase in the level of klotho protein, nrf-2 activity and antioxidant defense enzymes, suppression of nf-kb activity and expression of pro-inflammatory cytokines. 2023-09-11 2023-10-07 Not clear
I N Tyurenkov, T I Faibisovich, D A Bakuli. [Synergistic effects of GABA and hypoglycemic drugs]. Problemy endokrinologii. vol 69. issue 4. 2023-09-11. PMID:37694868. keywords: diabetes mellitus, gamma-aminobutyric acid, glucagon-like peptide-1, glp-1 receptor agonists, glucose-dependent insulinotropic peptide, dipeptidyl peptidase inhibitors, sodium-glucose cotransporter 2 inhibitors. 2023-09-11 2023-10-07 Not clear
Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. these results demonstrate that gaba and phe identified in zeins synergistically stimulate glp-1 secretion in enteroendocrine cells. 2023-09-05 2023-09-07 Not clear
Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. in particular, γ-aminobutyric acid (gaba) exhibited significant glp-1 releasing activity both alone and synergistically with l-phenylalanine (phe). 2023-09-05 2023-09-07 Not clear
Hiroki Noguchi, Noriyuki Kohda, Hiroshi Hara, Tohru Hir. Synergistic enhancement of glucagon-like peptide-1 release by γ-aminobutyric acid and L-phenylalanine in enteroendocrine cells - searching active ingredients in a water extract of Corn Zein protein. Bioscience, biotechnology, and biochemistry. 2023-09-05. PMID:37667511. moreover, zeins-induced glp-1 secretion was attenuated by antagonists for the gaba receptor and calcium sensing receptor. 2023-09-05 2023-09-07 Not clear
Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. the glucagon-like peptide-1 (glp-1) analogue semaglutide reduces alcohol drinking and modulates central gaba neurotransmission. 2023-05-16 2023-08-14 mouse
Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L Pince, Sophie K Elvig, Roman Vlkolinsky, Renata Cn Marchette, George F Koob, Marisa Roberto, Leandro F Vendruscolo, Lorenzo Leggi. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI insight. 2023-05-16. PMID:37192005. in conclusion, the glp-1 analogue semaglutide decreased alcohol intake across different drinking models and species and modulated central gaba neurotransmission in rodents, providing support for clinical testing of semaglutide as a potential novel pharmacotherapy for aud. 2023-05-16 2023-08-14 mouse
Anna Grete Wessel. Influence of the Gut Microbiome on Feed Intake of Farm Animals. Microorganisms. vol 10. issue 7. 2022-07-27. PMID:35889024. based on current evidence, the major mediators appear to be short-chain fatty acids (scfa), peptide hormones such as peptide yy (pyy) and glucagon-like peptide-1 (glp-1), as well as the amino acid tryptophan with the associated neurotransmitter serotonin, dopamine and γ-aminobutyrate (gaba). 2022-07-27 2023-08-14 Not clear
Tao Zhang, Hang-Ze Ruan, Yong-Chen Wang, Yu-Qi Shao, Wei Zhou, Shi-Jun Weng, Yong-Mei Zhon. Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells. Neuroscience bulletin. 2022-03-12. PMID:35278196. signaling mechanism for modulation by glp-1 and exendin-4 of gaba receptors on rat retinal ganglion cells. 2022-03-12 2023-08-13 rat
b' Volkan Solmaz, Aslan Tekatas, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Oytun Erba\\xc5\\x9. Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32745285.' exenatide, a glp-1 analog, has healing effects on lps-induced autism model: inflammation, oxidative stress, gliosis, cerebral gaba, and serotonin interactions. 2021-08-26 2023-08-13 rat
Wenjuan Liu, Harry Kevin Lau, Dong Ok Son, Tianru Jin, Yehong Yang, Zhaoyun Zhang, Yiming Li, Gerald J Prud'homme, Qinghua Wan. Combined use of GABA and sitagliptin promotes human β-cell proliferation and reduces apoptosis. The Journal of endocrinology. vol 248. issue 2. 2021-07-20. PMID:33258801. we previously demonstrated that gaba and sitagliptin (sita), a dipeptidyl peptidase-4 inhibitor which increases endogenous glp-1 levels, mediated a synergistic β-cell protective effect in mice islets. 2021-07-20 2023-08-13 mouse
Samantha M Fortin, Rachele K Lipsky, Rinzin Lhamo, Jack Chen, Eun Kim, Tito Borner, Heath D Schmidt, Matthew R Haye. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Science translational medicine. vol 12. issue 533. 2021-06-23. PMID:32132220. gaba neurons in the nucleus tractus solitarius express glp-1 receptors and mediate anorectic effects of liraglutide in rats. 2021-06-23 2023-08-13 rat
Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. knockdown txnip in ins-1 cells increased glp-1r, pdx1, nkx6.1 and mafa levels, associated with increased responses to gaba or glp-1 on stimulating insulin secretion. 2021-01-25 2023-08-13 mouse
Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. we found that gaba and sitagliptin possess additive effect on pancreatic β-cells, which prompted us to ask the existence of common or unique targets of glp-1 and gaba in pancreatic β-cells. 2021-01-25 2023-08-13 mouse
Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. we, hence, identified txnip as a common target of gaba and glp-1 and suggest that, upon stz or other stress challenge, the glp-1r-camp-β-cat signaling cascade also mediates beneficial effects of gaba in pancreatic β-cell, involving txnip reduction. 2021-01-25 2023-08-13 mouse
Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. we found that gaba shares a common feature with glp-1 on inhibiting txnip, while this function was attenuated in glp-1r-/- islets. 2021-01-25 2023-08-13 mouse
Qian Wang, Xiaoqian Zhang, Hui Leng, Xiao Luan, Feifei Guo, Xiangrong Sun, Shengli Gao, Xuehuan Liu, Hao Qin, Luo X. Zona incerta projection neurons and GABAergic and GLP-1 mechanisms in the nucleus accumbens are involved in the control of gastric function and food intake. Neuropeptides. vol 80. 2020-12-10. PMID:32000986. our aim was to explore the effect of γ-aminobutyric acid (gaba) signaling in the nucleus accumbens (nac) on promoting gastric function and food intake through glucagon-like peptide 1 (glp-1)-sensitive gastric distension (gd) neurons under the regulatory control of the zona incerta (zi). 2020-12-10 2023-08-13 Not clear