| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Omprakash Singh, Sean B Ogden, Salil Varshney, Kripa Shankar, Deepali Gupta, Subhojit Paul, Sherri Osborne-Lawrence, Corine P Richard, Nathan P Metzger, Connor Lawrence, Luis León-Mercado, Jeffrey M Zigma. Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance. JCI insight. 2023-11-14. PMID:37962950. |
to investigate whether ghrelin-responsive mediobasal hypothalamus (mbh) neurons mediate these effects, we stereotaxically delivered the inhibitory dreadd virus aav2-hsyn-dio-hm4(gi)-mcherry to the mbh of ghsr-ires-cre mice, which express cre-recombinase directed by the ghsr promoter. |
2023-11-14 |
2023-11-20 |
mouse |
| Andrea Smith, Lindsay Hyland, Hiyam Al-Ansari, Bethany Watts, Zachary Silver, Longfei Wang, Miski Dahir, Aleyna Akgun, Andre Telfer, Alfonso Abizai. Metabolic, neuroendocrine and behavioral effects of social defeat in male and female mice using the chronic non-discriminatory social defeat stress model. Hormones and behavior. vol 155. 2023-08-26. PMID:37633226. |
furthermore, females exposed to chronic stress displayed changes in growth hormone secretatogue receptor (ghsr) and neuropeptide-y (npy) expression in the arcuate nucleus of the hypothalamus, potentially increasing ghrelin sensitivity and inducing changes in diet choice and caloric intake. |
2023-08-26 |
2023-09-07 |
mouse |
| Guangpin Chu, Hualing Peng, Nana Yu, Yuejin Zhang, Xueling Lin, Yisheng L. Involvement of POMC neurons in LEAP2 regulation of food intake and body weight. Frontiers in endocrinology. vol 13. 2022-11-17. PMID:36387867. |
interestingly, this aav-leap2 treatment increased proopiomelanocortin (pomc) expression while agouti-related peptide (agrp)/neuropeptide y (npy) and ghsr levels remained unchanged in the hypothalamus. |
2022-11-17 |
2023-08-14 |
mouse |
| Jocemara Patrícia Silva de Souza Parrela, Ingridys Regina Borkenhagen, Sarah Ramany Faria Salmeron, Thalyne Aparecida Leite Lima, Ginislene Dias Souza Miranda, Hercules de Oliveira Costermani, Camila Luiza Rodrigues Dos Santos Ricken, Ester Vieira Alves, Rodrigo Mello Gomes, Júlio Cezar de Oliveir. Intrauterine malnutrition disrupts leptin and ghrelin milk hormones, programming rats. The Journal of endocrinology. vol 255. issue 1. 2022-09-09. PMID:35904490. |
in addition, the protein expression of growth hormone secretagogue receptor (ghsr) in the hypothalamus was increased by almost 4-fold in fr50 pups. |
2022-09-09 |
2024-02-12 |
rat |
| Xianxian Chen, Jicong Mi, Hongbin Huang, Jing Wang, Yu Wu, Xiaobing Wu, Shengzhou Zhan. Ghrelin and Ghrelin receptor (GHSR) in Chinese alligator, Alligator sinensis:Molecular characterization, tissue distribution and mRNA expression changes during the active and hibernating periods. General and comparative endocrinology. 2022-07-19. PMID:35853503. |
ghsr expression level was higher in hypothalamus, epencephalon and medulla oblongata, and moderate in multiple peripheral tissues including lung, kindey, stomach and oviduct, implicating that ghrelin/ghsr system may participate in the regulation of energy balance, food intake, water and mineral balance, gastrointestinal motility, gastric acid secretion and reproduction. |
2022-07-19 |
2023-08-14 |
Not clear |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
in the same study, in contrast to the drop in npy5r and ghsr, spx treatment could induce parallel rises of transcript expression of leptin receptor (lepr) and melanocortin 4 receptor (mc4r) in the hypothalamus. |
2021-11-18 |
2023-08-13 |
mouse |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
through galr3 activation, this spx signal can act within the hypothalamus to trigger feedback inhibition on feeding by differential modulation of feeding regulators (npy and agrp) and their receptors (npy5r, ghsr, lepr, and mc4r) involved in the feeding circuitry within the cns. |
2021-11-18 |
2023-08-13 |
mouse |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
furthermore, ip injection of spx was effective in reducing food intake with parallel attenuation in transcript expression of npy, agrp, npy type 5 receptor (npy5r), and ghrelin receptor (ghsr) in the hypothalamus, and these inhibitory effects could be blocked by galr3 but not galr2 antagonism. |
2021-11-18 |
2023-08-13 |
mouse |
| Candice Marion, Philippe Zizzari, Raphaël Gp Denis, Rim Hassouna, Yacine Chebani, Thierry Leste-Lasserre, Hélène Doat, Gwenaëlle Le Pen, Daniela Cota, Florence Noble, Serge Luquet, Jacques Pante. The GhsrQ343X allele favors the storage of fat by acting on nutrient partitioning. The Journal of endocrinology. 2021-09-28. PMID:34582357. |
enhanced ratio of ghsr hormones leap2:acyl-ghrelin and increased ghsr expression in the hypothalamus). |
2021-09-28 |
2023-08-13 |
rat |
| Tomoaki Hayakawa, Tetsuhiro Kitamura, Daisuke Tamada, Kosuke Mukai, Reiko Hayashi, Mitsuyoshi Takahara, Michio Otsuki, Iichiro Shimomur. Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test. Journal of the Endocrine Society. vol 2. issue 8. 2020-09-30. PMID:30324179. |
gh-releasing peptide 2 (ghrp2) stimulates the hypothalamic-pituitary-adrenal axis (hpa) through the gh secretagogue receptor (ghsr) in the hypothalamus, in which ghrelin is a natural ligand. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jithine Jayakumar Rajeswari, Azadeh Hatef, Mahdi Golshan, Sayyed Mohammad Hadi Alavi, Suraj Unniappa. Metabolic stress leads to divergent changes in the ghrelinergic system in goldfish (Carassius auratus) gonads. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 235. 2020-08-24. PMID:31158494. |
in fish deprived of food for 28 days, preproghrelin, ghsr and goat mrna expression was significantly increased in the hypothalamus of male goldfish. |
2020-08-24 |
2023-08-13 |
Not clear |
| Shauna E Wallace Fitzsimons, Barbara Chruścicka, Clementine Druelle, Panagiota Stamou, Ken Nally, Timothy G Dinan, John F Cryan, Harriët Schelleken. A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling. Neuropharmacology. vol 152. 2020-03-30. PMID:30582955. |
co-localized expression of the otr and ghsr is shown in a heterologous cellular expression system and in primary cultures of the hypothalamus and hippocampus. |
2020-03-30 |
2023-08-13 |
Not clear |
| Gimena Fernandez, Agustina Cabral, María F Andreoli, Alexandra Labarthe, Céline M'Kadmi, Jorge G Ramos, Jacky Marie, Jean-Alain Fehrentz, Jacques Epelbaum, Virginie Tolle, Mario Perell. Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice. Endocrinology. vol 159. issue 2. 2018-02-15. PMID:29300858. |
as ghsr gene expression in the hypothalamus is known to increase in fasting conditions, we tested the hypothesis that constitutive ghsr activity at the hypothalamic level drives the fasting-induced hyperphagia. |
2018-02-15 |
2023-08-13 |
mouse |
| Gimena Fernandez, Agustina Cabral, María F Andreoli, Alexandra Labarthe, Céline M'Kadmi, Jorge G Ramos, Jacky Marie, Jean-Alain Fehrentz, Jacques Epelbaum, Virginie Tolle, Mario Perell. Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice. Endocrinology. vol 159. issue 2. 2018-02-15. PMID:29300858. |
ghrelin is a potent orexigenic peptide hormone that acts through the growth hormone secretagogue receptor (ghsr), a g protein-coupled receptor highly expressed in the hypothalamus. |
2018-02-15 |
2023-08-13 |
mouse |
| Julie-Ann P De Bond, Kristen P Tolson, Chanond Nasamran, Alexander S Kauffman, Jeremy T Smit. Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure. Journal of neuroendocrinology. vol 28. issue 10. 2018-01-08. PMID:27601011. |
in the present study, we investigated whether kiss1r kos develop this metabolic phenotype as a result of alterations in the expression of metabolic genes involved in the appetite regulating system of the hypothalamus, including neuropeptide y (npy) and pro-opiomelanocortin (pomc), as well as leptin receptor (lepr), ghrelin receptor (ghsr), and melanocortin receptors 3 and 4 (mc3r, mc4r). |
2018-01-08 |
2023-08-13 |
mouse |
| Yumiko Miyatake, Tetsuya Shiuchi, Kazuaki Mawatari, Satomi Toda, Yasuko Taniguchi, Akari Futami, Fukiko Sato, Masashi Kuroda, Mayu Sebe, Rie Tsutsumi, Nagakatsu Harada, Yasuhiko Minokoshi, Tadahiro Kitamura, Koro Gotoh, Masaki Ueno, Yutaka Nakaya, Hiroshi Sakau. Intracerebroventricular injection of ghrelin decreases wheel running activity in rats. Peptides. vol 87. 2017-11-30. PMID:27825986. |
growth hormone secretagogue receptor (ghsr) in the hypothalamus and hippocampus of sports rats was not difference that in control rats. |
2017-11-30 |
2023-08-13 |
rat |
| Mohammed Abu El-Magd, Ayman A Saleh, Tamer M Abdel-Hamid, Rasha M Saleh, Mohammed A Afif. Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH. General and comparative endocrinology. vol 237. 2017-09-04. PMID:27591070. |
the two snps were also correlated with mrna levels of ghsr and gh (in pituitary gland), and ghrl (in proventriculus and hypothalamus) as well as with serum level of gh and ghrl. |
2017-09-04 |
2023-08-13 |
chicken |
| Luba Sominsky, Ilvana Ziko, Thai-Xinh Nguyen, Zane B Andrews, Sarah J Spence. Early life disruption to the ghrelin system with over-eating is resolved in adulthood in male rats. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27671325. |
our data show that early life overfeeding influences the ghrelin system short-term, leading to an acute reduction in circulating des-acyl ghrelin and increased expression of the growth hormone secretagogue receptor (ghsr) in the arcuate nucleus of the hypothalamus (arc). |
2017-06-30 |
2023-08-13 |
rat |
| Jin Zhang, Wenge Ma, Yan He, Junjie Wu, Farman Ullah Dawar, Fan Ren, Xiaohan Zhao, Jie Me. Sex biased expression of ghrelin and GHSR associated with sexual size dimorphism in yellow catfish. Gene. vol 578. issue 2. 2016-05-31. PMID:26692148. |
real-time pcr indicated that both ghrelin and ghsr were more highly expressed in hypothalamus and gut of male fish than female. |
2016-05-31 |
2023-08-13 |
Not clear |
| Bharath K Mani, Angela K Walker, Eduardo J Lopez Soto, Jesica Raingo, Charlotte E Lee, Mario Perelló, Zane B Andrews, Jeffrey M Zigma. Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse. The Journal of comparative neurology. vol 522. issue 16. 2015-05-11. PMID:24825838. |
in summary, the ghsr-egfp reporter mouse model may be a useful tool for studying ghsr function, particularly within the brainstem and hippocampus; however, it underrepresents ghsr expression in nuclei within the hypothalamus and midbrain. |
2015-05-11 |
2023-08-13 |
mouse |