| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niels Møller, Jens Otto Lunde Jørgense. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocrine reviews. vol 30. issue 2. 2009-06-15. PMID:19240267. |
this ability of gh to induce insulin resistance is significant for the defense against hypoglycemia, for the development of "stress" diabetes during fasting and inflammatory illness, and perhaps for the "dawn" phenomenon (the increase in insulin requirements in the early morning hours). |
2009-06-15 |
2023-08-12 |
human |
| Niels Møller, Jens Otto Lunde Jørgense. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocrine reviews. vol 30. issue 2. 2009-06-15. PMID:19240267. |
adult patients with gh deficiency are insulin resistant-probably related to increased adiposity, reduced lbm, and impaired physical performance-which temporarily worsens when gh treatment is initiated. |
2009-06-15 |
2023-08-12 |
human |
| Brian J Potter, Catherine Beauregard, Omar Serr. Serum markers of cardiovascular risk in patients with acromegaly before and after six months of treatment with octreotide LAR. Pituitary. vol 11. issue 1. 2009-06-11. PMID:17917813. |
at baseline fasting blood was obtained for measurements of gh, igf-1, glucose, insulin, lipids, lipoprotein (a), c-reactive protein, leucocyte count, fibrinogen, factor viii and nt-pro bnp. |
2009-06-11 |
2023-08-12 |
human |
| Brian J Potter, Catherine Beauregard, Omar Serr. Serum markers of cardiovascular risk in patients with acromegaly before and after six months of treatment with octreotide LAR. Pituitary. vol 11. issue 1. 2009-06-11. PMID:17917813. |
octreotide lar reduced gh, igf-1 and insulin resistance index but did not alter levels of crp and nt-pro bnp. |
2009-06-11 |
2023-08-12 |
human |
| Michael J Ormsbee, Myung Dong Choi, Justin K Medlin, Gabriel H Geyer, Lauren H Trantham, Gabriel S Dubis, Robert C Hickne. Regulation of fat metabolism during resistance exercise in sedentary lean and obese men. Journal of applied physiology (Bethesda, Md. : 1985). vol 106. issue 5. 2009-06-11. PMID:19265063. |
plasma insulin concentrations were significantly lower (p = 0.002) and plasma growth hormone (gh) was significantly higher (p = 0.03) in ln compared with ob men. |
2009-06-11 |
2023-08-12 |
human |
| Thais de Castro Barbosa, José Edgar Nicoletti de Carvalho, Leonice Lourenço Poyares, Silvana Bordin, Ubiratan Fabres Machado, Maria Tereza Nune. Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine. Endocrinology. vol 150. issue 5. 2009-06-08. PMID:19106217. |
it was shown that arg treatment: 1) did not affect phosphotyrosine-ir, whereas it decreased phosphotyrosine-ir substrate 1/2 and phosphoserine-akt content in all tissues studied, indicating that insulin signaling is impaired at post-receptor level; 2) decreased pm glut4 content in both muscles and wat; 3) increased the pituitary gh mrna, gh, and liver igf-i mrna expression, the levels of phosphotyrosine-stat5 in both muscles, phosphotyrosine-janus kinase 2 in extensorum digitalis longus, phosphotyrosine-stat3 in liver, and wat as well as total p85alpha in soleus, indicating that gh signaling is enhanced in these tissues; and 4) increased p55alpha total content in muscles, wat, and liver. |
2009-06-08 |
2023-08-12 |
rat |
| Thais de Castro Barbosa, José Edgar Nicoletti de Carvalho, Leonice Lourenço Poyares, Silvana Bordin, Ubiratan Fabres Machado, Maria Tereza Nune. Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine. Endocrinology. vol 150. issue 5. 2009-06-08. PMID:19106217. |
the present findings provide the molecular mechanisms by which insulin resistance and, by extension, reduced glut4 content in pm of muscles and wat take place after chronic administration of arg, and further suggest a putative role for gh in its genesis, considering its diabetogenic effect. |
2009-06-08 |
2023-08-12 |
rat |
| Takara L Stanley, Steven K Grinspoo. GH/GHRH axis in HIV lipodystrophy. Pituitary. vol 12. issue 2. 2009-06-04. PMID:18270841. |
treatment with supraphysiologic gh is limited by side effects and exacerbation of insulin resistance, whereas administration of physiologic doses of gh demonstrates more modest treatment effects but fewer adverse effects. |
2009-06-04 |
2023-08-12 |
Not clear |
| Ken H Darzy, Stephen M Shale. Hypopituitarism following Radiotherapy Revisited. Endocrine development. vol 15. 2009-05-29. PMID:19293601. |
in children, failure of the hyper-stimulated partially damaged h-p axis to meet the increased demands for gh during growth and puberty may explain what has previously been described as radiation-induced gh neurosecretory dysfunction and, unlike in adults, the insulin tolerance test remains the gold standard for assessing h-p functional reserve. |
2009-05-29 |
2023-08-12 |
Not clear |
| Eva Gesteiro, Sara Bastida, Francisco J Sánchez-Muni. Insulin resistance markers in term, normoweight neonates. The Mérida cohort. European journal of pediatrics. vol 168. issue 3. 2009-05-27. PMID:18597116. |
the aim of our study was to assess normal ranges for glucose, growth hormone (gh), insulin-like growth factor-1 (igf-1), cortisol, insulin and the yet-to-be-published quantitative insulin sensitivity check index (quicki) for newborns and a number of homeostatic model assessment (homa)-related equations that have been proposed as indicators of insulin sensitivity (homa-s) and insulin resistance (homa-r). |
2009-05-27 |
2023-08-12 |
Not clear |
| Eva Gesteiro, Sara Bastida, Francisco J Sánchez-Muni. Insulin resistance markers in term, normoweight neonates. The Mérida cohort. European journal of pediatrics. vol 168. issue 3. 2009-05-27. PMID:18597116. |
neonatal normal values given as the mean (95% confidence interval) were: glucose, 75.3 mg/dl (68.29-82.29); cortisol, 7.4 microg/dl (6.85-7.97); gh, 16.7 ng/ml (14.87-18.60); insulin, 5.5 microui/ml (4.12-6.88), igf-155.2 ng/ml (50.82-59.53); quicki, 0.45 (0.43-0.48); homa-r, 1.36 (0.84-1.88); homa-s, 4.07 (2.66-5.49), the glucose/insulin ratio, 33.6 (24.58-42.67); the insulin/cortisol ratio, 0.8 (0.61-1.05). |
2009-05-27 |
2023-08-12 |
Not clear |
| Xiangdong Wang, Ning Yang, Luqin Deng, Xin Li, Jing Jiang, Yujun Gan, Stuart J Fran. Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1. Molecular endocrinology (Baltimore, Md.). vol 23. issue 4. 2009-05-26. PMID:19164446. |
insulin receptor substrate-1 (irs-1) is a docking protein tyrosine phosphorylated in response to insulin, igf-1, gh, and other cytokines. |
2009-05-26 |
2023-08-12 |
Not clear |
| Deniz Tuncel, Fatma Inanc Tolun, Ismail Tor. Serum insulin-like growth factor-1 and nitric oxide levels in Parkinson's disease. Mediators of inflammation. vol 2009. 2009-05-26. PMID:19300521. |
the aim of this study was to investigate the role of circulating growth hormone (gh), insulin growth factor-1 (igf-1), igf binding protein-3 (igfbp-3), and nitric oxide (no) concentrations in the patients suffering from parkinson's disease (pd). |
2009-05-26 |
2023-08-12 |
human |
| Michal M Masternak, Jacob A Panici, Michael S Bonkowski, Larry F Hughes, Andrzej Bartk. Insulin sensitivity as a key mediator of growth hormone actions on longevity. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 64. issue 5. 2009-05-18. PMID:19304940. |
we suggest that enhanced insulin sensitivity, in conjunction with reduced insulin levels, may represent an important (although almost certainly not exclusive) mechanism of increased longevity in hypopituitary, growth hormone (gh)-resistant, and calorie-restricted animals. |
2009-05-18 |
2023-08-12 |
mouse |
| Michal M Masternak, Jacob A Panici, Michael S Bonkowski, Larry F Hughes, Andrzej Bartk. Insulin sensitivity as a key mediator of growth hormone actions on longevity. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 64. issue 5. 2009-05-18. PMID:19304940. |
we also report that the effects of gh treatment on insulin sensitivity may be limited to the period of gh administration. |
2009-05-18 |
2023-08-12 |
mouse |
| Neelima Dubey, Bechan La. Paracrine role of macrophage produced-nitric oxide (NO) in Leydig cell steroidogenesis in a teleost, Clarias batrachus: Impact of gonadotropin, growth hormone and insulin on NO production by testicular macrophages. General and comparative endocrinology. vol 160. issue 1. 2009-05-05. PMID:18977357. |
significant decline in no production was also recorded following treatment of macrophages with the gonadotropin (gth), growth hormone (gh) and insulin indicating that macrophage-produced no is under endocrine inhibitory control. |
2009-05-05 |
2023-08-12 |
Not clear |
| Neelima Dubey, Bechan La. Paracrine role of macrophage produced-nitric oxide (NO) in Leydig cell steroidogenesis in a teleost, Clarias batrachus: Impact of gonadotropin, growth hormone and insulin on NO production by testicular macrophages. General and comparative endocrinology. vol 160. issue 1. 2009-05-05. PMID:18977357. |
further, effect of conditioned medium of testicular macrophages incubated with medium alone (non-treated tmcm) or gth (gth-treated tmcm) or gh (gh-treated tmcm) or insulin (insulin-treated tmcm) were also observed on leydig cell t production. |
2009-05-05 |
2023-08-12 |
Not clear |
| F Broglio, F Prodam, F Riganti, C Gottero, S Destefanis, R Granata, G Muccioli, T Abribat, A J van der Lely, E Ghig. The continuous infusion of acylated ghrelin enhances growth hormone secretion and worsens glucose metabolism in humans. Journal of endocrinological investigation. vol 31. issue 9. 2009-05-04. PMID:18997491. |
besides stimulation of gh secretion and appetite, it exerts other central and peripheral actions including modulation of insulin secretion, glucose and lipid metabolism. |
2009-05-04 |
2023-08-12 |
Not clear |
| P K Chelikani, D J Ambrose, D H Keisler, J J Kennell. Effects of dietary energy and protein density on plasma concentrations of leptin and metabolic hormones in dairy heifers. Journal of dairy science. vol 92. issue 4. 2009-04-24. PMID:19307624. |
our objectives were to determine the effects of diets differing in energy and protein density on dry matter intake (dmi), growth traits [body weight (bw), body condition score (bcs), back-fat (bf) thickness], and temporal changes in plasma concentrations of leptin, insulin, growth hormone (gh), insulin-like growth factor-1 (igf-1), glucose, and nonesterified fatty acids (nefa) in dairy heifers during the pre- and postpubertal periods. |
2009-04-24 |
2023-08-12 |
cattle |
| P K Chelikani, D J Ambrose, D H Keisler, J J Kennell. Effects of dietary energy and protein density on plasma concentrations of leptin and metabolic hormones in dairy heifers. Journal of dairy science. vol 92. issue 4. 2009-04-24. PMID:19307624. |
the data provide evidence that 1) dmi (18%), bw (17%), and bf (5%) together explained 40% of the variation in plasma leptin concentrations (r(2) = 0.396); 2) unlike the acute postprandial increase in plasma insulin as a result of increased nutrient density (h 1.42 +/- 0.09, m 1.02 +/- 0.09, l 0.68 +/- 0.11 ng/ml), plasma leptin concentrations did not respond acutely with a distinct postprandial profile; 3) although plasma leptin concentrations increased with age, leptin at puberty did not differ among treatment groups (h 5.63 +/- 2.48, m 4.28 +/- 0.55, l 4.12 +/- 0.72 ng/ml) and there was no evidence of an abrupt transition in prepubertal plasma leptin concentrations; 4) plasma leptin concentrations may not be a critical trigger for puberty in rapidly growing heifers, but are apparently essential for puberty in heifers with normal or restricted growth rates; and 5) plasma concentrations of insulin (h 0.59 +/- 0.07, m 0.43 +/- 0.09, l 0.30 +/- 0.09 ng/ml), igf-1 (h 151.08 +/- 16.47, l 82.51 +/- 17.47 ng/ml), and glucose (h 81.35 +/- 3.39, m 73.59 +/- 2.34, l 68.25 +/- 3.39 mg/dl) reflected nutrient density, whereas gh (h 1.82 +/- 0.23, l 5.87 +/- 0.45 ng/ml) and nefa (h 209.54 +/- 50.83, l 234.93 +/- 48.97 microm) were inversely related to the plane of nutrition. |
2009-04-24 |
2023-08-12 |
cattle |