| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun Woo Kim, Zhejiu Quan, Young-Beom Kim, Eunji Cheong, Heung Dong Kim, Minjung Cho, Jiho Jang, Young Rang Yoo, Joon Soo Lee, Ji Hun Kim, Yang In Kim, Dae-Sung Kim, Hoon-Chul Kan. Differential effects on sodium current impairments by distinct SCN1A mutations in GABAergic neurons derived from Dravet syndrome patients. Brain & development. vol 40. issue 4. 2018-08-20. PMID:29295803. |
we investigated how two distinct mutations in scn1a differentially affect electrophysiological properties of the patient-derived gabaergic neurons and clinical severities in two dravet syndrome (ds) patients. |
2018-08-20 |
2023-08-13 |
Not clear |
| Fatemeh S Mojabi, Atoossa Fahimi, Shahrzad Moghadam, Sarah Moghadam, M Windy McNerneny, Ravikumar Ponnusamy, Alexander Kleschevnikov, William C Mobley, Ahmad Saleh. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. vol 26. issue 12. 2018-01-15. PMID:27701794. |
it has been suggested that increased gabaergic innervation in the hippocampus plays a significant role in cognitive dysfunction in down syndrome (ds). |
2018-01-15 |
2023-08-13 |
mouse |
| Fatemeh S Mojabi, Atoossa Fahimi, Shahrzad Moghadam, Sarah Moghadam, M Windy McNerneny, Ravikumar Ponnusamy, Alexander Kleschevnikov, William C Mobley, Ahmad Saleh. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. vol 26. issue 12. 2018-01-15. PMID:27701794. |
bolstering this notion, are studies linking hyper-innervation of the dentate gyrus (dg) by gabaergic terminals to failure in ltp induction in the ts65dn mouse model of ds. |
2018-01-15 |
2023-08-13 |
mouse |
| Alon Poleg-Polsky, Jeffrey S Diamon. Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 21. 2017-07-03. PMID:27225774. |
in the retina, ff inhibition is an essential feature of the circuitry underlying direction selectivity (ds): glutamatergic bipolar cells (bcs) provide excitatory input to direction-selective ganglion cells (dsgcs) and gabaergic starburst amacrine cells (sacs), and the sacs then provide ff inhibition onto dsgcs. |
2017-07-03 |
2023-08-13 |
mouse |
| Bruno Henrique Silva Araujo, Laila Brito Torres, Laura Maria F F Guilhot. Cerebal overinhibition could be the basis for the high prevalence of epilepsy in persons with Down syndrome. Epilepsy & behavior : E&B. vol 53. 2016-07-11. PMID:26558714. |
this review discusses the gabaergic system in the human ds brain and the possible implication of the gabaergic network circuit in the epileptogenic process in individuals where the pathogenetic basis for epilepsy is unknown. |
2016-07-11 |
2023-08-13 |
mouse |
| Franck Kalume, John C Oakley, Ruth E Westenbroek, Jennifer Gile, Horacio O de la Iglesia, Todd Scheuer, William A Catteral. Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome. Neurobiology of disease. vol 77. 2016-01-06. PMID:25766678. |
although sleep disorders in epilepsies have been attributed to anti-epileptic drugs, our results show that sleep disorder in ds mice arises from loss of nav1.1 channels in forebrain gabaergic interneurons without drug treatment. |
2016-01-06 |
2023-08-13 |
mouse |
| Gabriele Deidda, Martina Parrini, Shovan Naskar, Ignacio F Bozarth, Andrea Contestabile, Laura Cancedd. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome. Nature medicine. vol 21. issue 4. 2015-06-19. PMID:25774849. |
down syndrome (ds) is the most frequent genetic cause of intellectual disability, and altered gabaergic transmission through cl(-)-permeable gabaa receptors (gabaars) contributes considerably to learning and memory deficits in ds mouse models. |
2015-06-19 |
2023-08-13 |
mouse |
| Gabriele Deidda, Martina Parrini, Shovan Naskar, Ignacio F Bozarth, Andrea Contestabile, Laura Cancedd. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome. Nature medicine. vol 21. issue 4. 2015-06-19. PMID:25774849. |
however, the efficacy of gabaergic transmission has never been directly assessed in ds. |
2015-06-19 |
2023-08-13 |
mouse |
| Alex Hoggarth, Amanda J McLaughlin, Kara Ronellenfitch, Stuart Trenholm, Rishi Vasandani, Santhosh Sethuramanujam, David Schwab, Kevin L Briggman, Gautam B Awatraman. Specific wiring of distinct amacrine cells in the directionally selective retinal circuit permits independent coding of direction and size. Neuron. vol 86. issue 1. 2015-06-15. PMID:25801705. |
here, we demonstrate that increasing ambient illumination leads to the recruitment of gabaergic wide-field amacrine cells (wacs) endowing the ds circuit with an additional feature: size selectivity. |
2015-06-15 |
2023-08-13 |
Not clear |
| Ryan J Schutte, Soleil S Schutte, Jacqueline Algara, Eden V Barragan, Jeff Gilligan, Cynthia Staber, Yiannis A Savva, Martin A Smith, Robert Reenan, Diane K O'Dow. Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. Journal of neurophysiology. vol 112. issue 4. 2015-04-10. PMID:24805083. |
electrophysiological studies of gabaergic interneurons in the brains of adult ds flies reveal, for the first time in an in vivo model system, that a missense ds mutation causes a constitutive and conditional reduction in sodium current activity and repetitive firing. |
2015-04-10 |
2023-08-13 |
drosophila_melanogaster |
| Ryan J Schutte, Soleil S Schutte, Jacqueline Algara, Eden V Barragan, Jeff Gilligan, Cynthia Staber, Yiannis A Savva, Martin A Smith, Robert Reenan, Diane K O'Dow. Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. Journal of neurophysiology. vol 112. issue 4. 2015-04-10. PMID:24805083. |
the distinct alterations of sodium currents in ds and gefs+ gabaergic interneurons demonstrate that both loss- and gain-of-function alterations in sodium currents are capable of causing reduced repetitive firing and seizure phenotypes. |
2015-04-10 |
2023-08-13 |
drosophila_melanogaster |
| Francesca Rossi, Ida Marabese, Maria De Chiaro, Serena Boccella, Livio Luongo, Francesca Guida, Danilo De Gregorio, Catia Giordano, Vito de Novellis, Enza Palazzo, Sabatino Maion. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. Journal of neurophysiology. vol 111. issue 11. 2015-01-24. PMID:24304862. |
furthermore, a decreased level of mglur8 gene and immunoreactivity, expressed on gabaergic terminals, associated with a protein increase was found in the ds of sni rats. |
2015-01-24 |
2023-08-12 |
rat |
| Genevieve K Smith, Raymond P Kesner, Julie R Korenber. Dentate gyrus mediates cognitive function in the Ts65Dn/DnJ mouse model of Down syndrome. Hippocampus. vol 24. issue 3. 2014-10-07. PMID:24339224. |
although dentate gyrus (dg) dysfunction is suggested by excessive gabaergic inhibition, its role in perturbing dg functions in ds is unknown. |
2014-10-07 |
2023-08-12 |
mouse |
| Carmen Martínez-Cué, Paula Martínez, Noemí Rueda, Rebeca Vidal, Susana García, Verónica Vidal, Andrea Corrales, Juan A Montero, Ángel Pazos, Jesús Flórez, Rodolfo Gasser, Andrew W Thomas, Michael Honer, Frédéric Knoflach, Jose Luis Trejo, Joseph G Wettstein, Maria-Clemencia Hernánde. Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 9. 2013-04-22. PMID:23447605. |
these data demonstrate that reducing gabaergic inhibition with ro4938581 can reverse functional and neuromorphological deficits of ts mice by facilitating brain plasticity and support the potential therapeutic use of selective gaba(a) α5 nams to treat cognitive dysfunction in ds. |
2013-04-22 |
2023-08-12 |
mouse |
| Hanns Möhle. Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model. Biochemical pharmacology. vol 84. issue 8. 2012-12-13. PMID:22898099. |
the cognitive behavioral deficits of ts65dn mice can be rescued by reducing gabaergic inhibition, most selectively by partial inverse agonists acting on α(5) gaba-a receptors, of which one compound has recently entered clinical trials in ds. |
2012-12-13 |
2023-08-12 |
mouse |
| Christine S Cheah, Frank H Yu, Ruth E Westenbroek, Franck K Kalume, John C Oakley, Gregory B Potter, John L Rubenstein, William A Catteral. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 36. 2012-11-26. PMID:22908258. |
previous studies using a mouse model of ds revealed reduced sodium currents and impaired excitability in gabaergic interneurons in the hippocampus, leading to the hypothesis that impaired excitability of gabaergic inhibitory neurons is the cause of epilepsy and premature death in ds. |
2012-11-26 |
2023-08-12 |
mouse |
| Christine S Cheah, Frank H Yu, Ruth E Westenbroek, Franck K Kalume, John C Oakley, Gregory B Potter, John L Rubenstein, William A Catteral. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 36. 2012-11-26. PMID:22908258. |
evidently, loss of na(v)1.1 channels in forebrain gabaergic neurons is both necessary and sufficient to cause epilepsy and premature death in ds. |
2012-11-26 |
2023-08-12 |
mouse |
| Alex C Bender, Richard P Morse, Rod C Scott, Gregory L Holmes, Pierre-Pascal Lenck-Santin. SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy & behavior : E&B. vol 23. issue 3. 2012-07-30. PMID:22341965. |
we hypothesize that disruptions in gabaergic firing may directly contribute to the poor cognitive outcomes in children with ds, and discuss the therapeutic implications of this possibility. |
2012-07-30 |
2023-08-12 |
Not clear |
| Alexander M Kleschevnikov, Pavel V Belichenko, Jessica Gall, Lizzy George, Rachel Nosheny, Michael T Maloney, Ahmad Salehi, William C Moble. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease. vol 45. issue 2. 2012-05-18. PMID:22062771. |
to investigate this important feature of neurobiology of ds, we examined synaptic and molecular properties of the gabaergic system in the dentate gyrus (dg) of adult ts65dn mice. |
2012-05-18 |
2023-08-12 |
mouse |
| Tyler K Best, Nathan P Cramer, Lina Chakrabarti, Tarik F Haydar, Zygmunt Galdzick. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178330. |
gabaergic dysfunction is implicated in hippocampal deficits of the ts65dn mouse model of down syndrome (ds). |
2012-03-26 |
2023-08-12 |
mouse |