| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabrizio Capitano, Mathieu Kuchenbuch, Jennifer Lavigne, Hava Chaptoukaev, Maria A Zuluaga, Marco Lorenzi, Rima Nabbout, Massimo Mantegazz. Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low-voltage-fast onset seizures in Dravet syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 23. 2024-05-29. PMID:38809712. |
we investigated electrographic activities and neural dynamics leading to convulsive seizures in patients and mouse models of dravet syndrome (ds), a developmental and epileptic encephalopathy in which hypoexcitability of gabaergic neurons is considered to be the main dysfunction. |
2024-05-29 |
2024-06-11 |
mouse |
| Megan K Gautier, Christy M Kelley, Sang Han Lee, Melissa J Alldred, John McDaid, Elliott J Mufson, Grace E Stutzmann, Stephen D Ginsber. Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Neurobiology of disease. vol 188. 2023-11-04. PMID:37890559. |
we also examined the effect of trisomy, and mcs, on gabaergic basal forebrain parvalbumin neurons (bfpns), an unexplored neuronal population in this ds model. |
2023-11-04 |
2023-11-08 |
mouse |
| Alexandra Scott, Dakota Palmer, Bailey Newell, Iris Lin, Christelle A Cayton, Anika Paulson, Paige Remde, Jocelyn M Richar. Ventral pallidal GABAergic neuron calcium activity encodes cue-driven reward seeking and persists in the absence of reward delivery. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-06-20. PMID:37339880. |
here, we used an intersectional viral approach with fiber photometry to record bulk calcium activity in vp gabaergic (vp gaba) neurons in male and female rats as they learned and performed the ds task. |
2023-06-20 |
2023-08-14 |
rat |
| Hao Liu, René N Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M Hull, Geng Pan, Ruonan Li, Macy W Veling, Lori L Isom, Kenneth Y Kwan, Z Josh Huang, Peter G Fuerst, Paul M Jenkins, Bing Y. DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. PLoS biology. vol 21. issue 4. 2023-04-20. PMID:37079499. |
in the ts65dn mouse model for ds, where dscam is overexpressed due to dscam triplication, gabaergic innervation of pyns by basket and chandelier interneurons is increased. |
2023-04-20 |
2023-08-14 |
mouse |
| Hao Liu, René N Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M Hull, Geng Pan, Ruonan Li, Macy W Veling, Lori L Isom, Kenneth Y Kwan, Z Josh Huang, Peter G Fuerst, Paul M Jenkins, Bing Y. DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. PLoS biology. vol 21. issue 4. 2023-04-20. PMID:37079499. |
these findings demonstrate excessive gabaergic innervation and synaptic transmission in the neocortex of ds mouse models and identify dscam overexpression as the cause. |
2023-04-20 |
2023-08-14 |
mouse |
| Lei Xu, Hai-Qin Huo, Kai-Qin Lu, Xiao-Yan Tang, Yuan Hong, Xiao Han, Zi-Xing Fu, Kai-Heng Fang, Min Xu, Xing Guo, Yan Li. Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids. Biochimica et biophysica acta. Molecular basis of disease. 2022-03-18. PMID:35301086. |
in this study, we first generated gabaergic interneurons and medial ganglionic eminence (mge) organoids from ds patients and control induced pluripotent stem cells. |
2022-03-18 |
2023-08-13 |
Not clear |
| R G K Munn, A Freeburn, D P Finn, H C Helle. Hyper-rigid phasic organisation of hippocampal activity but normal spatial properties of CA1 place cells in the Ts65Dn mouse model of Down Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-04. PMID:34980635. |
one of the primary functional differences in ds is thought to be an excess of gabaergic innervation from medial septum (ms) to the hippocampus. |
2022-01-04 |
2023-08-13 |
mouse |
| Melissa J Alldred, Sai C Penikalapati, Sang Han Lee, Adriana Heguy, Panos Roussos, Stephen D Ginsber. Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer's Disease. Molecular neurobiology. vol 58. issue 10. 2021-11-27. PMID:34263425. |
we propose both expected and novel therapeutic targets for ds and ad, including specific degs within cholinergic, glutamatergic, gabaergic, and neurotrophin pathways, as well as select targets for repairing oxidative phosphorylation status in neurons. |
2021-11-27 |
2023-08-13 |
mouse |
| Arnaud Duchon, Agnès Gruart, Christelle Albac, Benoît Delatour, Javier Zorrilla de San Martin, José María Delgado-García, Yann Hérault, Marie-Claude Potie. Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABA British journal of pharmacology. vol 177. issue 5. 2021-06-21. PMID:31652355. |
long-lasting correction of in vivo ltp and cognitive deficits of mice modelling down syndrome with an α5-selective gaba excessive gabaergic inhibition contributes to cognitive dysfunctions in down syndrome (ds). |
2021-06-21 |
2023-08-13 |
mouse |
| Joseph Pottackal, Joshua H Singer, Jonathan B Dem. Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry. Frontiers in cellular neuroscience. vol 14. 2021-05-14. PMID:33324168. |
the ds mechanism depends on starburst amacrine cells (sacs), which provide null direction-tuned gabaergic inhibition and untuned cholinergic excitation to dsgcs. |
2021-05-14 |
2023-08-13 |
mouse |
| Joseph Pottackal, Joshua H Singer, Jonathan B Dem. Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry. Frontiers in cellular neuroscience. vol 14. 2021-05-14. PMID:33324168. |
despite its paracrine mode of transmission, cholinergic excitation is more transient than gabaergic inhibition, yielding a temporal difference that contributes essentially to the ds computation. |
2021-05-14 |
2023-08-13 |
mouse |
| Andrea Contestabile, Salvatore Magara, Laura Cancedd. The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28326014. |
a large body of evidence has shown that synaptic deficits and memory impairment are largely determined by altered gabaergic signaling in trisomic mouse models of ds. |
2020-09-29 |
2023-08-13 |
mouse |
| Andrea Contestabile, Salvatore Magara, Laura Cancedd. The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28326014. |
accordingly, different pharmacological interventions targeting gabaergic signaling have proven promising preclinical approaches to rescue cognitive impairment in ds mouse models. |
2020-09-29 |
2023-08-13 |
mouse |
| Andrea Contestabile, Salvatore Magara, Laura Cancedd. The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28326014. |
in this review, we will discuss recent data regarding the complex scenario of gabaergic dysfunctions in the trisomic brain of ds mice and patients, and we will evaluate the state of current clinical research targeting gabaergic signaling in individuals with ds. |
2020-09-29 |
2023-08-13 |
mouse |
| Benoit Souchet, Arnaud Duchon, Yuchen Gu, Julien Dairou, Claire Chevalier, Fabrice Daubigney, Valérie Nalesso, Nicole Créau, Yuejin Yu, Nathalie Janel, Yann Herault, Jean Maurice Delaba. Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models. Scientific reports. vol 9. issue 1. 2020-09-29. PMID:30850713. |
similar results for gabaergic and glutamatergic markers and interneuron density were obtained in dp(16)1yey mice, trisomic for 140 chromosome 21 orthologs; thus, prenatal egcg exhibits efficacy in a more complex ds model. |
2020-09-29 |
2023-08-13 |
mouse |
| Rosa Anna Vacca, Sweta Bawari, Daniela Valenti, Devesh Tewari, Seyed Fazel Nabavi, Samira Shirooie, Archana N Sah, Mariateresa Volpicella, Nady Braidy, Seyed Mohammad Nabav. Down syndrome: Neurobiological alterations and therapeutic targets. Neuroscience and biobehavioral reviews. vol 98. 2019-07-11. PMID:30615933. |
impairments in gabaergic transmission, noradrenergic neuronal loss, anomalous glutamatergic transmission and n-methyl-d-aspartate receptor signalling, mitochondrial dysfunction, increased oxidative stress and inflammation, differentially expressed micrornas, increased expression of crucial chromosome 21 genes, and dna hyper-methylation and hyperactive homocysteine trans-sulfuration pathway, are common incongruities that have been reported in ds and might contribute to cognitive impairment and intellectual disability. |
2019-07-11 |
2023-08-13 |
human |
| Sandra Guidi, Andrea Giacomini, Fiorenza Stagni, Marco Emili, Beatrice Uguagliati, Maria Paola Bonasoni, Renata Bartesagh. Abnormal development of the inferior temporal region in fetuses with Down syndrome. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29509279. |
immunohistochemistry for calretinin (cr), a marker of gabaergic interneurons, showed that in ds fetuses the ratio of cr-positive vs. cr-negative cells was greater than in euploid fetuses, both in the fg (177%) and itg (161%). |
2019-05-28 |
2023-08-13 |
Not clear |
| Hai-Qin Huo, Zhuang-Yin Qu, Fang Yuan, Lixiang Ma, Lin Yao, Min Xu, Yao Hu, Jing Ji, Anita Bhattacharyya, Su-Chun Zhang, Yan Li. Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29526735. |
such phenotypes were replicated following transplantation of the ds gabaergic progenitors into the mouse medial septum. |
2019-04-23 |
2023-08-13 |
mouse |
| Hai-Qin Huo, Zhuang-Yin Qu, Fang Yuan, Lixiang Ma, Lin Yao, Min Xu, Yao Hu, Jing Ji, Anita Bhattacharyya, Su-Chun Zhang, Yan Li. Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29526735. |
these results suggest that impaired migration of ds gabaergic neurons may contribute to the reduced number of interneurons in the cerebral cortex and hippocampus in ds patients. |
2019-04-23 |
2023-08-13 |
mouse |
| J Levenga, D J Peterson, P Cain, C A Hoeffe. Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model. Neuroscience. vol 376. 2019-02-21. PMID:29454635. |
these results in dp16 mice are consistent with sleep disturbances found in individuals with ds, and the abnormal eeg oscillations in aged dp16 mice suggest a potential role for gabaergic activity in these sleep and eeg abnormalities. |
2019-02-21 |
2023-08-13 |
mouse |