| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oscar Gómez, José Antonio Bals. Autocrine/paracrine action of pituitary vasoactive intestinal peptide on lactotroph hyperplasia induced by estrogen. Endocrinology. vol 144. issue 10. 2003-10-29. PMID:12960047. |
des treatment also increased pituitary vip content and vip mrna levels, but not in the hypothalamus and cerebral cortex. |
2003-10-29 |
2023-08-12 |
rat |
| K A Gould, J D Shull, J Gorsk. DES action in the thymus: inhibition of cell proliferation and genetic variation. Molecular and cellular endocrinology. vol 170. issue 1-2. 2001-08-23. PMID:11162888. |
here, we demonstrate that the estrogen diethylstilbestrol (des) inhibits cell proliferation within the thymic cortex, the primary site of thymocyte proliferation. |
2001-08-23 |
2023-08-12 |
rat |
| A P D'Costa, X Xu, R L Ingram, W E Sonnta. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. vol 65. issue 3. 1995-08-17. PMID:7609879. |
male brown norway rats (5-7 and 27-28 months old) were used to determine (1) whether in vivo protein synthesis in cortex, hippocampus, hypothalamus and cerebellum decreases with age and (2) whether these deficiencies are associated with age-related alterations in response to insulin-like growth factor-1, des (1-3) igf-1 or insulin. |
1995-08-17 |
2023-08-12 |
rat |
| S Bar-Ami, Z Amiri, A Weizman, F Fares, M Gavis. Long-term testosterone or diethylstilbestrol treatment affects gamma-aminobutyric acid and central-type benzodiazepine receptors but not peripheral-type benzodiazepine receptors in the female rat brain. Neuroendocrinology. vol 57. issue 6. 1993-12-22. PMID:8232768. |
in the present study, the effect of the synthetic estrogen diethylstilbestrol (des) and testosterone (t) on the density of peripheral and central benzodiazepine (bz) and gamma-aminobutyric acid (gabaa) receptors was evaluated in the frontoparietal cortex and whole cerebellum of female rats during the peripubertal period. |
1993-12-22 |
2023-08-12 |
rat |
| S Bar-Ami, Z Amiri, A Weizman, F Fares, M Gavis. Long-term testosterone or diethylstilbestrol treatment affects gamma-aminobutyric acid and central-type benzodiazepine receptors but not peripheral-type benzodiazepine receptors in the female rat brain. Neuroendocrinology. vol 57. issue 6. 1993-12-22. PMID:8232768. |
the density of peripheral-type bz receptors was not altered in either of these organs, whether or not treated with des or t. the density of central bz and gabaa receptors in either frontoparietal cortex or whole cerebellum was significantly reduced following treatment with des or t; however, the effect of des was much more pronounced. |
1993-12-22 |
2023-08-12 |
rat |
| C J Chang, Y C Lin, R W Brueggemeier, Y Rikihis. Morphometric analysis of renal cortex changes induced by diethylstilbestrol (DES) in Syrian hamsters. Research communications in chemical pathology and pharmacology. vol 78. issue 3. 1993-02-01. PMID:1475531. |
morphometric analysis of renal cortex changes induced by diethylstilbestrol (des) in syrian hamsters. |
1993-02-01 |
2023-08-11 |
Not clear |
| L A Bach, A J Cox, F A Mendelsohn, A C Herington, G A Werther, G Jerum. Focal induction of IGF binding proteins in proximal tubules of diabetic rat kidney. Diabetes. vol 41. issue 4. 1992-07-23. PMID:1376703. |
binding specificity in the cortex and outer medulla was typical of the type i igf receptor (igf-i = des[1-3]igf-i greater than igf-ii much greater than insulin). |
1992-07-23 |
2023-08-11 |
rat |
| A S Brown, P F Hal. Stimulation by endozepine of the side-chain cleavage of cholesterol in a reconstituted enzyme system. Biochemical and biophysical research communications. vol 180. issue 2. 1991-12-02. PMID:1953731. |
homogeneous endozepine prepared from bovine brain, the corresponding genetically engineered peptide and des(glu-ilu)-endozepine isolated from bovine adrenal cortex are all approximately equipotent in this system. |
1991-12-02 |
2023-08-11 |
cattle |
| M L McCormick, T D Oberley, J H Elwell, L W Oberley, Y Sun, J J L. Superoxide dismutase and catalase levels during estrogen-induced renal tumorigenesis, in renal tumors and their autonomous variants in the Syrian hamster. Carcinogenesis. vol 12. issue 6. 1991-07-12. PMID:2044204. |
the activity of these enzymes in renal tumors were compared to those in the kidney cortex of untreated male castrated hamsters of different ages and in age-matched animals treated with diethylstilbestrol (des) for varying periods. |
1991-07-12 |
2023-08-11 |
Not clear |
| G H Degen, G Blaich, M Metzle. Multiple pathways for the oxidative metabolism of estrogens in Syrian hamster and rabbit kidney. Journal of biochemical toxicology. vol 5. issue 2. 1991-03-18. PMID:2126561. |
monooxygenase-catalyzed metabolism was apparently responsible for the majority of des oxidation in microsomes from whole hamster kidneys in vitro and this activity is preferentially localized in the kidney cortex. |
1991-03-18 |
2023-08-11 |
rabbit |
| E Tribollet, C Barberis, J J Dreifuss, S Jar. Autoradiographic localization of vasopressin and oxytocin binding sites in rat kidney. Kidney international. vol 33. issue 5. 1988-08-17. PMID:3392884. |
specific [3h]vasopressin binding in the cortex was insensitive to the v1-selective ligand, des(gly(nh2)9d(ch2)5-avp, but was inhibited by ddavp. |
1988-08-17 |
2023-08-11 |
rat |
| S P Adams, A C Notide. Reduction of irreversible binding of diethylstilbestrol in hamster renal cortex by inhibitors of cytochrome P-450. Toxicology and applied pharmacology. vol 88. issue 1. 1987-04-30. PMID:2436352. |
these findings suggest that cytochrome p-450 isozymes in the hamster renal cortex metabolize des to reactive species that covalently bind to macromolecules. |
1987-04-30 |
2023-08-11 |
Not clear |
| S P Adams, A C Notide. Metabolism and irreversible binding of diethylstilbestrol in the kidney of the Syrian golden hamster. Biochemical pharmacology. vol 35. issue 13. 1986-07-31. PMID:3729974. |
the male hamster renal cortex showed a 2- to 3-fold greater capacity to form irreversible macromolecular-[3h]des complexes than the female hamster renal cortex. |
1986-07-31 |
2023-08-11 |
Not clear |
| S P Adams, A C Notide. Metabolism and irreversible binding of diethylstilbestrol in the kidney of the Syrian golden hamster. Biochemical pharmacology. vol 35. issue 13. 1986-07-31. PMID:3729974. |
the cortex as compared with the medulla of the male hamster kidney displayed a 5-fold greater capacity to irreversibly bind [3h]des metabolites. |
1986-07-31 |
2023-08-11 |
Not clear |