| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ivan Odak, Christian R Schultze-Florey, Swantje I Hammerschmidt, Christiane Ritter, Stefanie Willenzon, Michaela Friedrichsen, Inga Ravens, Ruth Sikora, Lâle M Bayir, Rodrigo Gutierrez Jauregui, Günter Bernhardt, Metodi V Stankov, Anne Cossmann, Guido Hansen, Thomas Krey, Markus Cornberg, Christian Koenecke, Georg M N Behrens, Berislav Bošnjak, Reinhold Förste. Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of Concern. Frontiers in immunology. vol 13. 2022-04-01. PMID:35359969. |
overall, our data suggest that even 7 month after the clearance of covid-19 many patients possess a protective layer of immunity, indicated by the persistence of spike-specific memory b cells and by the presence of neutralizing antibodies against the alpha and delta variants. |
2022-04-01 |
2023-08-13 |
Not clear |
| Alvin X Han, Eva Kozanli, Jelle Koopsen, Harry Vennema, Karim Hajji, Annelies Kroneman, Ivo van Walle, Don Klinkenberg, Jacco Wallinga, Colin A Russell, Dirk Eggink, Chantal B E M Reuske. Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands. medRxiv : the preprint server for health sciences. 2022-03-30. PMID:35350194. |
we also found that the alpha and delta variants largely circulated more populous regions with international connections after their respective introduction before asymmetric bidirectional transmissions occurred with the rest of the country and the variant dominated infections in the netherlands. |
2022-03-30 |
2023-08-13 |
Not clear |
| Gary McLean, Jeremy Kamil, Benhur Lee, Penny Moore, Thomas F Schulz, Alexander Muik, Ugur Sahin, Özlem Türeci, Shanti Pathe. The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines. mBio. 2022-03-30. PMID:35352979. |
data from clinical trials and real-world evidence suggest that current vaccines remain highly effective against the alpha variant (b.1.1.7), while some vaccines have reduced efficacy and effectiveness against symptomatic disease caused by the beta variant (b.1.351) and the delta variant (b.1.617.2); however, effectiveness against severe disease and hospitalization caused by delta remains high. |
2022-03-30 |
2023-08-13 |
Not clear |
| Jeroen Pollet, Ulrich Strych, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rakhi Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Syamala Rani Thimmiraju, Brianna Lopez, Portia M Gillespie, Shannon Ronca, Jason T Kimata, Martin Reers, Vikram Paradkar, Peter Hotez, Maria Elena Bottazz. Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. bioRxiv : the preprint server for biology. 2022-03-29. PMID:34268512. |
compared to two doses of the /alum formulation, the rbd/alum+cpg vaccine induced a stronger and more balanced th1/th2 cellular immune response, with high levels of neutralizing antibodies against the original wuhan isolate of sars-cov-2 as well as the b.1.1.7 (alpha), b.1.351 (beta), b.1.617.2 and (delta) variants. |
2022-03-29 |
2023-08-16 |
mouse |
| Yishan Fu, Fei Pan, Lei Zhao, Shuai Zhao, Junjie Yi, Shengbao Ca. Interfering effects on the bioactivities of several key proteins of COVID-19/variants in diabetes by compounds from Lianqiao leaves: In silico and in vitro analyses. International journal of biological macromolecules. 2022-03-29. PMID:35346677. |
results showed that, among the main ingredients in the leaves, forsythoside a showed the strongest docking affinities with the proteins sars-cov-2-rbd-hace2 of covid-19 and its variants (alpha (b.1.1.7), beta (b.1.351), and delta (b.1.617)), as well as neuropilin-1 (nrp1), and sars-cov-2 main protease (m |
2022-03-29 |
2023-08-13 |
Not clear |
| Zhiyuan Chen, Andrew S Azman, Xinhua Chen, Junyi Zou, Yuyang Tian, Ruijia Sun, Xiangyanyu Xu, Yani Wu, Wanying Lu, Shijia Ge, Zeyao Zhao, Juan Yang, Daniel T Leung, Daryl B Domman, Hongjie Y. Global landscape of SARS-CoV-2 genomic surveillance and data sharing. Nature genetics. 2022-03-29. PMID:35347305. |
here, we characterize increasing circulation of the alpha variant in early 2021, subsequently replaced by the delta variant around may 2021. |
2022-03-29 |
2023-08-13 |
Not clear |
| Alexander T Yu, Bridgette Hughes, Marlene K Wolfe, Tomas Leon, Dorothea Duong, Angela Rabe, Lauren C Kennedy, Sindhu Ravuri, Bradley J White, Krista R Wigginton, Alexandria B Boehm, Duc J Vugi. Estimating Relative Abundance of 2 SARS-CoV-2 Variants through Wastewater Surveillance at 2 Large Metropolitan Sites, United States. Emerging infectious diseases. vol 28. issue 5. 2022-03-29. PMID:35349402. |
we developed digital reverse transcription pcrs to monitor abundance of select mutations in alpha and delta vocs in wastewater settled solids, applied these to july 2020-august 2021 samples from 2 large us metropolitan sewersheds, and compared results to estimates of voc abundance from case isolate sequencing. |
2022-03-29 |
2023-08-13 |
Not clear |
| Yuan Liu, Anyin Feng, Shi Zhao, Weiming Wang, Daihai H. Large-scale synchronized replacement of Alpha (B.1.1.7) variant by the Delta (B.1.617.2) variant of SARS-COV-2 in the COVID-19 pandemic. Mathematical biosciences and engineering : MBE. vol 19. issue 4. 2022-03-28. PMID:35341265. |
large-scale synchronized replacement of alpha (b.1.1.7) variant by the delta (b.1.617.2) variant of sars-cov-2 in the covid-19 pandemic. |
2022-03-28 |
2023-08-13 |
Not clear |
| Yuan Liu, Anyin Feng, Shi Zhao, Weiming Wang, Daihai H. Large-scale synchronized replacement of Alpha (B.1.1.7) variant by the Delta (B.1.617.2) variant of SARS-COV-2 in the COVID-19 pandemic. Mathematical biosciences and engineering : MBE. vol 19. issue 4. 2022-03-28. PMID:35341265. |
in this work, we report a large-scale synchronized replacement pattern of the alpha (b.1.1.7) variant by the delta (b.1.617.2) variant of sars-cov-2. |
2022-03-28 |
2023-08-13 |
Not clear |
| Mikako Ueno, Naoko Iwata-Yoshikawa, Akihito Matsunaga, Tadashi Okamura, Sho Saito, Shinobu Ashida, Isao Yoshida, Mami Nagashima, Hiroyuki Asakura, Yuu I Yaoita, Jun Suzuki, Kenji Sadamasu, Kazuhisa Yoshimura, Satoshi Kutsuna, Nozomi Shiwa-Sudo, Noriyo Nagata, Tadaki Suzuki, Akinori Suzuki, Miwa Okamoto, Moto Kimura, Norio Ohmagari, Ryu Miura, Yukihito Ishizak. Isolation of human monoclonal antibodies with neutralizing activity to a broad spectrum of SARS-CoV-2 viruses including the Omicron variants. Antiviral research. 2022-03-28. PMID:35341809. |
ev053273 exerted potent antiviral activity against the wunan wild-type virus as well as the alpha and delta variants in vitro, whereas the antiviral activity of ev053286 was moderate, but it had a wide-range of suppressive activity on the wild-type virus as well as the alpha, beta, delta, kappa, omicron ba.1, and ba.2 variants. |
2022-03-28 |
2023-08-13 |
mouse |
| Manli Zhang, Lars Riecke, Gorka Fraga-González, Milene Bont. Altered brain network topology during speech tracking in developmental dyslexia. NeuroImage. 2022-03-28. PMID:35342007. |
the network topology of the phase synchronization of evoked cortical oscillations was investigated in four frequency bands (delta, theta, alpha and beta) using minimum spanning tree graphs. |
2022-03-28 |
2023-08-13 |
Not clear |
| Pallab Kar, Md Moshfekus Saleh-E-In, Nishika Jaishee, Akash Anandraj, Emil Kormuth, Balachandar Vellingiri, Claudio Angione, Pattanathu K S M Rahman, Suntheren Pillay, Arnab Sen, Devashan Naidoo, Ayan Roy, Yong E Cho. Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS-CoV-2 wild-type and the variants of concern, viral cell-entry process, and cytokine storm in COVID-19. Journal of cellular biochemistry. 2022-03-28. PMID:35342986. |
in this study, we explored the inhibitory potential of a library of 605 phytocompounds, selected from indian medicinal plants with reported antiviral and anti-inflammatory activities, against the receptor-binding domain of spike proteins of the sars-cov-2 wild-type and the variants of concern, including variants b.1.1.7 (alpha), b.1.351 (beta), p.1 (gamma), b.1.617.2 (delta), and b.1.1.529 (omicron). |
2022-03-28 |
2023-08-13 |
human |
| Evangelos Kontopodis, Vasileios Pierros, Dimitrios J Stravopodis, George T Tsangari. Prediction of SARS-CoV-2 Omicron Variant Immunogenicity, Immune Escape and Pathogenicity, through the Analysis of Spike Protein-Specific Core Unique Peptides. Vaccines. vol 10. issue 3. 2022-03-26. PMID:35334990. |
in this study, we identified the core unique peptides (crups) that reside exclusively in the omicron variant of spike protein and are absent from the human proteome, creating a new dataset of peptides named as sars-cov-2 crups against the human proteome (c/h-crups), and we analyzed their locations in comparison to the alpha and delta variants. |
2022-03-26 |
2023-08-13 |
human |
| Marco Fabiani, Katia Margiotti, Manuela Sabatino, Antonella Viola, Alvaro Mesoraca, Claudio Giorlandin. A Rapid and Consistent Method to Identify Four SARS-CoV-2 Variants during the First Half of 2021 by RT-PCR. Vaccines. vol 10. issue 3. 2022-03-26. PMID:35335115. |
several vocs have been detected, including alpha variant (b.1.1.7), beta variant (b.1.351), gamma variant (p.1/b.1.1.28.1) and delta variant (b.1.617.2), first identified in the uk, south africa, brazil and india, respectively. |
2022-03-26 |
2023-08-13 |
Not clear |
| Jing Pu, Xiaoyang He, Wei Xu, Cong Wang, Qiaoshuai Lan, Chen Hua, Kai Wang, Lu Lu, Shibo Jian. The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants. Viruses. vol 14. issue 3. 2022-03-26. PMID:35336896. |
here, we report a series of small-molecule compounds that proved effective against human coronaviruses (hcov), such as sars-cov-2 and its variants of concern (vocs), including alpha (b.1.1.7), beta (b.1.351), gamma (p.1), delta (b.1.617.2), and omicron (b.1.1.529), sars-cov, mers-cov, hcov-oc43, and other viruses with class i viral fusion proteins, such as influenza virus, ebola virus (ebov), nipah virus (niv), and lassa fever virus (lasv). |
2022-03-26 |
2023-08-13 |
human |
| Anissa Chouikha, Wasfi Fares, Asma Laamari, Sondes Haddad-Boubaker, Zeineb Belaiba, Kais Ghedira, Wafa Kammoun Rebai, Kaouther Ayouni, Marwa Khedhiri, Samar Ben Halima, Henda Krichen, Henda Touzi, Imen Ben Dhifallah, Fatma Z Guerfali, Chiraz Atri, Saifeddine Azouz, Oussema Khamessi, Monia Ardhaoui, Mouna Safer, Nissaf Ben Alaya, Ikram Guizani, Rym Kefi, Mariem Gdoura, Henda Trik. Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19. Viruses. vol 14. issue 3. 2022-03-26. PMID:35337031. |
during the second wave, a large number of lineages were detected; the third wave was marked by the predominance of the alpha voc, and the fourth wave was characterized by the predominance of the delta voc. |
2022-03-26 |
2023-08-13 |
Not clear |
| Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang, Ke Xia, Reena Thara, Robert J Linhardt, Robert J Doerksen, Michael A McVoy, Vitor H Pomi. Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties. The Journal of biological chemistry. 2022-03-26. PMID:35337800. |
we observed distinct affinities of bosg derivatives for the s-proteins of different sars-cov-2 strains, including wild type, n501y (alpha), k417t/e484k/n501y (gamma), and l542r (delta) mutants, and stronger affinity for the n501y-containing variants. |
2022-03-26 |
2023-08-13 |
Not clear |
| Diego Cantoni, Martin Mayora-Neto, Angalee Nadesalingam, David A Wells, George W Carnell, Luis Ohlendorf, Matteo Ferrari, Phil Palmer, Andrew C Y Chan, Peter Smith, Emma M Bentley, Sebastian Einhauser, Ralf Wagner, Mark Page, Gianmarco Raddi, Helen Baxendale, Javier Castillo-Olivares, Jonathan Heeney, Nigel Temperto. Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds. Frontiers in immunology. vol 13. 2022-03-25. PMID:35330908. |
using pseudotyped virus, we examine the capacity of convalescent sera, from a well-defined cohort of healthcare workers (hcw) and patients infected during the first wave from a national critical care centre in the uk to neutralise b.1.1.298, variants of interest (voi) b.1.617.1 (kappa), and four vocs, b.1.1.7 (alpha), b.1.351 (beta), p.1 (gamma) and b.1.617.2 (delta), including the b.1.617.2 k417n, informally known as delta plus. |
2022-03-25 |
2023-08-13 |
Not clear |
| Qi Chen, Xing-Yao Huang, Yu Liu, Meng-Xu Sun, Bin Ji, Chao Zhou, Hang Chi, Rong-Rong Zhang, Dan Luo, Ying Tian, Xiao-Feng Li, Zhao Hui, Cheng-Feng Qi. Comparative characterization of SARS-CoV-2 variants of concern and mouse-adapted strains in mice. Journal of medical virology. 2022-03-24. PMID:35322439. |
in this study, we systematically investigated the infectivity and pathogenicity of three vocs, alpha, beta and delta, in mice in comparison with two well-understood sars-cov-2 mouse-adapted strains, mascp6 and mascp36，sharing key mutations in receptor binding domain (rbd) with alpha or beta, respectively. |
2022-03-24 |
2023-08-13 |
mouse |
| Qi Chen, Xing-Yao Huang, Yu Liu, Meng-Xu Sun, Bin Ji, Chao Zhou, Hang Chi, Rong-Rong Zhang, Dan Luo, Ying Tian, Xiao-Feng Li, Zhao Hui, Cheng-Feng Qi. Comparative characterization of SARS-CoV-2 variants of concern and mouse-adapted strains in mice. Journal of medical virology. 2022-03-24. PMID:35322439. |
our results showed that the beta variant had the strongest infectivity and pathogenicity among the three vocs, while delta variant only caused limited replication and mild pathogenic changes in mouse lung, which is much weaker than alpha variant did. |
2022-03-24 |
2023-08-13 |
mouse |