| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Thompson, J Pelkonen, J L Hurwit. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164690. |
a debate has recently surfaced concerning the degree of precommitment attained by alpha beta and gamma delta t-cell precursors prior to t-cell receptor (tcr) gene rearrangement. |
1990-08-23 |
2023-08-11 |
mouse |
| S D Thompson, J Pelkonen, J L Hurwit. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164690. |
it has been suggested that precursors may be precommitted to rearrange either alpha or delta genes, but not both, thus giving rise to alpha beta- and gamma delta-producing t cells, respectively. |
1990-08-23 |
2023-08-11 |
mouse |
| S D Thompson, J Pelkonen, J L Hurwit. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164690. |
six probes spanning the delta and alpha loci were used in southern blot analyses to characterize the rearrangements which occurred on homologous chromosomes in each cell. |
1990-08-23 |
2023-08-11 |
mouse |
| S D Thompson, J Pelkonen, J L Hurwit. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164690. |
although homologous chromosomes often rearranged in synchrony within the alpha locus, a number of hybridomas were found which had retained a delta rearrangement on one chromosome and an alpha rearrangement on the second. |
1990-08-23 |
2023-08-11 |
mouse |
| S D Thompson, J Pelkonen, J L Hurwit. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164690. |
results show that a precommitment by t cells to rearrange delta or alpha genes in a mutually exclusive manner is not an absolute feature of mouse thymocyte development. |
1990-08-23 |
2023-08-11 |
mouse |
| M A Vazquez-Padua, M C Starnes, Y C Chen. Incorporation of 3'-azido-3'-deoxythymidine into cellular DNA and its removal in a human leukemic cell line. Cancer communications. vol 2. issue 1. 1990-08-23. PMID:2369551. |
cellular dna polymerases alpha, beta, gamma, and delta from human leukemic cells were inhibited by azt trisphosphate to different degrees, polymerase alpha being the least potently inhibited. |
1990-08-23 |
2023-08-11 |
human |
| Y M Hwang, I N Sunwoo, I H Chung, B Jun. Comparison between electrophysiologic and morphologic changes in lead induced peripheral neuropathy in rats. Journal of Korean medical science. vol 4. issue 4. 1990-08-22. PMID:2561732. |
compound nerve action potential (cnap) of the mixed peripheral nerve is composed of a alpha beta, a delta, and c potentials. |
1990-08-22 |
2023-08-11 |
rat |
| Y M Hwang, I N Sunwoo, I H Chung, B Jun. Comparison between electrophysiologic and morphologic changes in lead induced peripheral neuropathy in rats. Journal of Korean medical science. vol 4. issue 4. 1990-08-22. PMID:2561732. |
marked decrease of nerve conduction velocity and prolonged duration were found in a alpha beta and a delta fibers especially in large myelinated a alpha beta fibers. |
1990-08-22 |
2023-08-11 |
rat |
| A Winoto, D Baltimor. Developmental regulation of the TCR alpha delta locus. Cold Spring Harbor symposia on quantitative biology. vol 54 Pt 1. 1990-08-21. PMID:2534801. |
developmental regulation of the tcr alpha delta locus. |
1990-08-21 |
2023-08-11 |
Not clear |
| C W Luetje, K Wada, S Rogers, S N Abramson, K Tsuji, S Heinemann, J Patric. Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. Journal of neurochemistry. vol 55. issue 2. 1990-08-17. PMID:1973456. |
partial blockade of the alpha 4 beta 2 neuronal and alpha 1 beta 1 gamma delta muscle subunit combinations was caused by 1,000 nm neuronal bungarotoxin. |
1990-08-17 |
2023-08-11 |
xenopus_laevis |
| C W Luetje, K Wada, S Rogers, S N Abramson, K Tsuji, S Heinemann, J Patric. Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. Journal of neurochemistry. vol 55. issue 2. 1990-08-17. PMID:1973456. |
nearly complete blockade of all neuronal subunit combinations resulted from incubation with 2 nm neosurugatoxin, whereas 200 nm neosurugatoxin was required for partial blockade of the alpha 1 beta 1 gamma delta muscle subunit combination. |
1990-08-17 |
2023-08-11 |
xenopus_laevis |
| C W Luetje, K Wada, S Rogers, S N Abramson, K Tsuji, S Heinemann, J Patric. Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. Journal of neurochemistry. vol 55. issue 2. 1990-08-17. PMID:1973456. |
the alpha 2 beta 2 and alpha 3 beta 2 neuronal subunit combinations were partially blocked by 10,000 nm lophotoxin analog-1, whereas complete blockade of the alpha 4 beta 2 neuronal and alpha 1 beta 1 gamma delta muscle subunit combinations resulted from incubation with this concentration of lophotoxin analog-1. |
1990-08-17 |
2023-08-11 |
xenopus_laevis |
| C W Luetje, K Wada, S Rogers, S N Abramson, K Tsuji, S Heinemann, J Patric. Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. Journal of neurochemistry. vol 55. issue 2. 1990-08-17. PMID:1973456. |
the alpha 1 beta 1 gamma delta muscle subunit combination was blocked by the alpha-conotoxins g1a and m1 at concentrations of 100 nm. |
1990-08-17 |
2023-08-11 |
xenopus_laevis |
| M S Saedi, R Anand, W G Conroy, J Lindstro. Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis. FEBS letters. vol 267. issue 1. 1990-08-16. PMID:2365090. |
we have studied the contribution of amino acids alpha 68 and alpha 71 to the antigenicity of the mir on intact achr by replacing alpha 68 (n) and alpha 71 (d) of torpedo achr alpha with alpha 68 (d) and alpha 71 (k) by site-directed mutagenesis, expressing the mutated transcripts in xenopus oocytes along with wild-type torpedo beta, gamma and delta subunits, and analyzing the expressed achr for the binding of mabs to the mir. |
1990-08-16 |
2023-08-11 |
xenopus_laevis |
| P Huang, D Farquhar, W Plunket. Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases. The Journal of biological chemistry. vol 265. issue 20. 1990-08-14. PMID:1694849. |
the action of 3'-azido-3'-deoxythymidine 5'-triphosphate (n3dttp) on dna strand elongation catalyzed by human immunodeficiency virus type 1 reverse transcriptase was evaluated in comparison with human dna polymerase alpha and proliferating cell nuclear antigen-independent dna polymerase delta. |
1990-08-14 |
2023-08-11 |
human |
| P Huang, D Farquhar, W Plunket. Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases. The Journal of biological chemistry. vol 265. issue 20. 1990-08-14. PMID:1694849. |
in contrast, human dna polymerases alpha and delta did not incorporate detectable amounts of n3dttp into the dna and were not inhibited by 300 microm n3dttp. |
1990-08-14 |
2023-08-11 |
human |
| S Mukund, M W Adam. Characterization of a tungsten-iron-sulfur protein exhibiting novel spectroscopic and redox properties from the hyperthermophilic archaebacterium Pyrococcus furiosus. The Journal of biological chemistry. vol 265. issue 20. 1990-08-14. PMID:2164004. |
the em values are dependent on temperature (delta em/delta t = -2 mv/degrees c between 20 and 70 degrees c) and ph with pk alpha values of 8.0 (a) and approximately 8.5 (b). |
1990-08-14 |
2023-08-11 |
Not clear |
| H S Kim, X Y Wei, P Ruth, E Perez-Reyes, V Flockerzi, F Hofmann, L Birnbaume. Studies on the structural requirements for the activity of the skeletal muscle dihydropyridine receptor/slow Ca2+ channel. Allosteric regulation of dihydropyridine binding in the absence of alpha 2 and beta components of the purified protein complex. The Journal of biological chemistry. vol 265. issue 20. 1990-08-14. PMID:2164019. |
a rabbit skeletal muscle dihydropyridine (dhp) receptor can be purified as an alpha 1-alpha 2-delta-beta-gamma complex, of which alpha 2 and delta are disulfide bonded. |
1990-08-14 |
2023-08-11 |
mouse |
| H S Kim, X Y Wei, P Ruth, E Perez-Reyes, V Flockerzi, F Hofmann, L Birnbaume. Studies on the structural requirements for the activity of the skeletal muscle dihydropyridine receptor/slow Ca2+ channel. Allosteric regulation of dihydropyridine binding in the absence of alpha 2 and beta components of the purified protein complex. The Journal of biological chemistry. vol 265. issue 20. 1990-08-14. PMID:2164019. |
the studies neither exclude roles for gamma and delta, nor for alpha 2 or beta in determining more subtle properties of this channel. |
1990-08-14 |
2023-08-11 |
mouse |
| W K Kaufmann, S J Wilso. DNA repair endonuclease activity during synchronous growth of diploid human fibroblasts. Mutation research. vol 236. issue 1. 1990-08-13. PMID:1694964. |
incubation of irradiated cells with aphidicolin, an inhibitor of dna polymerases alpha and delta, delayed the sealing of repair patches and allowed estimation of rates of strand incision by the repair endonuclease. |
1990-08-13 |
2023-08-11 |
human |