| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
mechanisms that generate junctional diversity in alpha and delta chains that use the tcrd-v3 gene product. |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
the signals that dictate whether a thymocyte will express the alpha beta or gamma delta t-cell receptors are unknown. |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
although it is also not known if these two different cell types use identical recombinational machinery during rearrangement, the same variable (v) region genes can be used by both alpha and delta chains. |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
by examining the products of rearrangements in alpha beta or gamma delta thymocytes that express identical v genes, we hoped to determine whether these cell types might differ in particular aspects of their recombinational activity. |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
during early development both alpha and delta chain junctional diversity is generated primarily by variability in the position of joining two gene segments (i.e., tcrd-v3 to tcra-j in alpha chains; tcrd-v3 to tcrd-d2 and tcrd-d2 to tcrd-j1 in delta chains). |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
the pattern of base pair deletion from the end of the tcrd-v3 gene was identical in alpha and delta chains and deletions occurred in fetal as well as adult t cells. |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
in later development t cells use not only this mechanism for alpha and delta chains but also the addition of bases at gene segment junctions, presumably through the action of terminal deoxynucleotidyl transferase (tdt). |
1992-02-12 |
2023-08-11 |
mouse |
| P O Holman, M J Lacy, M E Roth, D M Kran. Mechanisms that generate junctional diversity in alpha and delta chains that use the Tcrd-V3 gene product. Immunogenetics. vol 35. issue 1. 1992-02-12. PMID:1309508. |
finally, a comparison of the variable domains of these alpha and delta chains shows that a notable difference is the variability in length of the cdr 3 region which can be significantly longer in delta-chains than in alpha-chains. |
1992-02-12 |
2023-08-11 |
mouse |
| L M Yu, T W Chan. Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes. Journal of immunology (Baltimore, Md. : 1950). vol 148. issue 2. 1992-02-11. PMID:1729378. |
it has also been observed that human mb-1 is expressed not only by b cell lines expressing membrane-bound ig of mu and delta isotypes but also those expressing membrane-bound ig of alpha and gamma isotypes. |
1992-02-11 |
2023-08-11 |
mouse |
| R G Ridley, J H White, S M McAleese, M Goman, P Alano, E de Vries, B J Kilbe. DNA polymerase delta: gene sequences from Plasmodium falciparum indicate that this enzyme is more highly conserved than DNA polymerase alpha. Nucleic acids research. vol 19. issue 24. 1992-02-11. PMID:1762904. |
dna polymerase delta: gene sequences from plasmodium falciparum indicate that this enzyme is more highly conserved than dna polymerase alpha. |
1992-02-11 |
2023-08-11 |
human |
| R G Ridley, J H White, S M McAleese, M Goman, P Alano, E de Vries, B J Kilbe. DNA polymerase delta: gene sequences from Plasmodium falciparum indicate that this enzyme is more highly conserved than DNA polymerase alpha. Nucleic acids research. vol 19. issue 24. 1992-02-11. PMID:1762904. |
genes encoding proteins homologous to the catalytic subunits of dna polymerase alpha and delta have been cloned from the human malaria parasite plasmodium falciparum. |
1992-02-11 |
2023-08-11 |
human |
| J Holoshitz, L M Vila, B J Keroack, D R McKinley, N K Bayn. Dual antigenic recognition by cloned human gamma delta T cells. The Journal of clinical investigation. vol 89. issue 1. 1992-02-10. PMID:1345917. |
these results suggest that much like alpha beta t cells, v gamma 9/v delta 2 cells may contribute to the immune response against foreign antigens in an antigen-specific and mhc-restricted manner. |
1992-02-10 |
2023-08-11 |
human |
| C Baumstark-Kha. [Effects of aphidicolin on cell recovery and repair of DNA damage in irradiated human fibroblasts]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. vol 167. issue 12. 1992-02-07. PMID:1763409. |
the effect of aphidicolin, a specific inhibitor of dna polymerases alpha and delta, on recovery and repair of x-irradiated human fibroblasts was investigated. |
1992-02-07 |
2023-08-11 |
human |
| S Murosaki, Y Yoshikai, A Ishida, T Nakamura, G Matsuzaki, H Takimoto, H Yuuki, K Nomot. Failure of T cell receptor V beta negative selection in murine intestinal intra-epithelial lymphocytes. International immunology. vol 3. issue 10. 1992-02-03. PMID:1661605. |
the intestinal intra-epithelial lymphocytes (iel) are divided into several subsets on the basis of expression of t cell receptor (tcr) alpha beta and gamma delta, intensity of thy-1 expression and expression of lyt-3 chain. |
1992-02-03 |
2023-08-11 |
mouse |
| S M Denning, D M Jones, R E Ware, K J Weinhold, M B Brenner, B F Hayne. Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. International immunology. vol 3. issue 10. 1992-02-03. PMID:1721831. |
using a culture system of phytohemagglutinin, il-2, and irradiated allogeneic lymphoid feeder cells, we found that 48% of clones (104 total) derived from tn thymocyte suspensions were tcr gamma delta cells, 12% of clones were tcr alpha beta cells, and 34% were cd16+cd3- cells. |
1992-02-03 |
2023-08-11 |
human |
| S M Denning, D M Jones, R E Ware, K J Weinhold, M B Brenner, B F Hayne. Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. International immunology. vol 3. issue 10. 1992-02-03. PMID:1721831. |
the majority of tcr alpha beta, tcr gamma delta, and cd16+cd3- clones expressed low levels of cd4. |
1992-02-03 |
2023-08-11 |
human |
| S M Denning, D M Jones, R E Ware, K J Weinhold, M B Brenner, B F Hayne. Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. International immunology. vol 3. issue 10. 1992-02-03. PMID:1721831. |
these data provide evidence at the clonal level for the presence of precursors of the tcr alpha beta and tcr gamma delta lineages in the human tn thymocyte pool. |
1992-02-03 |
2023-08-11 |
human |
| S M Denning, D M Jones, R E Ware, K J Weinhold, M B Brenner, B F Hayne. Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. International immunology. vol 3. issue 10. 1992-02-03. PMID:1721831. |
whether these precursors of the tcr alpha beta and tcr gamma delta lineages mature from cells already containing tcr gene rearrangements into stcr+ cells or differentiate in vitro from cells with tcr genes in germline configuration remains to be determined. |
1992-02-03 |
2023-08-11 |
human |
| T Ito, K Ishibashi, K Imai, H Koseki, C S Ra, E Fernandez, M Kantake, T Saito, M Taniguch. Monoclonal antibody against murine T cell receptor V alpha 14 cross-reacts with human CD3 epsilon and detects disulfide-linked dimeric form. International immunology. vol 3. issue 10. 1992-02-03. PMID:1836739. |
unexpectedly, the antibody showed cross-reactivity to the human cd3 epsilon molecule and detected a disulfide-linked 20 kda dimeric form of human cd3 epsilon, which is a novel family component of the cd3 complex and is associated closely with the cd3 zeta-zeta homodimer as well as tcr alpha beta or tcr gamma delta. |
1992-02-03 |
2023-08-11 |
human |
| C M Michel, D Lehmann, B Henggeler, D Brandei. Localization of the sources of EEG delta, theta, alpha and beta frequency bands using the FFT dipole approximation. Electroencephalography and clinical neurophysiology. vol 82. issue 1. 1992-01-30. PMID:1370142. |
localization of the sources of eeg delta, theta, alpha and beta frequency bands using the fft dipole approximation. |
1992-01-30 |
2023-08-11 |
human |