| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W R Drobyski, D Majewsk. Donor gamma delta T lymphocytes promote allogeneic engraftment across the major histocompatibility barrier in mice. Blood. vol 89. issue 3. 1997-03-11. PMID:9028343. |
the role of gamma delta t cells was then investigated using transgenic donors (c57bl/6 x 129 background) in which a portion of the t-cell receptor-beta chain gene was deleted by gene targeting so that these mice lack alpha beta t cells. |
1997-03-11 |
2023-08-12 |
mouse |
| W R Drobyski, D Majewsk. Donor gamma delta T lymphocytes promote allogeneic engraftment across the major histocompatibility barrier in mice. Blood. vol 89. issue 3. 1997-03-11. PMID:9028343. |
addition of 2.5 x 10(4) mature alpha beta t cells, which alone were incapable of facilitating engraftment, to t-cell depleted marrow grafts containing 160 x 10(6) activated gamma delta t cells resulted in long-term (> 100 day) complete donor engraftment, indicating that limiting numbers of alpha beta t cells were required in the marrow graft for the eradication of residual host t cells. |
1997-03-11 |
2023-08-12 |
mouse |
| W R Drobyski, D Majewsk. Donor gamma delta T lymphocytes promote allogeneic engraftment across the major histocompatibility barrier in mice. Blood. vol 89. issue 3. 1997-03-11. PMID:9028343. |
these data show that, whereas less potent than alpha beta t cells, gamma delta t cells are able to promote engraftment and enhance hematopoietic reconstitution in allogeneic marrow transplant recipients. |
1997-03-11 |
2023-08-12 |
mouse |
| S L Peng, J M McNiff, M P Madaio, J Ma, M J Owen, R A Flavell, A C Hayday, J Craf. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 5. 1997-03-11. PMID:9036998. |
to explore the mechanisms by which alpha beta t cells and gamma delta t cells regulate systemic autoimmunity, lupus-prone mice were rendered deficient in cd40 ligand and/or alpha beta t cells by intercrossing cd40l -/- and tcr-alpha -/- knockouts, generating cd40l-intact or -deficient (cd40l+ or cd40l-), alpha beta t cell-intact or -deficient (alpha beta+ or alpha beta-) mrl-lpr/lpr animals. |
1997-03-11 |
2023-08-12 |
mouse |
| S L Peng, J M McNiff, M P Madaio, J Ma, M J Owen, R A Flavell, A C Hayday, J Craf. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 5. 1997-03-11. PMID:9036998. |
thus, both alpha beta and non-alpha beta t cells, such as gamma delta t cells, regulate systemic autoimmunity by cd40l-dependent and -independent mechanisms. |
1997-03-11 |
2023-08-12 |
mouse |
| M D Sørensen, S M Kristensen, S Bjørn, K Norris, O Olsen, J J Le. Elucidation of the origin of multiple conformations of the human alpha 3-chain type VI collagen C-terminal Kunitz domain: the reorientation of the Trp21 ring. Journal of biomolecular NMR. vol 8. issue 4. 1997-03-10. PMID:9008360. |
biol., 246, 609-617], have very different chemical shifts in the two conformations, the most affected being gln48(54) h(beta 2) (delta sigma = 3 ppm), which is placed directly above the trp21(27) ring in the crystal structure of alpha 3(vi). |
1997-03-10 |
2023-08-12 |
human |
| T D Tom, L H Malkas, R J Hicke. Identification of multiprotein complexes containing DNA replication factors by native immunoblotting of HeLa cell protein preparations with T-antigen-dependent SV40 DNA replication activity. Journal of cellular biochemistry. vol 63. issue 3. 1997-03-07. PMID:8913877. |
apparent complexes of 620 kda and 500 kda were identified by monoclonal antibodies directed against dna polymerase alpha and dna polymerase delta, respectively. |
1997-03-07 |
2023-08-12 |
human |
| A Elbe, C A Foster, G Sting. T-cell receptor alpha beta and gamma delta T cells in rat and human skin--are they equivalent? Seminars in immunology. vol 8. issue 6. 1997-03-07. PMID:8961385. |
t-cell receptor alpha beta and gamma delta t cells in rat and human skin--are they equivalent? |
1997-03-07 |
2023-08-12 |
human |
| B Zhang, J Berger, E Hu, D Szalkowski, S White-Carrington, B M Spiegelman, D E Molle. Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Molecular endocrinology (Baltimore, Md.). vol 10. issue 11. 1997-03-06. PMID:8923470. |
the effect of tnf alpha was specific for the gamma-isoform of ppars, since the expression of ppar delta mrna was not affected by treatment with tnf alpha. |
1997-03-06 |
2023-08-12 |
Not clear |
| V Chan, V W Chan, M Tang, K Lau, D Todd, T K Cha. Molecular defects in Hb H hydrops fetalis. British journal of haematology. vol 96. issue 2. 1997-03-06. PMID:9029003. |
both cases are due to co-inheritance of a 'non-deletion' defect affecting the alpha2 gene: at codon 30 delta gag, glu) and codon 59 (g --> a, gly --> asp) respectively, and a zeta-alpha thalassaemia (thal) 1 or alpha thal 1 genotype. |
1997-03-06 |
2023-08-12 |
Not clear |
| J P Sullivan, D Donnelly-Roberts, C A Briggs, D J Anderson, M Gopalakrishnan, M Piattoni-Kaplan, J E Campbell, D G McKenna, E Molinari, A M Hettinger, D S Garvey, J T Wasicak, M W Holladay, M Williams, S P Arneri. A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887981. |
the r-enantiomer of a-85380, a-159470, displays little enantioselectivity towards the alpha 4 beta 2 and alpha 1 beta 1 delta gamma subtypes but does not display 12-fold enantioselectivity towards the alpha 7 subtype (ki = 1275 +/- 199 nm). |
1997-03-05 |
2023-08-12 |
human |
| J P Sullivan, D Donnelly-Roberts, C A Briggs, D J Anderson, M Gopalakrishnan, M Piattoni-Kaplan, J E Campbell, D G McKenna, E Molinari, A M Hettinger, D S Garvey, J T Wasicak, M W Holladay, M Williams, S P Arneri. A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887981. |
(+)- and(-)-epibatidine display similar potencies at the human human alpha 4 beta 2 (ki = 0.04 +/- 0.02 nm and 0.07 +/- 0.02 nm, respectively), human alpha 7 (ki = 16 +/- 2 nm and 22 +/- 3 nm, respectively) and muscle alpha 1 beta 1 delta gamma g (ki = 2.5 +/- 0.9 nm and 5.7 +/- 1.0 nm, respectively) nachrs. |
1997-03-05 |
2023-08-12 |
human |
| J P Sullivan, D Donnelly-Roberts, C A Briggs, D J Anderson, M Gopalakrishnan, M Piattoni-Kaplan, J E Campbell, D G McKenna, E Molinari, A M Hettinger, D S Garvey, J T Wasicak, M W Holladay, M Williams, S P Arneri. A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand. Neuropharmacology. vol 35. issue 6. 1997-03-05. PMID:8887981. |
thus, a-85380 displays a profile of robust activation of a number of nachr subtypes with substantially less affinity for [125i] alpha-bgt sites than [3h](-)-cytisine sites, suggesting that it may serve as a more selective pharmacologic probe for the alpha 4 beta 2 subtype relative to the alpha 7 and alpha 1 beta 1 delta g nachrs than (+/-)-epibatidine. |
1997-03-05 |
2023-08-12 |
human |
| L Luo, H Chen, B R Zirki. Are Leydig cell steroidogenic enzymes differentially regulated with aging? Journal of andrology. vol 17. issue 5. 1997-03-04. PMID:8957694. |
to address the possible mechanism(s) by which aging leydig cells lose steroidogenic function, we determined the effect of age on the steady-state levels of the mrnas for the steroidogenic enzymes p450 cholesterol side-chain cleavage (p450scc), delta 5-3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-hsd), and 17 alpha-hydroxylase/c17-20 lyase (p450(17) alpha), and on the levels of immunoreactive steroidogenic enzyme proteins and enzyme activities. |
1997-03-04 |
2023-08-12 |
rat |
| A Pacheco-Castro, C Márquez, M L Toribio, A R Ramiro, C Trigueros, J R Regueir. Herpesvirus saimiri immortalization of alpha beta and gamma delta human T-lineage cells derived from CD34+ intrathymic precursors in vitro. International immunology. vol 8. issue 11. 1997-03-03. PMID:8943575. |
herpesvirus saimiri immortalization of alpha beta and gamma delta human t-lineage cells derived from cd34+ intrathymic precursors in vitro. |
1997-03-03 |
2023-08-12 |
human |
| A Pacheco-Castro, C Márquez, M L Toribio, A R Ramiro, C Trigueros, J R Regueir. Herpesvirus saimiri immortalization of alpha beta and gamma delta human T-lineage cells derived from CD34+ intrathymic precursors in vitro. International immunology. vol 8. issue 11. 1997-03-03. PMID:8943575. |
in the presence of il-7, tcr alpha beta + cells with three different phenotypes (mainly cd4+cd8-, but also cd4+cd8+ and cd4-cd8+) were immortalized, whereas no tcr gamma delta + cells were recovered. |
1997-03-03 |
2023-08-12 |
human |
| A Pacheco-Castro, C Márquez, M L Toribio, A R Ramiro, C Trigueros, J R Regueir. Herpesvirus saimiri immortalization of alpha beta and gamma delta human T-lineage cells derived from CD34+ intrathymic precursors in vitro. International immunology. vol 8. issue 11. 1997-03-03. PMID:8943575. |
the results show that hvs can be used to read the cd3+ cellular outcome of t cell differentiation assays, including gamma delta + cd4-cd8+, gamma delta + cd4-cd8-, alpha beta + cd4+cd8-, alpha beta + cd4-cd8+ and alpha beta + cd4+cd8+ t cells. |
1997-03-03 |
2023-08-12 |
human |
| A Pacheco-Castro, C Márquez, M L Toribio, A R Ramiro, C Trigueros, J R Regueir. Herpesvirus saimiri immortalization of alpha beta and gamma delta human T-lineage cells derived from CD34+ intrathymic precursors in vitro. International immunology. vol 8. issue 11. 1997-03-03. PMID:8943575. |
a clear role for different cytokines (il-2 for gamma delta + cells, il-7 for alpha beta + cells) in early t cell commitment was also apparent. |
1997-03-03 |
2023-08-12 |
human |
| Y Kawanishi, N Flomenberg, A Cook-Craig, P McFadden, F Garbrecht, C A Keever-Taylo. A new limiting dilution culture system for the detection of T cell subsets in T cell-depleted marrow grafts. Journal of hematotherapy. vol 5. issue 5. 1997-02-28. PMID:8938520. |
the epitope recognized by t10b9 on tcr gamma delta + cells appears to be differentially expressed compared with tcr alpha beta + t cells based on antibody blocking studies. |
1997-02-28 |
2023-08-12 |
Not clear |
| H Yaw. Noradrenaline modulates transmitter release by enhancing the Ca2+ sensitivity of exocytosis in the chick ciliary presynaptic terminal. The Journal of physiology. vol 493 ( Pt 2). 1997-02-27. PMID:8782103. |
the ca2+ increment produced by an action potential (delta[ca2+]pre) was reduced by na through an alpha 2-adrenergic receptor. |
1997-02-27 |
2023-08-12 |
chicken |