| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V C Njar, K Kato, I P Nnane, D N Grigoryev, B J Long, A M Brodi. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer. Journal of medicinal chemistry. vol 41. issue 6. 1998-04-16. PMID:9526564. |
some of these novel delta 16-17-azolyl steroids, 6, 17, 19, and 27-29, prepared in good overall yields, are very potent inhibitors of human and rat testicular p450(17) alpha. |
1998-04-16 |
2023-08-12 |
human |
| C L Chou, S I Rapko, M A Kneppe. Phosphoinositide signaling in rat inner medullary collecting duct. The American journal of physiology. vol 274. issue 3. 1998-04-14. PMID:9530273. |
we identified one classic pkc isoform (alpha), three novel pkc isoforms (delta, epsilon, eta), and one atypical pkc isoform (zeta) in the imcd. |
1998-04-14 |
2023-08-12 |
rat |
| b' J Krejsek, B Kr\\xc3\\xa1l, D Vokurkov\\xc3\\xa1, V Derner, M Touskov\\xc3\\xa1, Z Par\\xc3\\xa1kov\\xc3\\xa1, O Kopeck\\xc3\\xb. Decreased peripheral blood gamma delta T cells in patients with bronchial asthma. Allergy. vol 53. issue 1. 1998-04-13. PMID:9491232.' |
we examined by flow cytometry the relative and absolute number of cd3+, cd4+, cd8+, alpha beta tcr+ or gamma delta tcr+ t cells, cd19+ b cells; and cd56+ natural killer (nk) cells in the peripheral blood of 26 adult patients with difficult-to-control asthma (dca) and 22 patients with minimally symptomatic asthma (msa). |
1998-04-13 |
2023-08-12 |
Not clear |
| H Yang, R M Parkhous. Differential activation requirements associated with stimulation of T cells via different epitopes of CD3. Immunology. vol 93. issue 1. 1998-04-10. PMID:9536115. |
finally, the above conclusions apply only to alpha beta t cells, as porcine gamma delta t cells, either in bulk culture or isolated, did not proliferate in response to anti-cd3 stimulation. |
1998-04-10 |
2023-08-12 |
Not clear |
| H Yang, R M Parkhous. Differential activation requirements associated with stimulation of T cells via different epitopes of CD3. Immunology. vol 93. issue 1. 1998-04-10. PMID:9536115. |
therefore, the mechanism underlying gamma delta t-cell activation may be different from that of alpha beta t cells. |
1998-04-10 |
2023-08-12 |
Not clear |
| M J Maeurer, M T Lotz. Interleukin-7 (IL-7) knockout mice. Implications for lymphopoiesis and organ-specific immunity. International reviews of immunology. vol 16. issue 3-4. 1998-04-07. PMID:9505193. |
for instance, analysis of il-7 gene-deleted mice revealed reduced numbers of total t-lymphocytes with preservation of the cd4/cd8 ratio and increased ratio of alpha beta + t-cells compared to gamma delta + t-cells. |
1998-04-07 |
2023-08-12 |
mouse |
| M J Maeurer, M T Lotz. Interleukin-7 (IL-7) knockout mice. Implications for lymphopoiesis and organ-specific immunity. International reviews of immunology. vol 16. issue 3-4. 1998-04-07. PMID:9505193. |
however, there are clear differences in the requirements of alpha beta or gamma delta t-cells for il-7. |
1998-04-07 |
2023-08-12 |
mouse |
| M J Maeurer, M T Lotz. Interleukin-7 (IL-7) knockout mice. Implications for lymphopoiesis and organ-specific immunity. International reviews of immunology. vol 16. issue 3-4. 1998-04-07. PMID:9505193. |
in contrast, alpha beta + iiel can be detected in il-7 gene-deleted animals, but not in gamma c, or in jak-3 deficient mice suggesting that alternative cytokines may be involved in development of iiel alpha beta + t-cells, but not necessarily for gamma delta t-cells. |
1998-04-07 |
2023-08-12 |
mouse |
| L J Burke, M Downes, V Laudet, G E Musca. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. Molecular endocrinology (Baltimore, Md.). vol 12. issue 2. 1998-03-30. PMID:9482666. |
ligand-independent repression of transcription by rev-erba alpha and rvr is mediated by the nuclear receptor corepressors, n-cor and its variants rip (rxr interacting protein) 13a and rip13 delta 1. |
1998-03-30 |
2023-08-12 |
human |
| L J Burke, M Downes, V Laudet, G E Musca. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. Molecular endocrinology (Baltimore, Md.). vol 12. issue 2. 1998-03-30. PMID:9482666. |
our previous study demonstrated that the e region of rvr and rev-erba alpha is necessary and sufficient for the in vivo interaction with the nuclear receptor corepressor, rip13 delta 1. |
1998-03-30 |
2023-08-12 |
human |
| L J Burke, M Downes, V Laudet, G E Musca. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. Molecular endocrinology (Baltimore, Md.). vol 12. issue 2. 1998-03-30. PMID:9482666. |
in contrast, the d and e regions of rev-erba alpha were necessary for the interaction with the n-cor and rip13a-rids in vivo, suggesting that rip13 delta 1 and n-cor/rip13a differentially interact with rev-erba alpha. |
1998-03-30 |
2023-08-12 |
human |
| L J Burke, M Downes, V Laudet, G E Musca. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. Molecular endocrinology (Baltimore, Md.). vol 12. issue 2. 1998-03-30. PMID:9482666. |
furthermore, overexpression of either the n-cor/rip13a or rip13 delta 1-rids alleviated rvr-mediated repression of the rev-erba alpha promoter, demonstrating that corepressor binding mediates the repression of a native target gene by rvr. |
1998-03-30 |
2023-08-12 |
human |
| J P Brown, V U Dissanayake, A R Briggs, M R Milic, N S Ge. Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine. Analytical biochemistry. vol 255. issue 2. 1998-03-27. PMID:9451509. |
isolation of the [3h]gabapentin-binding protein/alpha 2 delta ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3h]leucine. |
1998-03-27 |
2023-08-12 |
Not clear |
| J P Brown, V U Dissanayake, A R Briggs, M R Milic, N S Ge. Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine. Analytical biochemistry. vol 255. issue 2. 1998-03-27. PMID:9451509. |
the novel antiepileptic agent gabapentin (neurontin) binds with high affinity to the alpha 2 delta subunit of a voltage-dependent ca2+ channel. |
1998-03-27 |
2023-08-12 |
Not clear |
| J P Brown, V U Dissanayake, A R Briggs, M R Milic, N S Ge. Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine. Analytical biochemistry. vol 255. issue 2. 1998-03-27. PMID:9451509. |
we report here a simple purification scheme for detergent-solubilized alpha 2 delta subunits from porcine brain. |
1998-03-27 |
2023-08-12 |
Not clear |
| J P Brown, V U Dissanayake, A R Briggs, M R Milic, N S Ge. Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine. Analytical biochemistry. vol 255. issue 2. 1998-03-27. PMID:9451509. |
we also developed and validated a novel binding assay for alpha 2 delta ca2+ channel subunits using the ligand pair l-[3h]leucine/l-isoleucine. |
1998-03-27 |
2023-08-12 |
Not clear |
| J P Brown, V U Dissanayake, A R Briggs, M R Milic, N S Ge. Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine. Analytical biochemistry. vol 255. issue 2. 1998-03-27. PMID:9451509. |
even in binding assays of crude brain membrane fractions, [3h]leucine proved to be remarkably stable and specific for the alpha 2 delta ca2+ channel subunit. |
1998-03-27 |
2023-08-12 |
Not clear |
| S Micheloyannis, S Arvanitis, E Papanikolaou, C J Sta. Electroencephalographic signal analysis and desynchronization effect caused by two differing mental arithmetic skills. Clinical EEG (electroencephalography). vol 29. issue 1. 1998-03-25. PMID:9472420. |
furthermore, the two tasks affected differently the power spectrum values of the delta, theta and the alpha bands thus indicating the involvement of different brain mechanisms. |
1998-03-25 |
2023-08-12 |
human |
| M Honda, E Koga, T Ishikawa, T Kobayashi, A Sawa, Y Takahashi, Y Hond. Alpha-delta sleep in a case with non-24 h sleep-wake syndrome: quantitative electroencephalogram analysis of alpha and delta band waves. Psychiatry and clinical neurosciences. vol 51. issue 6. 1998-03-23. PMID:9472124. |
alpha-delta sleep in a case with non-24 h sleep-wake syndrome: quantitative electroencephalogram analysis of alpha and delta band waves. |
1998-03-23 |
2023-08-12 |
Not clear |
| M Honda, E Koga, T Ishikawa, T Kobayashi, A Sawa, Y Takahashi, Y Hond. Alpha-delta sleep in a case with non-24 h sleep-wake syndrome: quantitative electroencephalogram analysis of alpha and delta band waves. Psychiatry and clinical neurosciences. vol 51. issue 6. 1998-03-23. PMID:9472124. |
the integrated area of the alpha band waves in the analysis epochs showed a strong positive correlation to the delta band components in the power spectrum of the same epoch during sleep (correlation coefficients r = 0.762-0.815). |
1998-03-23 |
2023-08-12 |
Not clear |