| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María José De Rosa, Diego Rayes, Guillermo Spitzmaul, Cecilia Bouza. Nicotinic receptor M3 transmembrane domain: position 8' contributes to channel gating. Molecular pharmacology. vol 62. issue 2. 2002-08-05. PMID:12130694. |
the replacement of (alpha)f8', (beta)l8', (delta)l8', and (epsilon)v8' by a series of hydrophobic amino acids reveals that the structural bases of the observed kinetic effects are nonequivalent among subunits. |
2002-08-05 |
2023-08-12 |
Not clear |
| María José De Rosa, Diego Rayes, Guillermo Spitzmaul, Cecilia Bouza. Nicotinic receptor M3 transmembrane domain: position 8' contributes to channel gating. Molecular pharmacology. vol 62. issue 2. 2002-08-05. PMID:12130694. |
in the alpha subunit, hydrophobic amino acids at 8' lead to prolonged channel lifetimes, whereas they lead either to normal kinetics (delta and epsilon subunits) or impaired channel gating (beta subunit) in the non-alpha subunits. |
2002-08-05 |
2023-08-12 |
Not clear |
| V Ie Dosenko, D I Goldenber. [The role of gamma-delta T-lymphocyte subtypes in normal and pathologic conditions]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 47. issue 6. 2002-07-30. PMID:11962096. |
in the phylogenesis tl gamma delta are supposed to be older than t lymphocytes with tcr alpha beta. |
2002-07-30 |
2023-08-12 |
Not clear |
| Hideaki Noguchi, Kazuhiro Kitazumi, Megumi Mori, Toshiharu Shib. Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic. European journal of pharmacology. vol 434. issue 1-2. 2002-07-25. PMID:11755161. |
spectral analysis of the electroencephalogram (eeg) of rabbits showed that zaleplon and 3-methyl-6-[3-(trifluoromethyl) phenyl]-1,2,4,-triazolo [4,3-beta] pyridazine (cl218,872), an omega(1) receptor-selective compound (1 mg/kg, i.v., respectively), produced large increases in energy of the delta frequency band without affecting the energy of the alpha and beta frequency bands. |
2002-07-25 |
2023-08-12 |
Not clear |
| Haihong Sun, Lori K Sanders, Eric Oldfiel. Carbon-13 NMR shielding in the twenty common amino acids: comparisons with experimental results in proteins. Journal of the American Chemical Society. vol 124. issue 19. 2002-07-24. PMID:11996591. |
in addition, we describe the results of calculations of c(alpha), c(beta), c(gamma)1, c(gamma)2, and c(delta) shifts in the two isoleucine residues in bovine pancreatic trypsin inhibitor and the four isoleucines in a cytochrome c and demonstrate that the side chain chemical shifts are strongly influenced by chi(2) torsion angle effects. |
2002-07-24 |
2023-08-12 |
cattle |
| Akira Yamane, Takashi Saito, Yoichi Nakagawa, Yoshiki Ohnuki, Yasutake Saek. Changes in mRNA expression of nicotinic acetylcholine receptor subunits during embryonic development of mouse masseter muscle. Zoological science. vol 19. issue 2. 2002-07-24. PMID:12012784. |
nicotinic acetylcholine receptors (nachrs) switch from the embryonic-type (alpha 2 beta gamma delta subunits) to the adult-type (alpha 2 beta epsilon delta subunits), and disappear besides the neuromuscular junctions with the development of trunk and limb skeletal muscles. |
2002-07-24 |
2023-08-12 |
mouse |
| Alexei F Kisselev, Daniel Kaganovich, Alfred L Goldber. Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. The Journal of biological chemistry. vol 277. issue 25. 2002-07-19. PMID:11927581. |
the stimulation by hydrophobic peptides was not observed in the yeast delta n alpha 3 mutant 20 s proteasomes, in 20 s-pa26 complexes, or sds-activated proteasomes and was significantly lower in 26 s proteasomes, all of which appear to have the gated channel in the alpha-rings in an open conformation and hydrolyze peptides at much faster rates than 20 s proteasomes. |
2002-07-19 |
2023-08-12 |
Not clear |
| Alexei F Kisselev, Daniel Kaganovich, Alfred L Goldber. Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. The Journal of biological chemistry. vol 277. issue 25. 2002-07-19. PMID:11927581. |
also the hydrophobic peptides altered k(m), v(max) of active sites in a similar fashion as pa26 and the delta n alpha 3 mutation. |
2002-07-19 |
2023-08-12 |
Not clear |
| Sarra N Campbell Roberts, Adrian C Williams, Ian M Grimsey, Steven W Boot. Quantitative analysis of mannitol polymorphs. FT-Raman spectroscopy. Journal of pharmaceutical and biomedical analysis. vol 28. issue 6. 2002-07-16. PMID:12049978. |
mannitol is a polymorphic excipient which is usually used in pharmaceutical products as the beta form, although other polymorphs (alpha and delta) are common contaminants. |
2002-07-16 |
2023-08-12 |
Not clear |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
furthermore, delta(12)pgj(2) and 15dpgj(2) inhibited lps-induced i kappa b alpha degradation and subsequent inhibition of neutrophil apoptosis, suggesting that apoptosis is mediated via ppar-gamma-independent inhibition of nf-kappa b activation. |
2002-07-16 |
2023-08-12 |
Not clear |
| Fan-Kun Kong, Chen-lo H Chen, Max D Coope. Reversible disruption of thymic function by steroid treatment. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055271. |
repopulation of the peripheral t cell pool recapitulated the ontogenetic pattern of gamma delta t cell replenishment before alpha beta t cell reseeding, thereby indicating the complete recovery of thymic function after a course of steroid treatment. |
2002-07-16 |
2023-08-12 |
chicken |
| Tran Trung Tran, Jun Zeng, Herbert Treutlein, Antony W Burges. Effects of thioamide substitutions on the conformation and stability of alpha- and 3(10)-helices. Journal of the American Chemical Society. vol 124. issue 18. 2002-07-12. PMID:11982387. |
in terms of relative stability, the most prominent change upon thio substitution is the decrease in the free energy difference, delta a(alpha --> 3(10)), from 14 to 3.5 kcal/mol. |
2002-07-12 |
2023-08-12 |
Not clear |
| Tran Trung Tran, Jun Zeng, Herbert Treutlein, Antony W Burges. Effects of thioamide substitutions on the conformation and stability of alpha- and 3(10)-helices. Journal of the American Chemical Society. vol 124. issue 18. 2002-07-12. PMID:11982387. |
component analysis of the delta a(alpha --> 3(10)) reviews that the entropy advantage of the 3(10)-helix for both ac-ala(10)-nhme and act-alat(10)-nhme is attributed to the 3(10)-helix being more flexible than the alpha-helix. |
2002-07-12 |
2023-08-12 |
Not clear |
| Tomoichi Yokozeki, Hiroshi Ueda, Ryoichi Arai, Walt Mahoney, Teruyuki Nagamun. A homogeneous noncompetitive immunoassay for the detection of small haptens. Analytical chemistry. vol 74. issue 11. 2002-07-12. PMID:12069229. |
as a model system, the reassociation of two fusion proteins, an anti 4-hydroxy-3-nitrophenylacetyl (np) antibody heavy-chain variable-region fragment fused to an n-terminal deletion mutant of beta-gal (v(h)delta alpha) and the light-chain variable-region fragment fused to a c-terminal deletion mutant of beta-gal (v(l)delta omega), was monitored by the enzymatic complementation between the two. |
2002-07-12 |
2023-08-12 |
Not clear |
| A Stevens, T Kircher, M Nickola, M Bartels, N Rosellen, H Wormstal. Dynamic regulation of EEG power and coherence is lost early and globally in probable DAT. European archives of psychiatry and clinical neuroscience. vol 251. issue 5. 2002-07-09. PMID:11829205. |
electroencephalographic (eeg) findings in dementia of alzheimer type (dat) include slowing of alpha frequency, loss of alpha band power, increased theta and delta power and reduced coherence. |
2002-07-09 |
2023-08-12 |
Not clear |
| Marcos Aldea, Kisun Jun, Hee-Sup Shin, Eva Andrés-Mateos, Luisa M Solís-Garrido, Carmen Montiel, Antonio G García, Almudena Albillo. A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice. Journal of neurochemistry. vol 81. issue 5. 2002-07-09. PMID:12065603. |
simultaneous recordings of inward whole-cell ca(2+) channel currents (i(ca) ) and increments of capacitance as an indication of exocytosis (delta(cm)), were performed in voltage-clamped single adrenal chromaffin cells from wild-type and alpha(1a) subunit deficient mice, using the perforated-patch configuration of the patch-clamp technique. |
2002-07-09 |
2023-08-12 |
mouse |
| Jutta Rötter, Roland P Kuiper, Gerrit Bouw, Gerard J M Marten. Cell-type-specific and selectively induced expression of members of the p24 family of putative cargo receptors. Journal of cell science. vol 115. issue Pt 5. 2002-07-05. PMID:11870223. |
extensive cdna library screening revealed the identity of six p24 proteins expressed in the xenopus melanotrope cells, namely one member of the p24alpha (alpha(3)), one of the p24beta (beta(1)), two of the p24gamma (gamma(2), gamma(3)) and two of the p24delta (delta(1), delta(2)) subfamily. |
2002-07-05 |
2023-08-12 |
xenopus_laevis |
| Simon J Slater, Jodie L Seiz, Anthony C Cook, Christopher J Buzas, Steve A Malinowski, Jennifer L Kershner, Brigid A Stagliano, Christopher D Stubb. Regulation of PKC alpha activity by C1-C2 domain interactions. The Journal of biological chemistry. vol 277. issue 18. 2002-07-02. PMID:11850425. |
the alpha c1a-c1b domain also activated conventional pkc beta i, -beta ii, and -gamma isoforms, but not novel pkc delta or -epsilon. |
2002-07-02 |
2023-08-12 |
Not clear |
| R S Gupt. The branching order and phylogenetic placement of species from completed bacterial genomes, based on conserved indels found in various proteins. International microbiology : the official journal of the Spanish Society for Microbiology. vol 4. issue 4. 2002-07-02. PMID:12051562. |
using such indels, all of the main groups within the bacteria can be defined in clear molecular terms and it has become possible to deduce that they branched from a common ancestor in the following order: low g + c gram-positive --> high g+c gram-positive --> deinococcus thermus --> cyanobacteria --> spirochetes --> aquifex-chlamydia-cytophaga --> proteobacteria-1 (epsilon, delta) --> proteobacteria-2 (alpha) --> proteobacteria-3 (beta) --> proteobacteria -4 (gamma). |
2002-07-02 |
2023-08-12 |
Not clear |
| Zoltan Nusser, Istvan Mod. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. Journal of neurophysiology. vol 87. issue 5. 2002-06-28. PMID:11976398. |
transient activation of synaptic receptors generates phasic inhibition, whereas tonic inhibition originates from gaba acting on extrasynaptic receptors, like in cerebellar granule cells, where it is thought to result from the activation of extrasynaptic gaba(a) receptors with a specific subunit composition (alpha(6)beta(x)delta). |
2002-06-28 |
2023-08-12 |
rat |