| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaojie Yang, Jiamin Hu, Yuzhuang Chen, Zhengrong Zhang, Jingji Wang, Guoqi Zh. DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress. Neurobiology of stress. vol 32. 2024-09-03. PMID:39224830. |
specific overexpression of dcc in the hippocampus induced similar impairment of long-term potentiation (ltp) and fear memory extinction as observed in sps mice. |
2024-09-03 |
2024-09-05 |
mouse |
| Shaojie Yang, Jiamin Hu, Yuzhuang Chen, Zhengrong Zhang, Jingji Wang, Guoqi Zh. DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress. Neurobiology of stress. vol 32. 2024-09-03. PMID:39224830. |
mechanistic studies have shown that knocking down or inhibiting μ-calpain in hippocampal neurons increased dcc expression and induced impairment of fear memory extinction. |
2024-09-03 |
2024-09-05 |
mouse |
| Shaojie Yang, Jiamin Hu, Yuzhuang Chen, Zhengrong Zhang, Jingji Wang, Guoqi Zh. DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress. Neurobiology of stress. vol 32. 2024-09-03. PMID:39224830. |
dcc, a potential target for controlling fear memory extinction and hippocampal ltp in male mice receiving single prolonged stress. |
2024-09-03 |
2024-09-05 |
mouse |
| Shaojie Yang, Jiamin Hu, Yuzhuang Chen, Zhengrong Zhang, Jingji Wang, Guoqi Zh. DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress. Neurobiology of stress. vol 32. 2024-09-03. PMID:39224830. |
our study provides evidence that calpain-mediated regulation of dcc controls hippocampal ltp and fear memory extinction in sps mice, which likely through activation of the rac1-pak1 signaling pathway. |
2024-09-03 |
2024-09-05 |
mouse |
| Shaojie Yang, Jiamin Hu, Yuzhuang Chen, Zhengrong Zhang, Jingji Wang, Guoqi Zh. DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress. Neurobiology of stress. vol 32. 2024-09-03. PMID:39224830. |
the impairment of fear memory extinction in sps mice was improved by inhibiting the function of hippocampal dcc using a neutralizing antibody. |
2024-09-03 |
2024-09-05 |
mouse |
| Xiang Zuo, Shuhui Zhang, Huijuan Bai, Qian Yu, Qili Zhao, Mingzhu Sun, Xin Zhao, Xizeng Fen. Effects of fluorene-9-bisphenol exposure on anxiety-like and social behavior in mice and protective potential of exogenous melatonin. Environmental science and pollution research international. 2024-04-04. PMID:38573577. |
in addition, bhpf exposure upregulated the expression of excitatory and inhibitory (e/i) vesicle transporter genes (vglut1, vglut2, vgat, gad67, gabra) and axon growth gene (dcc) in the mouse hippocampus. |
2024-04-04 |
2024-04-06 |
mouse |
| Teresa M L Cramer, Berangere Pinan-Lucarre, Anna Cavaccini, Angeliki Damilou, Yuan-Chen Tsai, Musadiq A Bhat, Patrizia Panzanelli, Nicolas Rama, Patrick Mehlen, Dietmar Benke, Theofanis Karayannis, Jean-Louis Bessereau, Shiva K Tyagaraja. Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function. Cell reports. vol 42. issue 8. 2023-08-12. PMID:37572323. |
here, we identify that the secreted protein adamtsl3 functions as critical hippocampal synapse organizer acting through the transmembrane receptor dcc (deleted in colorectal cancer). |
2023-08-12 |
2023-08-16 |
Not clear |
| Jie Yin Chua, Shi Jun Ng, Oleksandr Yagensky, Erich E Wanker, John Jia En Chu. FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. eNeuro. vol 8. issue 2. 2021-07-02. PMID:33771901. |
supporting this, fez1 colocalizes with vamp2 in developing hippocampal neurons and forms a separate complex with deleted in colorectal cancer (dcc) and syntaxin-1 (stx1), components of the netrin-1 signaling pathway that are also involved in regulating axon and dendrite development. |
2021-07-02 |
2023-08-13 |
rat |
| Stephen D Glasgow, Edwin W Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S Ruthazer, Timothy E Kenned. Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32264905. |
netrin-1 recruits glua1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampars) and is critical for long-term potentiation (ltp) at ca3-ca1 hippocampal schaffer collateral synapses, while conditional dcc deletion from glutamatergic neurons impairs hippocampal-dependent spatial memory and severely disrupts ltp induction. |
2021-02-03 |
2023-08-13 |
mouse |
| Stephen D Glasgow, Edwin W Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S Ruthazer, Timothy E Kenned. Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32264905. |
together, these findings reveal specific pre- and post-synaptic contributions of dcc to hippocampal synaptic plasticity underlying spatial memory. |
2021-02-03 |
2023-08-13 |
mouse |
| Stephen D Glasgow, Edwin W Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S Ruthazer, Timothy E Kenned. Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32264905. |
employing hippocampal subregion-specific conditional deletion of dcc, we show that dcc loss from ca1 hippocampal pyramidal neurons resulted in deficits in spatial memory, increased resting membrane potential, abnormal dendritic spine morphology, weaker spontaneous excitatory postsynaptic activity, and reduced levels of postsynaptic adaptor and signaling proteins; however, the capacity to induce ltp remained intact. |
2021-02-03 |
2023-08-13 |
mouse |
| Stephen D Glasgow, Edwin W Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S Ruthazer, Timothy E Kenned. Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32264905. |
pre- and post-synaptic roles for dcc in memory consolidation in the adult mouse hippocampus. |
2021-02-03 |
2023-08-13 |
mouse |
| Daisuke Hasegawa, Yumi Ohnishi, Eiji Koyama, Satoru Matsunaga, Shouhei Ohtani, Akio Nakanishi, Takanori Shiga, James K Chambers, Kazuyuki Uchida, Norihiko Yokoi, Yuko Fukata, Masaki Fukat. Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis. Journal of veterinary internal medicine. vol 33. issue 3. 2019-09-09. PMID:30942925. |
this report describes a case of feline autoimmune limbic encephalitis and hippocampal necrosis that were presumably associated with dcc autoantibodies. |
2019-09-09 |
2023-08-13 |
cat |
| Olav B Smeland, Yunpeng Wang, Oleksandr Frei, Wen Li, Derrek P Hibar, Barbara Franke, Francesco Bettella, Aree Witoelar, Srdjan Djurovic, Chi-Hua Chen, Paul M Thompson, Anders M Dale, Ole A Andreasse. Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms. Schizophrenia bulletin. vol 44. issue 4. 2019-01-09. PMID:29136250. |
based on conjunctional fdr < 0.05, we identified 2 loci shared between scz and icv implicating genes foxo3 (rs10457180) and itih4 (rs4687658), 2 loci shared between scz and hippocampal volume implicating slc4a10 (rs4664442) and spats2l (rs1653290), and 2 loci shared between scz and volume of putamen implicating dcc (rs4632195) and dlg2 (rs11233632). |
2019-01-09 |
2023-08-13 |
Not clear |
| Hiroshi Tawarayama, Hirohisa Yamada, Ruhul Amin, Yuiko Morita-Fujimura, Helen M Cooper, Yohei Shinmyo, Masakado Kawata, Shuntaro Ikawa, Hideaki Tanak. Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis. Scientific reports. vol 8. issue 1. 2018-11-19. PMID:29339781. |
furthermore, in vitro assays using a hippocampal neural stem/progenitor cell (hnspc) line indicated that draxin inhibited apoptosis in differentiating hnspcs, which express dcc. |
2018-11-19 |
2023-08-13 |
Not clear |
| Jean-François Bouchard, Katherine E Horn, Thomas Stroh, Timothy E Kenned. Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18691385. |
the netrin-1 receptor deleted in colorectal cancer (dcc) is required for the formation of major axonal projections by embryonic cortical neurons, including the corpus callosum, hippocampal commissure, and cortico-thalamic tracts. |
2008-12-24 |
2023-08-12 |
Not clear |
| Craig D Albright, Mei-Heng Mar, Corneliu N Craciunescu, Jiannan Song, Steven H Zeise. Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain research. Developmental brain research. vol 159. issue 2. 2005-11-30. PMID:16109446. |
maternal dietary choline availability alters the balance of netrin-1 and dcc neuronal migration proteins in fetal mouse brain hippocampus. |
2005-11-30 |
2023-08-12 |
mouse |
| Craig D Albright, Mei-Heng Mar, Corneliu N Craciunescu, Jiannan Song, Steven H Zeise. Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain research. Developmental brain research. vol 159. issue 2. 2005-11-30. PMID:16109446. |
alterations in maternal dietary choline availability during days 12-17 of pregnancy led to an increase in the level of immunoreactive netrin-1 and a decrease in the level of dcc protein in the developing fetal mouse brain hippocampus compared with controls. |
2005-11-30 |
2023-08-12 |
mouse |
| M J Barallobre, J A Del Río, S Alcántara, V Borrell, F Aguado, M Ruiz, M A Carmona, M Martín, M Fabre, R Yuste, M Tessier-Lavigne, E Sorian. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice. Development (Cambridge, England). vol 127. issue 22. 2001-01-04. PMID:11044395. |
we also show that the hippocampus of netrin 1-deficient mice shows a misorientation of fiber tracts and pathfinding errors, as detected with antibodies against the surface proteins tag-1, l1 and dcc. |
2001-01-04 |
2023-08-12 |
mouse |
| M J Barallobre, J A Del Río, S Alcántara, V Borrell, F Aguado, M Ruiz, M A Carmona, M Martín, M Fabre, R Yuste, M Tessier-Lavigne, E Sorian. Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice. Development (Cambridge, England). vol 127. issue 22. 2001-01-04. PMID:11044395. |
we show that netrin 1 and its receptor, dcc, are expressed in the developing fimbria and in projection neurons, respectively, and that netrin 1 promotes the outgrowth of hippocampal axons in vitro via dcc receptors. |
2001-01-04 |
2023-08-12 |
mouse |