| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Goodhart, W E DeWolf, L I Krus. Mechanism-based inactivation of dopamine beta-hydroxylase by p-cresol and related alkylphenols. Biochemistry. vol 26. issue 9. 1987-08-28. PMID:3607034. |
the mechanism-based inhibition of dopamine beta-hydroxylase (dbh; ec 1.14.17.1) by p-cresol (4-methylphenol) and other simple structural analogues of dopamine, which lack a basic side-chain nitrogen, is reported. |
1987-08-28 |
2023-08-11 |
Not clear |
| P J Goodhart, W E DeWolf, L I Krus. Mechanism-based inactivation of dopamine beta-hydroxylase by p-cresol and related alkylphenols. Biochemistry. vol 26. issue 9. 1987-08-28. PMID:3607034. |
p-cresol binds dbh by a mechanism that is kinetically indistinguishable from normal dopamine substrate binding [dewolf, w. e., jr., & kruse, l. i. |
1987-08-28 |
2023-08-11 |
Not clear |
| T H Joh, O Hwan. Dopamine beta-hydroxylase: biochemistry and molecular biology. Annals of the New York Academy of Sciences. vol 493. 1987-07-23. PMID:3473965. |
dopamine beta-hydroxylase (dbh) catalyzes the conversion of dopamine to norepinephrine (ne), and is known to exist in two forms: soluble and membrane-bound. |
1987-07-23 |
2023-08-11 |
human |
| E H Ohlstein, L I Kruse, M Ezekiel, S S Sherman, R Erickson, W E DeWolf, B A Berkowit. Cardiovascular effects of a new potent dopamine beta-hydroxylase inhibitor in spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics. vol 241. issue 2. 1987-06-12. PMID:3572812. |
the cardiovascular effects of a new class of potent inhibitors of dopamine beta-hydroxylase (dbh) were evaluated in spontaneously hypertensive rats (shr). |
1987-06-12 |
2023-08-11 |
rat |
| E H Ohlstein, L I Kruse, M Ezekiel, S S Sherman, R Erickson, W E DeWolf, B A Berkowit. Cardiovascular effects of a new potent dopamine beta-hydroxylase inhibitor in spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics. vol 241. issue 2. 1987-06-12. PMID:3572812. |
sk&f 102698 inhibited dbh in vivo as demonstrated by its ability to increase vascular levels of dopamine (da) while concomitantly decreasing vascular levels of norepinephrine (ne), thus increasing the overall da/ne ratio. |
1987-06-12 |
2023-08-11 |
rat |
| M Ahonen, S Soinila, T H Jo. Pre- and postnatal development of rat retroperitoneal paraganglia. Journal of the autonomic nervous system. vol 18. issue 2. 1987-06-08. PMID:2883207. |
the analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
1987-06-08 |
2023-08-11 |
rat |
| M S Bitar, M Koulu, S I Rapoport, M Linnoil. Adrenal catecholamine metabolism and myocardial adrenergic receptors in streptozotocin diabetic rats. Biochemical pharmacology. vol 36. issue 7. 1987-05-08. PMID:2882757. |
adrenal tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt) activities were increased by 52, 28 and 39%, respectively, in the stz diabetic rats. |
1987-05-08 |
2023-08-11 |
rat |
| L I Kruse, C Kaiser, W E DeWolf, J S Frazee, S T Ross, J Wawro, M Wise, K E Flaim, J L Sawyer, R W Erickso. Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site. Journal of medicinal chemistry. vol 30. issue 3. 1987-04-15. PMID:3820219. |
1-aralkylimidazole-2-thiones have been shown to be potent multisubstrate inhibitors of dopamine beta-hydroxylase (dbh; ec 1.14.17.1). |
1987-04-15 |
2023-08-11 |
rat |
| R B Simerly, L W Swanso. The distribution of neurotransmitter-specific cells and fibers in the anteroventral periventricular nucleus: implications for the control of gonadotropin secretion in the rat. Brain research. vol 400. issue 1. 1987-03-30. PMID:2880634. |
in the present study we evaluated the distribution of biochemically specific cells and fibers within the avpv and adjacent regions by using an indirect immunohistochemical method with antisera to serotonin (5-ht), dopamine beta-hydroxylase (dbh), tyrosine hydroxylase (th), neuropeptide y (npy), cholecystokinin-8 (cck), vasoactive intestinal polypeptide (vip), substance p (sp), neurotensin (nt), corticotropin-releasing factor (crf), luteotropin-releasing hormone (lrh), somatostatin (ss), thyrotropin-releasing hormone (trh), oxytocin (oxy), vasopressin (vas), adrenocorticotropic hormone (acth1-24), alpha-melanocyte-stimulating hormone (alpha-msh), leucine-enkephalin (l-enk), and calcitonin gene-related peptide (cgrp). |
1987-03-30 |
2023-08-11 |
rat |
| E L Sabban, L J Kuhn, B E Levi. In vivo biosynthesis of two subunit forms of dopamine beta-hydroxylase in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 1. 1987-03-18. PMID:2433416. |
in vivo biosynthesis of the 2 subunit forms of dopamine beta-hydroxylase (dbh) was examined in the rat brain. |
1987-03-18 |
2023-08-11 |
rat |
| L I Kruse, W E DeWolf, P A Chambers, P J Goodhar. Design and kinetic characterization of multisubstrate inhibitors of dopamine beta-hydroxylase. Biochemistry. vol 25. issue 23. 1987-03-16. PMID:3801416. |
the synthesis and kinetics characterization of a new class of dopamine beta-hydroxylase (dbh; ec 1.14.17.1) inhibitor, 1-(4-hydroxybenzyl)imidazole-2-thiol, is reported. |
1987-03-16 |
2023-08-11 |
Not clear |
| T Sato, E Imura, A Murata, N Igarash. Thyroid hormone-catecholamine interrelationship during cold acclimation in rats. Compensatory role of catecholamine for altered thyroid states. Acta endocrinologica. vol 113. issue 4. 1987-01-22. PMID:2878553. |
they had increased cerebral dopamine, adrenal ca and bat norepinephrine (ne) contents, enhanced cerebral tyrosine hydroxylase and adrenal dopamine beta-hydroxylase (dbh) activities and elevated [3h]dihydroalprenolol (dha) binding to liver plasma membranes (p less than 0.01 vs controls). |
1987-01-22 |
2023-08-11 |
rat |
| L I Kruse, C Kaiser, W E DeWolf, J S Frazee, E Garvey, E L Hilbert, W A Faulkner, K E Flaim, J L Sawyer, B A Berkowit. Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione. Journal of medicinal chemistry. vol 29. issue 12. 1987-01-16. PMID:3783606. |
the synthesis and characterization of some 1-(phenylalkyl)imidazole-2-thiones as a novel class of "multisubstrate" inhibitors of dopamine beta-hydroxylase (dbh) are described. |
1987-01-16 |
2023-08-11 |
Not clear |
| L I Kruse, C Kaiser, W E DeWolf, J S Frazee, E Garvey, E L Hilbert, W A Faulkner, K E Flaim, J L Sawyer, B A Berkowit. Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione. Journal of medicinal chemistry. vol 29. issue 12. 1987-01-16. PMID:3783606. |
a series of structural congeners that incorporate different bridging chain lengths between the phenyl ring (dopamine mimic) and the imidazole-2-thione group (oxygen mimic) define the optimum distance for inhibitory potency and the likely intersite distance in the dbh active site. |
1987-01-16 |
2023-08-11 |
Not clear |
| R V Lloyd, J C Sisson, B Shapiro, A A Verhofsta. Immunohistochemical localization of epinephrine, norepinephrine, catecholamine-synthesizing enzymes, and chromogranin in neuroendocrine cells and tumors. The American journal of pathology. vol 125. issue 1. 1986-11-25. PMID:3777139. |
the immunohistochemical detection of tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt) was used to distinguish between uptake and biosynthesis of catecholamines. |
1986-11-25 |
2023-08-11 |
human |
| A E Rosser, T Hökfelt, M Goldstei. LHRH and catecholamine neuronal systems in the olfactory bulb of the mouse. The Journal of comparative neurology. vol 250. issue 3. 1986-10-21. PMID:2875086. |
sections adjacent to those stained with lhrh antibody were analysed for tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
1986-10-21 |
2023-08-11 |
mouse |
| B Lindh, T Hökfelt, L G Elfvin, L Terenius, J Fahrenkrug, R Elde, M Goldstei. Topography of NPY-, somatostatin-, and VIP-immunoreactive, neuronal subpopulations in the guinea pig celiac-superior mesenteric ganglion and their projection to the pylorus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 8. 1986-10-02. PMID:2875137. |
for comparison, the ganglion was also studied using antisera against the 2 catecholamine-synthesizing enzymes tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
1986-10-02 |
2023-08-11 |
Not clear |
| A Dahlström, P A Larsson, M Goldstein, K Lundmark, A G Dahllöf, S Böö. Immunocytochemical studies on axonal transport in adrenergic and cholinergic nerves using cytofluorimetric scanning. Medical biology. vol 64. issue 2-3. 1986-09-30. PMID:2875231. |
the substances must be made fluorescent, and in this study we have investigated noradrenaline (na), using formaldehyde induced fluorescence, and dopamine beta-hydroxylase (dbh), tyrosine hydroxylase (th), neuropeptide y (npy) and two cholinergic vesicle components (a transmembrane glycoprotein and synapsin i) using indirect immunofluorescence. |
1986-09-30 |
2023-08-11 |
rat |
| C Saligaut, P Chretien, M Daoust, N Moore, F Boismar. Dynamic characteristics of dopamine, norepinephrine and serotonin metabolism in axonal endings of the rat hypothalamus and striatum during hypoxia: a study using HPLC with electrochemical detection. Methods and findings in experimental and clinical pharmacology. vol 8. issue 6. 1986-09-17. PMID:2426539. |
hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of th, mao, and dopamine beta-hydroxylase (dbh)]. |
1986-09-17 |
2023-08-11 |
rat |
| M H Schöni, K Türler, H Käser, R Kraeme. Dopamine-beta-hydroxylase in patients with cystic fibrosis. European journal of pediatrics. vol 145. issue 1-2. 1986-09-16. PMID:3732334. |
however, due to the large variability of dbh within the groups and due to the lack of relationship of this enzymatic activity to plasma catecholamines, it is concluded that these differences may neither account for the observed elevation of plasma dopamine in cystic fibrosis patients (0.94-6.73 nmol/l vs. 0.01-0.986 nmol/l for controls) nor for their putative autonomic dysfunction. |
1986-09-16 |
2023-08-11 |
Not clear |