| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M K Sanghera, K F Manaye, C L Liang, A M Lacopino, M J Bannon, D C Germa. Low dopamine transporter mRNA levels in midbrain regions containing calbindin. Neuroreport. vol 5. issue 13. 1995-02-10. PMID:7819538. |
the dopamine transporter (dat) is the site at which the neurotoxic metabolite of mptp gains access to midbrain dopaminergic (da) neurons. |
1995-02-10 |
2023-08-12 |
mouse |
| M Fujita, S Shimada, K Fukuchi, M Tohyama, T Nishimur. Distribution of cocaine recognition sites in rat brain: in vitro and ex vivo autoradiography with [125I]RTI-55. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802967. |
the distribution of binding sites of [125i]rti-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), a phenyl tropane analog of cocaine, and the selective labeling of the dopamine transporter (dat) were studied by in vitro and ex vivo autoradiography in the rat whole brain. |
1995-01-31 |
2023-08-12 |
rat |
| C A Leslie, M W Robertson, A B Jung, J Liebermann, J P Bennet. Effects of prenatal cocaine exposure upon postnatal development of neostriatal dopaminergic function. Synapse (New York, N.Y.). vol 17. issue 3. 1994-11-29. PMID:7974205. |
brains from offspring were examined with quantitative receptor autoradiography [d1 receptor (d1r), d2 receptor (d2r) and dopamine transporter (dat)] and quantitative in situ hybridization [d1r mrna, d2r mrna, preproenkephalin (ppe) mrna] for markers of neostriatal dopaminergic function. |
1994-11-29 |
2023-08-12 |
rat |
| C Perrone-Capano, A Tino, U di Porzi. Target cells modulate dopamine transporter gene expression during brain development. Neuroreport. vol 5. issue 9. 1994-10-11. PMID:7521683. |
we have analysed the expression of the dopamine transporter (dat) gene and compared it with that of tyrosine hydroxylase, neuronal gaba transporter and synaptic vesicle monoamine transporter genes during pre- and post-natal development of rat mesencephalic dopaminergic (da) neurones. |
1994-10-11 |
2023-08-12 |
rat |
| D P Figlewicz, P Szot, M Chavez, S C Woods, R C Veit. Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain research. vol 644. issue 2. 1994-09-08. PMID:8050044. |
we determined the level of dopamine transporter (dat) mrna expression in the ventral tegmental area (vta)/substantia nigra compacta (snc) of rats which were chronically treated with vehicle or insulin via the third cerebral ventricle (i.c.v.). |
1994-09-08 |
2023-08-12 |
rat |
| D Lorang, S G Amara, R B Simerl. Cell-type-specific expression of catecholamine transporters in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 8. 1994-08-30. PMID:8046459. |
the dopamine transporter (dat) and norepinephrine transporter (net) terminate catecholaminergic neurotransmission at synapses by high-affinity sodium-dependent reuptake into presynaptic terminals, and are the initial sites of action for drugs of abuse and antidepressants. |
1994-08-30 |
2023-08-12 |
rat |
| V Blanchard, R Raisman-Vozari, S Vyas, P P Michel, F Javoy-Agid, G Uhl, Y Agi. Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon. Brain research. Molecular brain research. vol 22. issue 1-4. 1994-07-25. PMID:7912404. |
in the present study, th protein, th mrna and dopamine membrane transporter (dat) mrna were quantified at cellular level in 4 arbitrary subregions of the rat ventral mesencephalon (lateral, middle, medial snc and vta), using in situ hybridization and immunoautoradiography. |
1994-07-25 |
2023-08-12 |
rat |
| V Blanchard, R Raisman-Vozari, S Vyas, P P Michel, F Javoy-Agid, G Uhl, Y Agi. Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon. Brain research. Molecular brain research. vol 22. issue 1-4. 1994-07-25. PMID:7912404. |
the relative lower expression of the dat gene in vta neurons suggests a less efficient dopamine reuptake capacity, which may partly account for the relative sparing of the mesolimbic system reported in parkinson's disease and mptp-treated animals. |
1994-07-25 |
2023-08-12 |
rat |
| P O Allard, J Rinne, J O Marcusso. Dopamine uptake sites in Parkinson's disease and in dementia of the Alzheimer type. Brain research. vol 637. issue 1-2. 1994-06-16. PMID:8180805. |
the binding of [3h]gbr-12935 to dopamine (da) uptake sites was studied in post-mortem putamen from a control group and from patients with parkinson's disease (pd) or dementia of the alzheimer type (dat). |
1994-06-16 |
2023-08-12 |
Not clear |
| A Hitri, Y L Hurd, R J Wyatt, S I Deutsc. Molecular, functional and biochemical characteristics of the dopamine transporter: regional differences and clinical relevance. Clinical neuropharmacology. vol 17. issue 1. 1994-05-10. PMID:8149355. |
the carrier molecule that transports dopamine (da) across the synaptic membrane is known as the dopamine transporter (dat). |
1994-05-10 |
2023-08-12 |
human |
| K Y Little, J A Kirkman, F I Carroll, T B Clark, G E Dunca. Cocaine use increases [3H]WIN 35428 binding sites in human striatum. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:8313144. |
animal studies suggest that chronic cocaine exposure may increase the function and/or synthesis of the dopamine transporter (dat) under certain conditions, but the literature is complex. |
1994-03-23 |
2023-08-12 |
human |
| S Kitayama, J B Wang, G R Uh. Dopamine transporter mutants selectively enhance MPP+ transport. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310426. |
mpp+ (1-methyl-4-phenylpyridinium), a dopaminergic neurotoxin that provides the best available experimental model of parkinson's disease, is selectively concentrated in dopamine neurons by the dopamine transporter (dat). |
1994-03-17 |
2023-08-12 |
Not clear |
| B Meister, R Eld. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology. vol 58. issue 4. 1994-02-16. PMID:8284024. |
the membrane-bound dopamine transporter (dat) protein terminates dopaminergic neurotransmission by rapid reaccumulation of dopamine into presynaptic nerve endings. |
1994-02-16 |
2023-08-12 |
rat |
| B Meister, R Eld. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology. vol 58. issue 4. 1994-02-16. PMID:8284024. |
dat mrna-containing cell bodies were demonstrated in the ventral aspect of the periventricular nucleus (a14 dopamine cell group), in the zona incerta (a13), in the dorsomedial part of the arcuate nucleus (a12), and in scattered regions of the posterior hypothalamus. |
1994-02-16 |
2023-08-12 |
rat |
| B Meister, R Eld. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology. vol 58. issue 4. 1994-02-16. PMID:8284024. |
the results suggest that hypothalamic dopamine neurons have an active uptake mechanism for dopamine, however, that dat mrna levels may be considerably lower than those encountered in the ventral midbrain. |
1994-02-16 |
2023-08-12 |
rat |
| M Fujita, S Shimada, T Nishimura, G R Uhl, M Tohyam. Ontogeny of dopamine transporter mRNA expression in the rat brain. Brain research. Molecular brain research. vol 19. issue 3. 1993-11-03. PMID:8412565. |
the ontogeny of dopamine transporter (dat) gene expression was studied in the rat brain. |
1993-11-03 |
2023-08-12 |
rat |
| A M Persico, C W Schindler, M T Brannock, A M Gonzalez, C K Surratt, G R Uh. Dopaminergic gene expression during amphetamine withdrawal. Neuroreport. vol 4. issue 1. 1993-04-16. PMID:8095821. |
amphetamine withdrawal could involve the dopaminergic systems that are thought to underlie psychostimulant rewarding effects, and may thus conceivably alter expression of key genes for dopaminergic transmission, including those encoding tyrosine hydroxylase (th), the membrane dopamine transporter (dat) and the synaptic vesicle amine transporter (svat). |
1993-04-16 |
2023-08-12 |
rat |
| J W Boja, L Markham, A Patel, G Uhl, M J Kuha. Expression of a single dopamine transporter cDNA can confer two cocaine binding sites. Neuroreport. vol 3. issue 3. 1992-10-02. PMID:1515577. |
radiolabeled cocaine analogs can bind to low and high affinity sites on striatal dopamine transporters (dat). |
1992-10-02 |
2023-08-11 |
rat |
| S Kitayama, S Shimada, H Xu, L Markham, D M Donovan, G R Uh. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502198. |
polar amino acids lying within three hydrophobic regions of the dopamine transporter (dat) are analogous to those important for ligand recognition by catecholamine receptors. |
1992-09-15 |
2023-08-11 |
Not clear |
| S Kitayama, S Shimada, H Xu, L Markham, D M Donovan, G R Uh. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502198. |
these results demonstrate that aspartate and serine residues lying within the first and seventh hydrophobic putative transmembrane regions are crucial for dat function and provide identification of residues differentially important for cocaine binding and for dopamine uptake. |
1992-09-15 |
2023-08-11 |
Not clear |