| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F J Lee, F Liu, Z B Pristupa, H B Nizni. Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 6. 2001-05-10. PMID:11292651. |
since the selective vulnerability of dopaminergic neurons in pd has been ascribed in part to oxidative stress as a result of the cellular overaccumulation of dopamine or dopamine-like molecules by the presynaptic dat, these data provide mechanistic insight into the mode by which the activity of these two proteins may give rise to this process. |
2001-05-10 |
2023-08-12 |
human |
| D A Lewis, D S Melchitzky, S R Sesack, R E Whitehead, S Auh, A Sampso. Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. The Journal of comparative neurology. vol 432. issue 1. 2001-05-03. PMID:11241381. |
dopamine (da) influences a number of cognitive and motor functions that are mediated by the primate cerebral cortex, and the da membrane transporter (dat) is known to be a critical regulator of da neurotransmission in subcortical structures in rodents. |
2001-05-03 |
2023-08-12 |
monkey |
| Y Ouchi, T Kanno, H Okada, E Yoshikawa, M Futatsubashi, S Nobezawa, T Torizuka, K Tanak. Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain : a journal of neurology. vol 124. issue Pt 4. 2001-05-03. PMID:11287377. |
the aim of the present study was to investigate changes in dopamine transporter (dat) availability in the striatum and extrastriatal region in association with walking exercise in six normal subjects and seven age-matched unmedicated patients with parkinson's disease. |
2001-05-03 |
2023-08-12 |
human |
| A K Dutta, X S Fei, P M Beardsley, J L Newman, M E Reit. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. Journal of medicinal chemistry. vol 44. issue 6. 2001-05-03. PMID:11300876. |
in our effort to develop a pharmacotherapy for the treatment of cocaine addiction, we embarked on synthesizing novel molecules targeting the dopamine transporter (dat) molecule in the brain as dat has been implicated strongly in the reinforcing effect of cocaine. |
2001-05-03 |
2023-08-12 |
mouse |
| X Zhuang, R S Oosting, S R Jones, R R Gainetdinov, G W Miller, M G Caron, R He. Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172062. |
in an attempt to model aspects of these disorders, we have generated hyperdopaminergic mutant mice by reducing expression of the dopamine transporter (dat) to 10% of wild-type levels (dat knockdown). |
2001-04-19 |
2023-08-12 |
mouse |
| X Zhuang, R S Oosting, S R Jones, R R Gainetdinov, G W Miller, M G Caron, R He. Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172062. |
in addition, we show that both the indirect dopamine receptor agonist amphetamine and the direct agonists apomorphine and quinpirole inhibit locomotor activity in the dat knockdown mice, leading to the hypothesis that a shift in the balance between dopamine auto and heteroreceptor function may contribute to the therapeutic effect of psychostimulants in attention deficit hyperactivity disorder. |
2001-04-19 |
2023-08-12 |
mouse |
| A K Dutta, M E Reith, B K Madra. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180505. |
the compound 1b was characterized for its binding both in monkey and rat striatum tissue, which demonstrated its high selectivity for the dopamine transporter (dat) when its binding was compared with that at the serotonin transporter (sert). |
2001-04-19 |
2023-08-12 |
rat |
| A K Dutta, X S Fei, R A Vaughan, J D Gaffaney, N Wang, J R Lever, M E Reit. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life sciences. vol 68. issue 16. 2001-04-19. PMID:11292062. |
the dopamine transporter (dat) has been implicated strongly in cocaine's reinforcing effects. |
2001-04-19 |
2023-08-12 |
Not clear |
| A J Eshleman, K Wolfrum, D C Mash, K Christensen, A Janowsk. Drug interactions with the dopamine transporter in cryopreserved human caudate. The Journal of pharmacology and experimental therapeutics. vol 296. issue 2. 2001-04-05. PMID:11160629. |
although several model systems have been developed to characterize the function of the dopamine transporter (dat), there is a relative lack of data regarding dopamine (da) uptake by human caudate, as contrasted to binding studies. |
2001-04-05 |
2023-08-12 |
human |
| J P Wisor, S Nishino, I Sora, G H Uhl, E Mignot, D M Edga. Dopaminergic role in stimulant-induced wakefulness. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 5. 2001-04-05. PMID:11222668. |
in mice, deletion of the dopamine transporter (dat) gene reduced non-rapid eye movement sleep time and increased wakefulness consolidation independently from locomotor effects. |
2001-04-05 |
2023-08-12 |
mouse |
| G Page, M Peeters, M Najimi, J M Maloteaux, E Herman. Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238713. |
there is considerable evidence that the activity of the neuronal dopamine transporter (dat) is dynamically regulated and a putative implication of its phosphorylation in this process has been proposed. |
2001-04-05 |
2023-08-12 |
rat |
| J M Brown, G R Hanson, A E Fleckenstei. Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181904. |
the plasmalemmal dopamine (da) transporter (dat) is a principal site of action for cocaine. |
2001-03-15 |
2023-08-12 |
rat |
| S Doolen, N R Zahnise. Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181926. |
the dopamine (da) transporter (dat) regulates dopaminergic synaptic transmission by controlling extracellular levels of da. |
2001-03-15 |
2023-08-12 |
human |
| S Dresel, J Krause, K H Krause, C LaFougere, K Brinkbäumer, H F Kung, K Hahn, K Tatsc. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. European journal of nuclear medicine. vol 27. issue 10. 2001-03-01. PMID:11083541. |
involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (adhd) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (dat). |
2001-03-01 |
2023-08-12 |
human |
| L I Tsao, T Hayashi, T P S. Blockade of dopamine transporter and tyrosine hydroxylase activity loss by [D-Ala(2), D-Leu(5)]enkephalin in methamphetamine-treated CD-1 mice. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980266. |
here, we show that dadle was able to block the protein as well as the functional loss of dopamine transporter (dat) and tyrosine hydroxylase (th) induced by methamphetamine. |
2001-02-22 |
2023-08-12 |
mouse |
| M Romero-Ramos, J L Venero, J Cano, A Machad. Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat. Brain research. Molecular brain research. vol 84. issue 1-2. 2001-02-15. PMID:11113527. |
as a further step, we measured the levels of activity and mrna expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2001-02-15 |
2023-08-12 |
rat |
| J A Lile, D Morgan, C S Freedland, R S Sinnott, H M Davies, M A Nade. Self-administration of two long-acting monoamine transport blockers in rhesus monkeys. Psychopharmacology. vol 152. issue 4. 2001-02-08. PMID:11140334. |
2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt) is a cocaine analog with high affinity at and selectivity for the dopamine transporter (dat). |
2001-02-08 |
2023-08-12 |
monkey |
| H K Wayment, J O Schenk, B A Sor. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150317. |
rde studies indicate that inhibition by cocaine, specific inhibitors of the dopamine transporter (dat) and norepinephrine transporter (net), and low na(+) produced a 50-70% decrease in the velocity of dopamine clearance. |
2001-02-08 |
2023-08-12 |
rat |
| H K Wayment, J O Schenk, B A Sor. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150317. |
short-term incubation of l-deprenyl combined with dat and net uptake inhibitors increased dopamine above control levels, consistent with more than one mechanism of dopamine clearance. |
2001-02-08 |
2023-08-12 |
rat |
| R J Ralph, M P Paulus, F Fumagalli, M G Caron, M A Geye. Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150348. |
we used dopamine transporter (dat) (-/-) mice to examine the behavioral consequences of a chronically hyperdopaminergic state, challenging them with the preferential dopamine d2 receptor antagonist raclopride and d1 receptor antagonist sch23390. |
2001-02-08 |
2023-08-12 |
mouse |