| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y K Chen, R S Liu, W S Huang, S P Wey, G Ting, J C Liu, Y Y Shen, F J Wa. The role of dopamine transporter imaging agent [99mTc]TRODAT-1 in hemi-parkinsonism rat brain. Nuclear medicine and biology. vol 28. issue 8. 2002-02-21. PMID:11711311. |
for the striatum of the 6-ohda-lesioned side, dopamine content and dat counts are reduced to 97% and 90%, respectively. |
2002-02-21 |
2023-08-12 |
rat |
| Aloke K Dutta, Matthew C Davis, Xiang-Shu Fei, Patrick M Beardsley, Charles D Cook, Maarten E A Reit. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. Journal of medicinal chemistry. vol 45. issue 3. 2002-02-19. PMID:11806716. |
a series of substituted n-benzyl analogues of the dopamine transporter (dat) specific compound, 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine were synthesized and biologically characterized. |
2002-02-19 |
2023-08-12 |
mouse |
| M L Filipenko, O V Alekseyenko, A G Beilina, T P Kamynina, N N Kudryavtsev. Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731011. |
tyrosine hydroxylase (th) and dopamine transporter (dat) mrna levels in the ventral tegmental area (vta) of midbrain were measured by multiplex rt-pcr in male mice with repeated experience of social victories (winners) and social defeats (losers) in 10 daily agonistic confrontations. |
2002-02-14 |
2023-08-12 |
mouse |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
several previous human postmortem experiments have detected an increase in striatal [(3)h]win 35428 binding to the dopamine transporter (dat) in chronic cocaine users. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
the present experiments tested the hypothesis that [(3)h]win 35428 binding and [(3)h]dopamine uptake would be increased by exposure to cocaine through alterations in dat cellular trafficking, rather than increased protein synthesis. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
experiments were conducted in stably hdat-transfected n2a cells and assessed the dose response and time course of cocaine effects on [(3)h]win 35428 binding to the dat, [(3)h]dopamine uptake, measures of dat protein and mrna, as well as dat subcellular location. |
2002-02-07 |
2023-08-12 |
human |
| A L Svingos, C Chavkin, E E Colago, V M Picke. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746715. |
the behavioral effects of psychostimulants, which are produced at least in part through inhibition of the dopamine transporter (dat), are modulated by kappa-opioid receptors (kor) in the nucleus accumbens (acb). |
2002-02-05 |
2023-08-12 |
Not clear |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
we have tested this hypothesis by comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3h-dopamine into synaptosomes from frontal cortex, caudate nucleus, and nucleus accumbens from wild-type, net, and dopamine transporter (dat) knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
dopamine uptake was inhibited by cocaine and nisoxetine, but not by gbr12909, in frontal cortex synaptosomes from wild-type or dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
nisoxetine inhibited dopamine uptake by 20% in caudate and nucleus accumbens synaptosomes from wild-type and dat knock-out mice but had no effect in those from net knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
cocaine failed to block dopamine uptake into caudate or nucleus accumbens synaptosomes from dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
thus, whereas dopamine uptake in caudate and nucleus accumbens depends primarily on the dat, dopamine uptake in frontal cortex depends primarily on the net. |
2002-01-30 |
2023-08-12 |
mouse |
| A Varrone, K L Marek, D Jennings, R B Innis, J P Seiby. [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 6. 2002-01-25. PMID:11748733. |
in vivo imaging of the dopamine transporter (dat) with single photon emission computed tomography (spect) is a quantitative biomarker for parkinson's disease (pd) onset and severity. |
2002-01-25 |
2023-08-12 |
Not clear |
| K M Wilcox, K P Lindsey, J R Votaw, M M Goodman, L Martarello, F I Carroll, L L Howel. Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse (New York, N.Y.). vol 43. issue 1. 2002-01-24. PMID:11746736. |
drug effects on behavior were related to dopamine transporter (dat) occupancy in monkey striatum during neuroimaging with positron emission tomography. |
2002-01-24 |
2023-08-12 |
monkey |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
the dopamine (dat) and serotonin (sert) transporter genes both contain variable number of tandem repeats (vntr) in non-coding gene regions which have been correlated with a predisposition to a variety of cns disorders. |
2002-01-17 |
2023-08-12 |
human |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
this study demonstrates by lipid transfection into an immortalized dopaminergic cell line and biolistic transfection into dopamine neurons in neonatal rat midbrain slices that the human nine-repeat dat vntr can enhance transcription. |
2002-01-17 |
2023-08-12 |
human |
| R D Mayfield, R Maiya, D Keller, N R Zahnise. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739621. |
recent studies suggest that ethanol's action on central dopamine systems may also involve modulation of dopamine transporter (dat) activity. |
2002-01-17 |
2023-08-12 |
human |
| R D Mayfield, R Maiya, D Keller, N R Zahnise. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739621. |
thus, the increase in dopamine uptake was associated with a parallel increase in the number of dat molecules expressed at the cell surface. |
2002-01-17 |
2023-08-12 |
human |
| A M Allan, R Galindo, J Chynoweth, S R Engel, D D Savag. Conditioned place preference for cocaine is attenuated in mice over-expressing the 5-HT(3) receptor. Psychopharmacology. vol 158. issue 1. 2002-01-15. PMID:11685380. |
no changes in either the dopamine receptors (d1, d2, d3, and d4) or in the dopamine transporter (dat) were found over a wide range of brain regions. |
2002-01-15 |
2023-08-12 |
mouse |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harad. Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain. Synapse (New York, N.Y.). vol 42. issue 4. 2002-01-10. PMID:11746726. |
the effects of ketamine anesthesia on the binding of [(11)c]-labeled cocaine analogs, [(11)c]beta-cft (2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane) and [(11)c]beta-cit-fe (n-(2-fluoroethyl)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane), to the striatal dopamine transporter (dat) were evaluated in the monkey brain using positron emission tomography (pet). |
2002-01-10 |
2023-08-12 |
monkey |