| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krystyna Ossowska, Jadwiga Wardas, Katarzyna Kuter, Przemysław Nowak, Joanna Dabrowska, Aleksandra Bortel, Łukasz Labus, Adam Kwieciński, Anna Krygowska-Wajs, Stainsław Wolfart. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985715. |
the present study seems to suggest that systemic paraquat administration affects striatal dat and dopamine metabolism in the nigrostriatal neurons in rats which may be crucial for its neurotoxic effects on dopaminergic neurons. |
2006-09-07 |
2023-08-12 |
rat |
| Barbara Cagniard, Peter D Balsam, Daniela Brunner, Xiaoxi Zhuan. Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16319913. |
in order to investigate the involvement of dopamine in learning and motivation for a food reward, we used dopamine transporter knockdown mice (dat kd) that have chronically elevated levels of extracellular dopamine. |
2006-09-05 |
2023-08-12 |
mouse |
| Osnat Ben-Shahar, Justin M Moscarello, Aaron Ettenber. One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter. Brain research. vol 1095. issue 1. 2006-09-05. PMID:16712814. |
in an extension of our previous work, the current study, using receptor autoradiography, compared binding (by [3h]win35428) of the dopamine transporter (dat) in animals having experienced either brief or extended daily access to cocaine over 8 days, followed by 14 days of withdrawal. |
2006-09-05 |
2023-08-12 |
human |
| Zane B Andrews, Alicia Rivera, John D Elsworth, Robert H Roth, Luigi Agnati, Belen Gago, Alfonso Abizaid, Michael Schwartz, Kjell Fuxe, Tamas L Horvat. Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882005. |
ucp2-knockout (ko) mice also had reduced dopamine transporter immunoreactivity (dat ir) in the snc but not other brain regions examined. |
2006-09-05 |
2023-08-12 |
mouse |
| Tatiana Sorkina, Manuel Miranda, Kalen R Dionne, Brian R Hoover, Nancy R Zahniser, Alexander Sorki. RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 31. 2006-09-05. PMID:16885233. |
the function of the dopamine transporter (dat) to terminate dopamine neurotransmission is regulated by endocytic trafficking of dat. |
2006-09-05 |
2023-08-12 |
human |
| F Ivy Carroll, Bruce E Blough, Xiaodong Huang, Zhe Nie, S Wayne Mascarella, Jeffrey Deschamps, Hernán A Navarr. Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854064. |
the results show that binding to the dopamine and serotonin transporters (dat and 5-htt) is highly dependent on the specific linker used. |
2006-08-31 |
2023-08-12 |
Not clear |
| Kristopher M Kahlig, Brandon J Lute, Yuqiang Wei, Claus J Loland, Ulrik Gether, Jonathan A Javitch, Aurelio Gall. Regulation of dopamine transporter trafficking by intracellular amphetamine. Molecular pharmacology. vol 70. issue 2. 2006-08-28. PMID:16684900. |
the dopamine (da) transporter (dat) mediates the removal of released da. |
2006-08-28 |
2023-08-12 |
human |
| Sangmi Chung, Byoung-Soo Shin, Michelle Hwang, Thomas Lardaro, Un Jung Kang, Ole Isacson, Kwang-Soo Ki. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem cells (Dayton, Ohio). vol 24. issue 6. 2006-08-25. PMID:16543488. |
expanded es np-derived th(+) neurons coexpressed additional da markers such as dopa decarboxylase and dat (dopamine transporter). |
2006-08-25 |
2023-08-12 |
mouse |
| K R Kessler, N Hamscho, B Morales, C Menzel, F Barrero, F Vives, S Gispert, G Auburge. Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 10. 2006-08-18. PMID:15785866. |
in this family, we studied pre- and postsynaptic dopaminergic function using 123i-fp-cit- and 123i-iodobenzamide-spect to determine binding to the presynaptic dopamine transporter (dat) and postsynaptic d2 receptors respectively. |
2006-08-18 |
2023-08-12 |
Not clear |
| Evan L Riddle, Annette E Fleckenstein, Glen R Hanso. Role of monoamine transporters in mediating psychostimulant effects. The AAPS journal. vol 7. issue 4. 2006-08-16. PMID:16594636. |
monoamine transporters such as the dopamine (da) transporter (dat) and the vesicular monoamine transporter-2 (vmat-2) are critical regulators of da disposition within the brain. |
2006-08-16 |
2023-08-12 |
Not clear |
| John L Musachio, Jinsoo Hong, Masanori Ichise, Nicholas Seneca, Amira K Brown, Jeih-San Liow, Christer Halldin, Robert B Innis, Victor W Pike, Rong He, Jia Zhou, Alan P Kozikowsk. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 16. issue 12. 2006-08-16. PMID:16621532. |
[11c]5 and [11c]6 display high affinity for the net in vitro (ki = 0.94 and 0.68 nm, respectively) and significant selectivity over the dopamine (dat) and serotonin transporters (sert). |
2006-08-16 |
2023-08-12 |
Not clear |
| Dalit E Dar, Thomas G Metzger, David J Vandenbergh, George R Uh. Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter. European journal of pharmacology. vol 538. issue 1-3. 2006-08-16. PMID:16674939. |
the wild type human dopamine transporter (dat) and five dat mutants were transfected into cos-7 cells and their ability to uptake dopamine or to bind cocaine was examine three days later. |
2006-08-16 |
2023-08-12 |
human |
| Santosh S Kulkarni, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16460947. |
benztropine (bzt) and its analogues inhibit dopamine uptake and bind with moderate to high affinity to the dopamine transporter (dat). |
2006-08-14 |
2023-08-12 |
Not clear |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16481172. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-08-14 |
2023-08-12 |
Not clear |
| Terrence L Boos, Elisabeth Greiner, W Jason Calhoun, Thomas E Prisinzano, Barbara Nightingale, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16563775. |
a series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the n-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined. |
2006-08-14 |
2023-08-12 |
Not clear |
| Janelle M Silvers, Michael Y Aksenov, Marina V Aksenova, Jacob Beckley, Petra Olton, Charles F Mactutus, Rosemarie M Booz. Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. Journal of neurovirology. vol 12. issue 2. 2006-08-11. PMID:16798675. |
in this study, protein levels of tyrosine hydroxylase (th) and dopamine transporter (dat) in the substantia nigra of hiv-infected brains and -seronegative controls were determined by immunoblotting. |
2006-08-11 |
2023-08-12 |
human |
| Q David Walker, Rupa Ray, Cynthia M Kuh. Sex differences in neurochemical effects of dopaminergic drugs in rat striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16237396. |
these results indicate that nigrostriatal dopamine neurotransmission in the female rat is more tightly regulated by autoreceptor and transporter mechanisms, perhaps related by greater autoreceptor control of dat activity. |
2006-08-07 |
2023-08-12 |
rat |
| Dawn D Han, Howard H G. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC pharmacology. vol 6. 2006-08-03. PMID:16515684. |
the transporters for the monoamines dopamine, norepinephrine, and serotonin (dat, net, and sert) are targets for several popular psychostimulant drugs of abuse. |
2006-08-03 |
2023-08-12 |
mouse |
| Vibhuti Srivastava, Panchami G Varma, Suman Prasad, Prachi Semwal, Vishwajit L Nimgaonkar, Bernard Lerer, Smita N Deshpande, Thelma B. Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms. Pharmacogenetics and genomics. vol 16. issue 2. 2006-07-31. PMID:16424823. |
we tested the possible association of 24 polymorphisms from six dopaminergic genes: namely, dopamine receptors d1, d2, d3, d4; the dopamine transporter (dat); and the catalyzing enzyme catechol-o-methyltransferase (comt), with td. |
2006-07-31 |
2023-08-12 |
human |
| Pascal Frankhauser, Yvonne Grimmer, Peter Bugert, Michael Deuschle, Martin Schmidt, Patrick Schlos. Characterization of the neuronal dopamine transporter DAT in human blood platelets. Neuroscience letters. vol 399. issue 3. 2006-07-26. PMID:16490314. |
characterization of the neuronal dopamine transporter dat in human blood platelets. |
2006-07-26 |
2023-08-12 |
human |