| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ge Cao, Eryong Zhan. [Protective effects of dexmedetomidine against pulmonary ischemia-reperfusion injury during cardiopulmonary bypass in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 39. issue 8. 2019-09-17. PMID:31511220. |
to investigate the signaling pathways that mediate the protective effects of dexmedetomidine on lung tissue against ischemia-reperfusion (i/r) injury during cardiopulmonary bypass (cpb). |
2019-09-17 |
2023-08-13 |
rat |
| Nischal K Gautam, Yuliya Turiy, Chandra Srinivasa. Preincision Initiation of Dexmedetomidine Maximally Reduces the Risk of Junctional Ectopic Tachycardia in Children Undergoing Ventricular Septal Defect Repairs. Journal of cardiothoracic and vascular anesthesia. vol 31. issue 6. 2018-07-19. PMID:28774644. |
to evaluate whether initiation of dexmedetomidine (dex) infusion before surgical incision and cardiopulmonary bypass (cpb) versus initiation after cpb had an impact on the incidence of junctional ectopic tachycardia (jet). |
2018-07-19 |
2023-08-13 |
Not clear |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
furthermore, we observed that the beneficial effect of dexmedetomidine treatment following cpb was associated with a reduction in il6, an inflammatory cytokine in plasma and cortex. |
2018-06-11 |
2023-08-13 |
rat |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
therefore, we speculate that the jak2-stat3 pathway plays an important role in the neuroprotective effects of dexmedetomidine following brain injury induced by cpb. |
2018-06-11 |
2023-08-13 |
rat |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
here, rats were treated with different doses of dexmedetomidine by intravenous infusion 2 hours after cpb. |
2018-06-11 |
2023-08-13 |
rat |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
in this study, we aimed to investigate the effect and mechanism of dexmedetomidine on neuronal apoptosis caused by cpb. |
2018-06-11 |
2023-08-13 |
rat |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
in addition, dexmedetomidine administration inhibits phosphorylation of jak2 and stat3 proteins in the hippocampus of rats 2 hours after cpb. |
2018-06-11 |
2023-08-13 |
rat |
| Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou, Yubo Xi. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug design, development and therapy. vol 11. 2018-06-11. PMID:29033541. |
we observed that dexmedetomidine treatment to rats reduces the s100β, nse levels in plasma, and neuronal apoptosis following cpb in a dose-dependent manner. |
2018-06-11 |
2023-08-13 |
rat |
| Shoulin Chen, Fuzhou Hua, Jun Lu, Yu Jiang, Yanhua Tang, Lei Tao, Bing Zou, Qinghua W. Effect of dexmedetomidine on myocardial ischemia-reperfusion injury. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26885050. |
although dexmedetomidine (dex) is routinely used in cardiac surgery, the effect in reducing the inflammatory response in coronary artery bypass graft surgery (cabg) with cpb remains unclear. |
2016-02-17 |
2023-08-13 |
Not clear |
| Jae Bum Park, Seung Ho Bang, Hyun Keun Chee, Jun Seok Kim, Song Am Lee, Je Kyoun Shi. Efficacy and safety of dexmedetomidine for postoperative delirium in adult cardiac surgery on cardiopulmonary bypass. The Korean journal of thoracic and cardiovascular surgery. vol 47. issue 3. 2014-09-10. PMID:25207222. |
the aim of this study is to evaluate neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine, compared with the current postoperative sedative protocol (remifentanil) in patients undergoing open heart surgery with cardiopulmonary bypass (cpb). |
2014-09-10 |
2023-08-13 |
Not clear |
| Zeynep Tosun, Mehmet Baktir, Husnu Cemal Kahraman, Gulden Baskol, Gulen Guler, Adem Boyac. Does dexmedetomidine provide cardioprotection in coronary artery bypass grafting with cardiopulmonary bypass? A pilot study. Journal of cardiothoracic and vascular anesthesia. vol 27. issue 4. 2013-10-18. PMID:23725681. |
the purpose of this pilot study was to evaluate whether dexmedetomidine has a cardioprotective effect during coronary artery bypass graft surgery with cardiopulmonary bypass (cpb). |
2013-10-18 |
2023-08-12 |
Not clear |
| Jyrson Guilherme Klamt, Walter Villela de Andrade Vicente, Luis Vicente Garcia, Cesar Augusto Ferreir. Effects of Dexmedetomidine-Fentanyl Infusion on Blood Pressure and Heart Rate during Cardiac Surgery in Children. Anesthesiology research and practice. vol 2010. 2011-07-14. PMID:20827420. |
thirty-two children aged 1 month to 10 years undergoing surgery for repair congenital heart disease (chd) with cpb were randomly allocated into two groups: group mdz received midazolam 0.2 mg·kg(-1)·h(-1) and group dex received dexmedetomidine 1 μg·kg(-1)·h(-1) during the first hour followed by half of these rates of infusions thereafter. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jyrson Guilherme Klamt, Walter Villela de Andrade Vicente, Luis Vicente Garcia, César Augusto Ferreir. Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass. Revista brasileira de anestesiologia. vol 60. issue 4. 2011-01-06. PMID:20659607. |
to evaluate the efficacy of the combined infusion of dexmedetomidine and fentanyl on the hemodynamic response during cardiac surgery with cardiopulmonary bypass (cpb) in children. |
2011-01-06 |
2023-08-12 |
Not clear |