| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dian Kesumarini, Yunita Widyastuti, Cindy Elfira Boom, Lucia Kris Dinart. Effectiveness of Dexmedetomidine as Myocardial Protector in Children With Classic Tetralogy of Fallot Having Corrective Surgery: A Randomized Controlled Trial. Journal of cardiothoracic and vascular anesthesia. 2024-03-30. PMID:38555217. |
efficacy of dexmedetomidine (dex) as a cardioprotective agent in indonesian children undergoing classic tetralogy of fallot (tof) repair with cardiopulmonary bypass (cpb). |
2024-03-30 |
2024-04-02 |
Not clear |
| Dian Kesumarini, Yunita Widyastuti, Cindy E Boom, Lucia K Dinart. Dexmedetomidine as a myocardial protector in pediatric heart surgery using cardiopulmonary bypass: a systematic review. Annals of medicine and surgery (2012). vol 85. issue 10. 2023-10-09. PMID:37811026. |
this systematic review aimed to provide information on the cardioprotective effect of dexmedetomidine in children undergoing heart surgery using cpb. |
2023-10-09 |
2023-10-15 |
Not clear |
| Fang He, Yizhi Lu, Qi Mao, Lifang Zhou, Yanhua Chen, Yubo Xi. Effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery: a double-blind, randomized trial. BMC anesthesiology. vol 23. issue 1. 2023-07-13. PMID:37442959. |
to investigate the effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery with cardiopulmonary bypass (cpb). |
2023-07-13 |
2023-08-14 |
Not clear |
| Pei Gao, Wen Chen, Jin Rao, Chen Chen, Yao Lu, Yuan-Hai L. Effect of different modes of administration of dexmedetomidine on the quality of recovery in ambulatory thyroidectomy: a randomized, controlled trial. The Journal of international medical research. vol 51. issue 5. 2023-05-25. PMID:37226461. |
to compare the effects of two different administration methods of dexmedetomidine (dex) used as an adjuvant to ropivacaine in ultrasound-guided bilateral intermediate cervical plexus block (cpb) in terms of efficacy and the duration of postoperative analgesia in patients undergoing ambulatory thyroidectomy. |
2023-05-25 |
2023-08-14 |
Not clear |
| Yong-Qiang Qiu, Lv-Ping Zhuang, Pei-Yuan Wu, Li-Ying Zhong, Xiao-Hui Zhong, Bin Chen, Zhong-Kai Liu, Hui-Rong Luo, Li-Ping Yan. Effect of Dexmedetomidine on Postoperative Renal Function in Patients Undergoing Cardiac Valve Surgery Under Cardiopulmonary Bypass: A Randomized Clinical Trial. Journal of cardiothoracic and vascular anesthesia. 2023-05-13. PMID:37179127. |
the effect of dexmedetomidine on postoperative renal function was investigated in patients undergoing cardiac valve surgery under cardiopulmonary bypass (cpb). |
2023-05-13 |
2023-08-14 |
Not clear |
| Wentao Dong, Xia Li, Xiaokang Wang, Xiang Cheng, Lingde Kong, Zhiyong Guo, Hao Jin. Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869718. |
the study aimed to explore the influence of dexmedetomidine (dex) on cognitive function and inflammatory factors in rats after cardiac surgery under cardiopulmonary bypass (cpb). |
2022-07-23 |
2023-08-14 |
rat |
| Ke Peng, David R McIlroy, Bruce A Bollen, Frederic T Billings, Alexander Zarbock, Wanda M Popescu, Amanda A Fox, Linda Shore-Lesserson, Shaofeng Zhou, Mariya A Geube, Fuhai Ji, Meena Bhatia, Nanette M Schwann, Andrew D Shaw, Hong Li. Society of Cardiovascular Anesthesiologists Clinical Practice Update for Management of Acute Kidney Injury Associated With Cardiac Surgery. Anesthesia and analgesia. 2022-05-11. PMID:35544772. |
in addition, targeting a higher mean arterial pressure during cpb, perioperative use of dopamine, and use of dexmedetomidine did not reduce cs-aki (a low or very low level of grade evidence). |
2022-05-11 |
2023-08-13 |
Not clear |
| G-R Zhang, C-M Peng, Z-Z Liu, Y-F Len. The effect of dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis. European review for medical and pharmacological sciences. vol 25. issue 23. 2021-12-17. PMID:34919243. |
the purpose of this study was to evaluate the effect of dexmedetomidine administration on myocardial ischemia/reperfusion (i/r) injury in patients undergoing cardiac surgery with cardiopulmonary bypass (cpb). |
2021-12-17 |
2023-08-13 |
Not clear |
| Hyun-Jung Shin, Soo Lyoen Choi, Hyo-Seok N. Prevalence of postoperative delirium with different combinations of intraoperative general anesthetic agents in patients undergoing cardiac surgery: A retrospective propensity-score-matched study. Medicine. vol 100. issue 33. 2021-09-01. PMID:34414981. |
in this retrospective study, the incidence of pd was evaluated in patients who underwent cardiac surgery with cardiopulmonary bypass (cpb) according to different primary anesthetic agents: sevoflurane and dexmedetomidine- versus propofol-based anesthesia.a total of 534 patients who underwent heart-valve surgery or coronary artery bypass graft surgery with cpb between january 2012 and august 2017 were divided into 2 groups according to the main anesthetic agent: sevoflurane with dexmedetomidine (sevo-dex group, n = 340) and propofol (propofol group, n = 194). |
2021-09-01 |
2023-08-13 |
Not clear |
| Milian Chen, Xia Li, Guo M. Myocardial protective and anti-inflammatory effects of dexmedetomidine in patients undergoing cardiovascular surgery with cardiopulmonary bypass: a systematic review and meta-analysis. Journal of anesthesia. 2021-08-06. PMID:34342722. |
this meta-analysis aimed to systematically evaluate the cardioprotective effect of dexmedetomidine on cardiac surgery under cpb and its effect on accompanied inflammation. |
2021-08-06 |
2023-08-13 |
Not clear |
| Milian Chen, Xia Li, Guo M. Myocardial protective and anti-inflammatory effects of dexmedetomidine in patients undergoing cardiovascular surgery with cardiopulmonary bypass: a systematic review and meta-analysis. Journal of anesthesia. 2021-08-06. PMID:34342722. |
the application of dexmedetomidine in cardiac surgery with cpb can reduce ck-mb and ctn-i concentration and interleukin-6, tumor necrosis factor-α levels to a certain extent and shorten the length of intensive care unit stay, but it has no significant effect on il-10 level, c reactive protein level, the time on ventilator and length of hospital stay. |
2021-08-06 |
2023-08-13 |
Not clear |
| Nicole S Wilder, Dean B Andropoulos, Theron Paugh, Kathleen K Kibler, Susan C Nicolson, Athena F Zuppa, Ganesh S Moorth. Sequestration of Dexmedetomidine in Ex Vivo Cardiopulmonary Bypass Circuits. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2021-08-06. PMID:34352815. |
dexmedetomidine (dex) is a sedative used in combination with other drugs in neonates and infants undergoing cardiac surgery using cardiopulmonary bypass (cpb). |
2021-08-06 |
2023-08-13 |
Not clear |
| Yang Xie, Wenqiang Jiang, Jianfang Cao, Hong Xi. Dexmedetomidine attenuates acute kidney injury in children undergoing congenital heart surgery with cardiopulmonary bypass by inhibiting the TLR3/NF-κB signaling pathway. American journal of translational research. vol 13. issue 4. 2021-05-23. PMID:34017439. |
to investigate the effect of dexmedetomidine (dmed) on acute kidney injury in children undergoing congenital heart surgery (chs) with cardiopulmonary bypass (cpb). |
2021-05-23 |
2023-08-13 |
Not clear |
| Yongsheng Qiu, Chan Li, Xiaoqin Li, Yingping Ji. Effects of dexmedetomidine on the expression of inflammatory factors in children with congenital heart disease undergoing intraoperative cardiopulmonary bypass: a randomized controlled trial. Pediatric investigation. vol 4. issue 1. 2020-09-28. PMID:32851338. |
dexmedetomidine inhibits the inflammatory response associated with cardiopulmonary bypass (cpb) and protects neural function. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chaoliang Tang, Yida Hu, Jie Gao, Jiazhen Jiang, Si Shi, Jiawu Wang, Qingtian Geng, Xinghan Liang, Xiaoqing Cha. Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat. Life sciences. vol 257. 2020-09-11. PMID:32621918. |
patients undergoing cardiopulmonary bypass (cpb) often develop acute kidney injury (aki) caused by myocardial ischemia reperfusion (mi/r), and this renal injury can be resolved notably by dexmedetomidine. |
2020-09-11 |
2023-08-13 |
human |
| Kanecia O Zimmerman, Huali Wu, Matthew Laughon, Rachel G Greenberg, Richard Walczak, Scott R Schulman, P Brian Smith, Christoph P Hornik, Michael Cohen-Wolkowiez, Kevin M Wat. Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass. Anesthesia and analgesia. vol 129. issue 6. 2020-04-13. PMID:31743171. |
despite its frequent use, optimal dosing of dexmedetomidine in the setting of cpb has not been identified but is expected to differ from dosing in those not supported with cpb. |
2020-04-13 |
2023-08-13 |
Not clear |
| Kanecia O Zimmerman, Huali Wu, Matthew Laughon, Rachel G Greenberg, Richard Walczak, Scott R Schulman, P Brian Smith, Christoph P Hornik, Michael Cohen-Wolkowiez, Kevin M Wat. Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass. Anesthesia and analgesia. vol 129. issue 6. 2020-04-13. PMID:31743171. |
dexmedetomidine is increasingly used off-label in infants and children with cardiac disease during cardiopulmonary bypass (cpb) and in the postoperative period. |
2020-04-13 |
2023-08-13 |
Not clear |
| Kanecia O Zimmerman, Huali Wu, Matthew Laughon, Rachel G Greenberg, Richard Walczak, Scott R Schulman, P Brian Smith, Christoph P Hornik, Michael Cohen-Wolkowiez, Kevin M Wat. Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass. Anesthesia and analgesia. vol 129. issue 6. 2020-04-13. PMID:31743171. |
this study had the following aims: (1) characterize the effect of cpb on dexmedetomidine clearance (cl) and volume of distribution (v) in infants and young children; (2) characterize tolerance and sedation in patients receiving dexmedetomidine; and (3) identify preliminary dosing recommendations for infants and children undergoing cpb. |
2020-04-13 |
2023-08-13 |
Not clear |
| Sarah Soh, Jae-Kwang Shim, Jong-Wook Song, Jae-Chan Bae, Young-Lan Kwa. Effect of dexmedetomidine on acute kidney injury after aortic surgery: a single-centre, placebo-controlled, randomised controlled trial. British journal of anaesthesia. 2020-02-02. PMID:32007239. |
we investigated the effect of dexmedetomidine administration on aki after aortic surgery requiring cpb in a placebo-controlled randomised controlled trial. |
2020-02-02 |
2023-08-13 |
Not clear |
| Ge Cao, Eryong Zhan. [Protective effects of dexmedetomidine against pulmonary ischemia-reperfusion injury during cardiopulmonary bypass in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 39. issue 8. 2019-09-17. PMID:31511220. |
to investigate the signaling pathways that mediate the protective effects of dexmedetomidine on lung tissue against ischemia-reperfusion (i/r) injury during cardiopulmonary bypass (cpb). |
2019-09-17 |
2023-08-13 |
rat |