| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuri Ikeda-Matsu. [The role of prostaglandin E2 in stroke-reperfusion injury]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 133. issue 9. 2014-03-20. PMID:23995802. |
these results suggest that mpges-1 and cox-2 are co-induced by excessive glutamate in the ischemic brain and act together to exacerbate stroke injury through pge2 production followed by activation of ep3 receptors. |
2014-03-20 |
2023-08-12 |
mouse |
| Gopal Lingam, Tien Yin Won. Systemic medical management of diabetic retinopathy. Middle East African journal of ophthalmology. vol 20. issue 4. 2014-02-21. PMID:24339679. |
other drugs being tried are the protein kinase c (pkc) inhibitors, other peroxisome proliferator-activated receptors (ppar) agonists, forsoklin (which binds glut 1 receptor), minocycline (for its anti inflammatory effect), and celecoxib (cox-2 inhibitor). |
2014-02-21 |
2023-08-12 |
Not clear |
| Rongqing Chen, Jian Zhang, Ni Fan, Zhao-Qian Teng, Yan Wu, Hongwei Yang, Ya-Ping Tang, Hao Sun, Yunping Song, Chu Che. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell. vol 155. issue 5. 2014-02-10. PMID:24267894. |
pharmacological or genetic inhibition of cox-2 blocks downregulation and internalization of glutamate receptor subunits and alterations of the dendritic spine density of hippocampal neurons induced by repeated Δ(9)-thc exposures. |
2014-02-10 |
2023-08-12 |
Not clear |
| John H Anneken, Jacobi I Cunningham, Stuart A Collins, Bryan K Yamamoto, Gary A Gudelsk. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:23179355. |
treatment with the non-selective cyclooxygenase (cox) inhibitor ketoprofen and the cox-2 selective inhibitor nimesulide attenuated the increase in extracellular glutamate in the hippocampus evoked by repeated mdma exposure (10 mg/kg, i.p., every 2 h); no attenuation was observed in rats treated with the cox-1 selective inhibitor piroxicam. |
2013-08-16 |
2023-08-12 |
rat |
| Karen O Bazzo, André A Souto, Tiago G Lopes, Rafael F Zanin, Marcus V Gomez, Alessandra H Souza, Maria M Campo. Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. Journal of natural products. vol 76. issue 1. 2013-04-03. PMID:23273136. |
notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-fos and cox-2 labeling in the spinal cord and cox-2 expression in the cortex, but failed to affect c-fos and cox-2 expression in the glutamate model. |
2013-04-03 |
2023-08-12 |
mouse |
| Natália Veronez da Cunha, Phileno Pinge-Filho, Octávio Barbosa Neto, Sabrina Grassiolli, Marli Cardoso Martins-Ping. COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats. Autonomic neuroscience : basic & clinical. vol 165. issue 2. 2012-02-21. PMID:21824825. |
we evaluate the effects of chronic treatment with celecoxib, a cyclooxygenase-2 (cox-2) inhibitor, on blood pressure (bp) and heart rate variability (hrv) in obese rats induced by neonatal monosodium glutamate (msg). |
2012-02-21 |
2023-08-12 |
rat |
| Bradford D Fische. Preclinical assessment of drug combinations for the treatment of pain: isobolographic and dose-addition analysis of the opioidergic system. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631411. |
next, studies using these analyses to assess the interactive effects of opioids and novel adjunct drugs, including selective cox-2 inhibitors, α(2)-adrenergic receptor agonists, δ-opioids, glutamate receptor antagonists and cannabinoid receptor agonists, are reviewed. |
2012-02-03 |
2023-08-12 |
Not clear |
| Silvia Zoppi, Beatriz G Pérez Nievas, José L M Madrigal, Jorge Manzanares, Juan C Leza, Borja García-Buen. Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150911. |
daily acea pretreatment prevented stress-induced: (1) upregulation of cb1 mrna and protein, (2) decrease in glutamate uptake and glutamate astroglial transporter excitatory amino acid transporter 2 expression, (3) increase in consecutive proinflammatory molecules, such as cytokines (tumor necrosis factor-α and mcp-1), nuclear factor kappa b, and enzymatic sources, such as inducible nitric oxide synthase (nos-2) and cyclooxygenase-2 (cox-2), (4) increase in lipid peroxidation; although having no effect on plasma corticosterone. |
2011-12-12 |
2023-08-12 |
mouse |
| Irina Zemtsova, Boris Görg, Verena Keitel, Hans-Jürgen Bidmon, Karsten Schrör, Dieter Häussinge. Microglia activation in hepatic encephalopathy in rats and humans. Hepatology (Baltimore, Md.). vol 54. issue 1. 2011-09-30. PMID:21452284. |
however, ammonia had no effect on microglial glutamate release, prostaglandin synthesis, and messenger rna (mrna) levels of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and the proinflammatory cytokines interleukin (il)-1α/β, tumor necrosis factor α, or il-6, whereas in cultured astrocytes ammonia induced the release of glutamate, prostaglandins, and increased il-1β mrna. |
2011-09-30 |
2023-08-12 |
rat |
| Luca Caracciolo, Alessandro Barbon, Sara Palumbo, Cristina Mora, Christopher D Toscano, Francesca Bosetti, Sergio Barlat. Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice. PloS one. vol 6. issue 5. 2011-09-21. PMID:21589914. |
here, we investigated whether the increased susceptibility of cox-2(-/-) mice to ka is associated with altered mrna expression and editing of glutamate receptors. |
2011-09-21 |
2023-08-12 |
mouse |
| Luca Caracciolo, Alessandro Barbon, Sara Palumbo, Cristina Mora, Christopher D Toscano, Francesca Bosetti, Sergio Barlat. Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice. PloS one. vol 6. issue 5. 2011-09-21. PMID:21589914. |
we suggest that cox-2 plays a role in attenuating glutamate excitotoxicity by modulating rna editing of ampa/ka and mrna expression of all ionotropic glutamate receptor subunits and, in turn, neuronal excitability. |
2011-09-21 |
2023-08-12 |
mouse |
| Luca Caracciolo, Alessandro Barbon, Sara Palumbo, Cristina Mora, Christopher D Toscano, Francesca Bosetti, Sergio Barlat. Altered mRNA editing and expression of ionotropic glutamate receptors after kainic acid exposure in cyclooxygenase-2 deficient mice. PloS one. vol 6. issue 5. 2011-09-21. PMID:21589914. |
the overstimulation of glutamate receptors as a consequence of cox-2 gene deletion suggests a functional coupling between cox-2 and the glutamatergic system. |
2011-09-21 |
2023-08-12 |
mouse |
| N V Cunha, S B de Abreu, C Panis, S Grassiolli, F A Guarnier, R Cecchini, T L Mazzuco, P Pinge-Filho, M C Martins-Ping. Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats. Life sciences. vol 87. issue 11-12. 2010-11-04. PMID:20688085. |
the purpose of the present work was to investigate the effect of cyclooxygenase-2 (cox-2) inhibition on the cardiovascular and inflammatory aspects promoted by monosodium glutamate (msg)-induced obesity in rats. |
2010-11-04 |
2023-08-12 |
rat |
| A Castillo, M R Tolón, J Fernández-Ruiz, J Romero, J Martinez-Orgad. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19900555. |
cbd reduced acute (ldh efflux to the incubation medium) and apoptotic (caspase-9 concentration in tissue) hi brain damage by reducing glutamate and il-6 concentration, and tnfalpha, cox-2, and inos expression. |
2010-06-15 |
2023-08-12 |
mouse |
| Anika M S Hartz, Sylvia Notenboom, Bjorn Baue. Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy? Drug news & perspectives. vol 22. issue 7. 2010-01-19. PMID:19890496. |
we provide an overview of results demonstrating that glutamate released during seizures signals through n-methyl-daspartate (nmda) receptor and cyclooxygenase-2 (cox-2) to increase p-glycoprotein. |
2010-01-19 |
2023-08-12 |
Not clear |
| Guido Zibell, Bernadette Unkrüer, Anton Pekcec, Anika M S Hartz, Björn Bauer, David S Miller, Heidrun Potschk. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology. vol 56. issue 5. 2009-07-02. PMID:19371577. |
to explore further the role of cox-2 in signaling p-glycoprotein induction, we analyzed cox-2 protein expression in capillary endothelial cells in brain sections from rats that had undergone pilocarpine-induced seizures and in isolated capillaries exposed to glutamate and found no change from control levels. |
2009-07-02 |
2023-08-12 |
rat |
| Andrea Canellada, Belén G Ramirez, Takashi Minami, Juan Miguel Redondo, Eva Can. Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes. Glia. vol 56. issue 7. 2008-08-01. PMID:18293408. |
finally, we report that calcineurin-dependent expression of cox-2 and rcan 1-4 is induced by physiological calcium mobilizing agents, such as thrombin, agonists of purinergic and glutamate receptors, and l-type voltage-gated calcium channels. |
2008-08-01 |
2023-08-12 |
Not clear |
| Borja García-Bueno, José L M Madrigal, Beatriz G Pérez-Nievas, Juan Carlos Lez. Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. Endocrinology. vol 149. issue 4. 2008-05-06. PMID:18079203. |
finally, the selective blockade of the n-methyl-d-aspartate type of glutamate receptor after stress also negatively regulates 15d-pgj(2) and pge(2) production by cox-2 down-regulation and decrease in ppargamma transcriptional activity and expression. |
2008-05-06 |
2023-08-12 |
rat |
| Björn Bauer, Anika M S Hartz, Anton Pekcec, Kathrin Toellner, David S Miller, Heidrun Potschk. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Molecular pharmacology. vol 73. issue 5. 2008-05-06. PMID:18094072. |
in this regard, we tested the hypothesis that seizures increase brain extracellular glutamate, which signals through an n-methyl-d-aspartate (nmda) receptor and cyclooxygenase-2 (cox-2) in brain capillaries to increase blood-brain barrier p-glycoprotein expression. |
2008-05-06 |
2023-08-12 |
mouse |
| Robert W Robey, Alberto Lazarowski, Susan E Bate. P-glycoprotein--a clinical target in drug-refractory epilepsy? Molecular pharmacology. vol 73. issue 5. 2008-05-06. PMID:18314494. |
(p. 1444) demonstrate that glutamate can cause localized up-regulation of pgp via cyclooxygenase-2 (cox-2) and that this phenomenon can be prevented with cox-2 inhibitors. |
2008-05-06 |
2023-08-12 |
Not clear |