| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhi. Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels. Neurochemistry international. 2024-09-30. PMID:39349219. |
ws pre-supplementation was also observed to inhibit mcao induced increase in cox-2; nf-kβ proteins and reduce the glutamate levels. |
2024-09-30 |
2024-10-03 |
Not clear |
| Mohammad Abdullah Taher, Aysha Akter Laboni, Md Ashraful Islam, Hasin Hasnat, Mohammad Mahmudul Hasan, Jannatul Ferdous, Suriya Akter Shompa, Mala Kha. Isolation, characterization and pharmacological potentials of methanol extract of Heliyon. vol 10. issue 7. 2024-04-09. PMID:38590868. |
greater or close to equivalent binding affinity to the active binding sites of kappa opioid receptor, glucose transporter 3 (glut 3), and cyclooxygenase 2 was indicative of the potential anti-diarrheal, hypoglycemic, and analgesic characteristics of the isolated compounds (cox-2). |
2024-04-09 |
2024-04-11 |
mouse |
| Jie Wu, Mayijie Cao, Zhuolin Jia, Xiaoli Zhu, Ye Zhou, Yidian Dong, Lingying Yu, Changjiang Hu, Yu Huang, Zhimin Che. Synergistic mechanism of stir-baked curcumae radix with vinegar in dysmenorrhea rats based on UPLC-Q-TOF/MS metabolomics. Journal of pharmaceutical and biomedical analysis. vol 240. 2024-01-06. PMID:38183732. |
stir-baked hsyj with vinegar significantly inhibited the writhing response of rats, improved hemorheology, repaired damaged diseased uterus and inhibited high expression of cox-2 and otr proteins in uterus; 68 differential metabolites were screened from the urine of rats, compared with the raw hsyj, the levels of 14 metabolites were significantly changed in stir-baked hsyj with vinegar, involving the pathways of phenylalanine, tyrosine and tryptophan metabolism, cysteine and methionine metabolism, aspartate and glutamate metabolism. |
2024-01-06 |
2024-01-09 |
rat |
| Katarzyna Stachowic. Regulation of COX-2 expression by selected trace elements and heavy metals: Health implications, and changes in neuronal plasticity. A review. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 79. 2023-05-31. PMID:37257334. |
in parallel, an important regulatory element in the above diseases is cyclooxygenase-2 (cox-2), a modulator of the arachidonic acid (aa) pathway, and a cause of neuroinflammation, and glutamate (glu) dysregulation, affecting calcium (ca) metabolism in cells. |
2023-05-31 |
2023-08-14 |
human |
| K Stachowicz, P Panczyszyn-Trzewik, S Rzezniczek X, M Sowa-Kucm. Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 73. issue 2. 2022-10-04. PMID:36193971. |
since we previously discovered that simultaneous inhibition of cyclooxygenase-2 (cox-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin g2, which plays a predominant role in the cns) by ns398 and metabotropic glutamate receptor 5 (mglur5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; mtep] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes. |
2022-10-04 |
2023-08-14 |
mouse |
| Tabassum Jannat, Md Jamal Hossain, Ahmed M El-Shehawi, Md Ruhul Kuddus, Mohammad A Rashid, Sarah Albogami, Ibrahim Jafri, Mohamed El-Shazly, Mohammad Rashedul Haqu. Chemical and Pharmacological Profiling of Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-12. PMID:35807270. |
the isolated compounds exhibited higher binding affinity compared with the standard drugs towards the active binding sites of glutathione reductase, epidermal growth factor receptor (egfr), kappa opioid receptor, glucose transporter 3 (glut 3), mu opioid receptor, and cyclooxygenase 2 (cox-2) proteins due to their potent antioxidant, cytotoxic, anti-diarrheal, hypoglycemic, and central and peripheral analgesic properties, respectively. |
2022-07-12 |
2023-08-16 |
mouse |
| Katarzyna Stachowicz, Bartosz Bobula, Magdalena Kusek, Tomasz Lenda, Krzysztof Tokarsk. Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms. Brain research. vol 1771. 2021-12-09. PMID:34529964. |
since we found that inhibition of cyclooxygenase-2 (cox-2) with concomitant application of a metabotropic glutamate receptor subtype 5 (mglur5) antagonist (mtep) down-regulates mglur7 in the hippocampus (hc) and changes behavior of mice, our team decided to investigate the mechanism responsible for the observed changes. |
2021-12-09 |
2023-08-13 |
mouse |
| Aren van Waarde, Sofia Marcolini, Peter Paul de Deyn, Rudi A J O Dierck. PET Agents in Dementia: An Overview. Seminars in nuclear medicine. vol 51. issue 3. 2021-12-02. PMID:33500121. |
many receptors belong to this category: ampa, cannabinoid, colony stimulating factor 1, metabotropic glutamate receptor 1 and 5 (mglur1, mglur5), opioid (kappa, mu), purinergic (p2x7, p2y12), sigma-1, sigma-2, receptor for advanced glycation endproducts, and triggering receptor expressed on myeloid cells-1, besides several enzymes: cyclooxygenase-1 and 2 (cox-1, cox-2), phosphodiesterase-5 and 10 (pde5, pde10), and tropomyosin receptor kinase. |
2021-12-02 |
2023-08-13 |
Not clear |
| Shaikh Jamal Uddin, Md Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A Shilpi, Mohammad S Mubara. Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:32981501. |
available pre-clinical data suggest the ameliorating effect of curcumin in pain and inflammation is rendered through the modulation of pain pathways, including inhibition of a number of pro-inflammatory mediators, inhibition of oxidative stress and cyclooxygenase-2 (cox-2), down-regulation of ca2+/calmodulin-depend protein kinase ii (camkiiα) and calcium channels like transient receptor potential (trp), modulation of metabotropic glutamate receptor-2 (mglu2), modulation of monoamine system, inhibition of jak2/stat3 signaling pathway, remodeling of extracellular matrix proteins, inhibition of apoptosis, inhibition of jnk/mapk and erk/creb signaling pathway, and activation of the opioid system. |
2021-11-26 |
2023-08-13 |
Not clear |
| Katarzyna Stachowic. Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34400127. |
cox-2 is a neuronal enzyme that is intensively produced during activation of the synapse and glutamate (glu) release. |
2021-11-15 |
2023-08-13 |
Not clear |
| Katarzyna Stachowic. Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34400127. |
so far, the interaction between ionotropic n-methyl-d-aspartate (nmda) receptors or metabotropic glutamate (mglurs) receptors and cox-2 was found. |
2021-11-15 |
2023-08-13 |
Not clear |
| Fernanda Marcelia Dos Santos, Pricila Fernandes Pflüger, Leticia Lazzarotto, Mariana Uczay, Wesley Roberto de Aguida, Lisiane Santos da Silva, Fernanda Brião Menezes Boaretto, Jayne Torres de Sousa, Jaqueline Nascimento Picada, Iraci Lucena da Silva Torres, Patrícia Pereir. Gamma-Decanolactone Alters the Expression of GluN2B, A Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34019198. |
we evaluated the expression of the inflammatory marker cyclooxygenase-2 (cox-2), glun2b, a subunit of the nmda glutamate receptor, adenosine a1 receptor, and gd genotoxicity and mutagenicity. |
2021-10-18 |
2023-08-13 |
mouse |
| Katarzyna Stachowic. Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice. European journal of pharmacology. vol 888. 2021-05-17. PMID:32971092. |
our previous study showed the involvement of the cyclooxygenase-2 (cox-2) pathway in behavioral changes mediated by an antagonist of metabotropic glutamate receptor subtype 5 (mglu5 receptor) 3-[(2-methyl-1,3-tiazol-4-yl)ethynyl]-pyridine (mtep). |
2021-05-17 |
2023-08-13 |
mouse |
| Katarzyna Stachowicz, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Marcin Marciniak, Bartosz Bobula, Krzysztof Tokarsk. Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2. Neuroscience letters. vol 741. 2021-05-04. PMID:33171212. |
our earlier study demonstrated, that antidepressant-like and also cognitive action of mtep, a metabotropic glutamate receptor subtype 5 (mglur5) antagonist, was influenced by cyclooxygenase-2 (cox-2) inhibition in mice. |
2021-05-04 |
2023-08-13 |
mouse |
| Xiaopeng Sun, Entezar Mehrabi Nasab, Seyyede Masoume Athari, Seyyed Shamsadin Athar. Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma. Allergologie select. vol 5. 2021-04-24. PMID:33884360. |
measurements of il-4, il-5, il-13, glutamate oxaloacetate transaminase (got), glutamic pyruvic transaminase (gpt), ige, histamine, percentages of eosinophils in bronchoalveolar lavage fluid (balf), gene expression of cox-2, ccl24, ccl11, eotaxin, and histopathological study of lung were done. |
2021-04-24 |
2023-08-13 |
mouse |
| Qian-Qian Chen, Caroline Haikal, Wen Li, Jia-Yi L. Gut Inflammation in Association With Pathogenesis of Parkinson's Disease. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31572126. |
thereafter, we will address how alterations in the brain subsequently lead to dopaminergic neuron degeneration, in which oxidative stress, glutamate excitotoxicity, t cell driven inflammation and cyclooxygenase-2 (cox-2) are involved. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cong Lu, Jingwei Lv, Ning Jiang, Haixia Wang, Hong Huang, Lijing Zhang, Shuying Li, Nana Zhang, Bei Fan, Xinmin Liu, Fengzhong Wan. Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation. Phytotherapy research : PTR. vol 34. issue 4. 2020-07-27. PMID:32115816. |
additionally, the cortex and hippocampus were dissected to measure the oxidative stress markers and the antioxidant element nuclear erythroid-2-related factor 2 (nrf2) and its downstream targets, including glutamate cysteine ligase catalytic, glutamate cysteine ligase modifier, heme oxygenase 1, and quinone oxidoreductase 1, as well as nuclear factor kappa b (nf-κb) p65, nitric oxide synthase (inos), and cyclooxygenase 2 (cox-2) protein expression. |
2020-07-27 |
2023-08-13 |
mouse |
| Zhipeng Qi, Chao Mi, Fengdi Wu, Xinxin Yang, Yanqi Sang, Yanan Liu, Jiashuo Li, Haibo Yang, Bin Xu, Wei Liu, Zhaofa Xu, Yu Den. The effect of manganese exposure on GnRH secretion via Nrf2/mGluR5/COX-2/PGE2/signaling pathway. Toxicology and industrial health. vol 35. issue 3. 2020-01-03. PMID:30862296. |
the objective of the present study was to explore the mechanism of mn disruption of gnrh synthesis via nuclear factor erythroid-2-related factor-2 (nrf2)/metabotropic glutamate receptor-5 (mglur5)/cyclooxygenase-2 (cox-2)/prostaglandin e2 (pge |
2020-01-03 |
2023-08-13 |
Not clear |
| Tzu-Yu Lin, Cheng-Wei Lu, Chia-Chuan Wang, Shu Kuei Huang, Su-Jane Wan. Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings. The Journal of pharmacology and experimental therapeutics. vol 351. issue 1. 2014-11-25. PMID:25047516. |
in this study, we investigated the effect of celecoxib, a selective cyclooxygenase-2 (cox-2) inhibitor that reduces the level of prostaglandin e2 (pge2), on endogenous glutamate release in rat cerebral cortex nerve terminals (synaptosomes). |
2014-11-25 |
2023-08-13 |
rat |
| Luke Weaver-Mikaere, Alistair J Gunn, Murray D Mitchell, Laura Bennet, Mhoyra Frase. LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24344780. |
the current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (cox-2) inhibition for inflammatory wmi. |
2014-06-25 |
2023-08-12 |
Not clear |