| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Darcy Litteljohn, Emily N Mangano, Shawn Hayle. Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice. The European journal of neuroscience. vol 28. issue 4. 2008-10-20. PMID:18657183. |
the present investigation assessed the impact of the putative dopamine toxin paraquat (a widely used herbicide) upon motor functioning, behavioural indices of anxiety-like states and central monoamine levels and whether these effects were altered in mice lacking cox-2. |
2008-10-20 |
2023-08-12 |
mouse |
| Darcy Litteljohn, Emily N Mangano, Shawn Hayle. Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice. The European journal of neuroscience. vol 28. issue 4. 2008-10-20. PMID:18657183. |
indeed, paraquat did induce motor impairment and altered dopamine utilization within the striatum, and cox-2 deletion moderately attenuated these effects. |
2008-10-20 |
2023-08-12 |
mouse |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
these data suggest that an abnormal increase in cox-2 expression causes dopamine oxidation and contributes to the preferential vulnerability of dopaminergic cells as in pd. |
2008-08-13 |
2023-08-12 |
Not clear |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
cox-2 has attracted significant attention as an important source of oxidative stress in dopaminergic neurons due to its potential to oxidize catechols including dopamine. |
2008-08-13 |
2023-08-12 |
Not clear |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
here, we show that cox-2 induces dopamine oxidation, as evidenced by the findings that cox-2 can facilitate dopamine oxidation in a cell-free system and in cox-2-overexpressing sh-sy5y cells, and that this can be completely abolished by the selective cox-2 inhibitor meloxicam. |
2008-08-13 |
2023-08-12 |
Not clear |
| Makoto Mizuno, Hidekazu Sotoyama, Eri Narita, Hiroki Kawamura, Hisaaki Namba, Yingjun Zheng, Takeyoshi Eda, Hiroyuki Naw. A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 38. 2007-10-11. PMID:17881518. |
intrastriatal egf infusion also increased cox-2 expression, elevated tyrosine hydroxylase activity, and upregulated the levels of dopamine and its metabolites. |
2007-10-11 |
2023-08-12 |
rat |
| Makoto Mizuno, Hidekazu Sotoyama, Eri Narita, Hiroki Kawamura, Hisaaki Namba, Yingjun Zheng, Takeyoshi Eda, Hiroyuki Naw. A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 38. 2007-10-11. PMID:17881518. |
we conclude that this egf-triggered neuroinflammatory process is mediated in part by cox-2 activity and perturbs dopamine metabolism to generate neurobehavioral abnormalities. |
2007-10-11 |
2023-08-12 |
rat |
| Sung-Wook Chae, Yeo Jin Bang, Kyeong-Man Kim, Kwang Youl Lee, Bok Yun Kang, Eun Mee Kim, Hiroyasu Inoue, Onyou Hwang, Hyun Jin Cho. Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. Biochemical and biophysical research communications. vol 359. issue 3. 2007-08-07. PMID:17560944. |
these data suggest that bh4-induced cox-2 expression is responsible for dopamine oxidation, leading to the preferential vulnerability of dopaminergic cells in parkinson's disease. |
2007-08-07 |
2023-08-12 |
rat |
| Sung-Wook Chae, Yeo Jin Bang, Kyeong-Man Kim, Kwang Youl Lee, Bok Yun Kang, Eun Mee Kim, Hiroyasu Inoue, Onyou Hwang, Hyun Jin Cho. Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. Biochemical and biophysical research communications. vol 359. issue 3. 2007-08-07. PMID:17560944. |
cox-2 can oxidize dopamine and cause oxidative stress, which is evidenced by the findings that significant increase in dopamine-chrome formation and protein carbonyl contents by bh4-induced cox-2 up-regulation, and the increases are abolished by cox-2 selective inhibitor meloxicam. |
2007-08-07 |
2023-08-12 |
rat |
| Ennio Esposito, Vincenzo Di Matteo, Arcangelo Benigno, Massimo Pierucci, Giuseppe Crescimanno, Giuseppe Di Giovann. Non-steroidal anti-inflammatory drugs in Parkinson's disease. Experimental neurology. vol 205. issue 2. 2007-07-10. PMID:17433296. |
indeed, it has been demonstrated that the cyclooxygenase type 2 (cox-2) is up-regulated in snc daergic neurons in both pd patients and animal models of pd and, furthermore, non-steroidal anti-inflammatory drugs (nsaids) pre-treatment protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or 6 hydroxydopamine (6-ohda)-induced nigro-striatal dopamine degeneration. |
2007-07-10 |
2023-08-12 |
Not clear |
| David M Thomas, Donald M Kuh. Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15718289. |
instead, the peroxidase activity associated with cox-2, which can lead to the formation of reactive oxygen species and dopamine quinones, can account for its role. |
2005-07-05 |
2023-08-12 |
mouse |
| Ming-Zhi Zhang, Bing Yao, James A McKanna, Raymond C Harri. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15613619. |
these results indicate that dopamine modulates renal cortical cox-2 expression by modifying pt reabsorption. |
2005-04-18 |
2023-08-12 |
rat |
| Ming-Zhi Zhang, Bing Yao, James A McKanna, Raymond C Harri. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15613619. |
in rats fed a control diet, the dopamine precursor l-dihydroxyphenylalanine (l-dopa) or the da1 receptor agonist skf-81297 suppressed cortical cox-2 expression. |
2005-04-18 |
2023-08-12 |
rat |
| Ming-Zhi Zhang, Bing Yao, James A McKanna, Raymond C Harri. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15613619. |
the current study investigated interactions between renal dopamine and cortical cox-2 systems. |
2005-04-18 |
2023-08-12 |
rat |
| Ming-Zhi Zhang, Bing Yao, James A McKanna, Raymond C Harri. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15613619. |
high salt suppressed cortical cox-2 expression, which was attenuated by inhibition of dopamine production with benserazide or the da1 receptor antagonist, sch-23390. |
2005-04-18 |
2023-08-12 |
rat |
| Z-H Feng, T-G Wang, D-D Li, P Fung, B C Wilson, B Liu, Syed F Ali, R Langenbach, J-S Hon. Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183047. |
these results indicate that loss of cox-2 activity reduces mptp-induced damage to the dopaminergic neurons of the snc, but does not alter the levels of dopamine and its metabolites in the striatum. |
2002-10-28 |
2023-08-12 |
mouse |
| Z-H Feng, T-G Wang, D-D Li, P Fung, B C Wilson, B Liu, Syed F Ali, R Langenbach, J-S Hon. Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183047. |
furthermore, electrochemical analysis revealed a more than 70% decrease in the levels of dopamine and its metabolites (3,4-dihydroxyphenylacetic acid and homovanillic acid) in the striatum of the wt control cox-1(-/-) and cox-2(-/-) mutant mice. |
2002-10-28 |
2023-08-12 |
mouse |
| Monika Hellstrand, Elias Eriksson, Christer L Nilsso. Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. Biochemical pharmacology. vol 63. issue 12. 2002-08-15. PMID:12110374. |
the results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of d(2) receptor activation, and implicate an involvement of cpla(2) and cox-2 in this effect. |
2002-08-15 |
2023-08-12 |
rat |
| T Kita, K Shimada, Y Mastunari, G C Wagner, K Kubo, T Nakashim. Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698006. |
the expression of cyclooxygenase-2 (cox-2) and striatal dopamine (da) depletion in balb/canncrj (balb/c) mice following a neurotoxic dose of methamphetamine (meth) was investigated. |
2000-05-16 |
2023-08-12 |
mouse |