| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neeraj Rawat, Mahendra Pratap Sing. Effect of chlorpyrifos on cypermethrin-induced dopaminergic neurotoxicity in rats. Toxicology and industrial health. 2024-07-30. PMID:39075981. |
the striatal dopamine content and expression of tyrosine hydroxylase (th), α-synuclein, cyclooxygenase-2 (cox-2), and tumour necrosis factor-α (tnf-α) proteins in the nigrostriatal tissue were measured. |
2024-07-30 |
2024-08-02 |
rat |
| Neeraj Rawat, Mahendra Pratap Sing. Effect of chlorpyrifos on cypermethrin-induced dopaminergic neurotoxicity in rats. Toxicology and industrial health. 2024-07-30. PMID:39075981. |
chlorpyrifos impaired the neurobehavioural indexes, reduced the striatal dopamine level, augmented the level of α-synuclein, cox-2, and tnf-α and attenuated the expression of th similar to but a little less than cypermethrin. |
2024-07-30 |
2024-08-02 |
rat |
| Magda Sa Abdeltawab, Iman R Abdel-Shafi, Basma Emad Aboulhoda, Amal M Mahfoz, Alshaimaa Mr Hame. The neuroprotective potential of curcumin on T. Spiralis infected mice. BMC complementary medicine and therapies. vol 24. issue 1. 2024-02-22. PMID:38388410. |
blood levels of reduced glutathione (gsh) and dopamine were measured, and brain tissue expression of cyclooxygenase-2 enzyme (cox-2) and cd34 was assessed by immunohistochemistry. |
2024-02-22 |
2024-02-25 |
mouse |
| Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serran. Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels. Heliyon. vol 4. issue 2. 2020-10-01. PMID:29560440. |
compared to controls, the voma paradigm also induced decreases in hippocampal levels of dopamine transporter (dat) and tyrosine hydroxylase (th), as well as increases in dopamine 1 receptor (d1r), glial fibrillary acidic protein (gfap) and cyclooxygenase-2 (cox-2), with a decrease in prostaglandins e2 (pge2) and d2 (pgd2). |
2020-10-01 |
2023-08-13 |
mouse |
| Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamot. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31228610. |
neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: protection by cox-2 antagonism. |
2020-08-14 |
2023-08-13 |
rat |
| Rosario Sánchez-Pernaute, Andrew Ferree, Oliver Cooper, Meixiang Yu, Anna-Liisa Brownell, Ole Isacso. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285796. |
in the present study we examined the protective effect of celecoxib, a selective inhibitor of the inducible form of cyclooxygenase (cox-2), on dopamine (da) cell loss in a rat model of pd. |
2019-11-20 |
2023-08-12 |
rat |
| Rosario Sánchez-Pernaute, Andrew Ferree, Oliver Cooper, Meixiang Yu, Anna-Liisa Brownell, Ole Isacso. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285796. |
selective cox-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of parkinson's disease. |
2019-11-20 |
2023-08-12 |
rat |
| Amanda L Blaker, Bryan K Yamamot. Methamphetamine-Induced Brain Injury and Alcohol Drinking. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 1. 2019-10-02. PMID:28856500. |
cyclooxygenase inhibition by ketoprofen during etoh drinking blocked the increases in lps and cox-2 and the enhanced decreases in dopamine and serotonin produced by meth. |
2019-10-02 |
2023-08-13 |
rat |
| Amit Kumar Chauhan, Namrata Mittra, Devendra Kumar Patel, Chetna Sing. Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism. Molecular neurobiology. vol 55. issue 3. 2018-12-31. PMID:28290146. |
cxb significantly attenuated zn-induced increase in cox-2 expression and restored th-expression, dopamine content, level of inflammatory cytokines and neurobehavioral indexes towards normalcy. |
2018-12-31 |
2023-08-13 |
rat |
| Ya Wang, Pierluigi Plastina, Jean-Paul Vincken, Renate Jansen, Michiel Balvers, Jean Paul Ten Klooster, Harry Gruppen, Renger Witkamp, Jocelijn Meijerin. N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:28292183. |
n-docosahexaenoyl dopamine, an endocannabinoid-like conjugate of dopamine and the n-3 fatty acid docosahexaenoic acid, attenuates lipopolysaccharide-induced activation of microglia and macrophages via cox-2. |
2017-10-25 |
2023-08-13 |
Not clear |
| Asmaa M Teema, Sawsan A Zaitone, Yasser M Moustaf. Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis. Neuropharmacology. vol 107. 2017-06-19. PMID:27016022. |
rotenone-treated rats showed motor dysfunction, lower striatal dopamine, lower staining for nigral tyrosine hydroxylase but higher level of striatal cyclooxygenase-2 (cox-2) and vascular endothelial growth factor (vegf) compared to vehicle-treated rats (p < 0.05). |
2017-06-19 |
2023-08-13 |
rat |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
mpp(+)-induced toxicity in the presence of dopamine is mediated by cox-2 through oxidative stress. |
2011-12-12 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
these results suggest that dopamine itself mediates mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis in the presence of cox-2. |
2011-12-12 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Ross B Mounsey, Peter Teisman. MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 2. 2011-12-12. PMID:21667279. |
in this study, we examined whether dopamine mediates 1-methyl-4-phenylpyridinium (mpp(+))-induced toxicity in primary ventral mesencephalic (vm) neurons, an in vitro model of pd, and if so, whether the protective effects of cox-2 inhibitors on dopamine mediated mpp(+)-induced vm neurotoxicity and vm dopaminergic cell apoptosis result from the reduction of ros. |
2011-12-12 |
2023-08-12 |
Not clear |
| Carmen M Navarrete, Moisés Pérez, Amaya García de Vinuesa, Juan A Collado, Bernd L Fiebich, Marco A Calzado, Eduardo Muño. Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway. Biochemical pharmacology. vol 79. issue 12. 2010-05-04. PMID:20206142. |
we found that nada activates a redox-sensitive p38 mapk pathway that stabilizes cox-2 mrna resulting in the accumulation of the cox-2 protein, which depends on the dopamine moiety of the molecule and that is independent of cb(1) and trpv1 activation. |
2010-05-04 |
2023-08-12 |
Not clear |
| Yi Sui, Davor Stanić, Doris Tomas, Bevyn Jarrott, Malcolm K Horn. Meloxicam reduces lipopolysaccharide-induced degeneration of dopaminergic neurons in the rat substantia nigra pars compacta. Neuroscience letters. vol 460. issue 2. 2009-09-02. PMID:19450656. |
using the intranigral lipopolysaccharide (lps) rat model, we show that meloxicam, a preferential cox-2 inhibitor, diminishes the activation of ox-42-immunoreactive (ir) microglia and reduces the loss of tyrosine hydroxylase (th)-ir dopamine (da) neurons in the substantia nigra pars compacta (snpc) that is normally induced by exposure to lps. |
2009-09-02 |
2023-08-12 |
rat |
| Ming-Zhi Zhang, Bing Yao, Xiaofeng Fang, Suwan Wang, James P Smith, Raymond C Harri. Intrarenal dopaminergic system regulates renin expression. Hypertension (Dallas, Tex. : 1979). vol 53. issue 3. 2009-03-09. PMID:19139376. |
because macula densa cox-2 stimulates renal renin expression, our current studies investigated dopamine regulation of renal renin release and synthesis in vivo. |
2009-03-09 |
2023-08-12 |
mouse |
| Ming-Zhi Zhang, Bing Yao, Xiaofeng Fang, Suwan Wang, James P Smith, Raymond C Harri. Intrarenal dopaminergic system regulates renin expression. Hypertension (Dallas, Tex. : 1979). vol 53. issue 3. 2009-03-09. PMID:19139376. |
these results suggest that dopamine predominantly inhibits renal renin expression and release by inhibiting macula densa cox-2, but suppression of renal cortical cox-2 activity reveals a contrasting effect of dopamine to stimulate renal renin expression through activation of d1-like receptors. |
2009-03-09 |
2023-08-12 |
mouse |
| Ming-Zhi Zhang, Bing Yao, Xiaofeng Fang, Suwan Wang, James P Smith, Raymond C Harri. Intrarenal dopaminergic system regulates renin expression. Hypertension (Dallas, Tex. : 1979). vol 53. issue 3. 2009-03-09. PMID:19139376. |
we have reported previously that macula densa cyclooxygenase-2 (cox-2) is suppressed by dopamine. |
2009-03-09 |
2023-08-12 |
mouse |
| Ming-Zhi Zhang, Bing Yao, Xiaofeng Fang, Suwan Wang, James P Smith, Raymond C Harri. Intrarenal dopaminergic system regulates renin expression. Hypertension (Dallas, Tex. : 1979). vol 53. issue 3. 2009-03-09. PMID:19139376. |
in catechol-o-methyl transferase knockout (comt(-/-)) mice, which have increased kidney dopamine levels because of deletion of the major intrarenal dopamine metabolizing enzyme, there was attenuation in response to a low-salt diet of the increases of renal cortical cox-2 and renin expression and renin release. |
2009-03-09 |
2023-08-12 |
mouse |