| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Sho Izawa, Kazuhiro Nishii, Naoki Aizu, Takumi Kito, Daiki Iwata, Takeshi Chihara, Hirohide Sawada, Runhong Yao, Kouji Yamad. Effects of aerobic exercise and resistance training on cognitive function: Comparative study based on FNDC5/irisin/BDNF pathway. Dementia and geriatric cognitive disorders. 2024-08-26. PMID:39186932. |
the expression levels of fndc5/irisin and mbdnf in the hippocampus were significantly increased in both ae and rt compared with that in con, but that if trkb was increased only in ae. |
2024-08-26 |
2024-08-30 |
mouse |
| Nadia Cattane, Monica Mazzelli, Veronica Begni, Elisa Mombelli, Mariusz Papp, Carlo Maj, Marco Andrea Riva, Annamaria Cattane. Molecular mechanisms underlying stress vulnerability and resilience in the chronic mild stress model: New insights from mRNA and miRNAs data combining. Brain, behavior, and immunity. 2024-07-29. PMID:39074628. |
in order to cover this, we here used both transcriptomic and mirnomic based approaches in the ventral hippocampus of control (con) and rats exposed to the chronic mild stress (cms) paradigm, which were then divided into vulnerable (vuln) or resilient (res) animals according to the sucrose consumption test. |
2024-07-29 |
2024-08-02 |
human |
| Camila Berbert-Gomes, Júlia S Ramos, João G Silveira-Rodrigues, Daniel M M Leite, Bruno P Melo, Danusa D Soare. An acute bout of resistance exercise increases BDNF in hippocampus and restores the long-term memory of insulin-resistant rats. Experimental brain research. 2024-03-07. PMID:38453752. |
insulin-resistant rats had 20% worse long-term memory (ltm) (p < 0.01) and lower bdnf concentration in the hippocampus (-14.6%; p < 0.05) when compared to non-insulin-resistant rats (con). |
2024-03-07 |
2024-03-10 |
rat |
| Yanan Deng, Liping Ma, Ziwei Du, Huixin Ma, Yuxi Xia, Liran Ping, Zhaoxing Chen, Yinghua Zhan. The Notch1/Hes1 pathway regulates Neuregulin 1/ErbB4 and participates in microglial activation in rats with VPA-induced autism. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242426. |
our results suggest that the levels of notch1, hes1, nrg1, and phosphorylated erbb4 in the cerebellum (cb), hippocampus (hc), and prefrontal cortex (pfc) were increased in rats with valproic acid (vpa)-induced autism compared to those in the con group. |
2024-01-19 |
2024-01-22 |
rat |
| Yanfang Li, Liping Ma, Yanan Deng, Ziwei Du, Bingqian Guo, Jianing Yue, Xianxian Liu, Yinghua Zhan. The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model. Neuropharmacology. 2023-08-05. PMID:37543138. |
our results showed notch1 and hes1 were upregulated, while dnmt3a and dnmt3b were downregulated at the protein level in the prefrontal cortex (pfc), hippocampus (hc) and cerebellum (cb) of vpa-induced asd rats compared with control (con) group. |
2023-08-05 |
2023-08-14 |
rat |
| Mingzhu Zhang, Zizheng Suo, Yinyin Qu, Yuxiang Zheng, Wenjie Xu, Bowen Zhang, Qiang Wang, Linxin Wu, Shuai Li, Yaozhong Cheng, Ting Xiao, Hui Zheng, Cheng N. Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction. Frontiers in aging neuroscience. vol 15. 2023-04-13. PMID:37051377. |
whole-transcriptome sequencing was performed on the hippocampus of control group (con) and surgery group. |
2023-04-13 |
2023-08-14 |
mouse |
| Kayvan Khoramipour, Mohammad Abbas Bejeshk, Mohammad Amin Rajizadeh, Hamid Najafipour, Padideh Dehghan, Fattaneh Farahman. High-Intensity Interval Training Ameliorates Molecular Changes in the Hippocampus of Male Rats with the Diabetic Brain: the Role of Adiponectin. Molecular neurobiology. 2023-03-06. PMID:36877358. |
this study investigated the impact of high-intensity interval training (hiit) on diabetes-induced disturbances in ad-related factors (including amp-activated protein kinase (ampk), glycogen synthase kinase-3β (gsk3β), and tau protein) in the hippocampus, with the main focus on adiponectin signaling.in total, 28 male wistar rats at the age of 8 weeks were randomly assigned to four groups (n = 7 in each group): control (con), type 2 diabetes (t2d), hiit (ex), and type 2 diabetes + hiit (t2d + ex). |
2023-03-06 |
2023-08-14 |
rat |
| Katarzyna Skrobisz, Grazyna Piotrowicz, Agata Rudnik, Patrycja Naumczyk, Agnieszka Sabisz, Karolina Markiet, Edyta Szurowsk. Evaluation of Subcortical Structure Volumes in Patients with Non-Specific Digestive Diseases. Diagnostics (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36140600. |
(1) background: to evaluate volume of subcortical structures such as hippocampus, globus pallidus, putamen, thalamus, nucleus accumbens, amygdala, caudate in patients with non-specific digestive diseases (functional dyspepsia-fd, irritable bowel syndrome-ibs) and non-specific inflammatory bowel diseases-ibd (colitis ulcerosa and crohn's disease) in comparison to healthy control group (con). |
2022-09-23 |
2023-08-14 |
Not clear |
| Chunguang Hao, Xiaguang Duan, Xiaoyan Yang, Zaiqing Huang, Fang Li, Jianping Yan. Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats. Pakistan journal of pharmaceutical sciences. vol 35. issue 1. 2022-02-28. PMID:35221274. |
the expression of rgs2 mrna and protein in hippocampus of sevo group was lower compared to the con group, while ca |
2022-02-28 |
2023-08-13 |
rat |
| Xi Fang, Wenwu Sun, Julie Jeon, Michael Azain, Holly Kinder, Jeongyoun Ahn, Hee Cheol Chung, Ryan S Mote, Nikolay M Filipov, Qun Zhao, Srujana Rayalam, Hea Jin Par. Perinatal Docosahexaenoic Acid Supplementation Improves Cognition and Alters Brain Functional Organization in Piglets. Nutrients. vol 12. issue 7. 2021-03-11. PMID:32679753. |
maternal dha supplementation increased fiber length and tended to increase fractional anisotropy in the hippocampus of offspring than con. |
2021-03-11 |
2023-08-13 |
Not clear |
| Chia-Shu Lin, Hsiao-Han Lin, Shin-Woei Fann, Wei-Ju Lee, Ming-Lun Hsu, Shuu-Jiun Wang, Jong-Ling Fu. Association between tooth loss and gray matter volume in cognitive impairment. Brain imaging and behavior. vol 14. issue 2. 2021-01-04. PMID:32170642. |
(c) in the ci group, but not the con group, an increased nmt was associated with both smaller total gmv and regional gmv of the left medial temporal lobe, including the left hippocampus and parahippocampus. |
2021-01-04 |
2023-08-13 |
human |
| Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wan. Influence of exposure to nicotine during pregnancy on the learning and memory for adult offspring. Experimental and therapeutic medicine. vol 15. issue 3. 2020-10-01. PMID:29456645. |
the level of products of related factors in the hippocampus of mice in the nic and the con groups were compared using the |
2020-10-01 |
2023-08-13 |
mouse |
| Yeqing Zhang, Yuwang Li, Yinxiao Wang, Gengyin Wang, Lingqun Mao, Danhong Zhang, Jinhua Wan. Effects of resveratrol on learning and memory in rats with vascular dementia. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702039. |
compared with the rats in the con group, the rats in the vd group exhibited decreased cognitive function, significantly increased hippocampal content of mda, bax and caspase‑3 (p<0.05), and significantly reduced hippocampal expression of sod and bcl‑2 (p<0.05). |
2020-03-31 |
2023-08-13 |
rat |
| Min Zhao, Xiao Wan Li, De Z Chen, Fang Hao, Shu X Tao, Hai Yan Yu, Rui Cheng, Hong Li. Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-08-20. PMID:30905926. |
the primary fetal rat hippocampal neurons were gradually matured after 7 days of culture, and divided into the control group (con), the oxygen-glucose deprivation model group (mod), and the metformin group (met). |
2019-08-20 |
2023-08-13 |
rat |
| Xiankun Zhu, Pei Wang, Haijun Liu, Jing Zhan, Jin Wang, Mi Li, Ling Zeng, Ping X. Changes and Significance of SYP and GAP-43 Expression in the Hippocampus of CIH Rats. International journal of medical sciences. vol 16. issue 3. 2019-07-24. PMID:30911273. |
in this study, 25 adult male sprague dawley (sd) rats were randomly divided into a normal control group (con) and a chronic intermittent hypoxia group (cih) with four time points as follows: 1 w, 2 w, 3 w, and 4 w. the behavioural changes (primarily learning and memory abilities) were observed by the morris water maze in each group, consisting of 5 rats per group.the localization of syp and gap-43 in hippocampal ca1 neurons was observed, and the expression of syp and gap-43 in the hippocampus was detected by western blotting. |
2019-07-24 |
2023-08-13 |
rat |
| Lauren A Gross, Eileen M Moore, Jeffrey R Wozniak, Claire D Coles, Julie A Kable, Elizabeth R Sowell, Kenneth L Jones, Edward P Riley, Sarah N Mattso. Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. Brain imaging and behavior. vol 12. issue 3. 2019-03-07. PMID:28656347. |
as part of an ongoing multisite project, subjects (age 10-16 years) with prenatal alcohol exposure (ae, n = 81) and controls (con, n = 81) were tested using the cvlt-c and measures of cortical volume, surface area, and thickness as well as hippocampal volume were derived from mri. |
2019-03-07 |
2023-08-13 |
human |
| Chunhua Liu, Shuang Hao, Minghui Zhu, Yingxuan Wang, Tao Zhang, Zhuo Yan. Maternal Separation Induces Different Autophagic Responses in the Hippocampus and Prefrontal Cortex of Adult Rats. Neuroscience. vol 374. 2018-11-20. PMID:29391188. |
compared with the con group, the glutamate level was obviously increased in the hippocampus (hp) and prefrontal cortex (pfc) of rats in the ms group. |
2018-11-20 |
2023-08-13 |
rat |
| I Bin-Jaliah, H F Sak. Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia. Physiology international. vol 105. issue 1. 2018-07-30. PMID:29602294. |
in addition, bccao significantly decreased (p < 0.05) the expression of both opn and smp30 and the levels of ach, ne, and dop in the hippocampus compared with con treatment. |
2018-07-30 |
2023-08-13 |
rat |
| Greg L West, Benjamin Rich Zendel, Kyoko Konishi, Jessica Benady-Chorney, Veronique D Bohbot, Isabelle Peretz, Sylvie Bellevill. Playing Super Mario 64 increases hippocampal grey matter in older adults. PloS one. vol 12. issue 12. 2018-01-10. PMID:29211727. |
in contrast, the con group displayed significant grey matter loss in the hippocampus, cerebellum and the dlpfc. |
2018-01-10 |
2023-08-13 |
Not clear |