| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y P Liao, D Zhang, W Zhou, F M Meng, M S Bao, P Xiang, C Q Li. Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668664. |
however, when gene-gene interactions between these two polymorphisms together with previous studied c677t and a1298c polymorphisms in the methylenetetrahydrofolate reductase (mthfr) gene were analyzed, the combined mthfr 677ct/tt and mthfd 1958aa/ga genotype was found to be significantly associated with the risk of having a down syndrome child [odds ratio (or) = 3.11; 95% confidence interval (95%ci) = 1.07-9.02]. |
2014-11-04 |
2023-08-12 |
Not clear |
| Y P Liao, D Zhang, W Zhou, F M Meng, M S Bao, P Xiang, C Q Li. Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668664. |
in addition, the combined tc 776cg and mthfr 677tt genotype increased the risk of having a child with down syndrome 3.64-fold (or = 3.64; 95%ci = 1.28-10.31). |
2014-11-04 |
2023-08-12 |
Not clear |
| Efrén Martínez-Quintana, Fayna Rodríguez-González, Vicente Nieto-Lag. Subclinical hypothyroidism in grown-up congenital heart disease patients. Pediatric cardiology. vol 34. issue 4. 2013-09-25. PMID:23143351. |
in the multivariate analysis, cyanosis (odds ratio [or], 6,399; 95 % confidence interval [ci] 2,296-17,830; p < 0.001), down syndrome (or, 6,208; 95 % ci, 1,963-19,636; p = 0.002), and nt-pro-bnp concentrations (or, 1,001; 95 % ci, 1,000-1,002; p < 0.026) proved to be risk factors for tsh levels higher than 5.6 miu/l. |
2013-09-25 |
2023-08-12 |
Not clear |
| Sonali S Patel, Trudy L Burns, Lazaros Kochila. Early outcomes and prognostic factors for left atrioventricular valve reoperation after primary atrioventricular septal defect repair. Pediatric cardiology. vol 33. issue 1. 2012-09-24. PMID:21910021. |
independent predictors of in-hospital death after valve replacement included presence of down syndrome (hazard ratio [hr] 2.34, 95% ci 1.19-4.58) and prosthetic valve size-to-weight ratio >3 mm/kg (hr 3.02, 95% ci 1.52-6.01). |
2012-09-24 |
2023-08-12 |
Not clear |
| Elizabeth De Souza, Eva Alberman, Joan K Morri. Down syndrome and paternal age, a new analysis of case-control data collected in the 1960s. American journal of medical genetics. Part A. vol 149A. issue 6. 2009-07-30. PMID:19449414. |
our results showed the estimated odds ratio for a down syndrome pregnancy associated with a 10-year increase in paternal age was 1.13, 95%ci (0.85, 1.52). |
2009-07-30 |
2023-08-12 |
Not clear |
| Nándor Acs, Ferenc Bánhidy, Erzsébet H Puhó, Andrew E Czeize. Senna treatment in pregnant women and congenital abnormalities in their offspring--a population-based case-control study. Reproductive toxicology (Elmsford, N.Y.). vol 28. issue 1. 2009-07-23. PMID:19491001. |
of 22,843 cases with ca, 506 (2.2%) had mothers with senna treatment, while of 38,151 control newborn infants without ca, 937 (2.5%) were born to mothers with senna treatment (adjusted or with 95% ci: 1.0, 0.9-1.1), and of 834 malformed controls with down syndrome, 26 (3.1%) had mothers with the use of senna (or with 95% ci: 0.7, 0.5-1.1). |
2009-07-23 |
2023-08-12 |
Not clear |
| Nándor Acs, Ferenc Bánhidy, Erzsébet Horváth-Puhó, Andrew E Czeize. Population-based case-control study of the common cold during pregnancy and congenital abnormalities. European journal of epidemiology. vol 21. issue 1. 2007-09-13. PMID:16450209. |
of 834 malformed controls with down syndrome, 114 (17.3%) had mothers with the common cold (por: 0.96 with 95% ci: 0.80-1.16). |
2007-09-13 |
2023-08-12 |
Not clear |
| Nándor Acs, Ferenc Bánhidy, Erzsébet Horváth-Puhó, Andrew E Czeize. Population-based case-control study of the common cold during pregnancy and congenital abnormalities. European journal of epidemiology. vol 21. issue 1. 2007-09-13. PMID:16450209. |
the comparison of cases with different congenital abnormalities and malformed controls (including offspring with down syndrome) as referent, indicated a higher prevalence of the common cold during the second and third month of gestation only in the mothers of cases with cleft lip+/-palate (adjusted por: 1.7 with 95% ci: 1.2-2.5), however, congenital hydrocephaly, neural-tube defects and multiple cas had also mothers with a somewhat higher occurrence of the common cold. |
2007-09-13 |
2023-08-12 |
Not clear |
| Ryo Kimura, Kouzin Kamino, Mitsuko Yamamoto, Aidaralieva Nuripa, Tomoyuki Kida, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Hidehisa Yamagata, Yasuharu Tabara, Tetsuro Miki, Hiroyasu Akatsu, Kenji Kosaka, Eishi Funakoshi, Kouhei Nishitomi, Gaku Sakaguchi, Akira Kato, Hideyuki Hattori, Takeshi Uema, Masatoshi Taked. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Human molecular genetics. vol 16. issue 1. 2007-04-03. PMID:17135279. |
in logistic regression, the dyrk1a (dual-specificity tyrosine-regulated kinase 1a) gene, located in the down syndrome critical region, showed the highest significance [or = 2.99 (95% ci: 1.72-5.19), p = 0.001], whereas the runx1 gene showed a high odds ratio [or = 23.3 (95% ci: 2.76-196.5), p = 0.038]. |
2007-04-03 |
2023-08-12 |
mouse |
| Merete Stubkjaer Christensen, Mats Heyman, Merja Möttönen, Bernward Zeller, Gudmundur Jonmundsson, Henrik Hasl. Treatment-related death in childhood acute lymphoblastic leukaemia in the Nordic countries: 1992-2001. British journal of haematology. vol 131. issue 1. 2005-11-15. PMID:16173962. |
risk of trd was also higher in children with down syndrome (rr = 4.5; ci(95%): 2.0-10.2, p < 0.00). |
2005-11-15 |
2023-08-12 |
Not clear |
| Lorenzo D Botto, Joseph Mulinare, Quanhe Yang, Yecai Liu, J David Erickso. Autosomal trisomy and maternal use of multivitamin supplements. American journal of medical genetics. Part A. vol 125A. issue 2. 2004-09-28. PMID:14981710. |
the or was 0.8 (95% ci, 0.5-1.3) for down syndrome and 1.4 (95% ci, 0.5-3.6) for trisomies 13 and 18, with little variation by maternal race or age. |
2004-09-28 |
2023-08-12 |
Not clear |
| Jeanette Falck Winther, John D Boice, John J Mulvihill, Marilyn Stovall, Kirsten Frederiksen, E Janet Tawn, Jorgen H Olse. Chromosomal abnormalities among offspring of childhood-cancer survivors in Denmark: a population-based study. American journal of human genetics. vol 74. issue 6. 2004-07-06. PMID:15106125. |
there were no significant differences in the occurrence of down syndrome (relative risk [rr]=1.07; 95% ci 0.16-5.47) or turner syndrome (rr=1.32; 95% ci 0.17-7.96) among the children of cancer survivors, compared with the children of their siblings. |
2004-07-06 |
2023-08-12 |
Not clear |
| M Shyama, S A al-Mutawa, S Honkal. Malocclusions and traumatic injuries in disabled schoolchildren and adolescents in Kuwait. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 21. issue 3. 2001-11-01. PMID:11507844. |
children with down syndrome (or = 2.3; 95% ci = 1.51-3.52), those of increasing age (or = 1.1; 95% ci = 1.01-1.10), and males (or = 1.5; 95% ci = 1.05-2.07) had higher risk for the occurrence of severe malocclusion. |
2001-11-01 |
2023-08-12 |
human |
| C P Torfs, R E Christianso. Effect of maternal smoking and coffee consumption on the risk of having a recognized Down syndrome pregnancy. American journal of epidemiology. vol 152. issue 12. 2001-01-25. PMID:11130625. |
high alcohol consumption (> or =4 drinks/week) in the first month of pregnancy was associated with reduced risk for a recognized down syndrome conceptus (odds ratio (or) = 0.54; 95% confidence interval (ci): 0.34, 0.85). |
2001-01-25 |
2023-08-12 |
Not clear |
| C P Torfs, R E Christianso. Effect of maternal smoking and coffee consumption on the risk of having a recognized Down syndrome pregnancy. American journal of epidemiology. vol 152. issue 12. 2001-01-25. PMID:11130625. |
maternal smoking during the periconceptional period was not associated with risk of recognized down syndrome (or = 1.04; 95% ci: 0.79, 1.37), but maternal consumption of four or more cups of coffee per day was inversely associated (or = 0.63; 95% ci: 0.41, 0.96). |
2001-01-25 |
2023-08-12 |
Not clear |
| T M Marteau, G Saidi, S Goodburn, J Lawton, S Michie, M Bobro. Numbers or words? A randomized controlled trial of presenting screen negative results to pregnant women. Prenatal diagnosis. vol 20. issue 9. 2000-10-25. PMID:11015699. |
immediately after receipt of the results, 97% of those receiving their results in the form of a numerical probability and 91% of those receiving their results in the form of a verbal probability correctly understood that their baby probably did not have down syndrome (95% ci for difference: 0% to 12%; p=0.04). |
2000-10-25 |
2023-08-12 |
Not clear |
| C A Hobbs, S L Sherman, P Yi, S E Hopkins, C P Torfs, R J Hine, M Pogribna, R Rozen, S J Jame. Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. American journal of human genetics. vol 67. issue 3. 2000-09-19. PMID:10930360. |
the results are consistent with the preliminary observation that the mthfr 677c-->t polymorphism is more prevalent among mothers of children with down syndrome than among control mothers, with an odds ratio of 1.91 (95% confidence interval [ci] 1.19-3.05). |
2000-09-19 |
2023-08-12 |
Not clear |
| C A Hobbs, S L Sherman, P Yi, S E Hopkins, C P Torfs, R J Hine, M Pogribna, R Rozen, S J Jame. Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. American journal of human genetics. vol 67. issue 3. 2000-09-19. PMID:10930360. |
the combined presence of both polymorphisms was associated with a greater risk of down syndrome than was the presence of either alone, with an odds ratio of 4.08 (95% ci 1.94-8.56). |
2000-09-19 |
2023-08-12 |
Not clear |
| C Mansfield, S Hopfer, T M Martea. Termination rates after prenatal diagnosis of Down syndrome, spina bifida, anencephaly, and Turner and Klinefelter syndromes: a systematic literature review. European Concerted Action: DADA (Decision-making After the Diagnosis of a fetal Abnormality). Prenatal diagnosis. vol 19. issue 9. 1999-11-18. PMID:10521836. |
they were highest following a prenatal diagnosis of down syndrome (92 per cent; ci: 91 per cent to 93 per cent) and lowest following diagnosis of klinefelter syndrome (58 per cent; ci: 50 per cent to 66 per cent). |
1999-11-18 |
2023-08-12 |
Not clear |
| D C Rubinsztein, J Hon, F Stevens, I Pyrah, C Tysoe, F A Huppert, D F Easton, A J Hollan. Apo E genotypes and risk of dementia in Down syndrome. American journal of medical genetics. vol 88. issue 4. 1999-11-01. PMID:10402500. |
an additional parallel with late-onset alzheimer's disease was shown by the apo epsilon2 allele, which was associated with decreased dementia risk in down syndrome (odds ratio for apo epsilon2/epsilon2 + epsilon2/epsilon3 = 0.37 (95% ci 0.14-0. |
1999-11-01 |
2023-08-12 |
Not clear |