| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James B Wade, Liang Fang, Richard A Coleman, Jie Liu, P Richard Grimm, Tong Wang, Paul A Wellin. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. American journal of physiology. Renal physiology. vol 300. issue 6. 2011-08-05. PMID:21454252. |
we conclude 1) our new antibody provides a unique tool to characterize romk channel localization and expression and 2) high-k diet causes a large increase in apical expression of romk in dct2, cnt, and cd but not in dct1, indicating that different regulatory mechanisms are involved in k diet-regulated romk channel functions in the distal nephron. |
2011-08-05 |
2023-08-12 |
mouse |
| James D Stockan. Vasopressin regulation of renal sodium excretion. Kidney international. vol 78. issue 9. 2011-02-09. PMID:20736986. |
it is now clear that an increase in sodium reabsorption along the distal nephron (cnt + cd) mediated by activation of the epithelial na(+) channel (enac) by vasopressin makes an important contribution to maintenance of the axial corticomedullary osmotic gradient necessary for maximal water reabsorption. |
2011-02-09 |
2023-08-12 |
Not clear |
| Daniel Ackermann, Nikolay Gresko, Monique Carrel, Dominique Loffing-Cueni, Daniel Habermehl, Celso Gomez-Sanchez, Bernard C Rossier, Johannes Loffin. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American journal of physiology. Renal physiology. vol 299. issue 6. 2011-01-10. PMID:20861076. |
high expression levels of 11β-hsd2 characterize the aldosterone-sensitive distal nephron (asdn), which comprises the segment-specific cells of late distal convoluted tubule (dct2), connecting tubule (cnt), and collecting duct (cd). |
2011-01-10 |
2023-08-12 |
rat |
| Hans-Göran Tiselius, Bengt Lindbäck, Anne-Marie Fornander, Mari-Anne Nilsso. Studies on the role of calcium phosphate in the process of calcium oxalate crystal formation. Urological research. vol 37. issue 4. 2009-10-19. PMID:19444436. |
these experimental studies give support to the hypothesis that crystallization of caox at lower nephron levels or in caliceal urine might be induced by dissolution of cap formed at nephron levels above the cd, and that a low ph is prerequisite for the precipitation of caox. |
2009-10-19 |
2023-08-12 |
Not clear |
| Seishi Maeda, Sachi Kuwahara, Hisao Ito, Koichi Tanaka, Tetsu Hayakawa, Makoto Sek. Expression and localization of aquaporins in the kidney of the musk shrew (Suncus murinus). The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 56. issue 1. 2008-01-22. PMID:17938283. |
these indicate that the cd is the main water reabsorption segment of the nephron and is regulated by aqps. |
2008-01-22 |
2023-08-12 |
Not clear |
| Wencui Zheng, Jill W Verlander, I Jeanette Lynch, Melanie Cash, Jiahong Shao, Lisa R Stow, Brian D Cain, I David Weiner, Susan M Wall, Charles S Wing. Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16896189. |
kcnq1 was detected by immunohistochemistry throughout the distal nephron and cd. |
2007-02-12 |
2023-08-12 |
mouse |
| Wencui Zheng, Jill W Verlander, I Jeanette Lynch, Melanie Cash, Jiahong Shao, Lisa R Stow, Brian D Cain, I David Weiner, Susan M Wall, Charles S Wing. Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16896189. |
thus kcnq1 protein is widely distributed in mouse distal nephron and cd, with significant axial and cellular heterogeneity in location and intensity. |
2007-02-12 |
2023-08-12 |
mouse |
| Yuqiang Ge, Peter K Stricklett, Alisa K Hughes, Masashi Yanagisawa, Donald E Koha. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. American journal of physiology. Renal physiology. vol 289. issue 4. 2005-10-27. PMID:15928212. |
cd express the two known et receptors, et(a) and et(b); in the current study, the role of the cd et(a) receptor in mediating et-1 actions on this nephron segment was evaluated. |
2005-10-27 |
2023-08-12 |
mouse |
| Małgorzata M Brzóska, Marcin Kamiński, Mirosław Dziki, Janina Moniuszko-Jakoniu. Changes in the structure and function of the kidney of rats chronically exposed to cadmium. II. Histoenzymatic studies. Archives of toxicology. vol 78. issue 4. 2004-12-02. PMID:14997281. |
the histochemical observations indicate that cd causes damage to the organization and function of the nephron. |
2004-12-02 |
2023-08-12 |
human |
| O Barbier, G Jacquillet, M Tauc, P Poujeol, M Cougno. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. American journal of physiology. Renal physiology. vol 287. issue 5. 2004-11-09. PMID:15280159. |
this study investigates the effect in rats of acute cdcl(2) (5 microm) intoxication on renal function and characterizes the transport of ca(2+), cd(2+), and zn(2+) in the proximal tubule (pt), loop of henle (lh), and terminal segments of the nephron (dt) using whole kidney clearance and nephron microinjection techniques. |
2004-11-09 |
2023-08-12 |
rat |
| O Barbier, G Jacquillet, M Tauc, P Poujeol, M Cougno. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. American journal of physiology. Renal physiology. vol 287. issue 5. 2004-11-09. PMID:15280159. |
(109)cd and (65)zn(2+) microinjections showed that each segment of nephron was permeable to these metals. |
2004-11-09 |
2023-08-12 |
rat |
| O Barbier, G Jacquillet, M Tauc, P Poujeol, M Cougno. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. American journal of physiology. Renal physiology. vol 287. issue 5. 2004-11-09. PMID:15280159. |
(109)cd fluxes were inhibited by gd(3+) (90 microm), co(2+) (100 microm), and fe(2+) (100 microm) in all nephron segments. |
2004-11-09 |
2023-08-12 |
rat |
| O Barbier, G Jacquillet, M Tauc, P Poujeol, M Cougno. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. American journal of physiology. Renal physiology. vol 287. issue 5. 2004-11-09. PMID:15280159. |
in conclusion, these results indicate that 1) the renal effects of acute cd(2+) intoxication are suggestive of proximal tubulopathy; 2) cd(2+) inhibits ca(2+) reabsorption possibly through the epithelial ca(2+) channel in the dt, and this blockade could account for the hypercalciuria associated with cd(2+) intoxication; 3) the pt is the major site of cd(2+) reabsorption; 4) the paracellular pathway and dmt1 could be involved in cd(2+) reabsorption along the lh; 5) dmt1 may be one of the major transporters of cd(2+) in the dt; and 6) zn(2+) is taken up along each part of the nephron and its transport in the terminal segments could occur via dmt1. |
2004-11-09 |
2023-08-12 |
rat |
| K Schumacher, R Strehl, W W Minut. Characterization of micro-fibers at the interface between the renal collecting duct ampulla and the cap condensate. Nephron. Experimental nephrology. vol 95. issue 2. 2004-02-20. PMID:14610328. |
the development of renal histo-architecture substantially depends on the three-dimensional extension of the collecting duct (cd) ampulla, since under its influence, nephron induction takes place in the surrounding mesenchyme. |
2004-02-20 |
2023-08-12 |
Not clear |
| Fabienne Quentin, Dominique Eladari, Lydie Cheval, Claude Lopez, Dominique Goossens, Yves Colin, Jean-Pierre Cartron, Michel Paillard, Régine Chambre. RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron. Journal of the American Society of Nephrology : JASN. vol 14. issue 3. 2003-08-11. PMID:12595489. |
rt-pcr analysis on microdissected rat nephron segments confirmed that rhbg mrnas were chiefly expressed in cnt and cortical and outer medullary cd. |
2003-08-11 |
2023-08-12 |
mouse |
| Walter C Prozialeck, Peter C Lamar, Sean M Lync. Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium. Toxicology and applied pharmacology. vol 189. issue 3. 2003-07-08. PMID:12791303. |
visualization of pan-cadherin immunoreactive materials by immunoperoxidase labeling showed that cd caused a marked reduction in the intensity of cadherin labeling associated with the apical and the basolateral surfaces of the epithelial cells of the proximal tubule, but no change in the pattern of cadherin labeling in other segments of the nephron. |
2003-07-08 |
2023-08-12 |
rat |
| Wojciech M Kwiatek, Tomasz Drewniak, Mariusz Gajda, Marek Gałka, Albert L Hanson, Tadeusz Cichock. Preliminary study on the distribution of selected elements in cancerous and non-cancerous kidney tissues. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 16. issue 3. 2003-06-03. PMID:12437151. |
a low fe concentration was observed in nephron tubules while a converse observation has been made for cd. |
2003-06-03 |
2023-08-12 |
Not clear |
| Rudolfs K Zalups, Sarfaraz Ahma. Molecular handling of cadmium in transporting epithelia. Toxicology and applied pharmacology. vol 186. issue 3. 2003-04-11. PMID:12620369. |
particular attention has been placed on the molecular mechanisms involved in the absorption, retention, and secretion of cd in small intestinal enterocytes, hepatocytes, and tubular epithelial cells lining both proximal and distal portions of the nephron. |
2003-04-11 |
2023-08-12 |
Not clear |
| Karl Schumacher, Hayo Castrop, Raimund Strehl, Uwe de Vries, Will W Minut. Cyclooxygenases in the collecting duct of neonatal rabbit kidney. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 12. issue 2-3. 2003-01-16. PMID:12077551. |
in the fully embryonic cortical zone immunohistochemical expression of cox 1 is seen in all cells of the cd ampulla, while cox 2 is lacking within the nephron inducer. |
2003-01-16 |
2023-08-12 |
rabbit |
| James A Schafe. Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct. American journal of physiology. Renal physiology. vol 283. issue 2. 2002-08-08. PMID:12110505. |
although the aldosterone-responsive segments of the nephron together reabsorb <10% of the filtered na+, certain single-gene defects that affect the epithelial na+ channel (enac) in the luminal membrane of the collecting duct (cd) or its regulation by aldosterone cause severe hypertension, whereas others cause salt wasting and hypotension. |
2002-08-08 |
2023-08-12 |
Not clear |