| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LiJi Jin, ZhiChao Zhang, YuanYuan Wang, MeiJiao Wei, Qin X. A novel small molecule inhibitor targeted at Bcl-2. Science in China. Series C, Life sciences. vol 50. issue 5. 2008-01-15. PMID:17879060. |
these data were consistent with the results of circular dichroism (cd) spectra analysis, revealing that s1 inactivated the bcl-2 protein by destroying its critical alpha helices. |
2008-01-15 |
2023-08-12 |
Not clear |
| Xiong Wei, He Mingjia, Li Xiufeng, Gao Yang, Wu Qingy. Identification and biochemical properties of Dps (starvation-induced DNA binding protein) from cyanobacterium Anabaena sp. PCC 7120. IUBMB life. vol 59. issue 10. 2008-01-04. PMID:17852566. |
according to cd spectrum and non-denaturing electrophoresis assays, recombinant dps1173 was alpha helix riched, and was likely to form dodecametric oligomer under native conditions. |
2008-01-04 |
2023-08-12 |
Not clear |
| A Capilla, E Donat, D Planelles, C Espinós, C Ribes-Koninckx, F Pala. Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4. Tissue antigens. vol 70. issue 4. 2007-11-27. PMID:17767555. |
we have investigated how relevant regions contribute to cd susceptibility: celiac3 (cd28/ctla4/icos region on 2q33) and celiac4 (19p13) as well as the tumour necrosis factor alpha (tnf-alpha) and the linfotoxin loci by case-control and association analyses. |
2007-11-27 |
2023-08-12 |
human |
| E Eik Anda, E Nieboer, A A Dudarev, T M Sandanger, J Ø Odlan. Intra- and intercompartmental associations between levels of organochlorines in maternal plasma, cord plasma and breast milk, and lead and cadmium in whole blood, for indigenous peoples of Chukotka, Russia. Journal of environmental monitoring : JEM. vol 9. issue 8. 2007-11-26. PMID:17671671. |
the correlations of pts concentrations between the three body fluid compartments exceeded the minimum statistical requirements of alpha = 0.05 and beta = 0.20 for most of the compounds, with r > 0.46 except for cd (r = 0.05); lipid adjustments for the ocs did not affect the r-values to any significant extent. |
2007-11-26 |
2023-08-12 |
Not clear |
| H Tilg, T Feichtenschlager, P Knoflach, W Petritsch, R Schöfl, H Vogelsang, W Reinisc. [Use of infliximab in ulcerative colitis]. Zeitschrift fur Gastroenterologie. vol 45. issue 8. 2007-11-13. PMID:17701864. |
infliximab, a chimeric monoclonal anti-tumour necrosis factor alpha (tnf) antibody has dramatically changed the management of various chronic inflammatory disorders such as crohn's disease (cd), rheumatoid arthritis, ankylosing spondylitis or psoriasis. |
2007-11-13 |
2023-08-12 |
Not clear |
| Masayuki Ikeda, Fumiko Ohashi, Yoshinari Fukui, Shiro Takada, Jiro Moriguchi, Takafumi Ezak. Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas. International archives of occupational and environmental health. vol 80. issue 3. 2007-10-23. PMID:16821047. |
this study was initiated to investigate if and to what extent the elevations in urinary alpha(1)- and beta(2)-microglobulins (alpha(1)-mg and beta(2)-mg, respectively) are specific to cd nephro-toxicity. |
2007-10-23 |
2023-08-12 |
Not clear |
| David P Rangel, Greg P Brewood, Bryant S Fujimoto, J Michael Schur. Effects of ethylene glycol on the torsion elastic constant and hydrodynamic radius of p30delta DNA. Biopolymers. vol 85. issue 3. 2007-09-28. PMID:17111396. |
also at 20 degrees c, addition of 30 w/v % betaine caused a marginally significant increase in alpha and significant but modest change in the cd spectrum, but very little change in any other properties. |
2007-09-28 |
2023-08-12 |
Not clear |
| Ana Teresa Carvalho, Heitor Souza, Antonio Jose Carneiro, Morgana Castelo-Branco, Kalil Madi, Alberto Schanaider, Flavia Silv, Fernando Antonio Pereira Junior, Marcia G Pereira, Claudio Tortori, Ilana Dines, Jane Carvalho, Eduardo Rocha, Celeste Eli. Therapeutic and prophylactic thalidomide in TNBS-induced colitis: synergistic effects on TNF-alpha, IL-12 and VEGF production. World journal of gastroenterology. vol 13. issue 15. 2007-09-25. PMID:17465495. |
thalidomide has been reported to downregulate the expression of tumor necrosis factor alpha (tnf-alpha), il-12, and vascular endothelial growth factor (vegf), hallmarks of intestinal inflammation in crohnos disease (cd). |
2007-09-25 |
2023-08-12 |
Not clear |
| Silvio Danese, Nico Pagano, Erika Angelucci, Tommaso Stefanelli, Alessandro Repici, Paolo Omodei, Marco Daperno, Alberto Malesc. Tumor necrosis factor-alpha monoclonal antibodies for Crohn's disease: tipping the balance. Current medicinal chemistry. vol 14. issue 14. 2007-08-10. PMID:17584058. |
the aim of this paper is to critically review the rationale and state-of-the art for the use tnf- alpha inhibitors in the treatment of cd. |
2007-08-10 |
2023-08-12 |
Not clear |
| R MacColl, L E Eisel. R-phycoerythrins having two conformations for the same aggregate. Biophysical chemistry. vol 61. issue 2-3. 2007-07-25. PMID:17023373. |
unchanged visible absorption and protein secondary structure (61% alpha helix) contradicted by comparatively salient alterations in the visible cd spectra suggested very subtle structural changes are influencing some of the chromophores. |
2007-07-25 |
2023-08-12 |
Not clear |
| Shinji Toyota, Shinya Suzuki, Michio Goich. Chemistry of anthracene-acetylene oligomers: synthesis and enantiomeric resolution of a chiral 1,8-anthrylene-ethynylene cyclic tetramer. Chemistry (Weinheim an der Bergstrasse, Germany). vol 12. issue 9. 2007-07-20. PMID:16389621. |
its enantiomers were resolved by chiral hplc with a chiralcel od column, and the chiroptical properties were investigated by optical rotation ([alpha]d(23) = -95 and +91) and circular dichroism (cd) measurements. |
2007-07-20 |
2023-08-12 |
Not clear |
| Simon F Seibert, Gabriele M König, Elena Voloshina, Gerhard Raabe, Jörg Fleischhaue. An attempt to determine the absolute configuration of two ascolactone stereoisomers with time-dependent density functional theory. Chirality. vol 18. issue 6. 2007-06-26. PMID:16612802. |
although these compounds show virtually opposite cd spectra and [alpha]d, 1h- and 13c-nmr data exclude the presence of enantiomers and suggest ascolactone a and b to be epimeric lactones. |
2007-06-26 |
2023-08-12 |
Not clear |
| Luca Settimo, Serena Donnini, André H Juffer, Robert W Woody, Oriano Mari. Conformational changes upon calcium binding and phosphorylation in a synthetic fragment of calmodulin. Biopolymers. vol 88. issue 3. 2007-06-21. PMID:17173306. |
we have recently investigated by far-uv circular dichroism (cd) the effects of ca(2+) binding and the phosphorylation of ser 81 for the synthetic peptide cam [54-106] encompassing the ca(2+)-binding loops ii and iii and the central alpha helix of calmodulin (cam) (arrigoni et al., biochemistry 2004, 43, 12788-12798). |
2007-06-21 |
2023-08-12 |
Not clear |
| Yunhui Zhai, Yongwen Liu, Xijun Chang, Senbin Chen, Xinping Huan. Selective solid-phase extraction of trace cadmium(II) with an ionic imprinted polymer prepared from a dual-ligand monomer. Analytica chimica acta. vol 593. issue 1. 2007-06-21. PMID:17531833. |
the relative selective factor (alpha(r)) values of cd(ii)/cu(ii), cd(ii)/zn(ii) and cd(ii)/hg(ii) were 25.5, 35.3 and 62.1. |
2007-06-21 |
2023-08-12 |
Not clear |
| Kelly E Rigby Duncan, Martin J Stillma. Evidence for noncooperative metal binding to the alpha domain of human metallothionein. The FEBS journal. vol 274. issue 9. 2007-06-20. PMID:17388808. |
the metallation reaction of the metal-free alpha domain with cd2+ was unequivocally shown to proceed by a noncooperative mechanism at physiologic ph by cd and uv absorption spectroscopy and esi ms. |
2007-06-20 |
2023-08-12 |
human |
| Gabriel J Tobon, Carlos Cañas, Juan-Jose Jaller, Juan-Carlos Restrepo, Juan-Manuel Anay. Serious liver disease induced by infliximab. Clinical rheumatology. vol 26. issue 4. 2007-06-19. PMID:16547695. |
infliximab, a chimeric monoclonal antibody that binds the tumor necrosis factor alpha (tnfalpha), is used in the treatment of rheumatoid arthritis (ra) and crohn's disease (cd). |
2007-06-19 |
2023-08-12 |
Not clear |
| Cesare Ruffolo, Marco Scarpa, Diego Faggian, Giovanna Romanato, AnnaMaria De Pellegrin, Teresa Filosa, Daniela Prando, Lino Polese, Michele Scopelliti, Fabio Pilon, Elena Ossi, Mauro Frego, Davide Francesco D'Amico, Imerio Angrima. Cytokine network in chronic perianal Crohn's disease and indeterminate colitis after colectomy. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 11. issue 1. 2007-06-13. PMID:17390181. |
antitumor necrosis factor alpha (anti-tnf-alpha) therapy in perianal crohn's disease (cd) is widely established but recent studies suggest that the underlying fistula tract and inflammation may persist. |
2007-06-13 |
2023-08-12 |
Not clear |
| Anna Shkoda, Tanja Werner, Hannelore Daniel, Manuela Gunckel, Gerhard Rogler, Dirk Halle. Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease. Journal of proteome research. vol 6. issue 3. 2007-06-06. PMID:17330946. |
statistical significance was achieved for 9 proteins including the rho-gdp dissociation inhibitor alpha that was up-regulated in cd and uc patients. |
2007-06-06 |
2023-08-12 |
Not clear |
| Shinichiro Motohash. [Translational research in patients with lung cancer--clinical application of NKT cell immunotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 34. issue 4. 2007-05-08. PMID:17431340. |
human v alpha 24 natural killer t (nkt) cells bearing an invariant v alpha 24 j alpha q antigen receptor, the counterpart of murine v alpha 14 nkt cells, are activated by a specific ligand, alpha-galactosylceramide (alpha galcer; krn 7000), in a cd 1 d-dependent manner. |
2007-05-08 |
2023-08-12 |
mouse |
| Norihiko Fujii, Tooru Nakamura, Yutaka Sadakane, Takeshi Saito, Noriko Fuji. Differential susceptibility of alpha A- and alpha B-crystallin to gamma-ray irradiation. Biochimica et biophysica acta. vol 1774. issue 3. 2007-04-27. PMID:17258947. |
based on far-uv cd spectra, alpha a-crystallin retained beta-sheet conformation after gamma irradiation up to 3.0 kgy, whereas alpha b-crystallin lost beta-sheet conformation upon exposure to gamma irradiation at >1.0 kgy. |
2007-04-27 |
2023-08-12 |
human |