| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed K Hankir, Christelle Le Fol. Central nervous system pathways targeted by amylin in the regulation of food intake. Biochimie. 2024-10-19. PMID:39426704. |
in this review, we discuss the evidence derived from preclinical studies showing that amylin and the related peptide salmon calcitonin (sct) directly or indirectly target genetically distinct neurons in the caudal hindbrain (nucleus tractus solitarius and area postrema), rostral hindbrain (lateral parabrachial nucleus), midbrain (lateral dorsal tegmentum and ventral tegmental area) and hypothalamus (arcuate nucleus and parasubthalamic nucleus) via activation of amylin and/or calcitonin receptors. |
2024-10-19 |
2024-10-22 |
Not clear |
| Bernd Coester, Christelle Le Foll, Thomas A Lut. Viral depletion of calcitonin receptors in the area postrema: A proof-of-concept study. Physiology & behavior. vol 223. 2021-06-21. PMID:32497530. |
viral depletion of calcitonin receptors in the area postrema: a proof-of-concept study. |
2021-06-21 |
2023-08-13 |
Not clear |
| Mette Q Ludwig, Wenwen Cheng, Desiree Gordian, Julie Lee, Sarah J Paulsen, Stine N Hansen, Kristoffer L Egerod, Pernille Barkholt, Christopher J Rhodes, Anna Secher, Lotte Bjerre Knudsen, Charles Pyke, Martin G Myers, Tune H Per. A genetic map of the mouse dorsal vagal complex and its role in obesity. Nature metabolism. vol 3. issue 4. 2021-05-13. PMID:33767443. |
glp-1 receptor (glp-1r) agonist administration induces gene expression alterations specific to two distinct sets of glp1r neurons-one population in the area postrema and one in the nucleus of the solitary tract that also expresses calcitonin receptor (calcr). |
2021-05-13 |
2023-08-13 |
mouse |
| Lavinia Boccia, Christelle Le Foll, Thomas A Lut. Noradrenaline signaling in the LPBN mediates amylin's and salmon calcitonin's hypophagic effect in male rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 11. 2021-04-27. PMID:32985027. |
amylin and its long acting analog sct (salmon calcitonin) exert their anorectic actions primarily by directly activating neurons located in the area postrema (ap). |
2021-04-27 |
2023-08-13 |
rat |
| Hannah Louise Zakariassen, Linu Mary John, Jens Lykkesfeldt, Kirsten Raun, Tine Glendorf, Lauge Schaffer, Sofia Lundh, Anna Secher, Thomas Alexander Lutz, Christelle Le Fol. Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice. Neuropharmacology. vol 167. 2021-04-23. PMID:32035146. |
the amylin receptor (amy) and calcitonin receptor (ctr) agonists induce acute suppression of food intake in rodents by binding to receptors in the area postrema (ap) and potentially by targeting arcuate (arc) neurons directly. |
2021-04-23 |
2023-08-13 |
mouse |
| Lynda Whiting, James E McCutcheon, Christina N Boyle, Mitchell F Roitman, Thomas A Lut. The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc). Physiology & behavior. vol 176. 2018-03-08. PMID:28342771. |
the area postrema (ap) and the parabrachial nucleus (pbn) are important sites for salmon calcitonin (sct) to decrease evoked phasic dopamine release in the nucleus accumbens (nac). |
2018-03-08 |
2023-08-13 |
rat |
| Lynda Whiting, James E McCutcheon, Christina N Boyle, Mitchell F Roitman, Thomas A Lut. The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc). Physiology & behavior. vol 176. 2018-03-08. PMID:28342771. |
the pancreatic hormone amylin and its agonist salmon calcitonin (sct) act via the area postrema (ap) and the lateral parabrachial nucleus (pbn) to reduce food intake. |
2018-03-08 |
2023-08-13 |
rat |
| Fiona E Braegger, Lori Asarian, Kirsten Dahl, Thomas A Lutz, Christina N Boyl. The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping. The European journal of neuroscience. vol 40. issue 7. 2015-06-29. PMID:25040689. |
the role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping. |
2015-06-29 |
2023-08-13 |
rat |
| P M Sexton, J S McKenzie, F A Mendelsoh. Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain. Neurochemistry international. vol 12. issue 3. 2012-10-02. PMID:20501235. |
digital substraction mapping revealed calcitonin-sensitive calcitonin gene-related peptide binding sites over parts of the ventral striatum, including mid-caudal nucleus accumbens and fundus striati; over the lateral border of the lateral bed nucleus of the stria terminalis; part of the central amygdaloid nucleus; the organum vasculosum of the lamina terminalis and area postrema and over the wings of the dorsal raphe. |
2012-10-02 |
2023-08-12 |
rat |
| Catarina Soares Potes, Thomas Alexander Lut. Brainstem mechanisms of amylin-induced anorexia. Physiology & behavior. vol 100. issue 5. 2010-09-16. PMID:20226802. |
amylin's effect on eating has been shown to be mediated via a direct action at the area postrema (ap) via amylin receptors that are heterodimers of the calcitonin receptor core protein with a receptor activity modifying protein. |
2010-09-16 |
2023-08-12 |
Not clear |
| Eliana de Souza, Rafael Coveñas, Pedro Yi, Luís Angel Aguilar, Luís Lerma, Roy Andrade, Arturo Mangas, Zaida Díaz-Cabiale, José Angel Narváe. Mapping of CGRP in the alpaca (Lama pacos) brainstem. Journal of chemical neuroanatomy. vol 35. issue 4. 2008-08-21. PMID:18420379. |
a high density of calcitonin gene-related peptide-immunoreactive perikarya was found in the superior colliculus, the dorsal nucleus of the raphe, the trochlear nucleus, the lateral division of the marginal nucleus of the brachium conjunctivum, the motor trigeminal nucleus, the facial nucleus, the pons reticular formation, the retrofacial nucleus, the rostral hypoglossal nucleus, and in the motor dorsal nucleus of the vagus, whereas a high density of fibers containing calcitonin gene-related peptide was observed in the lateral division of the marginal nucleus of the brachium conjunctivum, the parvocellular division of the alaminar spinal trigeminal nucleus, the external cuneate nucleus, the nucleus of the solitary tract, the laminar spinal trigeminal nucleus, and in the area postrema. |
2008-08-21 |
2023-08-12 |
Not clear |
| Stephan W Barth, Thomas Riediger, Thomas A Lutz, Gerhard Rechkemme. Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat. Neuroscience letters. vol 341. issue 2. 2003-05-15. PMID:12686383. |
the pancreatic peptide hormone amylin (amy) and the amy receptor agonist salmon calcitonin (sct) reduce short-term food intake in rats primarily by activating neurons located in the circumventricular area postrema. |
2003-05-15 |
2023-08-12 |
rat |
| M Fodor, C Pammer, T Görcs, M Palkovit. Neuropeptides in the human dorsal vagal complex: an immunohistochemical study. Journal of chemical neuroanatomy. vol 7. issue 3. 1995-03-16. PMID:7848571. |
the area postrema contained only moderate to low densities of galanin-, substance p-, calcitonin gene-related peptide-, dynorphin b- and cholecystokinin-immunoreactive fibers. |
1995-03-16 |
2023-08-12 |
human |
| M Fodor, C Pammer, T Görcs, M Palkovit. Neuropeptides in the human dorsal vagal complex: an immunohistochemical study. Journal of chemical neuroanatomy. vol 7. issue 3. 1995-03-16. PMID:7848571. |
the distribution of twelve biologically active neuropeptides, i.e., thyrotropin-releasing hormone, corticotropin-releasing factor, pro-opiomelanocortin-derived peptides (adrenocorticotropic hormone, beta-endorphin, alpha-melanocyte-stimulating hormone), leucine-enkephalin, dynorphin a, dynorphin b, cholecystokinin, substance p, galanin and calcitonin gene-related peptide, was examined by immunohistochemistry in the human dorsal vagal complex including the nucleus of the solitary tract, the dorsal motor nucleus of the vagus and the area postrema. |
1995-03-16 |
2023-08-12 |
human |