| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Márcio M Costa, Aleksandro S da Silva, Francine C Paim, Raqueli França, Guilherme L Dornelles, Gustavo R Thomé, Jonas D S Serres, Roberta Schmatz, Rosélia M Spanevello, Jamile F Gonçalves, Maria Rosa C Schetinger, Cinthia M A Mazzanti, Sonia T A Lopes, Silvia G Monteir. Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits. Anais da Academia Brasileira de Ciencias. vol 84. issue 4. 2013-07-11. PMID:23011112. |
the increased activities of ache and bche probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. |
2013-07-11 |
2023-08-12 |
rat |
| Alvin V Terry, Jerry J Buccafusco, Elizabeth J Herman, Patrick M Callahan, Wayne D Beck, Samantha Warner, Leah Vandenhuerk, Kristy Bouchard, Gary M Schwarz, Jie Gao, James M Chapma. The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21106907. |
in the current study, jws was evaluated for binding activity at more than 60 neurotransmitter receptors, transporters, and ion channels, as well as for inhibitory activity at ache and butyrylcholinesterase (bche). |
2011-04-21 |
2023-08-12 |
rat |
| Liu Xue, Mei-Chuan Ko, Min Tong, Wenchao Yang, Shurong Hou, Lei Fang, Junjun Liu, Fang Zheng, James H Woods, Hsin-Hsiung Tai, Chang-Guo Zha. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Molecular pharmacology. vol 79. issue 2. 2011-02-22. PMID:20971807. |
an ideal, therapeutically valuable mutant of human bche should have not only a significantly improved catalytic activity against (-)-cocaine but also certain selectivity for (-)-cocaine over neurotransmitter acetylcholine (ach), such that one would not expect systemic administration of the bche mutant to interrupt cholinergic transmission. |
2011-02-22 |
2023-08-12 |
mouse |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
bche serves as a backup for acetylcholinesterase by hydrolyzing the neurotransmitter acetylcholine in acetylcholinesterase knockout mice. |
2009-07-08 |
2023-08-12 |
mouse |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| H Tago, T Maeda, P L McGeer, H Kimur. Butyrylcholinesterase-rich neurons in rat brain demonstrated by a sensitive histochemical method. The Journal of comparative neurology. vol 325. issue 2. 1993-01-14. PMID:1281176. |
the results suggest that bche may play a unique role in neuronal function, particularly since many bche-rich neurons have not been identified as to neurotransmitter type. |
1993-01-14 |
2023-08-11 |
rat |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |