| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
to reduce acetylcholine degradation and help restore the pool of the neurotransmitter, specific and potent bche inhibitors are sought. |
2023-06-26 |
2023-08-14 |
Not clear |
| Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. |
butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). |
2023-05-27 |
2023-08-14 |
Not clear |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Sliha Awan, Aisha N Hashmi, Rizwan Taj, Sadaf Munir, Rabia Habib, Sajida Batool, Maleeha Azam, Raheel Qamar, Syed M Nurulai. Genetic Association of Butyrylcholinesterase with Major Depressive Disorder. Biochemical genetics. 2021-08-20. PMID:34414522. |
in the present study butyrylcholinesterase (bche), a co-regulatory cholinergic neurotransmitter enzyme implicated in several putative neuronal and non-neuronal physiological roles was investigated for its role in mdd. |
2021-08-20 |
2023-08-13 |
Not clear |
| Congwei Yu, Ming Zhao, Zuchen Pan, Yiyang Bo, Weiwei Zhao, Xiongkui He, Jiaheng Zhan. Butyrylcholinesterase nanodepots with enhanced prophylactic and therapeutic performance for acute organophosphorus poisoning management. Journal of materials chemistry. B. vol 9. issue 7. 2021-05-31. PMID:33533366. |
as a potential alternative, delivery of mammalian-derived butyrylcholinesterase (bche) offers a cost-effective way to block organophosphorus attack on acetylcholinesterase, a key enzyme in the neurotransmitter cycle. |
2021-05-31 |
2023-08-13 |
mouse |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| Takeru Murakawa, Yuki Matsushita, Tomoya Suzuki, Mahmud Tareq Hassan Khan, Noriyuki Kurit. Ab initio molecular simulations for proposing potent inhibitors to butyrylcholinesterases. Journal of molecular graphics & modelling. vol 54. 2015-09-01. PMID:25259414. |
butyrylcholinesterase (bche) exists mainly at neuromuscular junctions and plays an important role in the hydrolyzing mechanism of neurotransmitter acetylcholine. |
2015-09-01 |
2023-08-13 |
Not clear |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Shurong Hou, Liu Xue, Wenchao Yang, Lei Fang, Fang Zheng, Chang-Guo Zha. Substrate selectivity of high-activity mutants of human butyrylcholinesterase. Organic & biomolecular chemistry. vol 11. issue 43. 2014-07-25. PMID:24077614. |
in particular, all the examined bche mutants have a slightly lower catalytic efficiency against neurotransmitter ach compared to the wild-type bche. |
2014-07-25 |
2023-08-12 |
human |
| Shurong Hou, Liu Xue, Wenchao Yang, Lei Fang, Fang Zheng, Chang-Guo Zha. Substrate selectivity of high-activity mutants of human butyrylcholinesterase. Organic & biomolecular chemistry. vol 11. issue 43. 2014-07-25. PMID:24077614. |
in the present study, we carried out both computational modeling and experimental kinetic analysis on the catalytic activities of these promising new bche mutants against other known substrates, including neurotransmitter acetylcholine (ach), acetylthiocholine (atc), butyrylthiocholine (btc), and (+)-cocaine, in comparison with the corresponding catalytic activity against (-)-cocaine. |
2014-07-25 |
2023-08-12 |
human |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |