| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze-Xu Chen, Wan-Nan Jia, Yang Sun, Yong-Xiang Jian. Genotype-phenotype profile of global ASPH-associated ectopia lentis and clinical findings from a Chinese cohort. Gene. 2024-05-24. PMID:38788814. |
traboulsi syndrome is an under-recognized syndromic form of ectopia lentis (el) caused by the aspartate beta-hydroxylase (asph) variant. |
2024-05-24 |
2024-05-27 |
Not clear |
| Pritha Mukherjee, Xin Zhou, Susana Galli, Bruce Davidson, Lihua Zhang, Jaeil Ahn, Reem Aljuhani, Julius Benicky, Laurie Ailles, Vitor H Pomin, Mark Olsen, Radoslav Goldma. Aspartate β-Hydroxylase Is Upregulated in Head and Neck Squamous Cell Carcinoma and Regulates Invasiveness in Cancer Cell Models. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732216. |
aspartate β-hydroxylase (asph) is a protein associated with malignancy in a wide range of tumors. |
2024-05-11 |
2024-05-27 |
Not clear |
| Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R Wands, Chiung-Kuei Huan. Elevated 2-oxoglutarate antagonizes DNA damage responses in cholangiocarcinoma chemotherapy through regulating aspartate beta-hydroxylase. Cancer letters. 2023-11-17. PMID:37977350. |
overexpression of full-length aspartate beta-hydroxylase (asph) could mimic the effects of 2-og on ddrs, suggesting the important role of asph in chemoresistance. |
2023-11-17 |
2023-11-20 |
Not clear |
| Yiran Zou, Jianbo Lin, Jian Liu, Fabiao Zhang, Tingsong Yang, Jian Gong, Tao Jiang, Jieliang Zuo, Ruimei Song, Hao Shen, Feng Shen, Jun L. Aspartate β-hydroxylase (ASPH) Accelerates Intrahepatic Cholangiocarcinoma Metastasis via Upregulating SHH Signaling Pathway. Current protein & peptide science. 2023-05-03. PMID:37132101. |
aspartate β-hydroxylase (asph) is an α-ketoglutarate-dependent dioxygenase involved in the post-translational hydroxylation of target proteins. |
2023-05-03 |
2023-08-14 |
Not clear |
| Yiran Zou, Jianbo Lin, Jian Liu, Fabiao Zhang, Tingsong Yang, Jian Gong, Tao Jiang, Jieliang Zuo, Ruimei Song, Hao Shen, Feng Shen, Jun L. Aspartate β-hydroxylase (ASPH) Accelerates Intrahepatic Cholangiocarcinoma Metastasis via Upregulating SHH Signaling Pathway. Current protein & peptide science. 2023-05-03. PMID:37132101. |
aspartate β-hydroxylase (asph) accelerates intrahepatic cholangiocarcinoma metastasis via upregulating shh signaling pathway. |
2023-05-03 |
2023-08-14 |
Not clear |
| Xuejun Gan, Shen Li, Yiding Wang, Hong Du, Ying Hu, Xiaofang Xing, Xiaojing Cheng, Yan Yan, Ziyu L. Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982561. |
aspartate β-hydroxylase (asph) represents an attractive target which is a highly conserved transmembrane enzyme overexpressed in |
2023-03-29 |
2023-08-14 |
Not clear |
| Lennart Brewitz, Bruce C Onisko, Christopher J Schofiel. Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation. The Journal of biological chemistry. vol 298. issue 8. 2022-09-08. PMID:35700824. |
both secreted and cell surface human egfds are subject to extensive modifications, including aspartate and asparagine residue c3-hydroxylations catalyzed by the 2-oxoglutarate oxygenase aspartate/asparagine-β-hydroxylase (asph). |
2022-09-08 |
2024-02-12 |
human |
| Gabriela Jones, Katie Johnson, Jacqueline Eason, Mark Hamilton, Deborah Osio, Farah Kanani, Julia Baptista, Mohnish Sur. Traboulsi syndrome caused by mutations in ASPH: An autosomal recessive disorder with overlapping features of Marfan syndrome. European journal of medical genetics. 2022-08-02. PMID:35918038. |
alterations in the aspartate beta-hydroxylase (asph) gene are known to be the cause of the condition. |
2022-08-02 |
2023-08-14 |
Not clear |
| Paola Barboro, Alessandra Rubagotti, Silvia Poddine, Federica Grillo, Luca Mastracci, Francesco Boccard. The prognostic value of aspartate beta-hydroxylase in early breast cancer. The International journal of biological markers. 2022-06-21. PMID:35726161. |
aspartate beta-hydroxylase (asph) is a transmembrane protein involved in cancer progression, which has been shown to imply a worse prognosis in several solid tumors. |
2022-06-21 |
2023-08-14 |
Not clear |
| Xuewei Bai, Yanmei Zhou, Yuki Yokota, Yoshihiro Matsumoto, Bo Zhai, Nader Maarouf, Hikaru Hayashi, Rolf Carlson, Songhua Zhang, Aryanna Sousa, Bei Sun, Hossein Ghanbari, Xiaoqun Dong, Jack R Wand. Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade. Journal of experimental & clinical cancer research : CR. vol 41. issue 1. 2022-04-08. PMID:35392977. |
aspartate β-hydroxylase (asph), an oncofetal protein and tumor associated antigen (taa), is a potential target for immunotherapy. |
2022-04-08 |
2023-08-13 |
Not clear |
| Noa G Holtzman, Michael S Lebowitz, Rima Koka, Maria R Baer, Kanam Malhotra, Amir Shahlaee, Hossein A Ghanbari, Søren M Bentzen, Ashkan Emad. Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target. Frontiers in oncology. vol 11. 2022-01-10. PMID:35004304. |
aspartate β-hydroxylase (asph) expression in acute myeloid leukemia: a potential novel therapeutic target. |
2022-01-10 |
2023-08-13 |
Not clear |
| Noa G Holtzman, Michael S Lebowitz, Rima Koka, Maria R Baer, Kanam Malhotra, Amir Shahlaee, Hossein A Ghanbari, Søren M Bentzen, Ashkan Emad. Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target. Frontiers in oncology. vol 11. 2022-01-10. PMID:35004304. |
aspartate β-hydroxylase (asph) is an embryonic transmembrane protein aberrantly upregulated in cancer cells, associated with malignant transformation and, in some reports, with poor clinical prognosis. |
2022-01-10 |
2023-08-13 |
Not clear |
| Xuewei Bai, Yanmei Zhou, Qiushi Lin, Chiung-Kuei Huang, Songhua Zhang, Rolf I Carlson, Hossein Ghanbari, Bei Sun, Jack R Wands, Xiaoqun Don. Bio-nanoparticle based therapeutic vaccine induces immunogenic response against triple negative breast cancer. American journal of cancer research. vol 11. issue 9. 2021-10-22. PMID:34659881. |
this study elucidates how aspartate beta-hydroxylase (asph) network promotes drug resistance, and immunotherapy targeting asph may improve the efficacy of doxorubicin (dox) therapy. |
2021-10-22 |
2023-08-13 |
mouse |
| Katsuya Nagaoka, Kousuke Ogawa, Chengcheng Ji, Kevin Y Cao, Xuewei Bai, Joud Mulla, Zhixiang Cheng, Jack R Wands, Chiung-Kuei Huan. Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis. Digestive diseases and sciences. vol 66. issue 4. 2021-08-18. PMID:32445050. |
the enzyme aspartate beta-hydroxylase (asph) has been demonstrated to be highly expressed in cholangiocarcinoma but not in normal bile ducts and found to stimulate tumor cell migration. |
2021-08-18 |
2023-08-13 |
Not clear |
| Qiushi Lin, Xuesong Chen, Fanzheng Meng, Kosuke Ogawa, Min Li, Ruipeng Song, Shugeng Zhang, Ziran Zhang, Xianglu Kong, Qinggang Xu, Fuliang He, Dan Liu, Xuewei Bai, Bei Sun, Mien-Chie Hung, Lianxin Liu, Jack R Wands, Xiaoqun Don. Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture. American journal of cancer research. vol 11. issue 6. 2021-07-13. PMID:34249415. |
aspartate β-hydroxylase (asph) is an α-ketoglutarate-dependent dioxygenase and oncofetal antigen involved in embryogenesis. |
2021-07-13 |
2023-08-13 |
Not clear |
| Hadi Bakhtiari, Abbas Ali Palizban, Hossein Khanahmad, Mohammad Reza Mofi. Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β-Hydroxylase. ACS omega. vol 6. issue 16. 2021-06-01. PMID:34056254. |
here, we introduced the counter-selex as part of our modified cell-selex and implemented deep sequencing to overcome these shortcomings in developing aptamers against aspartate β-hydroxylase (asph) as a known tumor marker. |
2021-06-01 |
2023-08-13 |
Not clear |
| Yanan Zhang, Yimeng Gao, Yingxue Li, Xuedong Zhang, Haitao Xi. Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-14. PMID:33380715. |
background this study aimed to investigate the relationship between the expression of aspartate b-hydroxylase (asph) and the molecular mechanisms of asph-related genes in breast cancer (bc). |
2021-05-14 |
2023-08-13 |
Not clear |
| Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova, Ruth Tachez. Aspartate β-hydroxylase as a target for cancer therapy. Journal of experimental & clinical cancer research : CR. vol 39. issue 1. 2021-04-27. PMID:32811566. |
aspartate β-hydroxylase (asph) is a key player in the malignant transformation of solid tumors by enhancing cell proliferation, migration, and invasion. |
2021-04-27 |
2023-08-13 |
mouse |
| Kosuke Ogawa, Qiushi Lin, Le Li, Xuewei Bai, Xuesong Chen, Hua Chen, Rui Kong, Yongwei Wang, Hong Zhu, Fuliang He, Qinggang Xu, Lianxin Liu, Min Li, Songhua Zhang, Katsuya Nagaoka, Rolf Carlson, Howard Safran, Kevin Charpentier, Bei Sun, Jack Wands, Xiaoqun Don. Prometastatic secretome trafficking via exosomes initiates pancreatic cancer pulmonary metastasis. Cancer letters. vol 481. 2020-12-15. PMID:32145343. |
to demonstrate multifaceted contribution of aspartate β-hydroxylase (asph) to pancreatic ductal adenocarcinoma (pdac) pathogenesis, in vitro metastasis assay and patient derived xenograft (pdx) murine models were established. |
2020-12-15 |
2023-08-13 |
Not clear |
| C Tang, Y Hou, H Wang, K Wang, H Xiang, X Wan, Y Xia, J Li, W Wei, S Xu, Z Lei, T M Pawlik, H Wang, M Wu, F She. Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma. Oncogenesis. vol 6. issue 7. 2020-10-01. PMID:28714949. |
our previous study demonstrated an increased expression of aspartate β-hydroxylase (asph) in hcc tissues, which was associated with tumor invasiveness and a worse prognosis. |
2020-10-01 |
2023-08-13 |
Not clear |