| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Peng Ke, Bao-Dong He, Mao-Lei Gong, Zhong-Ze Yan, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Li. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury. Cell communication and signaling : CCS. vol 22. issue 1. 2024-10-01. PMID:39350161. |
in this study, we generated a arid1a cko mouse line to investigate the potential roles of arid1a in microglia in response to tbi. |
2024-10-01 |
2024-10-03 |
mouse |
| Jin-Peng Ke, Bao-Dong He, Mao-Lei Gong, Zhong-Ze Yan, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Li. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury. Cell communication and signaling : CCS. vol 22. issue 1. 2024-10-01. PMID:39350161. |
arid1a (at-rich interaction domain 1 a), a pivotal subunit of the multi-protein swi/snf chromatin remodeling complex, has received little attention in microglia, especially in the context of brain injury. |
2024-10-01 |
2024-10-03 |
mouse |
| Jin-Peng Ke, Bao-Dong He, Mao-Lei Gong, Zhong-Ze Yan, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Li. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury. Cell communication and signaling : CCS. vol 22. issue 1. 2024-10-01. PMID:39350161. |
mechanistically, loss of arid1a led to an up-regulation of the chemokine ccl5 in microglia upon the injury, while the ccl5-neutralizing antibody reduced migration and inflammatory response of lps-stimulated arid1a cko microglia. |
2024-10-01 |
2024-10-03 |
mouse |
| Libo Su, Mengtian Zhang, Fen Ji, Jinyue Zhao, Yuanyuan Wang, Wenwen Wang, Shukui Zhang, Hongyan Ma, Yanyan Wang, Jianwei Jia. Microglia homeostasis mediated by epigenetic ARID1A regulates neural progenitor cells response and leads to autism-like behaviors. Molecular psychiatry. 2022-07-20. PMID:35858990. |
arid1a, an epigenetic subunit of the swi/snf chromatin-remodeling complex, disrupts genome-wide h3k9me3 occupancy in microglia and changes the epigenetic chromatin landscape of regulatory elements that influence the switching of microglial states. |
2022-07-20 |
2023-08-14 |
Not clear |
| Libo Su, Mengtian Zhang, Fen Ji, Jinyue Zhao, Yuanyuan Wang, Wenwen Wang, Shukui Zhang, Hongyan Ma, Yanyan Wang, Jianwei Jia. Microglia homeostasis mediated by epigenetic ARID1A regulates neural progenitor cells response and leads to autism-like behaviors. Molecular psychiatry. 2022-07-20. PMID:35858990. |
microglia homeostasis mediated by epigenetic arid1a regulates neural progenitor cells response and leads to autism-like behaviors. |
2022-07-20 |
2023-08-14 |
Not clear |