| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Wismayer, Rosie Matthews, Celina Whalley, Julius Kiwanuka, Fredrick Elishama Kakembo, Steve Thorn, Henry Wabinga, Michael Odida, Ian Tomlinso. Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer. BMC cancer. vol 24. issue 1. 2024-10-01. PMID:39350061. |
in our population, there is a scarcity of genetic oncological studies, therefore, we investigated the mutational status of crc tissues, focusing in particular on the adenomatous polyposis coli (apc), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and smad4 genes. |
2024-10-01 |
2024-10-03 |
Not clear |
| Martin Forster, Irene Brana, Antonio Lopez Pousa, Bernard Doger, Patricia Roxburgh, Pawan Bajaj, Julio Peguero, Matthew Krebs, Enric Carcereny, Grisma Patel, Christian Mueller, Chrystelle Brignone, Frederic Triebe. Eftilagimod alpha (soluble LAG-3 protein) combined with pembrolizumab as second-line therapy for patients with metastatic head and neck squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024-07-12. PMID:38995265. |
eftilagimod alpha (efti), a soluble lag-3 protein, activates antigen-presenting cells (apc) and downstream t-cells. |
2024-07-12 |
2024-07-14 |
Not clear |
| Xian Li, Xiaohong Song, Dlovan F D Mahmood, Martha M S Sim, Sara J Bidarian, Jeremy P Woo. Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation. Thrombosis research. vol 230. 2023-09-03. PMID:37660436. |
fxa and fva are inhibited by the anticoagulants tissue factor pathway inhibitor alpha (tfpiα) and activated protein c (apc), respectively, and their common cofactor protein s (ps). |
2023-09-03 |
2023-09-07 |
Not clear |
| Casey W Shuptrine, Vincent M Perez, Sara R Selitsky, Taylor H Schreiber, George From. Shining a LIGHT on myeloid cell targeted immunotherapy. European journal of cancer (Oxford, England : 1990). vol 187. 2023-05-11. PMID:37167762. |
achieving durable anti-tumour immunity will therefore likely require combination of adaptive and innate immune stimulation, myeloid repolarisation, enhanced apc activation and antigen processing/presentation, lifting of the cd47/sirpα (cluster of differentiation 47/signal regulatory protein alpha) 'do not eat me' signal, provision of an apoptotic 'pro-eat me' or 'find me' signal, and blockade of immune checkpoints. |
2023-05-11 |
2023-08-14 |
Not clear |
| Herm Jan M Brinkman, Josefin Ahnström, Elisabetta Castoldi, Björn Dahlbäck, Richard A Marla. Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH. Journal of thrombosis and haemostasis : JTH. vol 19. issue 1. 2021-05-14. PMID:33405384. |
ps has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the activated protein c (apc) and tissue factor pathway inhibitor alpha (tfpiα) cofactor activities. |
2021-05-14 |
2023-08-13 |
Not clear |
| Abigail Dickinson, Kandice J Varcin, Mustafa Sahin, Charles A Nelson, Shafali S Jest. Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex. Autism research : official journal of the International Society for Autism Research. vol 12. issue 12. 2020-09-21. PMID:31419043. |
we measured features of spontaneous alpha oscillations (6-12 hz) that are closely associated with neural network development: alpha power, alpha phase coherence (apc), and peak alpha frequency (paf). |
2020-09-21 |
2023-08-13 |
Not clear |
| Lars Heslet, Jakob Steen Andersen, Henrik Sengeløv, Björn Dahlbäck, Jorgen Dalsgaard-Nielse. Inhalation of activated protein C: A possible new adjunctive intervention in acute respiratory distress syndrome. Biologics : targets & therapy. vol 1. issue 4. 2011-07-14. PMID:19707316. |
after inhalation of 190 mug/kg of apc (drotrecogin alpha activated) three times a day for seven days, a clear reduction in infiltrates on chest x-ray and a 138% increase in oxygenation capacity as reflected by the pao(2)/fio(2) ratio was brought about. |
2011-07-14 |
2023-08-12 |
Not clear |
| Myriam Loyo, Mariana Brait, Myoung S Kim, Kimberly L Ostrow, Chunfa C Jie, Alice Y Chuang, Joseph A Califano, Nanette J Liégeois, Shahnaz Begum, William H Westra, Mohammad O Hoque, Qian Tao, David Sidransk. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. International journal of cancer. vol 128. issue 6. 2011-03-24. PMID:20473931. |
the methylation status of aim1, apc, calca, deleted in colorectal carcinomas (dcc), dlec, deleted in liver cancer 1 (dlc1), estrogen receptor alpha (esr), fhit, kif1a and pgp9.5 was significantly associated with npc compared to controls. |
2011-03-24 |
2023-08-12 |
Not clear |
| Pooja Thakurdas, Shweta Sharma, Boynao Sinam, Meenakshi Chib, Dilip Josh. Nocturnal illumination dimmer than starlight altered the circadian rhythm of adult locomotor activity of a fruit fly. Chronobiology international. vol 27. issue 1. 2010-05-25. PMID:20205559. |
duration of the active phase (alpha) and activity passes/fly/cycle (apc) in the experimental flies was far greater than in controls. |
2010-05-25 |
2023-08-12 |
drosophila_melanogaster |
| Pooja Thakurdas, Shweta Sharma, Boynao Sinam, Meenakshi Chib, Dilip Josh. Nocturnal illumination dimmer than starlight altered the circadian rhythm of adult locomotor activity of a fruit fly. Chronobiology international. vol 27. issue 1. 2010-05-25. PMID:20205559. |
after-effects of the nocturnal illumination of the light-dark cycles when the flies were transferred to constant darkness were evident as the period of the free-running rhythm was shortened, alpha was lengthened, and apc was enhanced in the experimental compared to control flies. |
2010-05-25 |
2023-08-12 |
drosophila_melanogaster |
| Naohisa Kuriyama, Shuji Isaji, Takashi Hamada, Masashi Kishiwada, Ichiro Ohsawa, Masanobu Usui, Hiroyuki Sakurai, Masami Tabata, Tatsuya Hayashi, Koji Suzuk. The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 16. issue 1. 2010-03-31. PMID:20035525. |
apc exerted cytoprotective effects, as evidenced by (1) increased 7-day graft survival; (2) decreased initial portal pressure and improved hepatic microcirculation; (3) decreased levels of aminotransferase and improved histological features of hepatic ischemia-reperfusion injury; (4) suppressed infiltration of neutrophils and monocytes/macrophages; (5) reduced hepatic expression of tumor necrosis factor alpha and interleukin 6; (6) decreased serum levels of hyaluronic acid, which indicated attenuation of sinusoidal endothelial cell injury; (7) increased hepatic levels of nitric oxide via up-regulated hepatic endothelial nitric oxide synthesis expression together with down-regulated hepatic inducible nitric oxide synthase expression; (8) decreased hepatic levels of endothelin 1; and (9) reduced hepatocellular apoptosis by down-regulated caspase-8 and caspase-3 activities. |
2010-03-31 |
2023-08-12 |
rat |
| S B Yan, J T Brandt, N L Correll, S L Um, J S Bourdag. Evaluation of anti-activated protein C antibody development in patients with severe sepsis from four clinical studies with drotrecogin alpha (activated). Journal of thrombosis and haemostasis : JTH. vol 7. issue 11. 2010-03-02. PMID:20015319. |
drotrecogin alpha (activated) (daa) is a recombinant human activated protein c (apc), which is an antithrombotic protein. |
2010-03-02 |
2023-08-12 |
human |
| Feijun Luo, David G Brooks, Hongtao Ye, Rifat Hamoudi, George Poulogiannis, Charles E Patek, Douglas J Winton, Mark J Arend. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. International journal of experimental pathology. vol 90. issue 5. 2009-12-14. PMID:19765110. |
k-ras(asp12) increased activation of mapk and akt signalling pathway targets phospho-extracellular signal-regulated kinase (perk) and pakt, and increased relative expression levels of wnt pathway targets vascular endothelial growth factor (vegf), gastrin, cyclo-oxygenase 2 (cox2) and t-cell lymphoma invasion and metastasis 1 (tiam1) in k-ras(asp12)/cre/apc(min/+) adenomas compared with that of apc(min/+) adenomas, although other wnt signalling pathway target genes such as peroxisome proliferator-activated receptor delta (ppard), matrix metalloproteinase 7 (mmp7), protein phosphatase 1 alpha (pp1a) and c-myc remained unchanged. |
2009-12-14 |
2023-08-12 |
mouse |
| Suresh R Volate, Stephanie J Muga, Ala Y Issa, Daniela Nitcheva, Theresa Smith, Michael J Wargovic. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Molecular carcinogenesis. vol 48. issue 10. 2009-10-15. PMID:19378291. |
in contrast, other retinoic receptors including retinoic acid receptor alpha (rar alpha), rar beta, rxr beta, and rxr gamma were all expressed in apc(min/+) adenomas. |
2009-10-15 |
2023-08-12 |
mouse |
| Suresh R Volate, Stephanie J Muga, Ala Y Issa, Daniela Nitcheva, Theresa Smith, Michael J Wargovic. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Molecular carcinogenesis. vol 48. issue 10. 2009-10-15. PMID:19378291. |
the results suggest that a low concentration of gt is sufficient to desilence rxr alpha and inhibit intestinal tumorigenesis in the apc(min/+) mouse. |
2009-10-15 |
2023-08-12 |
mouse |
| Charles T Esmo. Crosstalk between inflammation and thrombosis. Maturitas. vol 61. issue 1-2. 2009-06-11. PMID:19437587. |
in vitro, apc inhibits tnf alpha elaboration from monocytes and to block leukocyte adhesion to selectins. |
2009-06-11 |
2023-08-12 |
Not clear |
| Martina Ahlmann, Georg Varga, Karsten Sturm, Ralph Lippe, Konrad Benedyk, Dorothee Viemann, Thomas Scholzen, Jan Ehrchen, Frank U Müller, Matthias Seidl, Marek Matus, George C Tsokos, Johannes Roth, Klaus Tenbroc. The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 7. 2009-04-14. PMID:19299714. |
the cyclic amp response element modulator {alpha} suppresses cd86 expression and apc function. |
2009-04-14 |
2023-08-12 |
mouse |
| Anke Osterloh, Alexandra Veit, André Gessner, Bernhard Fleischer, Minka Breloe. Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. International immunology. vol 20. issue 3. 2009-02-03. PMID:18256040. |
lps-free hsp60 did not induce il-6, il-12 or tumor necrosis factor alpha production in apc nor were these cytokines needed for hsp60-mediated t cell co-stimulation in the absence of lps. |
2009-02-03 |
2023-08-12 |
Not clear |
| Anke Osterloh, Alexandra Veit, André Gessner, Bernhard Fleischer, Minka Breloe. Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. International immunology. vol 20. issue 3. 2009-02-03. PMID:18256040. |
furthermore, we show that lps-free hsp60 enhances ifn alpha expression in apc and that this cytokine represents one important mediator in immune stimulation by hsp60 in the absence of lps. |
2009-02-03 |
2023-08-12 |
Not clear |
| Ian R Radford, Pavel N Lobachevsk. Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis. Mutation research. vol 646. issue 1-2. 2009-01-06. PMID:18824008. |
we used statistical analyses to search for sets of dinucleotide sequences (designated target sequences) that are present at and in close proximity to mutation sites in four genes associated with human colorectal tumourigenesis (adenomatosis polyposis coli (apc), v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (kras), phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca), and tumour protein p53 (tp53)). |
2009-01-06 |
2023-08-12 |
human |