| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
compared with the control group, the morin groups showed decreased viability of sk-hep-1 cells in a time-and concentration-dependent manner, increased number of apoptotic cells, up-regulated expression level of apoptosis marker parp, up-regulated phosphorylation level of apoptosis-regulating protein h2ax, decreased number of positive cells and the colony formation rate, an upward trend of expression levels of autophagy-related proteins lc3-Ⅱ, atg5, and atg7, and decreased phosphorylation levels of akt, mtor, and stat3. |
2023-10-06 |
2023-10-15 |
human |
| Nan Yao, Yulin Li, Jinrui Han, Siting Wu, Xin Liu, Qiuyu Wang, Zhiguo Li, Fu-Dong Sh. Microglia-derived CCL20 deteriorates neurogenesis following intraventricular hemorrhage. Experimental neurology. 2023-10-06. PMID:37802382. |
blocking ccl20 in microglia leads to downregulation of protein kinase b (akt)/mammalian target of rapamycin (mtor)/the nuclear factor-κb (nf-κb) signaling pathway, which may contribute to ccl20-dependent pro-inflammatory responses and neural injury. |
2023-10-06 |
2023-10-15 |
mouse |
| Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Müller, Laura Musazz. Changes in neurotrophic signaling pathways in brain areas of the chronic mild stress rat model of depression as a signature of ketamine fast antidepressant response/non-response. Progress in neuro-psychopharmacology & biological psychiatry. 2023-10-04. PMID:37793481. |
we measured the activation by phosphorylation of protein kinase b (akt), extracellular signal-regulated kinases (erks), glycogen synthase kinase-3 beta (gsk3 β), mammalian target of rapamycin (mtor), and eukaryotic elongation factor 2 (eef2), key effectors in the regulation of neuroplasticity and glutamatergic transmission which were previously associated to ketamine's fast antidepressant effect. |
2023-10-04 |
2023-10-07 |
rat |
| Bo Liu, Han Xie, Xiongbing Du, Yuyang Zhou, Jiashun Huan. Catalpol Inhibits Autophagy to Ameliorate Doxorubicin-Induced Cardiotoxicity via the AKT-mTOR Pathway. International heart journal. vol 64. issue 5. 2023-10-01. PMID:37778994. |
in addition, ctp decreased the levels of beclin1 and lc3ii/lc3i, increased the levels of p62, and activated the protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway in dox-treated mice.ctp ameliorated dox-induced cardiotoxicity by inhibiting oxidative stress, myocardial apoptosis, and autophagy via the akt-mtor pathway. |
2023-10-01 |
2023-10-07 |
mouse |
| Vivek Panwar, Aishwarya Singh, Manini Bhatt, Rajiv K Tonk, Shavkatjon Azizov, Agha Saquib Raza, Shinjinee Sengupta, Deepak Kumar, Manoj Gar. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-01. PMID:37779156. |
mtor catalyzes the phosphorylation of several critical proteins like akt, protein kinase c, insulin growth factor receptor (igf-1r), 4e binding protein 1 (4e-bp1), ribosomal protein s6 kinase (s6k), transcription factor eb (tfeb), sterol-responsive element-binding proteins (srebps), lipin-1, and unc-51-like autophagy-activating kinases. |
2023-10-01 |
2023-10-07 |
human |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. 2023-09-29. PMID:37772736. |
upon insulin stimulation, insulin signaling via phosphorylation of akt and nutrient sensing via phosphorylation of mtor target ribosomal s6 were evaluated in the offspring liver, white adipose tissue, and skeletal muscle. |
2023-09-29 |
2023-10-07 |
mouse |
| Enzo Pérez-Valenzuela, Roger Hudson, Taygun Uzuneser, Marta De Felice, Hanna Szkudlarek, Walter Rushlow, Steven R Laviolett. Sex-Dependent Synergism of an Edible THC: CBD Formulation in Reducing Anxiety and Depressive-like Symptoms Following Chronic Stress. Current neuropharmacology. 2023-09-13. PMID:37702237. |
furthermore, western-blot experiments examined the expression of biomarkers associated with mood and anxiety disorders, including protein kinase b (akt), glycogen synthase kinase-3 (gsk-3), bdnf, mtor, d1, and d2 receptor in nucleus accumbens (nac) and pfc.edible thc:cbd produces significant anxiolytic and antidepressant effects only in stressed male rats. |
2023-09-13 |
2023-10-07 |
rat |
| Yuri Yoh, Tadashi Shiohama, Tomoko Uchida, Ryota Ebata, Hironobu Kobayashi, Kentaro Okunushi, Mitsuhiro Kato, Kazuki Watanabe, Mitsuko Nakashima, Hirotomo Saitsu, Hiromichi Hamad. Case report: Progressive pulmonary artery hypertension in a case of megalencephaly-capillary malformation syndrome. Frontiers in genetics. vol 14. 2023-08-24. PMID:37614820. |
megalencephaly-capillary malformation syndrome (mcap, omim # 602501) is caused by hyperactivity of the thephosphoinositide-3-kinase (pi3k)-vakt murine thymoma viral oncogene homolog (akt)-mammalian target of rapamycin (mtor) pathway, which results in megalencephaly, capillary malformations, asymmetrical overgrowth, and connective tissue dysplasia. |
2023-08-24 |
2023-09-07 |
Not clear |
| Antonino Glaviano, Aaron S C Foo, Hiu Y Lam, Kenneth C H Yap, William Jacot, Robert H Jones, Huiyan Eng, Madhumathy G Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H Kulke, Richard D Baird, Jyothi S Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B L Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H Lin, Nathalie R Javidi-Sharifi, Eneda Toska, Matthew S Davids, Jennifer R Brown, Patrizia Diana, Justin Stebbing, David A Fruman, Alan P Kuma. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular cancer. vol 22. issue 1. 2023-08-21. PMID:37596643. |
in this review we highlight the major dysregulations in the pam signaling pathway in cancer, and discuss the results of pi3k, akt and mtor inhibitors as monotherapy and in co-administation with other antineoplastic agents in clinical trials as a strategy for overcoming treatment resistance. |
2023-08-21 |
2023-09-07 |
human |
| Zhongwei Xu, Jun Bao, Xiaohan Jin, Heng Li, Kaiyuan Fan, Zhidong Wu, Min Yao, Yan Zhang, Gang Liu, Dan Wang, Xiaoping Yu, Jia Guo, Ruicheng Xu, Qian Gong, Fengmei Wang, Jin Wan. The Effects of Cinobufagin on Hepatocellular Carcinoma Cells Enhanced by MRT68921, an Autophagy Inhibitor. The American journal of Chinese medicine. 2023-07-25. PMID:37489112. |
as determined using transcriptome analysis, cinobufagin-triggered protective autophagy suppressed cell apoptosis in liver cancer hepg2 and huh-7 cells by inhibiting the phosphoinositide-3-kinase (pi3k)-akt serine/threonine kinase (akt)-mammalian target of rapamycin (mtor) pathway. |
2023-07-25 |
2023-08-14 |
Not clear |
| Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Ab. 3',4'-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT-mTOR and NF-κB Pathways. Biological & pharmaceutical bulletin. vol 46. issue 7. 2023-07-02. PMID:37394643. |
lps-induced phosphorylation of mammalian target of rapamycin (mtor), nuclear factor-κb (nf-κb), and protein kinase b (akt) (which are all associated with the neuroinflammatory response in microglia) were attenuated by 3',4'-dihydroxyflavonol treatment. |
2023-07-02 |
2023-08-14 |
Not clear |
| Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Ab. 3',4'-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT-mTOR and NF-κB Pathways. Biological & pharmaceutical bulletin. vol 46. issue 7. 2023-07-02. PMID:37394643. |
treatment with the mtor inhibitor, rapamycin, nf-κb inhibitor, caffeic acid phenethyl ester, or akt inhibitor, ly294002, also attenuated lps-induced tumor necrosis factor-α and nitric oxide secretion in mg6 cells. |
2023-07-02 |
2023-08-14 |
Not clear |
| Mohaddeseh Rashedi Osqueei, Ali Zaree Mahmoudabadi, Zahra Bahari, Gholam Hossein Meftahi, Monireh Movahedi, Reza Taghipour, Naser Mousavi, Hasan Fallah Huseini, Zohreh Jangrav. Eryngium billardieri extract affects cardiac gene expression of master regulators of cardiomyaopathy in rats with high fatdiet-induced insulin resistance. Clinical nutrition ESPEN. vol 56. 2023-06-21. PMID:37344084. |
in the present study, we examined the effects of eryngium billardieri extract, as an anti-diabetic herbal medication, on the heart mrna level of akt serine/threonine kinase (akt), mechanistic target of rapamycin kinase (mtor), peroxisome proliferator-activated receptor gamma (pparγ), and forkhead box o1 (foxo1) in rats with high-fat diet (hfd)-induced insulin resistance (ir). |
2023-06-21 |
2023-08-14 |
rat |
| Eric Mayo. Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Frontiers in aging. vol 4. 2023-06-19. PMID:37334045. |
the most researched signaling pathways (pi3k, akt, mtor, ampk, gsk3β, ulk, mapk, pgc-1α, nf-κb, sirtuins, notch, sonic hedgehog and wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. |
2023-06-19 |
2023-08-14 |
Not clear |
| Lili Zhang, Jie Yang, Zhoujing Ji, Jie Zhang, Shengju Yan. PRR14 acts a novel oncogene activating the PI3K signal pathway in human cutaneous squamous cell carcinoma. Journal of Cancer. vol 14. issue 9. 2023-06-16. PMID:37325059. |
prr14 inhibition with rna interfering (rnai) method resulted in the suppression of cell proliferation, migration and invasion but promotion the apoptosis of cscc cells, and upregulation of the protein phosphorylation levels of mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k) and akt. |
2023-06-16 |
2023-08-14 |
human |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
the hippocampal neurons were transfected with mir-10a mimics, and transcript levels of mir-10a, pi3k, akt and mtor were detected by quantitative reverse transcription-pcr, and pi3k, mtor, akt, tnf-α, il-1β, il-6 protein expression levels were detected by western blot. |
2023-06-04 |
2023-08-14 |
rat |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
in the epileptic hippocampal neurons model, the expression levels of mir-10a were significantly increased, with decreasing levels of pi3k, akt and mtor, and increasing levels of tnf-α, il-1β and il-6. |
2023-06-04 |
2023-08-14 |
rat |
| Sarah J Barnard, Josephina Haunschild, Linda Heiser, Maja T Dieterlen, Kristin Klaeske, Michael A Borger, Christian D Et. Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108591. |
mtor as a downstream protein of akt was significantly higher in patients with bav, whereas bcl-2 was increased in patients with tav, assuming a better protection against apoptosis. |
2023-04-28 |
2023-08-14 |
human |
| Dorota Ciołczyk-Wierzbica, Agnieszka Krawczyk, Marta Zarzycka, Grzegorz Zemanek, Karol Wierzbick. Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells. Journal of cell communication and signaling. 2023-04-25. PMID:37097377. |
the subject of this research was the effect of protein kinase inhibitors involved in the akt, mek, and mtor kinase signaling pathways on the expression of pro-survival proteins, activity of caspase-3, proliferation, and induction of apoptosis in melanoma cells. |
2023-04-25 |
2023-08-14 |
human |