| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuliano Moreto Onaka, Marianna Rabelo de Carvalho, Patricia Kubalaki Onaka, Claudiane Maria Barbosa, Paula Felippe Martinez, Silvio Assis de Oliveira-Junio. Exercise, mTOR Activation, and Potential Impacts on the Liver in Rodents. Biology. vol 13. issue 6. 2024-06-27. PMID:38927242. |
in terms of molecular mechanisms, the regulation of hepatic fat formation would be directly related to the modulation of the mechanistic target of rapamycin (mtor), which would be stimulated by insulin signaling and akt activation, from the following three different primary signaling pathways: (i) growth factor, (ii) energy/atp-sensitive, and (iii) amino acid-sensitive signaling pathways, respectively. |
2024-06-27 |
2024-06-29 |
Not clear |
| Emilija Glavonic, Milorad Dragic, Milos Mitic, Minja Aleksic, Iva Lukic, Sanja Ivkovic, Miroslav Adzi. Ketamine's Amelioration of Fear Extinction in Adolescent Male Mice Is Associated with the Activation of the Hippocampal Akt-mTOR-GluA1 Pathway. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931336. |
ketamine also increased the akt and mtor activity and the glua1 and glun2a levels in the hpc and upregulated bdnf exon iv mrna expression in the hpc and pfc of the fear-extinguished mice. |
2024-06-27 |
2024-06-29 |
mouse |
| Tianchuang Zhao, Qi Li, Xiaodan Wang, Bo Tang, Xueming Zhang, Hao Yu, Ziyi L. Time-dependent effects of high-fat diet on cognition and cerebral insulin signaling: window for recovery and potential therapeutic target. Mechanisms of ageing and development. 2024-06-09. PMID:38852746. |
in brain insulin signaling, 2-month hfd increased irs-1 and p-irs-1(ser307)/irs-1, while decreasing pakt(ser473)/akt, pi3k and mtor; 4-month hfd decreased irs-1 and pakt(ser473)/akt, while increasing akt; 6-month hfd increased irs-1, pakt(ser473)/akt, and mtor, while decreasing p-irs-1(ser307)/irs-1, pi3k and akt. |
2024-06-09 |
2024-06-14 |
Not clear |
| Jesús Herrera-Bravo, Lisandra Herrera Belén, María Elena Reyes, Victor Silva, Soledad Fuentealba, Cristian Paz, Pía Loren, Luis A Salazar, Javad Sharifi-Rad, Daniela Calin. Thymol as adjuvant in oncology: molecular mechanisms, therapeutic potentials, and prospects for integration in cancer management. Naunyn-Schmiedeberg's archives of pharmacology. 2024-06-07. PMID:38847831. |
thymol has been shown to induce programmed cell death (apoptosis), halt the cell division cycle (cell cycle arrest), and inhibit cancer spread (metastasis) through modulation of critical signaling pathways, including phosphoinositide 3-kinase (pi3k), protein kinase b (akt), extracellular signal-regulated kinase (erk), mechanistic target of rapamycin (mtor), and wnt/β-catenin. |
2024-06-07 |
2024-06-10 |
Not clear |
| Stefano Rossetti, Aaron Broege, Adrish Sen, Salmaan Khan, Ian MacNeil, Jhomary Molden, Ross Kopher, Stephen Schulz, Lance Lain. Gedatolisib shows superior potency and efficacy versus single-node PI3K/AKT/mTOR inhibitors in breast cancer models. NPJ breast cancer. vol 10. issue 1. 2024-06-05. PMID:38839777. |
the pi3k, akt, and mtor (pam) pathway is frequently dysregulated in breast cancer (bc) to accommodate high catabolic and anabolic activities driving tumor growth. |
2024-06-05 |
2024-06-08 |
Not clear |
| Huang Xiaoyan, Yang Zhaoxi, Zhang Lingli, Chen Jinyuan, Qin We. Taurine Improved Autism-Like Behaviours and Defective Neurogenesis of the Hippocampus in BTBR Mice through the PTEN/mTOR/AKT Signalling Pathway. Folia biologica. vol 70. issue 1. 2024-06-03. PMID:38830122. |
our results showed that taurine improved the autism-like behaviour, increased the proliferation of hippocampal cells, promoted pten expression, and reduced phosphorylation of mtor and akt in hippocampal tissue of the btbr mice. |
2024-06-03 |
2024-06-06 |
mouse |
| Yichao Liao, Feng Wei, Zhelin He, Jingxue He, Yanlin Ai, Cui Guo, Li Zhou, Dan Luo, Chengen Li, Yueqiang Wen, Jinhao Zeng, Xiao M. Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives. Frontiers in pharmacology. vol 15. 2024-05-29. PMID:38803433. |
the mechanism of action involving apoptosis induction, autophagy induction, anti-proliferation, anti-migration, and anti-drug resistance via phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor), ras/extracellular signal regulated kinases (erk)/mitogen-activated protein kinase (mapk), wnt/β-catenin, and janus kinase (jak)/signal transducer and activator of transcription (stat) pathways. |
2024-05-29 |
2024-06-03 |
human |
| Janice M Santiago-O'Farrill, Alicia Blessing Bollu, Hailing Yang, Vivian Orellana, Marc Pina, Xudong Zhang, Jinsong Liu, Robert C Bast, Zhen L. Crizotinib enhances PARP inhibitor efficacy in ovarian cancer cells and xenograft models by inducing autophagy. Molecular cancer research : MCR. 2024-05-23. PMID:38780897. |
mechanistically, the combination resulted in increased levels of reactive oxygen species (ros), induced dna damage, and decreased the phosphorylation of akt, mtor, and ulk-1, contributing to increased olaparib-induced autophagy and apoptosis. |
2024-05-23 |
2024-05-27 |
human |
| Trong Thuan Ung, Christopher R Starr, Assylbek Zhylkibayev, Irina Saltykova, Marina Gorbatyu. Development of TRIB3-Based Therapy as a Gene-Independent Approach to Treat Retinal Degenerative Disorders. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731938. |
trib3 has been recognized as a key mediator of the perk upr arm, influencing various metabolic pathways, such as insulin signaling, lipid metabolism, and glucose homeostasis, by acting as an akt pseudokinase that prevents the activation of the akt → mtor axis. |
2024-05-11 |
2024-05-27 |
mouse |
| Fatemeh Sadat Hosseini, Abdolreza Ahmadi, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebka. Regulatory effects of statins on Akt signaling for prevention of cancers. Cellular signalling. vol 120. 2024-05-11. PMID:38729324. |
akt signaling plays a crucial role in key cancer cell features like proliferation, invasion, and apoptosis by activating multiple effectors in downstream pathways such as foxo, pten, nf-κb, gsk3β, and mtor. |
2024-05-11 |
2024-05-27 |
Not clear |
| Kayisaier Abudurousuli, Meng-Yuan Han, Sendaer Hailati, Nulibiya Maihemuti, Ziruo Talihati, Nuerbiye Nueraihemaiti, Dilihuma Dilimulati, Alehaer Baishan, Alifeiye Aikebaier, Wen-Ting Zho. [Total polyphenols of Cydonia oblonga inhibited proliferation and migration of renal cancer cells by PI3K/Akt/mTOR pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621912. |
additionally, tpcom at concentrations of 40, 80, and 160 μg·ml~(-1) was applied to kidney cancer cells to assess its effect on cell migration and its regulation of protein expression levels related to the protein kinase b(akt), mammalian target of rapamycin(mtor), and phosphoinositide 3-kinase(pi3k) signaling pathways. |
2024-04-15 |
2024-04-18 |
Not clear |
| Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Apirath Wangteeraprasert, Worasak Kaewkong, Julintorn Somran, Naphat Kaewpaeng, Supawadee Parhira, Piyarat Srisawan. Combination of ethyl acetate fraction from Calotropis gigantea stem bark and sorafenib induces apoptosis in HepG2 cells. PloS one. vol 19. issue 3. 2024-03-25. PMID:38527038. |
reactive oxygen species (ros) levels were assessed in combination with the expression of the phosphatidylinositol-3-kinase (pi3k)/ protein kinase b (akt)/ mammalian target of rapamycin (mtor) pathway, which was suggested for association with ros-induced apoptosis. |
2024-03-25 |
2024-03-28 |
Not clear |
| Liqiao Chen, Liangliang Wang, Zongqi Han, Peng Qin, Guangxu Niu, Jingxia D. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. The Tohoku journal of experimental medicine. vol 262. issue 3. 2024-03-18. PMID:38123304. |
then, sphk1/2 activity, cell viability, proliferation, apoptosis, invasion, and protein expressions of phosphorylated-protein kinase b (p-akt), akt, phosphorylated-mammalian target of rapamycin (p-mtor) and mtor were detected. |
2024-03-18 |
2024-03-20 |
Not clear |
| Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Chia-Hsun Hsieh, Jih-Hwa Gu. Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway. Oncology letters. vol 27. issue 4. 2024-03-08. PMID:38455663. |
in conclusion, the present study demonstrated that doxazosin displayed anti-vm activity in an nsclc cell model through the downregulation of vegf-a and ve-cadherin levels, and the suppression of signaling pathways related to the receptor tyrosine kinase, epha2, protein kinases, akt and mtor, and proteases, mmp-2 and mmp-9. |
2024-03-08 |
2024-03-10 |
human |
| Bahareh Shateri Amiri, Neda Sabernia, Behdokht Abouali, Parya Amini, Hadi Rezaeeya. Evaluation of MicroRNA as Minimal Residual Disease in Leukemia: Diagnostic and Prognostic Approach: A Review. Iranian journal of public health. vol 52. issue 12. 2024-03-04. PMID:38435763. |
among the studied mirnas, mir-99a, and mir-181a play an essential role in apoptosis, proliferation and oncogenesis via akt, mapk, ras, and mtor signaling pathways. |
2024-03-04 |
2024-03-06 |
Not clear |
| Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Rigant. The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition. Translational oncology. vol 43. 2024-02-27. PMID:38412661. |
roginolisib induced apoptosis in mpm cells and enhanced the anti-tumor efficacy of akt and mtor kinase inhibitors by suppressing pi3k-δ/akt/mtor and erk1/2 signaling. |
2024-02-27 |
2024-03-01 |
Not clear |
| Qiushi Xu, Yunhui Fan, John Mauck, Juan J Loor, Xudong Sun, Hongdou Jia, Xinwei Li, Chuang X. Role of diacylglycerol O-acyltransferase 1 (DGAT1) in lipolysis and autophagy of adipose tissue from ketotic dairy cows. Journal of dairy science. 2024-02-23. PMID:38395404. |
furthermore, when adipocytes isolated from the harvested adipose tissue of 15 healthy cows were transfected with dgat1 overexpression adenovirus or dgat1 small interfering rna followed by exposure to epinephrine (epi), it led to greater ratios and protein abundance of phosphorylated hormone-sensitive triglyceride lipase (lipe) to total lipe and adipose triglyceride lipase (atgl), while inhibiting the protein phosphorylation levels of ulk1, pi3k, akt and mtor. |
2024-02-23 |
2024-02-26 |
cattle |
| Jina Jiang, Tingting Qi, Li Li, Yunzhi Pan, Lijuan Huang, Lijuan Zhu, Dongyang Zhang, Xiaoqing Ma, Yinghui Qi. MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-02-21. PMID:38381220. |
in cells treated with the specific pi3k/akt/mtor inhibitor ly294002, phosphorylation levels of akt and mtor were decreased, cell viability decreased, and apoptosis increased compared to the mrps9 overexpression group. |
2024-02-21 |
2024-02-23 |
mouse |
| Renuga Devi Navaneethan, Packia Lekshmi N C J, Mariselvam Ramaiah, Rajeswari Ravindran, Ananth Kumar S, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Ananthi Sivagnanam, Ponnanikajamideen Mohemedibrahi. Caralluma pauciflora based Ag-NPs activate ROS - induced apoptosis through down-regulation of AKT, mTOR and pI3K signaling in human Gastric Cancer (AGS) cells. Nanotechnology. 2024-02-06. PMID:38320329. |
caralluma pauciflora based ag-nps activate ros - induced apoptosis through down-regulation of akt, mtor and pi3k signaling in human gastric cancer (ags) cells. |
2024-02-06 |
2024-02-09 |
human |
| Stuti Bhagat, Sanjay Sing. Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells. Biomedical materials (Bristol, England). 2024-01-12. PMID:38215478. |
other cellular events such as caspase-7 overexpression and pi3k, akt, parp, and mtor inhibition led to the apoptosis in hepatic cancer cells. |
2024-01-12 |
2024-01-15 |
Not clear |