| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. |
2013-10-17 |
2023-08-12 |
rat |
| Nobuhiro Nagai, Koichiro Watanab. [Olanzapine]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 4. 2013-09-25. PMID:23678597. |
olanzapine has various affinities for multiple receptors, including dopamine d2 receptor, serotonin 5-ht2a, 5-ht2c, 5-ht6 receptors, and adrenaline alpha1, histamine h1, muscarine m1-m5 receptors as well. |
2013-09-25 |
2023-08-12 |
Not clear |
| Tania Vitalis, Mark S Ansorge, Alexandre G Daye. Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes. Frontiers in cellular neuroscience. vol 7. 2013-06-27. PMID:23801939. |
serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-ht3a and 5-ht6 receptor subtypes. |
2013-06-27 |
2023-08-12 |
human |
| Ayaka Tatara, Saki Shimizu, Noriyuki Shin, Maho Sato, Tomone Sugiuchi, Junta Imaki, Yukihiro Ohn. Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22542492. |
in addition, 5-ht2a/2c, 5-ht3 and 5-ht6 receptors seem to be responsible for the augmentation of antipsychotic-induced eps by serotonin reuptake inhibitors. |
2013-01-21 |
2023-08-12 |
mouse |
| Ramakrishna V S Nirogi, Ramasastri Kambhampati, Prabhakar Kothmirkar, Jagadishbabu Konda, Thrinath Reddy Bandyala, Parandhama Gudla, Sobhanadri Arepalli, Narasimhareddy P Gangadasari, Anil K Shinde, Amol D Deshpande, Adireddy Dwarampudi, Anil K Chindhe, Pramod Kumar Dube. Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands. Journal of enzyme inhibition and medicinal chemistry. vol 27. issue 3. 2012-11-19. PMID:21774748. |
synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-ht6 receptor ligands. |
2012-11-19 |
2023-08-12 |
Not clear |
| Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Tsuyoshi Kitajima, Toshiya Inada, Norio Ozaki, Giovanna M Musso, John M Kane, Christoph U Correll, Nakao Iwat. Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis. Human psychopharmacology. vol 27. issue 1. 2012-06-29. PMID:22745941. |
several lines of evidence suggest that genetic alterations in serotonin 6 (5-ht6) receptors might be associated with the pathophysiology of schizophrenia. |
2012-06-29 |
2023-08-12 |
Not clear |
| Alfredo Meneses, Georgina Pérez-García, Teresa Ponce-Lopez, Carlos Castill. 5-HT6 receptor memory and amnesia: behavioral pharmacology--learning and memory processes. International review of neurobiology. vol 96. 2012-01-05. PMID:21329783. |
growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-ht6) improve memory and reverse amnesia, although the mechanisms involved are poorly understood. |
2012-01-05 |
2023-08-12 |
human |
| Fei Liu, Vattoly J Majo, Jaya Prabhakaran, Matthew S Milak, J John Mann, Ramin V Parsey, J S Dileep Kuma. Synthesis and in vivo evaluation of [O-methyl-11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide as an imaging probe for 5-HT6 receptors. Bioorganic & medicinal chemistry. vol 19. issue 17. 2011-12-20. PMID:21821420. |
the serotonin receptor 6 (5-ht(6)) is implicated in the pathophysiology of cognitive diseases, schizophrenia, anxiety and obesity and in vivo studies of this receptor would be of value for studying the pathophysiology of these disorders. |
2011-12-20 |
2023-08-12 |
Not clear |
| D Marazziti, S Baroni, M Catena Dell'Osso, F Bordi, F Borsin. Serotonin receptors of type 6 (5-HT6): what can we expect from them? Current medicinal chemistry. vol 18. issue 18. 2011-09-26. PMID:21649582. |
serotonin receptors of type 6 (5-ht6): what can we expect from them? |
2011-09-26 |
2023-08-12 |
Not clear |
| D Marazziti, S Baroni, M Catena Dell'Osso, F Bordi, F Borsin. Serotonin receptors of type 6 (5-HT6): what can we expect from them? Current medicinal chemistry. vol 18. issue 18. 2011-09-26. PMID:21649582. |
the serotonin (5-ht) receptors of type 6 (5-ht6) are relatively new. |
2011-09-26 |
2023-08-12 |
Not clear |
| Virginie Da Silva Costa-Aze, François Dauphin, Michel Boulouar. Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21443908. |
serotonin 5-ht6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. |
2011-09-02 |
2023-08-12 |
mouse |
| Concetta Crisafulli, Chiara Fabbri, Stefano Porcelli, Antonio Drago, Edoardo Spina, Diana De Ronchi, Alessandro Serrett. Pharmacogenetics of antidepressants. Frontiers in pharmacology. vol 2. 2011-07-14. PMID:21687501. |
they include the cytochrome p450 superfamily, the p-glycoprotein (abcb1), the tryptophan hydroxylase, the catechol-o-methyltransferase, the monoamine oxidase a, the serotonin transporter (5-httlpr), the norepinephrine transporter, the dopamine transporter, variants in the 5-hydroxytryptamine receptors (5-ht1a, 5-ht2a, 5-ht3a, 5-ht3b, and 5-ht6), adrenoreceptor beta-1 and alpha-2, the dopamine receptors (d2), the g protein beta 3 subunit, the corticotropin releasing hormone receptors (crhr1 and crhr2), the glucocorticoid receptors, the c-amp response-element binding, and the brain-derived neurotrophic factor. |
2011-07-14 |
2023-08-12 |
human |
| Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Kunihiro Kawashima, Hiroshi Naitoh, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwat. Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population. Drug and alcohol dependence. vol 113. issue 1. 2011-06-28. PMID:20705401. |
the serotonin 6 (5-ht6) receptor is therapeutically targeted by several second generation antipsychotics, such as clozapine and olanzapine, and d-amphetamine-induced hyperactivity in rats is corrected with the use of a selective 5-ht6 receptor antagonist. |
2011-06-28 |
2023-08-12 |
rat |
| Andreas Gravius, Judit Laszy, Malgorzata Pietraszek, Katalin Sághy, Jens Nagel, Caroline Chambon, Nico Wegener, Barbara Valastro, Wojciech Danysz, István Gyertyá. Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behavioural pharmacology. vol 22. issue 2. 2011-06-27. PMID:21301322. |
5-hydroxytryptamine 6 (5-ht6) receptors are involved in learning and memory processes and are discussed as promising targets for the treatment of cognitive impairment in central nervous system disorders. |
2011-06-27 |
2023-08-12 |
human |
| Alexandre V Ivachtchenko, Elena S Golovina, Madina G Kadieva, Angela G Koryakova, Oleg D Mitkin, Sergey E Tkachenko, Volodymyr M Kysil, Ilya Oku. 2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists. European journal of medicinal chemistry. vol 46. issue 4. 2011-06-06. PMID:21333408. |
2-substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-ht6 receptor antagonists. |
2011-06-06 |
2023-08-12 |
Not clear |
| Alexandre V Ivachtchenko, Elena S Golovina, Madina G Kadieva, Volodymyr M Kysil, Oleg D Mitkin, Sergey E Tkachenko, Ilya Oku. Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists. Bioorganic & medicinal chemistry. vol 19. issue 4. 2011-05-20. PMID:21277782. |
synthesis and sar of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-ht6 receptor antagonists. |
2011-05-20 |
2023-08-12 |
Not clear |
| V Valentini, R Frau, F Bordi, F Borsini, G Di Chiar. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21185318. |
the function of 5-ht6 receptors, one of the last additions to the large family of 5-ht receptors, is largely unknown due to the limited knowledge of their transduction mechanisms, lack of full centrally acting agonists and inconsistencies in the pharmacological and neurochemical effects of the antagonists. |
2011-05-12 |
2023-08-12 |
Not clear |
| N Krogsgaard-Larsen, A A Jensen, J Kehle. Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. Bioorganic & medicinal chemistry letters. vol 20. issue 18. 2010-12-28. PMID:20719507. |
novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-ht2c and 5-ht6 receptor ligands. |
2010-12-28 |
2023-08-12 |
Not clear |
| Taro Kishi, Yasuhisa Fukuo, Reiji Yoshimura, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Naitoh, Wakako Umene-Nakano, Jun Nakamura, Norio Ozaki, Nakao Iwat. Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population. Human psychopharmacology. vol 25. issue 6. 2010-12-14. PMID:20737521. |
several investigations have suggested that alterations in serotonin 6 (5-ht6) receptors might be associated with the pathophysiology of major depressive disorder (mdd), and that 5-ht6 receptors might be a therapeutic target for serotonin selective reuptake inhibitor (ssri) in mdd. |
2010-12-14 |
2023-08-12 |
Not clear |
| Alexandre V Ivachtchenko, Elena S Golovina, Madina G Kadieva, Angela G Koryakova, Sergiy M Kovalenko, Oleg D Mitkin, Ilya M Okun, Irina M Ravnyeyko, Sergey E Tkachenko, Oleg V Zaremb. Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists. Bioorganic & medicinal chemistry. vol 18. issue 14. 2010-11-23. PMID:20541425. |
synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-ht6 receptor antagonists. |
2010-11-23 |
2023-08-12 |
Not clear |