| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Min Xiao, Peng-Fei Li, Xue-Jiao Ma, Xing-Ke Yan, Chong-Bing M. Research progress of acupuncture regulating ERK signaling pathway in the treatment of depression. Zhen ci yan jiu = Acupuncture research. vol 49. issue 5. 2024-05-19. PMID:38764124. |
this article reviewed and summarized the research progress on the regulation of the erk signaling pathway by acupuncture in the treatment of depression in recent years, focusing on the physiological activation and regulatory mechanism of the erk signaling pathway, its association with the occurrence of depression, and the mechanisms through which acupuncture activates the erk signaling pathway to treat depression (including enhancing neuronal synaptic plasticity, promoting the release of neurotrophic factors, and inhibiting neuronal apoptosis). |
2024-05-19 |
2024-05-27 |
Not clear |
| Guopeng Chen, Yuhui Zhang, Ruiling Li, Liuyin Jin, Keke Hao, Jingtong Rong, Hao Duan, Yiwei Du, Lihua Yao, Dan Xiang, Zhongchun Li. Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity. Neurobiology of stress. vol 30. 2024-03-25. PMID:38524250. |
maternal rats subjected to ms developed depression-like behavior and cognitive dysfunction together with evidence of significant neuroinflammation including microglia activation, neuronal apoptosis, and impaired synaptic plasticity. |
2024-03-25 |
2024-03-27 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
histological analysis focused on gfap and glt-1 expression, synaptic plasticity, apoptosis and pi3k/akt/creb pathway-related proteins. |
2023-12-30 |
2024-01-05 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
these results suggest that rtms treatment ameliorates depression-like behaviors in the rat model by reversing the reduction of glt-1 on astrocytes and reducing glutamate accumulation in the synaptic cleft, which in turn ameliorates synaptic plasticity damage and neuronal apoptosis. |
2023-12-30 |
2024-01-05 |
rat |
| Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kon. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114205. |
puerarin can ameliorate cholinergic nervous system disorders, reduce excitotoxicity, anti-inflammation, inhibit apoptosis, alleviate oxidative stress injury, enhance synaptic plasticity, up-regulate neuroprotective factor expression, promote cerebral circulation metabolism, and mitigate aβ injury. |
2023-12-19 |
2023-12-23 |
Not clear |
| Ting Zhu, Hui Liu, Shiman Gao, Ning Jiang, Shuai Chen, Weijie Xi. Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-13. PMID:38091637. |
herein, we systematically summarise, analyse and discuss the therapeutic effects of salidroside in the prevention and treatment of psychiatric sequelae as well as its roles in preventing the progression of mental disorders, and fully clarify the potential of salidroside as a widely applicable agent for preventing mental disorders caused by stress; the mechanisms underlying the potential protective effects of salidroside are involved in the regulation of the oxidative stress, neuroinflammation, neural regeneration and cell apoptosis in the brain, the network homeostasis of neurotransmission, hpa axis and cholinergic system, and the improvement of synaptic plasticity. |
2023-12-13 |
2023-12-17 |
Not clear |
| Ruyu Wang, Yiwei Chen, Zhiying Wang, Baorui Cao, Jinxin Du, Tingting Deng, Meina Yang, Jinxiang Ha. Antidepressant effect of licorice total flavonoids and liquiritin: A review. Heliyon. vol 9. issue 11. 2023-12-11. PMID:38074876. |
studies have shown that lf and liquiritin can exert their antidepressant effects by improving depressive behavior, regulating endocrine and hypothalamic-pituitary-adrenal (hpa) axis function, affecting the brain-derived neurotrophic factor (bdnf)/tyrosine kinase b (trkb) signaling pathway, enhancing synaptic plasticity, increasing monoamine neurotransmitter levels, protecting nerve cells, reducing inflammation, preventing apoptosis, reducing oxidation and other ways. |
2023-12-11 |
2023-12-17 |
Not clear |
| Bingge Zhang, Huali Wan, Maimaitijian Maierwufu, Qian Liu, Ting Li, Ye He, Xin Wang, Gongping Liu, Xiaoyue Hong, Qiong Fen. STAT3 ameliorates truncated tau-induced cognitive deficits. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843229. |
evidence suggests that signal transduction and activator of transcription-3 (stat3) is associated with modulating synaptic plasticity, cell apoptosis, and cognitive function. |
2023-10-16 |
2023-11-08 |
mouse |
| Xing-Dong Chen, Jing-Xiang Wei, Hai-Yan Wang, Yu-Yuan Peng, Can Tang, Yang Ding, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats. Neuropharmacology. 2023-09-24. PMID:37742716. |
in conclusion, our results demonstrated that sal could attenuate sps-induced ptsd-like behaviors by inhibiting hippocampal neuronal apoptosis, enhancing hippocampal synaptic plasticity, and reducing neuroinflammatory responses. |
2023-09-24 |
2023-10-07 |
rat |
| Seyed Khalil Rashidi, Ata Kalirad, Shahram Rafie, Ebrahim Behzad, Mitra Ansari Dezfoul. The role of microRNAs in neurobiology and pathophysiology of the hippocampus. Frontiers in molecular neuroscience. vol 16. 2023-09-20. PMID:37727513. |
there is strong evidence that abnormalities in mirnas are contributed in neurodegenerative mechanisms in the hippocampus through imbalanced activity of ion channels, neuronal excitability, synaptic plasticity and neuronal apoptosis. |
2023-09-20 |
2023-10-07 |
Not clear |
| Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Y. N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype. European journal of pharmacology. 2023-09-06. PMID:37673363. |
in conclusion, the therapeutic potential of pea for depressive mood disorders may be through targeting the hippocampal neuroplasticity, including increasing adult neurogenesis and synaptic plasticity, as well as down-regulated neuronal apoptosis, to remodel hippocampal circuitries upon functional integration and pparα pathway may be involved in this process. |
2023-09-06 |
2023-10-07 |
rat |
| Yaoyao Ren, Shengtao Q. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023-08-24. PMID:37619620. |
these isoflavones prevent aβ aggregation, inhibit tau hyperphosphorylation, increase cholinergic neurotransmitter levels, reduce neuroinflammation and oxidative stress, improve synaptic plasticity, promote nerve regeneration, and prevent apoptosis. |
2023-08-24 |
2023-09-07 |
Not clear |
| Hao Lv, Ziang Gao, Yunfei Wang, Siyuan Chen, Peiqiang Liu, Yulie Xie, Mengting Guan, Jianchao Cong, Yu X. Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage. Neurochemical research. 2023-08-13. PMID:37574530. |
in addition, the levels of expression of synaptic plasticity markers (anti-microtubule-associated protein 2, synaptophysin, postsynaptic density protein 95), neurogenesis markers (doublecortin and ki-67), and brain-derived neurotrophic factor were decreased in the olfactory bulb (ob) of mice with ar, while metformin ameliorated all these alterations and reduced apoptosis in the ob of these mice. |
2023-08-13 |
2023-08-16 |
mouse |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
these obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as tnf-α, cox-2, and caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as neun, ki-67, creb-p, and bdnf. |
2023-06-29 |
2023-08-14 |
mouse |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
prebiotics inhibit neuroinflammation, neuronal apoptosis, and reactive gliosis in the hippocampus but restore synaptic plasticity, neuronal proliferation, and neurogenesis. |
2023-06-29 |
2023-08-14 |
mouse |
| Shamprasad Varija Raghu, Avinash Kundadka Kudva, Rajanikant Golgodu Krishnamurthy, Jayesh Mudgal, Thomas George, Manjeshwar Shrinath Balig. Neuroprotective effects of dietary plants and phytochemicals against radiation-induced cognitive and behavioral deficits: a comprehensive review of evidence and prospects for future research. Food & function. 2023-06-23. PMID:37350117. |
exposure to an unsafe dose of radiation can cause increased permeability of the blood-brain barrier (bbb), neuronal apoptosis, reduced neurogenesis, impaired synaptic plasticity, and cognitive dysfunction. |
2023-06-23 |
2023-08-14 |
Not clear |
| Jiawei Zhang, Yining Xiao, Hongna Liu, Lili Xu, Xing Guo, Yaran Gao, Meixi Li, Jing Xu, Qianqian Qi, Peiyuan L. Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats. Neurochemical research. 2023-06-20. PMID:37338792. |
more and more evidence shows that the pathological mechanism of vascular dementia (vd) is closely related to oxidative stress injury, cell apoptosis, autophagy, inflammatory response, excitatory amino acid toxicity, synaptic plasticity change, calcium overload, and other processes. |
2023-06-20 |
2023-08-14 |
rat |
| Eric Mayo. Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Frontiers in aging. vol 4. 2023-06-19. PMID:37334045. |
the most researched signaling pathways (pi3k, akt, mtor, ampk, gsk3β, ulk, mapk, pgc-1α, nf-κb, sirtuins, notch, sonic hedgehog and wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. |
2023-06-19 |
2023-08-14 |
Not clear |
| Ning Jiang, Jingwei Lv, Yiwen Zhang, Xinran Sun, Caihong Yao, Qiong Wang, Qinghu He, Xinmin Li. Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats. Frontiers in pharmacology. vol 14. 2023-05-11. PMID:37168997. |
altogether, rg1 and rb1 treatment attenuated cognitive deficits induced by hls, mitigated mitochondrial dysfunction, attenuated oxidative stress, inhibited apoptosis, increased synaptic plasticity, and restored bdnf-trkb/pi3k-akt signaling. |
2023-05-11 |
2023-08-14 |
rat |