| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Payal Bajaj, Harpal Singh, Shikha Kalotra, Gurcharan Kau. Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats. Neuromolecular medicine. 2021-08-19. PMID:34410631. |
sd was observed to impair the exploratory behavior and neuromuscular coordination, whereas, b-tce pre-treatment was observed to ameliorate these behavioral functions'- impairments and further suppressed the changes in the expression of markers for synaptic plasticity, inflammation, cell survival, and apoptosis pathways. |
2021-08-19 |
2023-08-13 |
rat |
| Zaara Liaquat, Xiaoying Xu, Prince Last Mudenda Zilundu, Rao Fu, Lihua Zho. The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review. Brain sciences. vol 11. issue 7. 2021-07-27. PMID:34202110. |
mechanism studies have linked dexmedetomidine's neuroprotective properties with its modulation of neuroinflammation, apoptosis, oxidative stress, and synaptic plasticity via the α2-adrenergic receptor, dependently or independently. |
2021-07-27 |
2023-08-13 |
Not clear |
| Xiao-Chen Yu, Zhen Li, Xin-Ran Liu, Jia-Ni Hu, Rui Liu, Na Zhu, Yong L. The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients. vol 13. issue 6. 2021-07-23. PMID:34205338. |
its specific mechanism may be related to reducing the degeneration of hippocampal nerve cells, reducing the apoptosis of nerve cells, improving the activity of ache, reducing the expression of inflammatory factors (tnf-α and il-1β) in brain tissue, reducing oxidative stress injury, and improving the expression of p-camkⅡ and bdnf synaptic plasticity protein. |
2021-07-23 |
2023-08-13 |
mouse |
| Xiujun Qin, Liang Li, Xiaohan Nie, Qiao Ni. Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31845204. |
effects of chronic aluminum lactate exposure on neuronal apoptosis and hippocampal synaptic plasticity in rats. |
2021-06-18 |
2023-08-13 |
rat |
| Xiujun Qin, Liang Li, Xiaohan Nie, Qiao Ni. Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31845204. |
this study investigated the effects of chronic aluminum exposure on apoptosis of hippocampal neurons, and synaptic plasticity in the hippocampus in rats. |
2021-06-18 |
2023-08-13 |
rat |
| Xiujun Qin, Liang Li, Xiaohan Nie, Qiao Ni. Effects of Chronic Aluminum Lactate Exposure on Neuronal Apoptosis and Hippocampal Synaptic Plasticity in Rats. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31845204. |
long-term exposure to aluminum could induce the apoptosis of hippocampal neurons, damage the synaptic plasticity, and impair the learning and memory functions in rats. |
2021-06-18 |
2023-08-13 |
rat |
| Jun-Jie Tang, Shuang Feng, Xing-Dong Chen, Hua Huang, Min Mao, Hai-Yan Wang, Sen Li, Xiu-Min Lu, Yong-Tang Wan. The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity. Current pharmaceutical design. vol 27. issue 4. 2021-04-26. PMID:32938344. |
the effects of p75ntr on learning memory mediated by hippocampal apoptosis and synaptic plasticity. |
2021-04-26 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Sharifa Hasana, Jamil Ahmad, Md Farhad Hossain, Md Mosiqur Rahman, Tapan Behl, Abdur Rauf, Ausaf Ahmad, Abdul Hafeez, Asma Perveen, Ghulam Md Ashra. Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease. Current pharmaceutical design. vol 27. issue 3. 2021-04-26. PMID:33213314. |
aβ can induce apoptosis, trigger an inflammatory response, and inhibit the synaptic plasticity of the hippocampus, which ultimately contributes to reducing cognitive functions and memory impairment. |
2021-04-26 |
2023-08-13 |
Not clear |
| Huang Kuang, Zhi-Feng Zhou, Yu-Ge Zhu, Zhi-Kai Wan, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yan. Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective. Aging and disease. vol 12. issue 1. 2021-02-06. PMID:33532143. |
this review summarizes the current status of pharmacological treatment for vad, from the perspective of the molecular mechanisms specified in various pathogenic hypotheses, including oxidative stress, the central cholinergic system, neuroinflammation, neuronal apoptosis, and synaptic plasticity. |
2021-02-06 |
2023-08-13 |
Not clear |
| Yang-Yang Song, Wen-Tao Xu, Xin-Chang Zhang, Guang-Xia N. Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies. Chinese journal of integrative medicine. vol 26. issue 6. 2020-12-04. PMID:32318906. |
four mechanisms of ea were studied: (1) protection of cerebral neurons from oxidative stress, apoptosis, neuroinflammation, synaptic plasticity and hormone levels; (2) regulation of metabolism, including glucose metabolism and plasma metabolism; (3) regulation of brain-derived neurotrophic factor; and (4) regulation of β-amyloid peptide protein deposition. |
2020-12-04 |
2023-08-13 |
Not clear |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
neuroprotection of the developing brain by dexmedetomidine is mediated by attenuating single propofol-induced hippocampal apoptosis and synaptic plasticity deficits. |
2020-11-14 |
2023-08-13 |
rat |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
after a single propofol exposure to p7 rats, dex pretreatment effectively rescued the profound apoptosis seen in hippocampal neurocytes, and strongly reversed the aberrant expression levels of bcl2-like 1 (bcl2l1), matrix metallopeptidase 9 (mmp-9) and cleaved caspase 3 (cc3), and sharply enhanced synaptic plasticity. |
2020-11-14 |
2023-08-13 |
rat |
| Hui Zhao, Yan Feng, Changjuan Wei, Yan Li, Hongshan Ma, Xuejiao Wang, Zhigang Cui, Wei-Na Jin, Fu-Dong Sh. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience. vol 416. 2020-09-24. PMID:31374230. |
colivelin is a neuroprotective humanin family peptide with potent long-term capacity against aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. |
2020-09-24 |
2023-08-13 |
mouse |
| Zahra Gholamnezhad, Mohammad Hossien Boskabady, Zahra Jahangir. Exercise and Dementia. Advances in experimental medicine and biology. vol 1228. 2020-08-12. PMID:32342466. |
the main positive effects suggested for exercise are less cognitive and behavioral impairment or decline, development of health-associated conditions (stress, sleep), reduction of dementia risk factors including chronic non-communicable disease (diabetes, cardiovascular disease), increase in neurotrophins, enhancement of brain blood flow, angiogenesis, neurogenesis, synaptogenesis and synaptic plasticity in the brain memory-related region (e.g., hippocampus), and reduction of neuroinflammation and apoptosis. |
2020-08-12 |
2023-08-13 |
human |
| Xiaolu Liu, Zhitao Feng, Lipeng Du, Yaguang Huang, Jinwen Ge, Yihui Deng, Zhigang Me. The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury. International journal of molecular sciences. vol 21. issue 1. 2020-05-07. PMID:31878035. |
paradoxically, mir-124 exerts beneficial effects in the age-related ie via regulating autophagy, neuroinflammation, oxidative stress, neuronal excitability, neurodifferentiation, aβ deposition, and hyperphosphorylation of tau protein, while it may play a dual role via regulating apoptosis and exerts detrimental effects on synaptic plasticity and axonal growth. |
2020-05-07 |
2023-08-13 |
Not clear |
| Mohammad Shabani, Fariba Ebrahimpoor, Maryam Arab Firouzjaei, Leila Kamali, Seyed Mostafa Shid Moosavi, Ali Noorafshan, Masoud Haghan. Modulation of sphingosine-1-phosphate receptor by FTY720 contributes in improvement of hepatic encephalopathy induced by bile duct ligation. Brain research bulletin. vol 146. 2020-03-10. PMID:30660717. |
the bdl led to considerable loss of hippocampal neurons and apoptosis, along with large impairments in their intrinsic electrophysiological properties, including decrease of firing frequency and increases of first spike latency (fsl), ahp amplitude, irregularity of firing, and half-width, as well as impaired long-term synaptic plasticity and memory. |
2020-03-10 |
2023-08-13 |
Not clear |
| Ahmad H Alhowail, Jenna Bloemer, Mohammed Majrashi, Priyanka D Pinky, Subhrajit Bhattacharya, Zhang Yongli, Dwipayan Bhattacharya, Matthew Eggert, Lauren Woodie, Manal A Buabeid, Nathaniel Johnson, Alyssa Broadwater, Bruce Smith, Muralikrishnan Dhanasekaran, Robert D Arnold, Vishnu Suppiramania. Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation. Toxicology mechanisms and methods. vol 29. issue 6. 2019-12-18. PMID:31010378. |
doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation. |
2019-12-18 |
2023-08-13 |
Not clear |
| Yu-Hao Zhao, Tie-Feng Ji, Qi Luo, Jin-Lu Y. Long non-coding RNA H19 induces hippocampal neuronal apoptosis Oncotarget. vol 8. issue 39. 2019-11-20. PMID:29029394. |
long non-coding rna h19 induces hippocampal neuronal apoptosis defects in hippocampal synaptic plasticity and disorders of memory and learning are the central nervous system complications of diabetes mellitus (dm). |
2019-11-20 |
2023-08-13 |
rat |
| G Gordo, J Tenorio, P Arias, F Santos-Simarro, S García-Miñaur, J C Moreno, J Nevado, E Vallespin, L Rodriguez-Laguna, R de Mena, I Dapia, M Palomares-Bralo, Á Del Pozo, K Ibañez, J C Silla, E Barroso, V L Ruiz-Pérez, V Martinez-Glez, P Lapunzin. mTOR mutations in Smith-Kingsmore syndrome: Four additional patients and a review. Clinical genetics. vol 93. issue 4. 2019-09-30. PMID:28892148. |
the mtor gene is a key regulator of cell growth, cell proliferation, protein synthesis and synaptic plasticity, and the mtor pathway (pi3k-akt-mtor) is highly regulated and critical for cell survival and apoptosis. |
2019-09-30 |
2023-08-13 |
Not clear |
| Yi-Xuan Li, Zi-He Ye, Tong Chen, Xiao-Feng Jia, Ling H. The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30218672. |
moreover, donepezil can also improve pcp-induced schizophrenia-like cognitive deficits by inhibiting neuronal apoptosis and regulating synaptic plasticity, which was possible through the up-regulation of p-akt, p-gsk-3β, bcl-2 and the down-regulation of bax, caspase-3. |
2019-09-30 |
2023-08-13 |
mouse |