| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucia Guerri, Lauren K Dobbs, Daniel A da Silva E Silva, Allen Meyers, Aaron Ge, Lea Lecaj, Caroline Djakuduel, Damien Islek, Dionisio Hipolito, Abdiel Badillo Martinez, Pei-Hong Shen, Cheryl A Marietta, Susanna P Garamszegi, Enrico Capobianco, Zhijie Jiang, Melanie Schwandt, Deborah C Mash, Veronica A Alvarez, David Goldma. Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons. Biological psychiatry global open science. vol 3. issue 4. 2023-10-26. PMID:37881572. |
a salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. |
2023-10-26 |
2023-11-08 |
Not clear |
| Kristin M Scaplen, Karla R Kau. Dopamine determines how reward overrides risk. Nature. 2023-10-25. PMID:37880521. |
dopamine determines how reward overrides risk. |
2023-10-25 |
2023-11-08 |
Not clear |
| Kevin Lloyd, Peter Daya. Reframing dopamine: A controlled controller at the limbic-motor interface. PLoS computational biology. vol 19. issue 10. 2023-10-17. PMID:37847681. |
in particular, when instrumental and pavlovian influences come into conflict, dopamine levels might be affected by the controlled deployment of a reframing mechanism that recasts the prospect of possible punishment as an opportunity to approach safety, and the prospect of future reward in terms of a possible loss of that reward. |
2023-10-17 |
2023-11-08 |
Not clear |
| Rami Hamati, Jessica Ahrens, Cecelia Shvetz, Matthew R Holahan, Lauri Tuomine. 65 years of research on dopamine's role in classical fear conditioning and extinction: A systematic review. The European journal of neuroscience. 2023-10-17. PMID:37848184. |
dopamine, a catecholamine neurotransmitter, has historically been associated with the encoding of reward, whereas its role in aversion has received less attention. |
2023-10-17 |
2023-11-08 |
Not clear |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
neuronal circuits of the basal ganglia have been strongly implicated in action selection, as well as the learning and execution of goal-directed behaviors, with accumulating evidence supporting the hypothesis that midbrain dopamine neurons might encode a reward signal useful for learning. |
2023-10-16 |
2023-11-08 |
Not clear |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
the increase of striatal dopamine accompanying an unexpected reward activates dopamine type 1 receptors (d1rs) initiating a signaling cascade that promotes long-term potentiation of recently active glutamatergic input onto striatonigral neurons. |
2023-10-16 |
2023-11-08 |
Not clear |
| Liang Gong, Kang Chen, Hongyu Zhang, Shang Zhang, Ronghua Xu, Duan Liu, Bei Zhang, Siyi Yu, Chunhua X. Dopamine multilocus genetic profile influence on reward network in chronic insomnia disorder with depression. Sleep medicine. vol 112. 2023-10-15. PMID:37839273. |
dopamine multilocus genetic profile influence on reward network in chronic insomnia disorder with depression. |
2023-10-15 |
2023-11-08 |
Not clear |
| Hao Guo, Jintao Guo, Zihang Gao, Fei Luo, Enming Zhan. The role of amygdala-ventral pallidum pathway in depression-like behaviors in male mice. Journal of neuroscience research. 2023-10-10. PMID:37814992. |
depressive symptoms, such as anhedonia are largely caused by dysfunction in the brain's reward system, in which the ventral pallidum (vp) participates in by controlling dopamine release. |
2023-10-10 |
2023-10-15 |
mouse |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
arousal, locomotion, cognition, reward, and other neurobiological functions are all regulated by dopamine and its receptors. |
2023-10-03 |
2023-10-07 |
Not clear |
| John D Salamone, Mercè Corre. The Neurobiology of Activational Aspects of Motivation: Exertion of Effort, Effort-Based Decision Making, and the Role of Dopamine. Annual review of psychology. 2023-10-03. PMID:37788571. |
animal studies have challenged the general idea that dopamine (da) is best viewed as the reward transmitter and instead have illustrated the involvement of da in activational and effort-related processes. |
2023-10-03 |
2023-10-07 |
human |
| Yuji K Takahashi, Zhewei Zhang, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781610. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which errors in the prediction of reward were induced by manipulating the number or timing of the expected rewards across blocks of trials. |
2023-10-02 |
2023-10-07 |
rat |
| Lorenz Gönner, Christian Baeuchl, Franka Glöckner, Philipp Riedel, Michael N Smolka, Shu-Chen L. Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults. Cerebral cortex (New York, N.Y. : 1991). 2023-10-02. PMID:37782941. |
accumulated evidence from animal studies suggests a role for the neuromodulator dopamine in memory processes, particularly under conditions of novelty or reward. |
2023-10-02 |
2023-10-07 |
human |
| Kenneth Blum, J Wesson Ashford, Babak Kateb, Daniel Sipple, Eric Braverman, Catherine A Dennen, David Baron, Rajendra Badgaiyan, Igor Elman, Jean Lud Cadet, Panayotis K Thanos, Colin Hanna, Abdalla Bowirrat, Edward J Modestino, Vicky Yamamoto, Ashim Gupta, Thomas McLaughlin, Mlan Makale, Mark S Gol. Dopaminergic dysfunction: Role for genetic & epigenetic testing in the new psychiatry. Journal of the neurological sciences. vol 453. 2023-09-29. PMID:37774561. |
the cornerstone of this paradigm shift is the brain reward circuitry, brain stem physiology, and neurotransmitter deficits due to the effects of genetic and epigenetic insults on the interrelated cascade of neurotransmission and the net release of dopamine at the ventral tegmental area -nucleus accumbens (vta-nac) reward site. |
2023-09-29 |
2023-10-07 |
human |
| Kenneth Blum, J Wesson Ashford, Babak Kateb, Daniel Sipple, Eric Braverman, Catherine A Dennen, David Baron, Rajendra Badgaiyan, Igor Elman, Jean Lud Cadet, Panayotis K Thanos, Colin Hanna, Abdalla Bowirrat, Edward J Modestino, Vicky Yamamoto, Ashim Gupta, Thomas McLaughlin, Mlan Makale, Mark S Gol. Dopaminergic dysfunction: Role for genetic & epigenetic testing in the new psychiatry. Journal of the neurological sciences. vol 453. 2023-09-29. PMID:37774561. |
the genetic addiction risk severity (gars) test and pro-dopamine regulator nutraceutical kb220 were combined to induce "dopamine homeostasis" across the brain reward circuitry. |
2023-09-29 |
2023-10-07 |
human |
| Kenneth Blum, J Wesson Ashford, Babak Kateb, Daniel Sipple, Eric Braverman, Catherine A Dennen, David Baron, Rajendra Badgaiyan, Igor Elman, Jean Lud Cadet, Panayotis K Thanos, Colin Hanna, Abdalla Bowirrat, Edward J Modestino, Vicky Yamamoto, Ashim Gupta, Thomas McLaughlin, Mlan Makale, Mark S Gol. Dopaminergic dysfunction: Role for genetic & epigenetic testing in the new psychiatry. Journal of the neurological sciences. vol 453. 2023-09-29. PMID:37774561. |
this article aims to encourage four future actionable items: 1) the neurophysiologically accurate designation of, for example, "hyperdopameism /hyperdopameism" to replace the blaming nomenclature like alcoholism; 2) encouraging continued research into the nature of dysfunctional brainstem neurotransmitters across the brain reward circuitry; 3) early identification of people at risk for all rds behaviors as a brain check (cognitive testing); 4) induction of dopamine homeostasis using "precision behavioral management" along with the coupling of gars and precision kb220 variants; 5) utilization of promising potential treatments include neuromodulating modalities such as transmagnetic stimulation (tms) and deep brain stimulation(dbs), which target different areas of the neural circuitry involved in addiction and even neuroimmune agents like n-acetyl-cysteine. |
2023-09-29 |
2023-10-07 |
human |
| Cristina Ibáñez, Tirso Acuña, María Elena Quintanilla, Diliana Pérez-Reytor, Paola Morales, Eduardo Karahania. Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism. Antioxidants (Basel, Switzerland). vol 12. issue 9. 2023-09-28. PMID:37760061. |
this inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse. |
2023-09-28 |
2023-10-07 |
rat |
| Birgitta Dresp-Langle. From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760910. |
when "hijacked" by compulsive behaviors that affect the reward and stress centers of the brain, functional changes in the dopamine circuitry occur as the consequence of pathological brain adaptation. |
2023-09-28 |
2023-10-07 |
human |
| Birgitta Dresp-Langle. From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760910. |
this narrative review offers a spotlight view of the transition from healthy reward function, under the control of dopamine, to the progressive deregulation of this function in interactions with other brain centers and circuits, producing what may be called an anti-reward brain state. |
2023-09-28 |
2023-10-07 |
human |
| Gioia Zanfino, Concetto Puzzo, Vincenzo de Laurenzi, Walter Adrian. Characterization of Behavioral Phenotypes in Heterozygous DAT Rat Based on Pedigree. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37761006. |
dopamine is an essential neurotransmitter whose key roles include movement control, pleasure and reward, attentional and cognitive skills, and regulation of the sleep/wake cycle. |
2023-09-28 |
2023-10-07 |
rat |
| Czarina Evangelista, Norhan Mehrez, Esthelle Ewusi Boisvert, Wayne G Brake, Peter Shizga. The priming effect of rewarding brain stimulation in rats depends on both the cost and strength of reward but survives blockade of D2-like dopamine receptors. The European journal of neuroscience. 2023-09-27. PMID:37752810. |
the priming effect of rewarding brain stimulation in rats depends on both the cost and strength of reward but survives blockade of d2-like dopamine receptors. |
2023-09-27 |
2023-10-07 |
rat |