| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martijn Figee, Tommy Pattij, Ingo Willuhn, Judy Luigjes, Wim van den Brink, Anneke Goudriaan, Marc N Potenza, Trevor W Robbins, Damiaan Deny. Compulsivity in obsessive-compulsive disorder and addictions. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 5. 2018-01-19. PMID:26774279. |
the reviewed data suggest that compulsivity in ocd and addictions is related to impaired reward and punishment processing with attenuated dopamine release in the ventral striatum, negative reinforcement in limbic systems, cognitive and behavioral inflexibility with diminished serotonergic prefrontal control, and habitual responding with imbalances between ventral and dorsal frontostriatal recruitment. |
2018-01-19 |
2023-08-13 |
Not clear |
| Nicole R Karcher, Bruce D Bartholow, Elizabeth A Martin, John G Kern. Associations between Electrophysiological Evidence of Reward and Punishment-Based Learning and Psychotic Experiences and Social Anhedonia in At-Risk Groups. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 4. 2018-01-19. PMID:27629367. |
behaviorally, consistent with increased striatal dopamine, the pe group exhibited better behavioral learning (ie, faster responses) after unexpected reward than after unexpected punishment. |
2018-01-19 |
2023-08-13 |
Not clear |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
prior cocaine experience impairs normal phasic dopamine signals of reward value in accumbens shell. |
2018-01-16 |
2023-08-13 |
rat |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
however, there is considerably less agreement on a role for dopamine in reward processing, and therefore whether neuroplastic changes in dopamine function following chronic exposure to drugs of abuse such as cocaine may impair appropriate valuation of rewarding stimuli. |
2018-01-16 |
2023-08-13 |
rat |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
to quantify this, we voltammetrically measured real-time dopamine release in the nucleus accumbens (nac) core or shell while rats received unsignaled deliveries of either a small (1 pellet) or large (2 pellets) reward. |
2018-01-16 |
2023-08-13 |
rat |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
in drug-naive controls, core dopamine signals did not discriminate between reward size at any point, while in the shell dopamine encoded magnitude differences only in a slower postpeak period. |
2018-01-16 |
2023-08-13 |
rat |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
in contrast, phasic dopamine reward signals were strongly altered by cocaine experience; core dopamine decreased peak response but increased discrimination between reward magnitudes while shell lost phasic responses to reward receipt altogether. |
2018-01-16 |
2023-08-13 |
rat |
| Michael P Saddoris, Jonathan A Sugam, Regina M Carell. Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 3. 2018-01-16. PMID:27604567. |
notably, animals with cocaine-associated alterations in dopamine signals for reward magnitude failed to subsequently discriminate between reward options. |
2018-01-16 |
2023-08-13 |
rat |
| Antony D Abraham, Kim A Neve, K Matthew Latta. Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26763483. |
we investigated whether fear and reward extinction share common mechanisms that could be enhanced with dopamine d1/5 receptor activation. |
2018-01-15 |
2023-08-13 |
Not clear |
| Antony D Abraham, Kim A Neve, K Matthew Latta. Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26763483. |
together, these findings show that dopamine d1/5 receptor activation is a target for the enhancement of fear or reward extinction. |
2018-01-15 |
2023-08-13 |
Not clear |
| Yong Sang Jo, Sheri J Y Mizumor. Prefrontal Regulation of Neuronal Activity in the Ventral Tegmental Area. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 10. 2018-01-10. PMID:26400913. |
growing evidence indicates that midbrain dopamine (da) cells integrate reward expectancy-related information from the prefrontal cortex to properly compute errors in reward prediction. |
2018-01-10 |
2023-08-13 |
rat |
| Rahul Pandit, Azar Omrani, Mieneke C M Luijendijk, Véronne A J de Vrind, Andrea J Van Rozen, Ralph J A Oude Ophuis, Keith Garner, Imre Kallo, Alexander Ghanem, Zsolt Liposits, Karl-Klaus Conzelmann, Louk J M J Vanderschuren, Susanne E la Fleur, Roger A H Ada. Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26852738. |
melanocortin 3 receptor signaling in midbrain dopamine neurons increases the motivation for food reward. |
2018-01-09 |
2023-08-13 |
rat |
| Antonia Manduca, Michela Servadio, Ruth Damsteegt, Patrizia Campolongo, Louk Jmj Vanderschuren, Viviana Trezz. Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26860202. |
nac dopamine has a well-known role in certain components of reward processes, such as incentive motivation. |
2018-01-09 |
2023-08-13 |
rat |
| Matthew Brodsky, Alec W Gibson, Denis Smirnov, Sunila G Nair, John F Neumaie. Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:27032690. |
the nucleus accumbens (nac) in the ventral striatum integrates many neurochemical inputs including dopamine and serotonin projections from midbrain nuclei to modulate drug reward. |
2018-01-09 |
2023-08-13 |
rat |
| Marcelo Febo, Kenneth Blum, Rajendra D Badgaiyan, David Baron, Panayotis K Thanos, Luis M Colon-Perez, Zsolt Demortrovics, Mark S Gol. Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome. Frontiers in bioscience (Landmark edition). vol 22. 2018-01-05. PMID:27814639. |
dopamine homeostasis: brain functional connectivity in reward deficiency syndrome. |
2018-01-05 |
2023-08-13 |
Not clear |
| Marcelo Febo, Kenneth Blum, Rajendra D Badgaiyan, David Baron, Panayotis K Thanos, Luis M Colon-Perez, Zsolt Demortrovics, Mark S Gol. Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome. Frontiers in bioscience (Landmark edition). vol 22. 2018-01-05. PMID:27814639. |
reward deficiency syndrome (rds) was first proposed by kenneth blum in 1995 to provide a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic dopamine function. |
2018-01-05 |
2023-08-13 |
Not clear |
| Marcelo Febo, Kenneth Blum, Rajendra D Badgaiyan, David Baron, Panayotis K Thanos, Luis M Colon-Perez, Zsolt Demortrovics, Mark S Gol. Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome. Frontiers in bioscience (Landmark edition). vol 22. 2018-01-05. PMID:27814639. |
a growing number of studies are helping to determine the putative roles of dopamine and glutamatergic neurotransmission in the regulation of activity in resting state networks, particularly in brain reward circuitry affected in drug use disorders. |
2018-01-05 |
2023-08-13 |
Not clear |
| Emily Barkley-Levenson, Adriana Galvá. Eye blink rate predicts reward decisions in adolescents. Developmental science. vol 20. issue 3. 2018-01-03. PMID:27061442. |
the ventral striatum displays hyper-responsiveness to reward in adolescents relative to other age groups, and animal research on the developmental trajectory of the dopaminergic system suggests that dopamine may underlie adolescent sensitivity to reward. |
2018-01-03 |
2023-08-13 |
human |
| Hailan H. Reward and Aversion. Annual review of neuroscience. vol 39. 2018-01-03. PMID:27145915. |
recent progress is pushing the boundaries of knowledge on two major fronts in research on reward and aversion: first, new layers of complexity have been reported on the functions of dopamine (da) and serotonin (5-ht) neuromodulatory systems in reward and aversion. |
2018-01-03 |
2023-08-13 |
Not clear |
| Mary R Lee, Elise M Weert. Oxytocin for the treatment of drug and alcohol use disorders. Behavioural pharmacology. vol 27. issue 8. 2018-01-03. PMID:27603752. |
ot exerts its effects through interactions with the hypothalamic-pituitary-adrenal axis and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. |
2018-01-03 |
2023-08-13 |
human |