| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linda P Dwoskin, B Matthew Joyce, Guangrong Zheng, Nichole M Neugebauer, Vamshi K Manda, Paul Lockman, Roger L Papke, Michael T Bardo, Peter A Crook. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17727820. |
one strategy is to develop subtype-selective nicotinic receptor (nachr) antagonists that inhibit nicotine-evoked dopamine (da) release, the primary neurotransmitter involved in nicotine reward. |
2007-11-06 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Zara M Fagen, Ben Chang, Robert Mitchum, Daniel S McGehe. Bupropion inhibits the cellular effects of nicotine in the ventral tegmental area. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17868653. |
many drugs of abuse, including nicotine, stimulate dopamine (da) release in the mesoaccumbens reward system. |
2007-11-06 |
2023-08-12 |
Not clear |
| Adam J Schwarz, Alessandro Gozzi, Torsten Reese, Christian A Heidbreder, Angelo Bifon. Pharmacological modulation of functional connectivity: the correlation structure underlying the phMRI response to d-amphetamine modified by selective dopamine D3 receptor antagonist SB277011A. Magnetic resonance imaging. vol 25. issue 6. 2007-11-05. PMID:17442525. |
the strongest modifications in the correlation patterns occurred in connection with the ventral tegmental area, the source of mesolimbic dopamine projections and a key substrate in the reward system. |
2007-11-05 |
2023-08-12 |
rat |
| Mahesh Menon, Jimmy Jensen, Irina Vitcu, Ariel Graff-Guerrero, Adrian Crawley, Mark A Smith, Shitij Kapu. Temporal difference modeling of the blood-oxygen level dependent response during aversive conditioning in humans: effects of dopaminergic modulation. Biological psychiatry. vol 62. issue 7. 2007-10-29. PMID:17224134. |
the prediction error (pe) hypothesized by the temporal difference model has been shown to correlate with the phasic activity of dopamine neurons during reward learning and the blood-oxygen level dependent (bold) response during reward and aversive conditioning tasks. |
2007-10-29 |
2023-08-12 |
Not clear |
| Harry N Shai. Acquisition and expression of a socially mediated separation response. Behavioural brain research. vol 182. issue 2. 2007-10-26. PMID:17379325. |
expression of potentiation is hypothesized to be related to reward processes in part because dopamine activity plays a regulatory role. |
2007-10-26 |
2023-08-12 |
rat |
| C Nordin, I Sjödi. CSF cholecystokinin, gamma-aminobutyric acid and neuropeptide Y in pathological gamblers and healthy controls. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 4. 2007-10-04. PMID:17109076. |
given that cck is a modulator of dopamine in the reward process, the increase in cck-8s and cck-4 is not unexpected. |
2007-10-04 |
2023-08-12 |
Not clear |
| E Dowd, S B Dunnet. Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions. Biochemical Society transactions. vol 35. issue Pt 2. 2007-09-27. PMID:17371292. |
the concurrence of motor performance parameters (which are considered to be dependent on striatal dopamine) and motor learning parameters (which are thought to be dependent on mesolimbocortical reward signalling) within the same task has revealed some surprising consequences of dopamine lesions and neuroprotective/neuroreparative approaches to repair in rat models of parkinson's disease. |
2007-09-27 |
2023-08-12 |
rat |
| E Dowd, S B Dunnet. Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions. Biochemical Society transactions. vol 35. issue Pt 2. 2007-09-27. PMID:17371292. |
the data generated using this task suggest that the motor deficits that occur as a consequence of dopamine lesions may be downstream of a deficit in reward signalling. |
2007-09-27 |
2023-08-12 |
rat |
| Leonid Yavich, Heikki Tanil. Mechanics of self-stimulation and dopamine release in the nucleus accumbens. Neuroreport. vol 18. issue 12. 2007-09-27. PMID:17632281. |
we suggest that dopamine release is a reliable indicator of the proximity of the stimulating electrode to the brain reward sites. |
2007-09-27 |
2023-08-12 |
mouse |
| Wolfram Schult. Multiple dopamine functions at different time courses. Annual review of neuroscience. vol 30. 2007-09-21. PMID:17600522. |
thus dopamine is involved in mediating the reactivity of the organism to the environment at different time scales, from fast impulse responses related to reward via slower changes with uncertainty, punishment, and possibly movement to the tonic enabling of postsynaptic motor, cognitive, and motivational systems deficient in parkinson's disease. |
2007-09-21 |
2023-08-12 |
Not clear |
| Matthias E Liechti, Loic Lhuillier, Klemens Kaupmann, Athina Marko. Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 34. 2007-09-11. PMID:17715344. |
metabotropic glutamate (mglu) 2/3 receptors regulate glutamate and dopamine release in the ventral tegmental area (vta) and the nucleus accumbens (nac) shell, two brain areas critically involved in reward and motivational processes. |
2007-09-11 |
2023-08-12 |
rat |
| X Coton, E Pinto, J Reggers, M Hansenne, M Parent, M Anssea. [Impact of personality on the alcohol withdrawal syndrome intensity: a preliminary study with the Cloninger's model]. L'Encephale. vol 33. issue 3 Pt 1. 2007-09-06. PMID:17675922. |
novelty seeking is linked with low levels of mesencephalic dopamine, harm avoidance with high levels of serotonin in the septo-hippocampic system and reward dependence with low levels of noradrenaline in the ascending pathways from the locus coeruleus to the limbic system. |
2007-09-06 |
2023-08-12 |
Not clear |
| David Weinshenker, Jason P Schroede. There and back again: a tale of norepinephrine and drug addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 7. 2007-08-31. PMID:17164822. |
however, reward experiments from the mid-1970s that could distinguish between the noradrenergic and dopaminergic systems resulted in the prevailing view that dopamine (da) was the primary 'reward transmitter' (a belief holding some sway still today), thereby pushing ne into the background. |
2007-08-31 |
2023-08-12 |
mouse |
| R M Costa, R Gutierrez, I E de Araujo, M R P Coelho, A D Kloth, R R Gainetdinov, M G Caron, M A L Nicolelis, S A Simo. Dopamine levels modulate the updating of tastant values. Genes, brain, and behavior. vol 6. issue 4. 2007-08-17. PMID:16848782. |
although there have been many studies investigating whether dopamine is necessary for reward, or for the association between stimuli and actions with rewards, less is known about the role of dopamine in the updating of the internal value of stimuli per se. |
2007-08-17 |
2023-08-12 |
mouse |
| R M Costa, R Gutierrez, I E de Araujo, M R P Coelho, A D Kloth, R R Gainetdinov, M G Caron, M A L Nicolelis, S A Simo. Dopamine levels modulate the updating of tastant values. Genes, brain, and behavior. vol 6. issue 4. 2007-08-17. PMID:16848782. |
these data suggest that dopamine levels can modulate the updating of tastant values, a finding with implications for understanding sensory-specific motivation and reward seeking. |
2007-08-17 |
2023-08-12 |
mouse |
| Boukje A G Dijkstra, Cor A J De Jong, Sarah M Bluschke, Paul F M Krabbe, Cees P F van der Staa. Does naltrexone affect craving in abstinent opioid-dependent patients? Addiction biology. vol 12. issue 2. 2007-08-17. PMID:17508990. |
naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. |
2007-08-17 |
2023-08-12 |
Not clear |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
cessation of nicotine administration in non-bupropion-treated rats elevated reward thresholds reflecting a reward deficit, increased somatic signs and diminished potassium-evoked dopamine overflow in the nucleus accumbens shell. |
2007-08-17 |
2023-08-12 |
human |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
chronic bupropion lowered reward thresholds and increased potassium-evoked dopamine release regardless of previous nicotine exposure, possibly by inhibition of dopamine reuptake, and thus attenuated the anhedonic and neurochemical effects of nicotine withdrawal. |
2007-08-17 |
2023-08-12 |
human |
| Masayuki Matsumoto, Okihide Hikosak. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature. vol 447. issue 7148. 2007-08-08. PMID:17522629. |
lateral habenula as a source of negative reward signals in dopamine neurons. |
2007-08-08 |
2023-08-12 |
monkey |
| Masayuki Matsumoto, Okihide Hikosak. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature. vol 447. issue 7148. 2007-08-08. PMID:17522629. |
midbrain dopamine neurons are key components of the brain's reward system, which is thought to guide reward-seeking behaviours. |
2007-08-08 |
2023-08-12 |
monkey |