| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Schult. Predictive reward signal of dopamine neurons. Journal of neurophysiology. vol 80. issue 1. 1998-08-25. PMID:9658025. |
the effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse suggest that midbrain dopamine systems are involved in processing reward information and learning approach behavior. |
1998-08-25 |
2023-08-12 |
Not clear |
| b' J Moisan, P P Rompr\\xc3\\xa. Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. Brain research. vol 786. issue 1-2. 1998-06-12. PMID:9554987.' |
electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. |
1998-06-12 |
2023-08-12 |
rat |
| b' J Moisan, P P Rompr\\xc3\\xa. Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. Brain research. vol 786. issue 1-2. 1998-06-12. PMID:9554987.' |
these results provide evidence that a subset of midbrain da neurons are trans-synaptically activated by rewarding pm stimulation and constitute a second, or subsequent, stage of the reward-relevant pathway that integrates the pm reward signal. |
1998-06-12 |
2023-08-12 |
rat |
| P G Overton, D Clar. Burst firing in midbrain dopaminergic neurons. Brain research. Brain research reviews. vol 25. issue 3. 1998-04-29. PMID:9495561. |
midbrain dopaminergic (da) neurons fire bursts of activity in response to sensory stimuli, including those associated with primary reward. |
1998-04-29 |
2023-08-12 |
rat |
| C R Gallistel, M Leon, B T Lim, J C Sim, M Waraczynsk. Destruction of the medial forebrain bundle caudal to the site of stimulation reduces rewarding efficacy but destruction rostrally does not. Behavioral neuroscience. vol 110. issue 4. 1997-01-17. PMID:8864268. |
it is suggested that the reward fibers are collaterals from neurons with both their somata and their behaviorally significant terminals located primarily in the midbrain. |
1997-01-17 |
2023-08-12 |
rat |
| b' R M Anderson, M D Fatigati, P P Rompr\\xc3\\xa. Estimates of the axonal refractory period of midbrain dopamine neurons: their relevance to brain stimulation reward. Brain research. vol 718. issue 1-2. 1996-11-25. PMID:8773768.' |
estimates of the axonal refractory period of midbrain dopamine neurons: their relevance to brain stimulation reward. |
1996-11-25 |
2023-08-12 |
rat |
| M Kimur. Role of basal ganglia in behavioral learning. Neuroscience research. vol 22. issue 4. 1995-12-14. PMID:7478299. |
for instance, midbrain dopamine neurons respond to external sensory stimuli or reward only during early stages of learning motor tasks. |
1995-12-14 |
2023-08-12 |
Not clear |
| A Heinz, L G Schmidt, F M Reischie. Anhedonia in schizophrenic, depressed, or alcohol-dependent patients--neurobiological correlates. Pharmacopsychiatry. vol 27 Suppl 1. 1995-01-04. PMID:7984706. |
these symptoms may be caused by a functional deficit of dopaminergic transmission in the dopaminergic reward system, ascending from the mesencephalon to the ventral striatum (nucleus accumbens). |
1995-01-04 |
2023-08-12 |
Not clear |
| J Grenhoff, M Nisell, S Ferré, G Aston-Jones, T H Svensso. Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat. Journal of neural transmission. General section. vol 93. issue 1. 1993-10-20. PMID:8373553. |
the influence from the locus coeruleus on midbrain dopamine neurons could be important in behavioural situations involving novelty and reward, and might also be of importance for the actions of psychotropic drugs. |
1993-10-20 |
2023-08-12 |
rat |
| G Elliso. Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus. Brain research. vol 598. issue 1-2. 1993-02-25. PMID:1486500. |
this finding supports a rich literature on the involvement of these same pathways in the actions of dopamine agonists, reward mechanisms, and the integration of limbic, extrapyramidal, and midbrain centers. |
1993-02-25 |
2023-08-11 |
rat |
| A Bechara, D van der Koo. Lesions of the tegmental pedunculopontine nucleus: effects on the locomotor activity induced by morphine and amphetamine. Pharmacology, biochemistry, and behavior. vol 42. issue 1. 1992-10-22. PMID:1528951. |
bilateral ibotenic acid lesions of the tegmental pedunculopontine nucleus (tpp) (a brainstem output of the limbic system that receives neuronal input from limbic forebrain and midbrain sites identified as primary sites for psychoactive drug reward) have been shown previously to block the acquisition, but not the retention, of morphine and amphetamine conditioned place preferences in formerly drug-naive rats. |
1992-10-22 |
2023-08-11 |
rat |
| C Heidbreder, M Gewiss, S Lallemand, B P Roques, P De Witt. Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon. Neuropharmacology. vol 31. issue 3. 1992-08-20. PMID:1321359. |
inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon. |
1992-08-20 |
2023-08-11 |
rat |
| A Herz, T S Shippenberg, R Bals-Kubik, R Spanage. [Opiate addiction. Pharmacologic and biochemical aspects]. Arzneimittel-Forschung. vol 42. issue 2A. 1992-06-16. PMID:1586396. |
opposite effects on da are observed in response to microinjections of selective antagonists for these receptor types, suggesting the existence of tonically active endogenous opioid systems which maintain da release in the mesolimbic system: a continuous "reward" tone, probably mediated by beta-endorphin in the ventral tegmentum of the midbrain and an "aversive" tone, mediated by dynorphin in the nucleus accumbens. |
1992-06-16 |
2023-08-11 |
Not clear |
| A Blander, R A Wis. Anatomical mapping of brain stimulation reward sites in the anterior hypothalamic area: special attention to the stria medullaris. Brain research. vol 483. issue 1. 1989-06-06. PMID:2706499. |
these data are consistent with the view that there exist at least two anatomically distinct brain stimulation reward pathways connecting the midbrain and forebrain: one in the medial forebrain bundle and a second in the dorsal diencephalic bundle. |
1989-06-06 |
2023-08-11 |
Not clear |
| L van Wolfswinkel, W F Seifert, J M van Re. Catecholamines and endogenous opioids in ventral tegmental self-stimulation reward. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:3211968. |
midbrain dopaminergic pathways and opioid receptor systems have been implicated in the reward experienced in electrical intracranial self-stimulation behavior. |
1989-02-23 |
2023-08-11 |
rat |
| M A Waraczynsk. Basal forebrain knife cuts and medial forebrain bundle self-stimulation. Brain research. vol 438. issue 1-2. 1988-04-18. PMID:3257893. |
current autoradiographic and electrophysiological data suggest that fibers coursing from the diagonal band/medial septum and lateral preoptic area through the medial forebrain bundle (mfb) to the midbrain may carry the reward signals generated by lateral hypothalamic stimulation. |
1988-04-18 |
2023-08-11 |
rat |
| R Thompson, P W Huestis, J Y. Motor learning: nonspecific subcortical mechanisms in rats. Archives of physical medicine and rehabilitation. vol 68. issue 7. 1987-08-13. PMID:3606364. |
adult rats with bilateral lesions in the globus pallidus, substantia nigra, median raphe, midbrain central gray, or pontine reticular formation were tested for novel motor skill learning (sliding a barrel bolt to the right in order to open a door leading to a reward). |
1987-08-13 |
2023-08-11 |
human |
| J E Kelsey, J D Belluzzi, L Stei. Does naloxone suppress self-stimulation by decreasing reward or by increasing aversion? Brain research. vol 307. issue 1-2. 1984-10-19. PMID:6467008. |
fifty-eight rats were implanted with electrodes in the ventrolateral midbrain central gray from which both self-stimulation reward and/or stimulation-produced analgesia can be obtained. |
1984-10-19 |
2023-08-12 |
rat |
| P W Glimcher, A A Giovino, D H Margolin, B G Hoebe. Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain. Behavioral neuroscience. vol 98. issue 2. 1984-06-22. PMID:6586195. |
endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain. |
1984-06-22 |
2023-08-12 |
rat |
| A G Phillips, A C McDonald, D M Wilki. Disruption of autoshaped responding to a single of brain-stimulation reward by neuroleptic drugs. Pharmacology, biochemistry, and behavior. vol 14. issue 4. 1981-07-20. PMID:7232475. |
repeated pairing of the onset of a stationary light (cs) that signalled electrical stimulation of brain-stimulation reward sites in the mesencephalon (us) resulted in autoshaped approach behavior to the cs. |
1981-07-20 |
2023-08-12 |
rat |