| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shyeilla V Dhuria, Leah R Hanson, William H Fre. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. Journal of pharmaceutical sciences. vol 99. issue 4. 2010-04-26. PMID:19877171. |
this review focuses on the current understanding of the mechanisms underlying intranasal delivery to the cns, with a discussion of pathways from the nasal cavity to the cns involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system. |
2010-04-26 |
2023-08-12 |
Not clear |
| Xia Li, Mingxin Fan, Yinxiang Cao, Zhen Hon. Electrical stimulation of the olfactory mucosa: an alternative treatment for the temporal lobe epilepsy? Medical hypotheses. vol 74. issue 1. 2010-03-16. PMID:19762161. |
different from vns, a tiny electrode for the stimulation will be minimized into a dimension small enough to fix into nasal cavity and attached to the olfactory mucosa through a nostril in current proposal, so the side effects of vns caused by operation will be totally avoided. |
2010-03-16 |
2023-08-12 |
Not clear |
| Kai-Li Hu, Ni Mei, Liang Feng, Xin-Guo Jian. Hydrophilic nasal gel of lidocaine hydrochloride. 2nd communication: Improved bioavailability and brain delivery in rats with low ciliotoxicity. Arzneimittel-Forschung. vol 59. issue 12. 2010-03-16. PMID:20108649. |
the pharmacokinetic parameters, along with olfactory and ventricle delivery of lid from nasal gel were compared with those of lid from nasal spray, intravenous injections and oral solutions in rats using microdialysis, and the drug targeting index (dti) was used to evaluate their brain delivery. |
2010-03-16 |
2023-08-12 |
rat |
| Satoru Kodama, Toshiaki Kawano, Masashi Suzuk. Endoscopic transnasal resection of ectopic esthesioneuroblastoma in the pterygopalatine fossa: technical case report. Neurosurgery. vol 65. issue 6 Suppl. 2010-03-05. PMID:19935009. |
esthesioneuroblastoma is a rare, malignant neoplasm arising from the olfactory neuroepithelium in the upper nasal cavity. |
2010-03-05 |
2023-08-12 |
Not clear |
| Andrew P Lane, Justin Turner, Lindsey May, Randall Ree. A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147558. |
inflammatory sinus and nasal disease is a common cause of human olfactory loss. |
2010-03-05 |
2023-08-12 |
mouse |
| Pedro Alberto Escada, Carlos Lima, José Madeira da Silv. The human olfactory mucosa. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 266. issue 11. 2010-02-25. PMID:19714350. |
the purpose of this review is to summarize the results of the most important studies and knowledge with regard to the human olfactory mucosa and its applications, emphasizing the issue of the distribution of the olfactory mucosa in the nasal cavities. |
2010-02-25 |
2023-08-12 |
human |
| J B Watelet, M Strolin-Benedetti, R Whomsle. Defence mechanisms of olfactory neuro-epithelium: mucosa regeneration, metabolising enzymes and transporters. B-ENT. vol 5 Suppl 13. 2010-02-23. PMID:20084803. |
finally, the permeability of nasal and olfactory mucosa is an important efficacy parameter for some anti-allergic drugs delivered by intranasal administration or inhalation. |
2010-02-23 |
2023-08-12 |
Not clear |
| P W Hellings, P Rombau. Medical therapy and smell dysfunction. B-ENT. vol 5 Suppl 13. 2010-02-23. PMID:20084807. |
olfactory dysfunction is deemed to be a significant contributor to poor quality of life in different nasal inflammatory conditions like common cold, allergic rhinitis, and acute and chronic rhinosinusitis with and without nasal polyps (np). |
2010-02-23 |
2023-08-12 |
Not clear |
| P W Hellings, P Rombau. Medical therapy and smell dysfunction. B-ENT. vol 5 Suppl 13. 2010-02-23. PMID:20084807. |
the mechanism underlying olfactory impairment in inflammatory sinonasal disease relates to either the obstruction of the olfactory cleft due to congestion of the nasal mucosa, the presence of secretions or polyps inside the nasal cavity, or to dysfunction of the sensory mucosa of the olfactory bulb resulting from local inflammation. |
2010-02-23 |
2023-08-12 |
Not clear |
| P W Hellings, P Rombau. Medical therapy and smell dysfunction. B-ENT. vol 5 Suppl 13. 2010-02-23. PMID:20084807. |
both nasal and systemic corticosteroids have a beneficial effect on olfactory dysfunction, with systemic treatment being the most powerful. |
2010-02-23 |
2023-08-12 |
Not clear |
| P Agthe, A R Caine, R N A Gear, J M Dobson, K J Richardson, M E Herrtag. Prognostic significance of specific magnetic resonance imaging features in canine nasal tumours treated by radiotherapy. The Journal of small animal practice. vol 50. issue 12. 2010-02-12. PMID:19954440. |
to investigate the prognostic significance of the magnetic resonance (mr) findings of meningeal hyperintensity of the olfactory bulbs and tumour extension into the caudal nasal recess (cnr) in dogs with nasal tumours treated by radiotherapy. |
2010-02-12 |
2023-08-12 |
Not clear |
| Guilherme J M Garcia, Julia S Kimbel. Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region. Inhalation toxicology. vol 21. issue 14. 2010-01-26. PMID:19831956. |
deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region. |
2010-01-26 |
2023-08-12 |
rat |
| Guilherme J M Garcia, Julia S Kimbel. Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region. Inhalation toxicology. vol 21. issue 14. 2010-01-26. PMID:19831956. |
previous in vivo and in vitro studies quantified the percentage of inhaled nanoparticles that deposit in the rat nasal passages, but olfactory dose was not determined. |
2010-01-26 |
2023-08-12 |
rat |
| Guilherme J M Garcia, Julia S Kimbel. Deposition of inhaled nanoparticles in the rat nasal passages: dose to the olfactory region. Inhalation toxicology. vol 21. issue 14. 2010-01-26. PMID:19831956. |
the purpose of this investigation, therefore, was to develop estimates of nanoparticle deposition in the nasal and, more specifically, olfactory regions of the rat. |
2010-01-26 |
2023-08-12 |
rat |
| Nikolaos Papadogeorgakis, Vassilis Petsinis, Efstathios Eleftheriades, Stefanos Dimtsas, Dimitra Protopappa, Constantinos Alexandridi. Large olfactory neuroblastoma (esthesioneuroblastoma) surgically treated with an Altemir technique modification: a case report. Oral and maxillofacial surgery. vol 13. issue 3. 2010-01-19. PMID:19506925. |
olfactory neuroblastomas are rare malignant tumors that usually occur in the upper nasal cavity. |
2010-01-19 |
2023-08-12 |
Not clear |
| Nikolaos Papadogeorgakis, Vassilis Petsinis, Efstathios Eleftheriades, Stefanos Dimtsas, Dimitra Protopappa, Constantinos Alexandridi. Large olfactory neuroblastoma (esthesioneuroblastoma) surgically treated with an Altemir technique modification: a case report. Oral and maxillofacial surgery. vol 13. issue 3. 2010-01-19. PMID:19506925. |
the purpose of this paper is to present a case of a large olfactory neuroblastoma filling the entire nasal cavity, treated with an altemir technique modification. |
2010-01-19 |
2023-08-12 |
Not clear |
| Yan J Zhang, Sherri Luroe, Frank Schieber, Joan Kelsey, Fizal Nabbie, Giovanni Rizzi, Penny Richards, Russell Weiner, Paul W Rhyn. Immunoassay-based measurement of clinical biomarkers for monitoring changes in nasal cavity. Journal of pharmaceutical and biomedical analysis. vol 50. issue 5. 2010-01-12. PMID:19625155. |
we assembled a panel of clinical biomarkers that can be used to monitor changes in the nasal epithelium, mucosa, and olfactory regions in preparation for clinical trials involving drugs administered via intranasal route. |
2010-01-12 |
2023-08-12 |
Not clear |
| Ruth Dooley, Sabrina Baumgart, Sebastian Rasche, Hanns Hatt, Eva M Neuhau. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. The FEBS journal. vol 276. issue 24. 2010-01-07. PMID:19909339. |
the unique ability of mammals to detect and discriminate between thousands of different odorant molecules is governed by the diverse array of olfactory receptors expressed by olfactory sensory neurons in the nasal epithelium. |
2010-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Bruce I Turetsky, Chang-Gyu Hahn, Karin Borgmann-Winter, Paul J Mober. Scents and nonsense: olfactory dysfunction in schizophrenia. Schizophrenia bulletin. vol 35. issue 6. 2010-01-06. PMID:19793796. |
with the opportunity to obtain olfactory neural tissue from live patients through nasal epithelial biopsy, the peripheral olfactory system offers a uniquely accessible window through which the pathophysiological antecedents and sequelae of schizophrenia may be observed. |
2010-01-06 |
2023-08-12 |
Not clear |
| Julie A Harris, Adrian K West, Meng Inn Chua. Olfactory ensheathing cells: nitric oxide production and innate immunity. Glia. vol 57. issue 16. 2010-01-05. PMID:19455713. |
olfactory nerves extend from the nasal cavity to the central nervous system and provide therefore, a direct route for pathogenic infection of the brain. |
2010-01-05 |
2023-08-12 |
rat |