| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G Schätzlein, Ijeoma F Uchegb. Nose-to-Brain Delivery. The Journal of pharmacology and experimental therapeutics. vol 370. issue 3. 2019-12-23. PMID:31126978. |
the key factors that determine the efficacy of delivery via this route include the following: delivery to the olfactory area of the nares as opposed to the respiratory region, a longer retention time at the nasal mucosal surface, penetration enhancement of the active through the nasal epithelia, and a reduction in drug metabolism in the nasal cavity. |
2019-12-23 |
2023-08-13 |
human |
| NTP Toxicity Studies of Cyclohexanone Oxime Administered by Drinking Water to B6C3F1 Mice (CAS No. 100-64-1). Toxicity report series. vol 50. 2019-11-20. PMID:11986677. |
some nasal olfactory epithelial degeneration was observed at all exposure levels; only at 625 ppm in males was the incidence of this lesion not significantly different from that in the controls. |
2019-11-20 |
2023-08-12 |
mouse |
| June Dunnuc. NTP technical report on the toxicity studies of of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CAS No. 110-54-3). Toxicity report series. vol 2. 2019-11-20. PMID:12209166. |
at the 10,000-ppm concentration, nasal lesions included inflammatory, erosive, and regenerative lesions of the olfactory and respiratory epithelium; luminal exudation and metaplastic lesions of the olfactory epithelium; and fibrosis of the submucosa. |
2019-11-20 |
2023-08-12 |
mouse |
| Charles Heber. NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity report series. vol 24. 2019-11-20. PMID:12209182. |
in rats, histopathologic lesions that were considered related to chemical exposure included inflammation and necrosis of laryngeal epithelium as well as focal inflammation and ulceration of the respiratory and olfactory nasal mucosa. |
2019-11-20 |
2023-08-12 |
mouse |
| Charles Heber. NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity report series. vol 24. 2019-11-20. PMID:12209182. |
nasal lesions, including focal inflammation and ulceration, and degeneration and necrosis of the olfactory and respiratory epithelium were also seen in mice. |
2019-11-20 |
2023-08-12 |
mouse |
| Charles Heber. NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity report series. vol 24. 2019-11-20. PMID:12209182. |
these lesions included minimal to mild focal erosion/ulceration, inflammation, and hyperplasia of the laryngeal epithelium as well as degeneration of the olfactory and respiratory nasal epithelium. |
2019-11-20 |
2023-08-12 |
mouse |
| Ronald Melnic. NTP technical report on the toxicity studies of Isoprene (CAS No. 78-79-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity report series. vol 31. 2019-11-20. PMID:12209193. |
in mice, exposure to isoprene caused decreases in hematocrit values, hemoglobin concentrations, and erythrocyte counts, atrophy of the testis and thymus, cytoplasmic vacuolization of the liver, olfactory epithelial degeneration in the nasal cavity, and epithelial hyperplasia in the forestomach. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 472. 2019-11-20. PMID:12579201. |
these lesions included necrosis, inflammation, hyperplasia, and squamous metaplasia of the epithelium; serous and suppurative exudate within the nasal passages; olfactory epithelial degeneration; and osteodystrophy of the turbinate bone. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 461. 2019-11-20. PMID:12587015. |
nasal lesions in exposed males and females included olfactory epithelial degeneration in males and females exposed to 375 ppm or greater and in one female exposed to 188 ppm and respiratory epithelial hyaline droplets and goblet cell hyperplasia in males and females in the 750 and 1,500 ppm groups; the severity of nasal lesions in males and females was minimal to mild. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Methyl Bromide (CAS: 74-83-9) in B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 385. 2019-11-20. PMID:12637959. |
an increased incidence of olfactory epithelial necrosis and metaplasia within the nasal cavity was seen in the mice exposed to 100 ppm, particularly males. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 376. 2019-11-20. PMID:12692645. |
conclusions: under the conditions of these 2-year inhalation studies, there was equivocal evidence of carcinogenic activity of allyl glycidyl ether for male osborne-mendel rats, based on the presence of one papillary adenoma of respiratory epithelial origin, one squamous cell carcinoma of respiratory epithelial origin, and one poorly differentiated adenocarcinoma of olfactory epithelial origin, all occurring in the nasal passage of males exposed to 10 ppm. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 376. 2019-11-20. PMID:12692645. |
significant exposure-related nonneoplastic lesions were restricted to the nasal passage in both rats and mice and induced inflammation, metaplasia, respiratory epithelial hyperplasia, and olfactory epithelial degeneration. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis Studies of Toluene (CAS No.108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program technical report series. vol 371. 2019-11-20. PMID:12692650. |
in the 15-month inhalation studies, the incidences and severity of nonneoplastic lesions of the nasal cavity (degeneration of olfactory and respiratory epithelium and goblet cell hyperplasia) were increased in exposed rats. |
2019-11-20 |
2023-08-12 |
mouse |
| . NTP Toxicology and Carcinogenesis of 1,2,3-Trichloropropane (CAS No. 96-18-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies). National Toxicology Program technical report series. vol 384. 2019-11-20. PMID:12692652. |
the principal toxic lesions associated with the administration of 1,2,3-trichloropropane to rats were hepatocellular necrosis, karyomegaly, and biliary hyperplasia of the liver; renal tubule necrosis, regeneration, and karyomegaly of the kidney; and necrosis and inflammation of the nasal olfactory and respiratory epithelium. |
2019-11-20 |
2023-08-12 |
mouse |
| S K Sarkar, A Acharya, S Jana, S K D. Macro-anatomical variation of the olfactory apparatus in some Indian teleosts with special reference to their ecological habitat. Folia morphologica. vol 73. issue 2. 2019-11-20. PMID:24902088. |
olfactory lamellae, olfactorychambers, accessory nasal sacs, olfactory nerve tracts, olfactory bulbs and brain) of some teleosts, viz. |
2019-11-20 |
2023-08-13 |
Not clear |
| A Mukherji, K S Reddy, S Vivekanandha. Case report: recurrent olfactory neuroblastoma nasal cavity in young boy refractory to chemotherapy with remission after radiotherapy and sparing of left eye. The Gulf journal of oncology. vol 1. issue 16. 2019-11-20. PMID:25316398. |
case report: recurrent olfactory neuroblastoma nasal cavity in young boy refractory to chemotherapy with remission after radiotherapy and sparing of left eye. |
2019-11-20 |
2023-08-13 |
Not clear |
| A Mukherji, K S Reddy, S Vivekanandha. Case report: recurrent olfactory neuroblastoma nasal cavity in young boy refractory to chemotherapy with remission after radiotherapy and sparing of left eye. The Gulf journal of oncology. vol 1. issue 16. 2019-11-20. PMID:25316398. |
olfactory neuroblastomas make up about 3-5% of malignant intra-nasal tumors and originate from the olfactory neuroepithelium lining the roof of the nasal vault. |
2019-11-20 |
2023-08-13 |
Not clear |
| Fumiaki Imamura, Sanae Hasegawa-Ishi. Environmental Toxicants-Induced Immune Responses in the Olfactory Mucosa. Frontiers in immunology. vol 7. 2019-11-20. PMID:27867383. |
although cell bodies are located in the olfactory mucosa (om) of the nasal cavity, osn axons directly project to the olfactory bulb (ob) that is a component of the central nervous system (cns). |
2019-11-20 |
2023-08-13 |
Not clear |
| Willem J Hilleniu. TURBINATES IN THERAPSIDS: EVIDENCE FOR LATE PERMIAN ORIGINS OF MAMMALIAN ENDOTHERMY. Evolution; international journal of organic evolution. vol 48. issue 2. 2019-11-20. PMID:28568303. |
the other mammalian turbinates principally retain the primitive, olfactory function of the nasal conchae. |
2019-11-20 |
2023-08-13 |
Not clear |
| Willem J Hilleniu. TURBINATES IN THERAPSIDS: EVIDENCE FOR LATE PERMIAN ORIGINS OF MAMMALIAN ENDOTHERMY. Evolution; international journal of organic evolution. vol 48. issue 2. 2019-11-20. PMID:28568303. |
ridges for olfactory turbinals are located posterodorsally, away from the main flow of respiratory air, whereas those of the respiratory maxilloturbinals are situated in the anterolateral portion of the nasal passage, directly in the path of respired air. |
2019-11-20 |
2023-08-13 |
Not clear |