| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Farnoud, Hesam Tofighian, Ingo Baumann, Andrew R Martin, Mohammad M Rashidi, Micheal P Menden, Otmar Schmi. Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study. Frontiers in pharmacology. vol 12. 2021-12-11. PMID:34887754. |
here we explore aerosol delivery with bi-directional pulsatile flow conditions for targeted drug delivery to the olfactory region using a computational fluid dynamics (cfd) model on the patient-specific nasal geometry. |
2021-12-11 |
2023-08-13 |
Not clear |
| Ali Farnoud, Hesam Tofighian, Ingo Baumann, Andrew R Martin, Mohammad M Rashidi, Micheal P Menden, Otmar Schmi. Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study. Frontiers in pharmacology. vol 12. 2021-12-11. PMID:34887754. |
the bi-directional aerosol delivery with steady flow rate of 4 l/min results in deposition efficiencies (des) of 50.9 and 0.48% in the nasal cavity and olfactory region, respectively. |
2021-12-11 |
2023-08-13 |
Not clear |
| Ali Farnoud, Hesam Tofighian, Ingo Baumann, Andrew R Martin, Mohammad M Rashidi, Micheal P Menden, Otmar Schmi. Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study. Frontiers in pharmacology. vol 12. 2021-12-11. PMID:34887754. |
in contrast, the local aerosol dose in the olfactory region of the left side is at least 100-fold lower than that in the nasal cavity independent of pulsation condition. |
2021-12-11 |
2023-08-13 |
Not clear |
| Jake J Lee, Andrew M Peterson, Dorina Kallogjeri, Pawina Jiramongkolchai, Sara Kukuljan, John S Schneider, Cristine N Klatt-Cromwell, Andrew J Drescher, Joseph D Brunworth, Jay F Piccirill. Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction. American journal of otolaryngology. vol 43. issue 2. 2021-12-11. PMID:34894449. |
smell changes and efficacy of nasal theophylline (scent) irrigation: a randomized controlled trial for treatment of post-viral olfactory dysfunction. |
2021-12-11 |
2023-08-13 |
Not clear |
| Katherine Chang, Dorina Kallogjeri, Jay Piccirillo, Stacey L House, Justin Turner, John Schneider, Nyssa Fox Farrel. Nasal inflammatory profile in patients with COVID-19 Olfactory Dysfunction. International forum of allergy & rhinology. 2021-12-10. PMID:34890110. |
nasal inflammatory profile in patients with covid-19 olfactory dysfunction. |
2021-12-10 |
2023-08-13 |
Not clear |
| Gian Pal, Vivian Ramirez, Phillip A Engen, Ankur Naqib, Christopher B Forsyth, Stefan J Green, Mahboobeh Mahdavinia, Pete S Batra, Bobby A Tajudeen, Ali Keshavarzia. Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease. NPJ Parkinson's disease. vol 7. issue 1. 2021-12-09. PMID:34880258. |
changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade and eventual dopamine loss in pd. |
2021-12-09 |
2023-08-13 |
human |
| Boo-Young Kim, Ju Y Park, Kwang J Cho, Jung H Ba. Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model. American journal of rhinology & allergy. vol 36. issue 1. 2021-12-07. PMID:34236242. |
although the nasal cavity is the first barrier to encounter upm, there is a lack of studies on the impact of upm on the olfactory area. |
2021-12-07 |
2023-08-13 |
mouse |
| Amit Jai. Olfactory Nasal Nitric Oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis? American journal of respiratory and critical care medicine. vol 204. issue 11. 2021-12-07. PMID:34491873. |
olfactory nasal nitric oxide link in covid-19: a marker of neurogenesis or risk factor for chronic rhinosinusitis? |
2021-12-07 |
2023-08-13 |
Not clear |
| Chad L Samuelsen, Roberto Vinci. Cortical Hub for Flavor Sensation in Rodents. Frontiers in systems neuroscience. vol 15. 2021-12-07. PMID:34867223. |
as foods and beverages enter the mouth, movements associated with chewing and swallowing activate somatosensory receptors in the oral cavity, dissolve tastants in the saliva to activate taste receptors, and release volatile odorant molecules to retronasally activate olfactory receptors in the nasal epithelium. |
2021-12-07 |
2023-08-13 |
human |
| Mario Turri-Zanoni, Giacomo Gravante, Gianluca Dalfino, Paolo Antognoni, Davide Locatelli, Paolo Battaglia, Paolo Castelnuov. Ectopic Primary Olfactory Neuroblastoma: Case Series and Literature Review. World neurosurgery. 2021-12-06. PMID:34785363. |
olfactory neuroblastoma (onb) is a rare malignant tumor arising in the upper nasal cleft. |
2021-12-06 |
2023-08-13 |
Not clear |
| Sapana Sharma, Harsha Jagadeesh, Ambrish Saxena, Harshini Chakravarthy, Vasudharani Devanatha. Central nervous system as a target of novel coronavirus infections: Potential routes of entry and pathogenic mechanisms. Journal of biosciences. vol 46. 2021-12-03. PMID:34840148. |
as soon as the virus enters the nasal region, it is exposed to the olfactory nervous system which is interlinked with the visual system, and hence we explore the mechanism of entry of this virus into cns, including brain, olfactory and retinal nervous systems. |
2021-12-03 |
2023-08-13 |
Not clear |
| Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowsk. Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa. Pharmaceutics. vol 13. issue 11. 2021-11-30. PMID:34834319. |
in this study, a previously developed catheter-based refined technique was validated against the conventional pipette-based method and used to specifically reach the olfactory or the respiratory nasal regions. |
2021-11-30 |
2023-08-13 |
mouse |
| Maria Julia Abrão Issa, Vitor Ramos Ribeiro de Oliveira, Flavio Barbosa Nunes, Luís Otávio Giovanardi Vasconcelos, Luiz Felipe Bartolomeu Souza, Giancarlo Bonotto Cherobin, Roberto Eustáquio Santos Guimarãe. Prevalence of respiratory epithelial adenomatoid hamartomas (REAH) associated with nasal polyposis: an epidemiological study - how to diagnose. Brazilian journal of otorhinolaryngology. 2021-11-30. PMID:34844870. |
to highlight the prevalence of respiratory epithelial adenomatoid hamartomas in the olfactory cleft of patients with nasal polyposis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiya. Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33433781. |
olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of parkinson disease. |
2021-11-29 |
2023-08-13 |
rat |
| Koichiro Muraki, Etsuyo Ogo, Gen Suzuki, Hiroaki Suefuji, Hidehiro Eto, Chiyoko Tsuji, Chikayuki Hattori, Yusaku Miyata, Jun Akiba, Toshi Ab. Radiation-Induced Olfactory Neuroblastoma Following Treatment for NK/T-cell Lymphoma, Nasal Type. The Kurume medical journal. 2021-11-29. PMID:34840203. |
radiation-induced olfactory neuroblastoma following treatment for nk/t-cell lymphoma, nasal type. |
2021-11-29 |
2023-08-13 |
Not clear |
| H L Sieron, F Sommer, J Lindemann, M O Scheithauer, M Wagenmann, F Stupp, T K Hoffman. [Symptoms, causes, and treatment options of geriatric nose]. HNO. vol 69. issue 12. 2021-11-26. PMID:34762159. |
many elderly patients complain about rhinitis with nasal obstruction, endonasal crusting, epistaxis, intermittent rhinorrhea, and olfactory disorders. |
2021-11-26 |
2023-08-13 |
Not clear |
| Filipa Gonçalves, Artur Ribeiro, Carla Silva, Artur Cavaco-Paul. Biotechnological applications of mammalian odorant-binding proteins. Critical reviews in biotechnology. vol 41. issue 3. 2021-11-25. PMID:33541154. |
in mammals, odorant-binding proteins (obps) are considered responsible to carry odorant molecules across the aqueous nasal mucus to the olfactory receptors (ors). |
2021-11-25 |
2023-08-13 |
Not clear |
| Richard L Doty, Vanina Popova, Crystal Wylie, Maggie Fedgchin, Ella Daly, Adam Janik, Rachel Ochs-Ross, Rosanne Lane, Pilar Lim, Kim Cooper, Rama Melkote, Carol Jamieson, Jaskaran Singh, Wayne C Drevet. Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies. CNS drugs. vol 35. issue 7. 2021-11-25. PMID:34235612. |
effect of esketamine nasal spray on olfactory function and nasal tolerability in patients with treatment-resistant depression: results from four multicenter, randomized, double-blind, placebo-controlled, phase iii studies. |
2021-11-25 |
2023-08-13 |
Not clear |
| Richard L Doty, Vanina Popova, Crystal Wylie, Maggie Fedgchin, Ella Daly, Adam Janik, Rachel Ochs-Ross, Rosanne Lane, Pilar Lim, Kim Cooper, Rama Melkote, Carol Jamieson, Jaskaran Singh, Wayne C Drevet. Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies. CNS drugs. vol 35. issue 7. 2021-11-25. PMID:34235612. |
however, in some cases such delivery may be harmful to nasal and olfactory epithelia. |
2021-11-25 |
2023-08-13 |
Not clear |
| A Bhadury, U K Roy, T Ghosh, D Barman, P Manda. Assessment of Prescribing Pattern and Safety Profile of Drugs Used in Intranasal Route in Paediatric Age Group of Patients in a Tertiary Care Hospital. Kathmandu University medical journal (KUMJ). vol 19. issue 73. 2021-11-24. PMID:34812160. |
background recently there has been an increased preference for intranasal delivery of drugs due to highly vascular nasal mucosa, bypassing first pass metabolism and the blood brain barrier (bbb) lead in quick drug absorption to the systemic circulation and direct access to brain from olfactory region. |
2021-11-24 |
2023-08-13 |
Not clear |